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PubMed Journals Articles About "Electron Microscopy Project Could Revolutionize Search Drugs∨derfield=score∨derval=desc" - Page: 20 RSS

02:49 EDT 19th July 2019 | BioPortfolio

Electron Microscopy Project Could Revolutionize Search Drugs∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Electron Microscopy Project Could Revolutionize Search Drugs∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "Electron microscopy project could revolutionize search drugs derfield" PubMed Articles 476–500 of 14,000+

Deep Learning Approach for Enhanced Detection of Surface Plasmon Scattering.

A deep learning approach has been taken to improve detection characteristics of surface plasmon microscopy (SPM) of light scattering. Deep learning based on convolutional neural network algorithm was used to estimate the effect of scattering parameters mainly the number and the position of scatterers. The improvement was assessed on a quantitative basis by applying the approach to SPM images formed by coherent interference of scatterers. It was found that deep learning significantly improves the accuracy ov...


Transcriptomic and GC-MS metabolomic profiling analysis of epidermis provides insights into cuticular wax regulation in developing 'Yuluxiang' pear fruit.

The layer of cuticular wax covering fruits plays important roles in protecting against disease, preventing nonstomatal water loss and extending shelf life. However, the molecular basis of cuticular wax biosynthesis in pear (Pyrus) fruits remains elusive. Our study thoroughly investigates cuticular wax biosynthesis during pear fruit development from morphologic, transcriptomic and gas chromatography-mass spectrometry (GC-MS) metabolomic perspectives. Our results showed that cuticular wax concentrations incre...

Bioactive Secondary Metabolites from : A Comprehensive Review.

is widely underappreciated for its inherent biosynthetic potential. This report comprehensively summarizes the known bioactive secondary metabolites from and highlights potential applications as plant pathogen control agents, drugs, and biosurfactants. is well known for the production of cyclic lipopeptides exhibiting strong surfactant and antimicrobial activities, such as surfactins, iturins, and fengycins. Several polyketide-derived macrolides as well as nonribosomal peptides, dihydroisocoumarins, and l...


Surfactant-Induced Competitive Displacement of Potato Pectin-Protein Conjugate from the Air-Water Interface.

Potato pectin contains some proteinaceous components and exhibits emulsifying and emulsion stabilizing abilities. The objective of this study was to elucidate the effect of the pectin moiety of pectin-protein conjugate present in pectic extracts from potato tubers on their interfacial properties. Potato pectin was extracted from highly purified cell wall materials to avoid the contamination of unconjugated proteins. Abilities of the potato pectin to adsorb to graphite surfaces and to resist surfactant-induc...

Adjuvant trastuzumab regimen for HER2-positive early-stage breast cancer: a systematic review and meta-analysis.

: Breast cancer remains to be the globally leading female cancer. About 15% to 20% of breast cancers have human epidermal growth factor receptor 2 (HER2)-positive tumors - a more aggressive breast cancer subtype with shortened survival. In the light of new and updated trial data on trastuzumab therapy for HER2-positive early-stage breast cancer (EBC), we conducted a systematic review and meta-analysis to update the pooling of its relative treatment effects. : Systematic search was performed through Pubmed a...

Feasibility, Acceptability, and Preliminary Efficacy of a Brief Online Sexual Health Program for Adolescents.

This study evaluated the feasibility, acceptability, and preliminary efficacy of a 45-minute interactive, online sexual health program for adolescents, called Health Education and Relationship Training (HEART). The program was originally developed and evaluated among adolescent girls (HEART for Girls); the current project describes and evaluates a new version of the program that was adapted for boys and girls. Participants were 226 high school students (mean age = 16.3; 58% girls; 46% White; 79% heterosex...

Promoting Pt catalysis for CO oxidation via the Mott-Schottky effect.

CO oxidation is an important reaction both experimentally and industrially, and its performance is usually dominated by the charge states of catalysts. For example, CO oxidation on the platinum (Pt) surface requires a properly charged state for the balance of adsorption and activation of CO and O2. Here, we present "Mott-Schottky modulated catalysis" on Pt nanoparticles (NPs) via an electron-donating carbon nitride (CN) support with a tunable Fermi level. We demonstrate that properly-charged Pt presents an ...

1,2-Addition versus homoconjugate addition reactions of indoles and electron-rich arenes to α-cyclopropyl N-acyliminium ions: synthetic and computational studies.

