PubMed Journals Articles About "Scientists Take First Step Towards Digital Channels Brain" - Page: 19 RSS

07:45 EST 22nd November 2019 | BioPortfolio

Scientists Take First Step Towards Digital Channels Brain PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Scientists Take First Step Towards Digital Channels Brain articles that have been published worldwide.

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Showing "Scientists take first step towards digital channels brain" PubMed Articles 451–475 of 14,000+

Dexamethasone reduces airway epithelial Cl secretion by rapid non-genomic inhibition of KCNQ1, KCNN4 and KATP K channels.

Basolateral membrane K channels play a key role in basal and agonist stimulated Cl transport across airway epithelial cells by generating a favourable electrical driving force for Cl efflux. The K channel sub-types and molecular mechanisms of regulation by hormones and secretagoues are still poorly understood. Here we have identified the type of K channels involved in cAMP and Ca stimulated Cl secretion and uncovered a novel anti-secretory effect of dexamethasone mediated by inhibition of basolateral membra...

Two-body dissociation of CH isomers investigated by 50 keV/u Ne impact.

The fragmentation of two isomers of CH, propyne (CHCCH) and allene (CHCCH), is investigated by 50 keV/u Ne impact. Obvious isomer effects are observed by comparing the time-of-flight spectra generated from the two isomers. Six two-body fragmentation channels of CH dications are identified for each isomer. CH + CH is found to be the most favored CC bond breaking channel for both isomers, indicating that CHCCH intends to rearrange to the structure containing the CH group before fragmentation. For CH bond brea...

Voxelwise statistical methods to localize practice variation in brain tumor surgery.

During resections of brain tumors, neurosurgeons have to weigh the risk between residual tumor and damage to brain functions. Different perspectives on these risks result in practice variation. We present statistical methods to localize differences in extent of resection between institutions which should enable to reveal brain regions affected by such practice variation.

Facetto: Combining Unsupervised and Supervised Learning for Hierarchical Phenotype Analysis in Multi-Channel Image Data.

Facetto is a scalable visual analytics application that is used to discover single-cell phenotypes in high-dimensional multi-channel microscopy images of human tumors and tissues. Such images represent the cutting edge of digital histology and promise to revolutionize how diseases such as cancer are studied, diagnosed, and treated. Highly multiplexed tissue images are complex, comprising 109 or more pixels, 60-plus channels, and millions of individual cells. This makes manual analysis challenging and error-...

Digital radiography as an alternative method in the evaluation of bone density in uremic rats.

Digital radiography (DRx) may provide a suitable alternative to investigate mineral and bone disorder (MBD) and loss of bone density (BD) in rodent models of chronic kidney disease (CKD). The objective of this study was to use DRx to evaluate BD in CKD rats, and to evaluate the correlation between DRx findings and serum MBD markers and bone histomorphometry.

Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis.

JBTS17 is a major gene mutated in ciliopathies such as Joubert syndrome and oral-facial-digital syndrome type VI. Most patients with loss of function mutations in JBTS17 exhibit cerebellar vermis hypoplasia and brain stem malformation. However, some patients with JBTS17 mutations show microcephaly and abnormal gyration. We examined potential roles of JBTS17 in neurogenesis to understand the pathological mechanism of JBTS17-related cortical abnormalities.

Fundamental constraints of vessels network architecture properties revealed by reconstruction of a rat brain vasculature.

The studies of mammalian vasculature are an essential part of biomedical research, enabling the development of physiological understanding and forming the background of medical techniques and therapy. Despite the fact that the basic principles of vessel network description were established in the first quarter of the twentieth century, a digital model describing the vasculature in full accordance with experimental data has not yet been created. In the present study, we combine the determined structure desig...

Neural oscillations and connectivity characterizing the state of tonic experimental pain in humans.

Pain is a complex phenomenon that is served by neural oscillations and connectivity involving different brain areas and frequencies. Here, we aimed to systematically and comprehensively assess the pattern of neural oscillations and connectivity characterizing the state of tonic experimental pain in humans. To this end, we applied 10-min heat pain stimuli consecutively to the right and left hand of 39 healthy participants and recorded electroencephalography. We systematically analyzed global and local measur...

Phosphorene-gold nanocomposite based microfluidic aptasensor for the detection of okadaic acid.

Okadaic acid (OA) is one of the most prevalent and largely distributed bio-toxin in the world. Consumption of OA results in a series of digestive ailments such as nausea and diarrhea. This study demonstrates the preparation and functioning of an electrochemical microfluidic biochip for the detection of OA. The screen-printed carbon electrode (SPCE) was modified by phosphorene-gold nanocomposite onto which an aptamer specific to OA was immobilized. BP-Au nanocomposites were synthesized by an in-situ, one-ste...

Spontaneous action potentials in retinal horizontal cells of goldfish () are dependent upon L-type Ca channels and ryanodine receptors.

Horizontal cells (HCs) are interneurons of the outer retina that undergo graded changes in membrane potential during the light response and provide feedback to photoreceptors. We characterized spontaneous Ca-based action potentials (APs) in isolated goldfish () HCs using electrophysiological and intracellular imaging techniques. Transient changes in intracellular Ca concentration ([Ca]) were observed with Fura-2, and were abolished by removal of extracellular Ca, or by inhibition of Ca channels by 50 µM Cd...

A comparison of presentation methods for conducting youth juries.

