PubMed Journals Articles About "Scientists Take First Step Towards Digital Channels Brain" - Page: 16 RSS

13:10 EST 13th November 2019 | BioPortfolio

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Showing "Scientists take first step towards digital channels brain" PubMed Articles 376–400 of 14,000+

Comparison of comfort between cone beam breast computed tomography and digital mammography.

To compare the comfort levels of cone beam breast computed tomography (CBBCT) and digital mammography.

Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.

Inhibition of voltage-gated calcium (CaV) channels is a potential therapy for many neurological diseases including chronic pain. Neuronal CaV1/CaV2 channels are composed of α, β, γ and α2δ subunits. The β subunits of CaV channels are cytoplasmic proteins that increase the surface expression of the pore-forming α subunit of CaV. We targeted the high-affinity protein-protein interface of CaVβ's pocket within the CaVα subunit. Structure-based virtual screening of 50,000 small molecule library docked t...

Chairside measurement of the marginal and internal fit of crowns: a new intraoral scan-based approach.

To investigate the marginal and internal fit of crowns, a new intraoral scanner-based digital approach for chairside measurement (D-IOS) was systematically analysed and compared with the conventional silicone replica technique (CV-SR) and digital 3D analysis software (D-GOM).

The Use of Artificially Intelligent Self-Diagnosing Digital Platforms by the General Public: Scoping Review.

Self-diagnosis is the process of diagnosing or identifying a medical condition in oneself. Artificially intelligent digital platforms for self-diagnosis are becoming widely available and are used by the general public; however, little is known about the body of knowledge surrounding this technology.

The difference of subcutaneous digital nerve block method efficacy according to injection location.

Finger injuries are commonly attended to in the emergency department, and digital nerve block is a frequently performed procedure for such injuries. This study compared the efficacy levels of the subcutaneous method according to the different injection sites.

Mouse vs Man: Organoid Models of Brain Development & Disease.

Brain organoids have rapidly become established as promising tools for studying both the normal embryonic development of the brain and the mechanistic roots of neurodevelopmental disorders. Most recent studies are based on brain organoids derived from human pluripotent stem cells (PSCs), as these are likely to be the best way to understand normal human development and disease. However, brain organoids grown from mouse cells still have a role to play. We discuss recent work showing how mice and mouse organoi...

Homomeric GluA2(R) AMPA receptors can conduct when desensitized.

Desensitization is a canonical property of ligand-gated ion channels, causing progressive current decline in the continued presence of agonist. AMPA-type glutamate receptors (AMPARs), which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization. Recent cryo-EM studies of AMPAR assemblies show their ion channels to be closed in the desensitized state. Here we present evidence that homomeric Q/R-edited AMPARs still allow ions to flow when the receptors are desensitized. GluA...

The psychophysics of stereopsis can be explained without invoking independent ON and OFF channels.

Early vision proceeds through distinct ON and OFF channels, which encode luminance increments and decrements respectively. It has been argued that these channels also contribute separately to stereoscopic vision. This is based on the fact that observers perform better on a noisy disparity discrimination task when the stimulus is a random-dot pattern consisting of equal numbers of black and white dots (a "mixed-polarity stimulus," argued to activate both ON and OFF stereo channels), than when it consists of ...

Development of a Multigenerational Digital Lifestyle Intervention for Women Cancer Survivors and their Families.

This paper presents the results of a study developed to inform the design of a multigenerational digital lifestyle intervention for overweight/obese women cancer survivors and their families. We followed the first six phases of the Integrate, Design, Assess, and Share (IDEAS) framework.

CaverDock: A Molecular Docking-Based Tool to Analyse Ligand Transport through Protein Tunnels and Channels.

Protein tunnels and channels are key transport pathways that allow ligands to pass between proteins' external and internal environments. These functionally important structural features warrant detailed attention. It is difficult to study the ligand binding and unbinding process experimentally, while molecular dynamics simulations can be time-consuming and computationally demanding.

Anti-oxidative lithium reservoir based on interstitial channels of carbon nanotube bundles.

Lithium (Li) metal has garnered considerable attention in next-generation battery anodes. However, its environmental vulnerability, along with the electrochemical instability and safety failures, poses a formidable challenge to commercial use. Here, we describe a new class of anti-oxidative Li reservoir based on interstitial channels of single-walled carbon nanotube (SWCNT) bundles. The Li preferentially confined in the interstitial channels exhibits unusual thermodynamic stability and exceptional capacity ...

Hyperbaric oxygen toxicity in brain: A case of hyperoxia induced hypoglycemic brain syndrome.

Hyperbaric oxygen exposure is a recent hazzard for higher animals that originated as humans began underwater construction, exploration, and sports. Exposure can lead to abnormal brain EEG, convulsions, and death, the time to onset of each stage of pathology decreasing with increase in oxygen pressure. We provide evidence that hyperoxia, through oxidative phosphorylation, increases the energy state ([ATP]/[ADP][Pi]) of cells critical to providing glucose to cells behind the blood brain barrier (BBB). Brain c...

