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PubMed Journals Articles About "Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc" - Page: 20 RSS

04:24 EDT 17th July 2019 | BioPortfolio

Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "Adalimumab biosimilar Idacio launched Germany derfield score derval" PubMed Articles 476–500 of 4,200+

The history and development of the Zeitschrift für Kinder- und Jugendpsychiatrie - Review and outlook on the occasion of its 45th anniversary.

The history and development of the - Review and outlook on the occasion of its 45th anniversary This article is based on archived documents and provides an overview of the founding of the and its precursor, the . The first volume of this journal appeared in 1973, 5 years after child and adolescent psychiatry had become an independent specialty in the Federal Republic of Germany. The founders of the journal and its first Editors-in-Chief were Hermann Stutte (1909-1982) and Hubert Harbauer (1019-1980). The...


Changes in chemical profile of Cascade hop cones according to the growing area.

The growing area has a substantial effect on plants, affecting secondary metabolism. In hops, different authors studied the effect of growing area on the chemical composition of cones with the aim of verifying and understanding the changes in hop characters. Despite the scant literature the subject receives an increasing attention by brewers and hop growers. The present study aimed to characterize with gas chromatography-mass spectrometry (GC-MS), and HPLC-UV, cones of hop (Humulus lupulus L.) cultivar Casc...

Dietary Manganese Exposure in the Adult Population in Germany - What Does it Mean in Relation to Health Risks?

Manganese is both an essential nutrient and a potential neurotoxicant. Therefore, the question arises whether the dietary manganese intake in the German population is on the low or high side. Results from a pilot total diet study in Germany presented here reveal that the average dietary manganese intake in the general population in Germany aged 14 to 80 years is about 2.8 mg/day for a person of 70 kg body weight. This exposure level is within the intake range of 2 - 5 mg per person and day as recommended ...


Lung ultrasound score as early predictor of bronchopulmonary dysplasia in very low birth weight infants.

Lung ultrasound (LU) has been widely used to diagnose and monitor acute lung diseases in neonates, but its role in chronic diseases has not been elucidated.

Fluorine-18-Labeled Fluciclovine PET/CT in Clinical Practice: Factors Affecting the Rate of Detection of Recurrent Prostate Cancer.

The purpose of this study is to show the performance and evaluate the factors influencing the positivity rate (PR) of commercially produced F-fluciclovine PET/CT in the detection of recurrent prostate cancer in clinical practice. We performed a retrospective cohort study of 152 men who had suspected biochemical recurrence of prostate cancer after receiving initial treatment and underwent fluciclovine PET/CT. PRs were calculated for whole-body, prostate and prostate bed, and extraprostatic locations. The in...

Apparent Diffusion Coefficient (ADC) Ratio Versus Conventional ADC for Detecting Clinically Significant Prostate Cancer With 3-T MRI.

The purpose of this study is to evaluate the performance of the apparent diffusion coefficient ratio (ADC; the ADC of the suspected prostate cancer [PCa] focus on MRI divided by the ADC in a noncancerous reference area) with that of conventional ADC for detection of high-grade PCa (Gleason score [GS] ≥ 3 + 4) versus low-grade PCa (GS = 3 + 3) with whole-mount (WM) histopathologic analysis used as a reference. The cohort of this retrospective study included 218 men with 240 unilateral PCa lesions assessed...

Interpretation of domain scores on the expanded prostate cancer index composite: How does the domain score translate into functional outcomes?

The Expanded Prostate Cancer Index-Short Form (EPIC-26) is a validated questionnaire for measuring health-related quality-of-life. However, the relationship between domain scores and functional outcomes remains unclear, leading to potential confusion about expectations after treatment. For instance, does a sexual function domain score of 80 mean a patient can obtain an erection sufficient for intercourse? Consequently, we sought to determine the relationship between domain score and response to obtaining th...

New insights into Early Celtic consumption practices: Organic residue analyses of local and imported pottery from Vix-Mont Lassois.

The rich Mediterranean imports found in Early Celtic princely sites (7th-5th cent. BC) in Southwestern Germany, Switzerland and Eastern France have long been the focus of archaeological and public interest. Consumption practices, particularly in the context of feasting, played a major role in Early Celtic life and imported ceramic vessels have consequently been interpreted as an attempt by the elite to imitate Mediterranean wine feasting. Here we present the first scientific study carried out to elucidate t...

Industrial perceptions of medicines regulatory harmonization in the East African Community.