An investigation of the reactivity of α-cyclopropyl N-acyliminium ions towards indoles has resulted in the unprecedented synthesis of 5-cyclopropyl-5-(3-indoyl)pyrrolidin-2-ones via 1,2-addition reactions and, in the case of highly electron deficient indoles and electron rich arenes, spiroheterocycles via sequential homoconjugate and 1,2-addition reactions with often high diastereoselective control at the C-5 quaternary stereocentres. Computational studies provided support for the proposed mechanisms and s...

Synthesis and electrochromic behavior of a multi-electron redox-active N-heteroheptacenequinone.

We report a novel N-heteroheptacenequinone derivative (C6OAHCQ) as a large π-conjugated framework. C6OAHCQ shows good electron-accepting behaviour owing to eight electron-deficient imino-N atoms and two carbonyl moieties and excellent solubility in common organic solvents. When a potential between 0 and -2.20 V is applied, C6OAHCQ is able to accept four electrons, which is more than fullerene C60 (three electrons) could accept in this voltage range. Moreover, a solution of C6OAHCQ and nBu4NPF6 in CH2Cl2 ex...

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research.

Each cancer is a complex system with unique molecular features determining its dynamics, such as its prognosis and response to therapies. Understanding the role of these biological traits is fundamental in order to personalize cancer clinical care according to the characteristics of each patient's disease. To achieve this, translational researchers propagate patients' samples through in vivo and in vitro cultures to test different therapies on the same tumor and to compare their outcomes with the molecular ...

Characterization of heart macrophages in rhesus macaques as a model to study cardiovascular disease in humans.

Rhesus macaques are physiologically similar to humans and, thus, have served as useful animal models of human diseases including cardiovascular disease. The purpose of this study was to characterize the distribution, composition, and phenotype of macrophages in heart tissues of very young (fetus: 0.5 years, n = 6), young adult (2-12 years, n = 12), and older adult (13-24 years, n = 9) rhesus macaques using histopathology and immunofluorescence microscopy. Results demonstrated that macrophages were uni...

Effects of levosimendan in heart failure: The role of echocardiography.

Heart failure (HF) represents a deadly epidemic that nowadays affects more than 2% of the general population, representing a major public health concern that implies a high economic burden for the health system. Levosimendan in HF patients is usually used for its inotropic and vasodilator effects that act without myocardial oxygen consumption, differently from other inotropic drugs. The symptoms and hemodynamic profile improve together with the myocardial function, and this can be demonstrated by an echocar...

Coordination Chemistry of P4S3 and P4Se3 towards the Iron Fragments Fe(Cp)(CO)2+ and Fe(Cp)(PPh3)(CO).

The complexes Ag(L)n[WCA] (L = P4S3, P4Se3, As4S3 and As4S4; [WCA] = [Al(ORF)4]- and [F{Al(ORF)3}2]-; RF = C(CF3)3) were tested for their performance as ligand transfer reagents to transfer the poorly soluble nortricyclane cages P4S3, P4Se3, and As4S3 as well as realgar As4S4 to different transition metal fragments. As4S4 and As4S3 with the poorest solubility did not yield complexes. However, the more soluble silver-coordinated P4S3 and P4Se3 cages were transferable to the electron poor Fp+ moiety ([CpFe(CO...

Cutaneous candidiasis - An evidence-based review of topical and systemic treatments to inform clinical practice.

Cutaneous candidiasis is a common skin disease and several treatments have been investigated within the last fifty years. Yet, systematic reviews are lacking, and evidence- based topical as well as systemic treatment strategies remain unclear. Thus, the aim of this review was to summarize efficacy and adverse effects of topical and oral therapies for cutaneous candidiasis in all age groups. Two individual researchers searched Pubmed and Embase for "cutaneous candidiasis" and "cutaneous candidiasis treatment...

Distribution of bacteria between different milk fractions, investigated using culture-dependent methods and molecular-based and fluorescent microscopy approaches.

To develop a protocol for DNA extraction using whole milk and further, to investigate how the use of whole instead of skimmed milk during DNA extraction affected the resulting microbial composition.

Cellular Imaging Using Stimulated Raman Scattering Microscopy.

Cellular imaging is an active area of research that enables researchers to monitor cellular dynamics, as well as responses to various external stimuli (physiological stress, exogenous compounds, etc.). Stimulated Raman scattering (SRS) microscopy is one popular experimental tool used to image cells, largely because of its chemical specificity, high spatial resolution, and high image acquisition speed. In this Perspective, the theoretical background and experimental implementation of SRS microscopy are discu...

The Clinically Used Iron Chelator Deferasirox is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.