A Radiomic-feature based Nipple Detection Algorithm on Digital Mammography.

In the diagnosis and detection of breast lesions, the nipple is an important anatomical landmark which can be used for registration on multi-view mammograms. In this study, we propose a new detection algorithm for nipples on digital mammography (DM) by applying pixel classification based on geometric and radiomic features extracted from breast boundary regions.

Scientists caught in U.S. crackdown on China.

The conservative bias of life scientists.

A sulfonated mesoporous silica nanoparticle for enzyme protection against denaturants and controlled release under reducing conditions.

Mesoporous silica nanoparticles (MSiNPs) are attractive enzyme hosts, but current MSiNPs are limited by leaching, poor enzyme stabilization/protection, and difficulty in controlling enzyme release. Sulfonated MSiNPs are promising alternatives, but are challenged by narrow channels, lack of control over enzyme adsorption to particle surfaces, and controlled release of enzyme. By introducing amines on particle surfaces and sulfonate groups into the channels via disulfide bonds, we developed a unique sulfonate...

Brain dysfunction underlying prolonged post-concussive syndrome: A systematic review.

One out of 4 patients who sustains a mild traumatic brain injury (mTBI) experiences persistent complaints, despite the absence of structural brain damage on conventional neuroimaging. Susceptibility to develop post concussive symptoms (PCS) is thought to originate from occult brain dysfunction. However, the influence of such neural changes on the development of persistent PCS is poorly characterized.

HCN ion channels and accessory proteins in epilepsy: genetic analysis of a large cohort of patients and review of the literature.

The Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels are highly expressed in the Central Nervous Systems, where they are responsible for the I current. Together with specific accessory proteins, these channels finely regulate neuronal excitability and discharge activity. In the last few years, a substantial body of evidence has been gathered showing that modifications of I can play an important role in the pathogenesis of epilepsy. However, the extent to which HCN dysfunction is spread amo...

Motor cost affects the decision of when to shift gaze for guiding movement.

Frequent gait modifications are often required to navigate our world. These can involve long or wide steps, or changes in direction. People generally prefer to minimize the motor cost (or effort) of a movement, though with changes in gait, this is not always possible. The decision of when and where to shift gaze is critical for controlling motor actions, since vision informs the brain about the available choices for movement-in this case, where to step. Here we asked how motor cost influences the allocation...

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.

KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders. Paradoxical, excitatory GABA signaling is usually assumed to contribute to abnormal network activity underlying the pathology. We tested this hypothesis and explored the functional impact of chronic KCC2 downregulation in the rat dentate gyrus. Although the reversal potential of GABAA receptor currents is depolarized in...

Microwave channelizer based on a photonic dual-output image-reject mixer.

A microwave channelizer based on a photonic dual-output image-reject mixer (IRM) is proposed and demonstrated. By introducing the dual-output IRM based on the balanced Hartley structure, 2N channels can be produced by using the optical frequency combs (OFCs) with N comb lines. The required electrical hybrids and the optical filters are also reduced by half. In addition, the channelization efficiency is doubled, and the in-band interferences, including the image and the nonlinear mixing spurs, are greatly su...

Image Thresholding Improves 3-Dimensional Convolutional Neural Network Diagnosis of Different Acute Brain Hemorrhages on Computed Tomography Scans.

Intracranial hemorrhage is a medical emergency that requires urgent diagnosis and immediate treatment to improve patient outcome. Machine learning algorithms can be used to perform medical image classification and assist clinicians in diagnosing radiological scans. In this paper, we apply 3-dimensional convolutional neural networks (3D CNN) to classify computed tomography (CT) brain scans into normal scans (N) and abnormal scans containing subarachnoid hemorrhage (SAH), intraparenchymal hemorrhage (IPH), ac...

Acid sensing ion channels in rat cerebral arteries: Probing the expression pattern and vasomotor activity.

The recent identification of acid sensing ion channels (ASICs) in vascular beds suggests their possible involvement in modulating vasomotor tone. Therefore, we investigated the gene expression profiles of ASIC subtypes in the middle cerebral artery (MCA) of Wistar rats and the functional implication of ASICs in acidosis-induced relaxation as well as maintenance of resting tension.

Brain Dynamics: Global Pulse and Brain State Switching.

A major challenge in systems-level neuroscience is to understand the dynamic formation and succession of brain states. A new study has extracted reproducible brain states from mouse resting-state fMRI data, revealing interactions between occurrences of these states and the phase of global signal fluctuations and alterations of the states in a mouse model of autism.

"I was considering surgery because I believed that was how it was treated": A qualitative study on willingness for joint surgery after completion of a digital management program for osteoarthritis.

To explore, using a qualitative approach, reasons for patients' continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA).

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