Medicines regulatory harmonization has been recommended as one way to improve access to quality-assured medicines in low- and middle-income countries. The rationale is that by lowering barriers to entry more manufacturers will be enticed to enter the market, while the capacity at the national medicines regulatory authorities is strengthened. The African Medicines Regulatory Harmonization Initiative, agreed in 2009, is developing regional platforms with harmonized regulatory procedures for the registration o...

Evaluating the welfare of extensively managed sheep.

The aim of this study was to identify the main on-farm welfare issues likely to be encountered in extensive sheep farming systems. Thirty-two commercial sheep farms in Victoria, Australia were involved in this study. Of the 32 farms involved, 30 were visited twice (at mid-pregnancy and weaning), and 2 farms only once (both at weaning). In total, 62 visits were conducted and 6,200 ewes (aged 2-5 years) were examined using six animal-based indicators: body condition score (BCS), fleece condition, skin lesions...

Palladium-Catalyzed Enantioselective Alkenylation of Enelactams using a Relay Heck Strategy.

In this report, we describe a palladium-catalyzed redox relay Heck process to access optically active alkenylated α,β-unsaturated lactams. Under mild reaction conditions, electron-deficient alkenyl triflates and electron-rich alkenyl iodonium salts undergo enantioselective and site-selective coupling with enelactams to deliver the products in high yields and excellent enantioselectivities. Furthermore, the products allow facile access to natural products such as (+)-Calvine and (+)-2-Epicalvine in additio...

Collateral Automation for Triage in Stroke: Evaluating Automated Scoring of Collaterals in Acute Stroke on Computed Tomography Scans.

Computed tomography angiography (CTA) collateral scoring can identify patients most likely to benefit from mechanical thrombectomy and those more likely to have good outcomes and ranges from 0 (no collaterals) to 3 (complete collaterals). In this study, we used a machine learning approach to categorise the degree of collateral flow in 98 patients who were eligible for mechanical thrombectomy and generate an e-CTA collateral score (CTA-CS) for each patient (e-STROKE SUITE, Brainomix Ltd., Oxford, UK). Three ...

Measures for evaluation of prognostic improvement under multivariate normality for nested and nonnested models.

When comparing performances of two risk prediction models, several metrics exist to quantify prognostic improvement, including the change in the area under the Receiver Operating Characteristic curve, the Integrated Discrimination Improvement, the Net Reclassification Index at event rate, the change in Standardized Net Benefit, the change in Brier score, and the change in scaled Brier score. We explore the behavior and interrelationships between these metrics under multivariate normality in nested and nonne...

β-CsB9O14: A Triple-Layered Borate with Edge-Sharing BO4 Tetrahedra Exhibiting a Short Cutoff Edge and a Large Birefringence.

The first triple-layered borate with edge-sharing BO4 tetrahedra, β-CsB9O14 was obtained under the vacuum sealed condition. It represents a new structure type and enriches the structural diversity of borates. Moreover, β-CsB9O14 exhibits a short UV cutoff edge and a large birefringence, indicating that it could be regarded as the DUV birefringent crystals.

Secret Paper Using Vinegar as an Invisible Security Ink and Fire as a Decryption Key for Information Protection.

Security inks based on photoluminescent materials are mostly investigated for security applications such as the information encryption and decryption, anti-counterfeiting, and data storage. Although they are invisible to naked eyes under the ambient light, they can be detected under ultraviolet or near-infrared light. Herein, a new kind of the secret paper made from network-structured ultralong hydroxyapatite nanowires and cellulose fibers has been developed. The white vinegar, one of common cooking ingredi...

5-Methylcytosine is oxidized to the natural metabolites of TET-enzymes by a biomimetic iron(IV)oxo complex.

Ten-eleven-translocation (TET) methyl cytosine dioxygen-ases play a key role in epigenetics by oxidizing the epigenetic marker 5-methyl cytosine (5mC) to 5-hydroxymethyl cytosine (5hmC), 5-formyl cytosine (5fC), and 5-carboxy cytosine (5cC). While much of the metabolism of 5mC has been studied closely, certain aspects - such as discrepancies among the observed catalytic activity of TET enzymes and calculated bond-dissociation energies of the different cytosine substrates - remain elusive. We report here tha...

Strategic capture of the {Nb7} polyoxometalate.

