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PubMed Journals Articles About "Building Pipeline∨derfield=score∨derval=DESC" - Page: 20 RSS

13:48 EDT 24th August 2019 | BioPortfolio

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Showing "Building Pipeline derfield score derval DESC" PubMed Articles 476–500 of 4,200+

Nickel-Catalyzed Asymmetric Hydrogenation of Cyclic Sulfamidate Imines: Efficient Synthesis of Chiral Cyclic Sulfamidates.

Chiral cyclic sulfamidates are useful building blocks to construct compounds, such as chiral amines, with important applications. Often these compounds can only be generated through expensive precious metal catalysts. Here, Ni(OAc)/(S, S)-Ph-BPE-catalyzed highly efficient asymmetric hydrogenation of cyclic sulfamidate imines was successfully developed, affording various chiral cyclic sulfamidates with high yields and excellent enantioselectivities (up to 99% yield, >99% enantiomeric excess [ee]). This Ni-ca...


The relevance of alpha phase in human perception.

Neural oscillations in the low frequencies, roughly in the alpha band (α, 5-15 Hz), have been suggested to act as a gateway from sensation to perception. This hypothesis assumes discrete perception. In particular, the amplitude and the phase of the low frequency rhythm entails a cortical mechanism which paces the access of sensory information into the cognitive system. Evidence supporting this idea includes correlations between the phase of neural oscillations and behavioral performance in perception, spa...

The Ottawa score performs poorly in cancer patients with incidental pulmonary embolism.

The Ottawa score was previously developed to predict recurrent venous thromboembolism (VTE) in cancer patients with VTE. The performance of this score in patients with incidental VTE is currently unclear.


Key aspects of building retrofitting: Strategizing sustainable cities.

Many cities are making efforts to develop an urban transformation strategy in order to transition from traditional cities to sustainable ones. Improving the energy efficiency of buildings, especially existing ones, is key to combating climate change. This paper uses a business perspective to analyze and compare three major retrofitting interventions under implementation in three different European cities, Nantes, Hamburg and Helsinki, to capture the principal needs and challenges and to identify governance...

Prenatal exposure to airborne polycyclic aromatic hydrocarbons and childhood growth trajectories from age 5-14 years.

There is evidence that exposures to polycyclic aromatic hydrocarbons (PAH) and fine particles in air pollution are associated with higher childhood body mass index (BMI). Birth cohort analyses of prenatal exposures to PAH and child BMI Z-scores from age 5-14 years were conducted. African-American and Hispanic children born in the Bronx or Northern Manhattan, New York (1998-2006), whose mothers underwent personal air monitoring for airborne PAH exposure during pregnancy, were followed up with measurements of...

Electronic Alberta Stroke Program Early CT score change and functional outcome in a drip-and-ship stroke service.

Debate continues as to whether patients with acute ischemic stroke with (suspected) large vessel occlusion benefit from direct referral versus secondary transportation.

A Clinical Risk Scoring System of Acute Respiratory Distress Syndrome-Induced Acute Kidney Injury.

BACKGROUND This study investigated the risk factors affecting development and prognosis of acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS). MATERIAL AND METHODS A total of 501 ARDS cases were retrospectively enrolled (296 males and 205 females) admitted to the First People's Hospital of Lianyungang from Aug 2015 to Aug 2017. Multivariable logistic modeling was conducted to select significant variables, and the assigned integer score was proportional to the adjusted odds...

High throughput quantification of the functional genes associated with RDX biodegradation using the SmartChip real-time PCR system.

The explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a contaminant at many military sites. RDX bioremediation as a clean-up approach has been gaining popularity because of cost benefits compared to other methods. RDX biodegradation has primarily been linked to six functional genes (diaA, nfsI, pnrB, xenA, xenB, xplA). However, current methods for gene quantification have the risk of false negative results because of low theoretical primer coverage. To address this, the current study designed new p...

Stroke Risk in Atrial Fibrillation: Beyond the CHADS-VASc Score.