The 5Rights Youth Juries are an educational intervention to promote digital literacy by engaging participants (i.e. jurors) in a deliberative discussion around their digital rights. The main objective of these jury-styled focus groups is to encourage children and young people to identify online concerns and solutions with a view to developing recommendations for government policy-makers and industry chiefs. The methodology included a series of dramatized scenarios that encourage jurors to deliberate about t...

Habenula: A Role in Brain State Transitions during Coping Behavior.

What is the link between behavioral states and neural dynamics in the brain? New research using zebrafish has revealed a unique activity pattern in the brain, sequentially recruiting multiple habenular neurons, during the transition from active to passive coping behavior.

Noninvasive Brain Stimulation for Rehabilitation of Paediatric Motor Disorders Following Brain Injury: Systematic Review of Randomized Controlled Trials.

To assess the evidence of the effectiveness of noninvasive brain stimulation (NIBS) for rehabilitation of paediatric motor disorders after brain injury.

The Scientific Case for Brain Simulations.

A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scales between the neuron and system levels in the brain, and why a set of brain simulators based on neuron models at different levels of biological detail should therefore be developed. To allow for systematic refinement of candidate network models by compari...

Joint functional brain network atlas estimation and feature selection for neurological disorder diagnosis with application to autism.

Image-based brain maps, generally coined as 'intensity or image atlases', have led the field of brain mapping in health and disease for decades, while investigating a wide spectrum of neurological disorders. Estimating representative brain atlases constitute a fundamental step in several MRI-based neurological disorder mapping, diagnosis, and prognosis. However, these are strikingly lacking in the field of brain connectomics, where connectional brain atlases derived from functional MRI (fRMI) or diffusion M...

Scientists on the Spot: The cycle of basic science and clinical trials.

Characterization and kinetic study of the brain and muscle acetylcholinesterase from Danio rerio.

Acetylcholinesterase (AChE) plays an important role in the therapy of Alzheimer's disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. The aim of this study is the physicochemical and kinetic characterization of brain and muscle ChE from Danio rerio (Zebrafish). Optimal activity was found for brain ChE at alkaline pH 9.0 at 30 °C, and for muscle ChE at alkaline pH 8.5 at temperatures between 20 °C and 35 °C. The apparent kinetic con...

Genetic and Environmental Influence on the Human Functional Connectome.

Detailed mapping of genetic and environmental influences on the functional connectome is a crucial step toward developing intermediate phenotypes between genes and clinical diagnoses or cognitive abilities. We analyzed resting-state functional magnetic resonance imaging data from two adult twin samples (Nos = 446 and 371) to quantify genetic and environmental influence on all pairwise functional connections between 264 brain regions (~35 000 functional connections). Nonshared environmental influence w...

Analysis of an Integrated Human Multi-organ Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics.

Human-on-a-chip systems are rapidly advancing due to the availability of human stem cells from a variety of tissues, but publications have utilized mostly simple methods of biochemical analysis. Here, we apply mass spectrometry to a sophisticated multi-organ human-on-a-chip system for the comprehensive study of tolcapone metabolite profiling and metabolomics. The developed human-on-a-chip includes seven interacting microphysiological systems (MPSs): brain, pancreas, liver, lung, heart, gut, endometrium, wit...

Age effect on thyroid hormone brain response in male mice.

Thyroid hormones (TH) are important for brain development and central nervous system (CNS) function. Disturbances of thyroid function occur with higher prevalence in the ageing population and may negatively impact brain function.

Hysteretic four-step spin-crossover in a 3D Hofmann-type metal-organic framework with aromatic guest.

A new Hofmann-type metal-organic framework with bent pillar ligand, [Fe(dpoda){Ag(CN)2}2] (dpoda = 2,5-di-(pyridyl)-1,3,4-oxadiazole), was synthesized. Four-, two- and one-step spin-crossover (SCO) properties were obtained by using different sizes of aromatic guests. Most importantly, hysteretic four-step SCO behaviour with the sequence of LS ↔ HS0.25LS0.75 ↔ HS0.5LS0.5 ↔ HS0.67LS0.33 ↔ HS is observed for the first time.

The efficacy of digital single-operator cholangioscopy and factors affecting its accuracy in the evaluation of indeterminate biliary stricture.

Indeterminate biliary stricture remains a significant diagnostic challenge. The current method of ERCP with bile duct brush cytology has a substantial room for improvement. We aimed to determine the efficacy of a digital single operator cholangioscopy (DSOC) in evaluation of indeterminate biliary stricture.

Evaluation of Step-Counting Interventions Differing on Intensity Messages.

Step-counting interventions with discrepant intensity emphases may elicit different effects.

Step Frequency Training Improves Running Economy in Well-Trained Female Runners.

Quinn, TJ, Dempsey, SL, LaRoche, DP, Mackenzie, AM, and Cook, SB. Step frequency training improves running economy in well-trained female runners. J Strength Cond Res XX(X): 000-000, 2019-The purpose was to determine whether a short training program (15 minutes for 10 days) to increase step frequency to 180 steps per min would elicit improvements in running economy (RE). Experimental (n = 11) and control (n = 11) female subjects reported to the laboratory for 12 consecutive days and completed 2 RE tests at ...

RE: Warnings and caveats in brain controllability.

The use of network control theory to analyze the organization of white matter fibers in the human brain has the potential to enable mechanistic theories of cognition, and to inform the development of novel diagnostics and treatments for neurological disease and psychiatric disorders (Gu et al., 2015). The recent article (Tu et al., 2018) aims to challenge several of the contributions of (Gu et al., 2015), and particularly the conclusions that brain networks are theoretically controllable from single regions...

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