Group V Nb-polyoxometalate (Nb-POM) chemistry generally lacks the elegant pH-controlled speciation exhibited by Group VI (Mo,W) POM chemistry. Here we isolate and structurally characterize three Nb-POM clusters; [Nb14O40(O2)2]14-, [((UO2)(H2O))3Nb46(UO2)2O136H8(H2O)4]24-, and [(Nb7O22H2)4(UO2)7(H2O)6]22-, that effectively capture the aqueous Nb-POM species from pH-7 to pH-10. These Nb-POMs illustrate a reaction pathway for control over speciation that is driven by countercations (Li+) rather than pH. The tw...

Template-Free, Surfactant-Mediated Orientation of Self-Assembled Supercrystals of Metal-Organic Framework Particles.

Mesoscale self-assembly of particles into supercrystals is important for the design of functional materials such as photonic and plasmonic crystals. However, while much progress has been made in self-assembling supercrystals adopting diverse lattices and using different types of particles, controlling their growth orientation on surfaces has received limited success. Most of the latter orientation control has been achieved via templating methods in which lithographic processes are used to form a patterned s...

A Facile and Effective Method for Patching Sulfur Vacancies of WS via Nitrogen Plasma Treatment.

Although transition metal dichalcogenides (TMDs) are attractive for the next-generation nanoelectronic era due to their unique optoelectronic and electronic properties, carrier scattering during the transmission of electronic devices, and the distinct contact barrier between the metal and the semiconductors, which is caused by inevitable defects in TMDs, remain formidable challenges. To address these issues, a facile, effective, and universal patching defect approach that uses a nitrogen plasma doping proto...

Superior Hydrogen Evolution Reaction Performance in 2H-MoS to that of 1T Phase.

In the hydrogen evolution reaction (HER), energy-level matching is a prerequisite for excellent electrocatalytic activity. Conventional strategies such as chemical doping and the incorporation of defects underscore the complicated process of controlling the doping species and the defect concentration, which obstructs the understanding of the function of band structure in HER catalysis. Accordingly, 2H-MoS and 1T-MoS are used to create electrocatalytic nanodevices to address the function of band structure in...

A Comparative Study of Two Modalities in Pain Management of Patients Presenting with Chronic Brachial Neuralgia.

The study aims to assess, evaluate, and compare the efficacy of acupressure and hypnotherapy in the management of pain in patients presenting with chronic brachial neuralgia (CBN). Randomized controlled trial. Department of Orthopaedic Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia. Forty patients with CBN following traumatic brachial plexus injury from 2012 to 2017. Therapy for a duration of 1 month in two groups; subjects in the hypnotherapy group received a weekly session of clinic...

Compression Vest Treatment for Symptomatic Breast Edema in Women Treated for Breast Cancer: A Pilot Study.

Lymphedema of the breast/chest wall after breast cancer treatment is often associated with pain and reduced quality of life. We conducted a pilot study to evaluate whether the use of a compression vest reduced symptoms of breast/chest wall edema in breast cancer patients. This single-center study included patients ( = 25) with symptomatic breast/chest wall edema with a pain score of ≥3 on the Numerical Rating Scales (range 1-10). The patients were instructed to wear a compression vest (Lymphatrex, Cl...

Association of Three Simple Insulin Resistance Indexes with Prehypertension in Normoglycemic Subjects.

Insulin resistance (IR) is the common pathophysiology of prehypertension and prediabetes. Recognition of IR in one of the two disease states is critical for carrying out preventive strategies of another disease state. This study aimed to explore which simple IR indexes were significantly associated with prehypertension in subjects with normoglycemia. A total of 108,370 adults without elevated fasting plasma glucose and hypertension were included in this study. The three simple IR indexes [triglycerides to ...

Novel approach to an early assessment of a patient's potential for neurological remission after acute spinal cord injury: Analysis of hemoglobin concentration dynamics.

Examining hemoglobin (Hb) dynamics with regard to the potential of neurological remission in patients with traumatic spinal cord injury (TSCI). Prospective Clinical Observational Study. BG Trauma Centre Ludwigshafen, Department of Paraplegiology, Rhineland-Palatinate, Germany. From 2011 to 2017 a total of 80 patients with acute spinal injury were enrolled and divided into three groups: initial neurological impairment either with (G1;  = 33) or without subsequent neurological remission (G0;  = 35)...

Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018.

In 2018, a cluster of pediatric human parechovirus (HPeV) infections in 2 neighboring German hospitals was detected. Viral protein 1 sequence analysis demonstrated co-circulation of different HPeV-3 sublineages and of HPeV-1 and -5 strains, thereby excluding a nosocomial outbreak. Our findings underline the need for HPeV diagnostics and sequence analysis for outbreak investigations.


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