Stroke prevention is the cornerstone of atrial fibrillation (AF) management and the anticoagulation decision is currently based on CHADS-VASc risk score. We discuss several novel risk factors besides those included in CHADS-VASc score and alternative models for stroke prediction.

Can digital X-ray radiogrammetry be an alternative for dual-energy X-ray absorptiometry in the diagnosis of secondary low bone quality in children?

Bone quality in children is generally measured with dual-energy X-ray absorptiometry (DXA). Digital X-ray radiogrammetry (DXR) uses BoneXpert to measure cortical bone quality on hand radiographs. This prospective study compared DXR and DXA results in children with high probability of secondary low bone quality, defined as DXA of the lumbar spine (DXA) Z-score ≤ - 2.0. One hundred one children underwent both DXA and DXR assessment. DXAZ-scores were also adjusted for bone age. DXR Z-scores were compared...

Quality of science and reporting of radiomics in oncologic studies: room for improvement according to radiomics quality score and TRIPOD statement.

To evaluate radiomics studies according to radiomics quality score (RQS) and Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) to provide objective measurement of radiomics research.

Wandering spiders recover more slowly than web-building spiders after fire.

Fire is a natural feature of many ecosystems, with some vegetation types highly adapted to fire. However, very little is known about the effect of fire on spiders, especially as fires have become more frequent owing to human activity. We determine whether different spider functional guilds (web builders vs. wanderers) respond differently to fires in the sclerophyllous fynbos. We determine also the effect of rockiness as refuge for these guilds and whether it influences their post-fire recovery. There were t...

The future of radiology is now: the first 100 articles published in European Radiology Experimental.

European Radiology Experimental reached the first 100 articles published in two years. Rejection rate was 30%, publication rate increased from 3.5/month in the first 12-month period to 4.8/month in the second 12-month period. The journal metrics were: 25 days from submission to first decision, 96 days from submission to acceptance, and 69 days from acceptance to publication. At the end of May 2019, we accumulated a total of 82,367 article accesses, 541 Altmetric score, and 110 citations for 92 published art...

Factors influencing community participation in the management of household electronic waste in West Surabaya, Indonesia.

The objective of the study was to determine the factors that influence community participation in the management of electronic waste. A survey of community willingness to participate in the management of electronic waste was conducted using questionnaires. Survey locations covered western areas of the city of Surabaya, Indonesia, where 238 respondents were selected proportionally from high-, medium-, and low-income groups during 2014. The group was divided by land and building taxes, which represents the so...

Clinical impact of complex percutaneous coronary intervention in patients with coronary artery disease.

For the revascularization of patients with clinical and anatomical complexities, several technical skills are often required. However, the prognostic effect of complex percutaneous coronary intervention (C-PCI) on the clinical outcomes is not well known. The aim of this study was to investigate the relationship between the C-PCI and mid-term clinical outcomes. We assessed 1062 patients who underwent PCI with newer-generation drug-eluting stent and stratified the patients according to whether they had comple...

Assessing Research Activity and Capacity of Community-Based Organizations: Refinement of the CREAT Instrument Using the Delphi Method.

Community-based organizations (CBOs) are essential partners in community-engaged research, yet little is known about their research capacity. Community experts and organizations bring unique knowledge of the community to research partnerships, but standard validated measures of CBO research capacity do not yet exist. We report here on the refinement through a structured Delphi panel of a previously developed and piloted framework of CBO research capacity and an accompanying instrument, the Community REsearc...

NMR-assisted protein structure prediction with MELDxMD.

We describe the performance of MELD-accelerated Molecular Dynamics (MELDxMD) in determining protein structures in the NMR-data-assisted category in CASP13. Seeded from web server predictions, MELDxMD was found best in the NMR category, over 17 targets, outperforming the next-best groups by a factor of ∼4 in Z-score. MELDxMD gives ensembles, not single structures; succeeds on a 326-mer, near the current upper limit for NMR structures; and predicts struc- tures that match experimental Residual Dipolar Coupl...