Fe(II)- and 2-oxoglutarate (2OG)-dependent JumonjiC domain-containing histone demethylases (JmjC KDMs) are epigenetic eraser enzymes involved in the regulation of gene expression and are emerging drug targets in oncology. We screened a set of clinically used iron chelators and report that they potently inhibit JMJD2A (KDM4A) in vitro. Mode of action investigations revealed that one compound, deferasirox, is a bona fide active site-binding inhibitor as shown by kinetic and spectroscopic studies. Synthesis of...

DARK Classics in Chemical Neuroscience: Gamma-hydroxybutyrate (GHB).

Gamma-hydroxybutyrate (GHB) is a naturally occurring short-chain fatty acid that rose to prominence as a popular club drug in the 1990s. Originally developed as an anesthetic in the early 1960s, it was later sold as an over-the-counter dietary supplement before becoming a rising substance of abuse in the following decades as one of the 'date rape' drugs. Despite its abuse potential, there has been a recent surge in therapeutic interest in the drug due to its clinical viability in the treatment of narcolepsy...

Robust Automatic Identification of Microplastics in Environmental Samples using FTIR Microscopy.

The analysis of microplastics is mainly performed using Fourier transformation infrared spectroscopy/ microscopy (FTIR/ µFTIR). However, in contrast to most aspects of the analysis process, e.g., sampling, sample preparation and measurement, there is less known about data evaluation. This particularly critical step becomes more and more important if a large number of samples has to be handled. In this context, it is concerning that the commonly used library searching is not suitable to identify microplasti...

Theoretical Insights into the Selective Extraction of Americium(III) over Europium(III) with Dithioamide-Based Ligands.

Separation of trivalent actinides An(III) from lanthanides Ln(III) is a worldwide challenge owing to their very similar chemical behaviors. It is highly desirable to understand the nature of selectivity for the An(III)/Ln(III) separation with various ligands through theoretical calculations because of their radiotoxicity and experimental difficulties. In this work, we have investigated three dithioamide-based ligands and their extraction behaviors with Am(III) and Eu(III) ions using the scalar-relativistic ...

Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy.

A novel traceless protecting strategy is presented for the long-standing challenge of conducting the palladium-catalyzed α-arylation of carboxylic aids and secondary amides with aryl halides. Both of the presented coupling processes occur with a variety of carboxylic acids and amides and with a variety of aryl bromides containing a broad range of functional groups, including base-sensitive functionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups. Five commercial drugs were prepared t...

Generalized Valence Bond Perfect-Pairing Made Versatile Through Electron-Pairs Embedding.

We present an electron-pairs-based method providing a uniformly accurate description of systems where various types of electron correlation play a role. The proposed EERPA-GVB approach employs a generalized valence bond perfect-pairing (GVB-PP) ansatz amended by adding electron-pairs correlation. The latter is achieved by embedding single pairs, or couples of pairs, in the environment of the other electron fragments and separately accounting for intra- and inter-fragment correlation effects. For this purpos...

Strongly-compressed Few-layered SnSe2 films grown on SrTiO3 substrate: the coexistence of charge order and enhanced interfacial superconductivity.

High pressure has been demonstrated to be a powerful approach of producing novel condensed matter states, particularly in tuning the Tc of the superconductivity in a clean fashion without involving the complexity of chemical doping. However, the challenge of high pressure experiment hinders further in-depth research for underlying mechanism. Here, we have successfully synthesized continuous layer-controllable SnSe2 films on SrTiO3 substrate using molecular beam epitaxy. By means of scanning tunneling micros...

Oxidation of Monolayer WS in Ambient is a Photoinduced Process.

We have studied the ambient air oxidation of chemical vapor deposition (CVD) grown monolayers of the semiconducting transition metal dichalcogenide (S-TMD) WS using optical microscopy, laser scanning confocal microscopy (LSCM), photoluminescence (PL) spectroscopy, and atomic force microscopy (AFM). Monolayer WS exposed to ambient conditions in the presence of light (typical laboratory ambient light for weeks, or typical PL spectroscopy map), exhibits damage due to oxidation which can be detected with the LS...

Visual search in breast imaging: A review.

Breast cancer is the most common cancer among females worldwide and large volumes of breast images are produced and interpreted annually. As long as radiologists interpret these images, the diagnostic accuracy will be limited by human factors and both false-positive and false-negative errors might occur. By understanding visual search in breast images, we may be able to identify causes of diagnostic errors, find ways to reduce them, and also provide a better education to radiology residents. Many visual sea...


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