A comparison of automated lesion segmentation approaches for chronic stroke T1-weighted MRI data.

Accurate stroke lesion segmentation is a critical step in the neuroimaging processing pipeline for assessing the relationship between poststroke brain structure, function, and behavior. Many multimodal segmentation algorithms have been developed for acute stroke neuroimaging, yet few algorithms are effective with only a single T1-weighted (T1w) anatomical MRI. This is a critical gap because multimodal MRI is not commonly available due to time and cost constraints in the stroke rehabilitation setting. Althou...

Development and validation of a brachycephalic risk (BRisk) score to predict the risk of complications in dogs presenting for surgical treatment of brachycephalic obstructive airway syndrome.

To develop and validate a preoperative brachycephalic risk (BRisk) score that objectively and accurately predicts the risk of major complications or death in dogs undergoing corrective surgery for brachycephalic obstructive airway syndrome (BOAS).

Robust inference on the average treatment effect using the outcome highly adaptive lasso.

Many estimators of the average effect of a treatment on an outcome require estimation of the propensity score, the outcome regression, or both. It is often beneficial to utilize flexible techniques such as semiparametric regression or machine learning to estimate these quantities. However, optimal estimation of these regressions does not necessarily lead to optimal estimation of the average treatment effect, particularly in settings with strong instrumental variables. A recent proposal addressed these issue...

Building Generalized Linear Models with Ultrahigh Dimensional Features: A Sequentially Conditional Approach.

Conditional screening approaches have emerged as a powerful alternative to the commonly used marginal screening as they can identify marginally weak but conditionally important variables. However, most existing conditional screening methods need to fix the initial conditioning set, which may determine the ultimately selected variables. If the conditioning set is not properly chosen, the methods may produce false negatives and positives. Moreover, screening approaches typically need to involve tuning paramet...

Genetic parameters of meat quality, carcass composition and growth traits in commercial swine.

Swine industry breeding goals are mostly directed towards meat quality and carcass traits due to their high economic value. Yet, studies on meat quality and carcass traits including both phenotypic and genotypic information remain limited, particularly in commercial crossbred swine. The objectives of this study were: to estimate the heritabilities for different carcass composition traits and meat quality traits; and to estimate the genetic and phenotypic correlations between meat quality, carcass compositio...

Effects of ${\rm \small L}$-methionine on growth performance, carcass quality, feather traits, and small intestinal morphology of Pekin ducks compared with conventional ${\rm \small {DL}}$-methionine.

The research studied the effects of l-methionine (l-Met) on growth performance, carcass quality, feather traits, and small intestinal morphology of Pekin ducks compared with conventional dl-methionine (dl-Met). A total of 1080, 1-day-old male Pekin ducks were randomly allotted to 9 groups with 6 replicate pens of 20 birds each. During the starter phase (1 to 14 d), ducks were fed a basal diet (Met, 0.30%) or that supplemented with dl-Met or l-Met at 0.05, 0.10, 0.15, or 0.20% of feed. During the grower phas...

Drug discovery for chagas disease: A viewpoint.

Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. It is a significant public health problem, affecting millions of people worldwide. And although it was described 110 years ago, only two old nitroheterocyclic drugs, benznidazole and nifurtimox, are currently available for the treatment of Chagas disease and both have several limitations. Besides the clear unmet medical need, many challenges preclude the development of new treatments, some of them related to a...

Clinical efficacy of clodronic acid in horses diagnosed with navicular syndrome: A field study using objective and subjective lameness evaluation.

Navicular syndrome, a common cause of equine forelimb lameness, is associated with pathological changes in the navicular bone. Consequently, administration of bisphosphonates (BPs) has been advocated in order to modify the rate of bone turnover. The present study aimed to assess the clinical efficacy of intramuscularly administered clodronic acid for the treatment of 11 horses with clinical and radiographic findings compatible with navicular syndrome. Magnetic resonance imaging was performed in 5 of the 11 ...


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