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PubMed Journals Articles About "Ganaxolone Phase Data Supports Progressing Phase Patients With" - Page: 20 RSS

02:42 EDT 23rd June 2018 | BioPortfolio

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Showing "Ganaxolone Phase Data Supports Progressing Phase Patients with" PubMed Articles 476–500 of 58,000+

Certolizumab Pegol for the Treatment of Chronic Plaque Psoriasis: Results Through 48 Weeks of a Phase 3, Multicenter, Randomized, Double-Blinded, Etanercept- and Placebo-Controlled Study (CIMPACT).

Phase 2 psoriasis studies with the Fc-free, PEGylated, anti-tumor necrosis factor biologic certolizumab pegol demonstrated meaningful clinical activity.


Ab Initio Calculation of the Miscibility Diagram for Hydrogen-Helium Mixtures.

We use finite-temperature density functional theory coupled to classical molecular dynamics simulation to calculate the miscibility gap of hydrogen-helium mixtures. The van der Waals density functional (vdW-DF) theory is used, which leads to lower demixing temperatures compared to computations using the Perdew-Burke-Ernzerhof functional. Our calculations suggest that current Jupiter models are most likely too hot to allow demixing in the interior. A Jupiter isentrope based on our vdW-DF data is presented. O...

Transmission out-of-plane interferometer to study thermal distributions in liquids.

An optical setup that does not need in-line alignment of the object illumination and camera sensor, or requires a reflection mirror after the sample, is introduced to observe the optical phase in a heating liquid. This system uses an out-of-plane transmission digital holographic interferometer that uniformly adds speckle to the image holograms by means of a neutral phase screen. The way in which the liquid is illuminated allows having a variable magnification of the observed area of the sample. As a proof o...


Phospholipid Chain Interactions with Cholesterol Drive Domain Formation in Lipid Membranes.

Cholesterol is a key component of eukaryotic membranes, but its role in cellular biology in general and in lipid rafts in particular remains controversial. Model membranes are used extensively to determine the phase behavior of ternary mixtures of cholesterol, a saturated lipid, and an unsaturated lipid with liquid-ordered and liquid-disordered phase coexistence. Despite many different experiments that determine lipid-phase diagrams, we lack an understanding of the molecular-level driving forces for liquid ...

Using machine-learning to optimize phase contrast in a low-cost cellphone microscope.

Cellphones equipped with high-quality cameras and powerful CPUs as well as GPUs are widespread. This opens new prospects to use such existing computational and imaging resources to perform medical diagnosis in developing countries at a very low cost. Many relevant samples, like biological cells or waterborn parasites, are almost fully transparent. As they do not exhibit absorption, but alter the light's phase only, they are almost invisible in brightfield microscopy. Expensive equipment and procedures for m...

The long periodicity phase (LPP) controversy part I: The influence of a natural-like ratio of the CEREOS analogue EOS-br in a CERNP/AP based stratum corneum modelling system: A neutron diffraction study.

This study used neutron diffraction to investigate a ceramide-[NP] C24/[AP] C24 /[EOS]-br C30/cholesterol/lignoceric acid (0.6: 0.3: 0.1: 0.7: 1) based stratum corneum modelling system. By adding specifically deuterated ceramides-[NP]-D, [AP]-D, and [EOS]-br-D, detailed information on the lamellar and the nanostructure of the system was obtained. For the short periodicity phase a natural-like lamellar repeat distance of 5.47 ± 0.02 nm was observed, similar to the [NP]/[AP] base system without the [EO...

Protonation of polyaniline-coated silica stationary phase affects the retention behavior of neutral hydrophobic solutes in reversed-phase capillary liquid chromatography.

Thanks to its high conductivity when acid doped, polyaniline is known as a synthetic metal and is used in a wide range of applications, such as supercapacitors, biosensors, electrochromic devices or solar and fuel cells. Emeraldine is the partly oxidized, stable form of polyaniline, consisting of alternating diaminobenzenoid and iminoquinoid segments. When acidified, the nitrogen atoms of emeraldine become protonated. Due to electrostatic repulsion between positive charges, the polarity and morphology of em...

Simulation of phase separation with temperature-dependent viscosity using lattice Boltzmann method.

This paper presents an exploration of the phase separation behavior and pattern formation in a binary fluid with temperature-dependent viscosity via a coupled lattice Boltzmann method (LBM). By introducing a viscosity-temperature relation into the LBM, the coupling effects of the viscosity-temperature coefficient [Formula: see text] , initial viscosity [Formula: see text] and thermal diffusion coefficient [Formula: see text] , on the phase separation were successfully described. The calculated results indic...

Population Pharmacokinetic Modeling With Enterohepatic Circulation for AZD3241 in Healthy Subjects and Patients With Multiple System Atrophy.

AZD3241 is a potent and selective myeloperoxidase inhibitor potentially for the treatment of a number of neurodegenerative disorders, including multiple system atrophy (MSA). The objectives of this work were to develop a population pharmacokinetic (PopPK) model for AZD3241 and to investigate the correlation between AZD3241 exposure and myeloperoxidase inhibition. The PopPK model was developed using AZD3241 data from one phase 1 study in healthy subjects and one phase 2 study in patients with MSA. A one-comp...

Design and Analysis of a Data Fusion Scheme in Mobile Wireless Sensor Networks Based on Multi-Protocol Mobile Agents.

Sensors are increasingly used in mobile environments with wireless network connections. Multiple sensor types measure distinct aspects of the same event. Their measurements are then combined to produce integrated, reliable results. As the number of sensors in networks increases, low energy requirements and changing network connections complicate event detection and measurement. We present a data fusion scheme for use in mobile wireless sensor networks with high energy efficiency and low network delays, that...

Randomised phase III trial of vinflunine plus capecitabine versus capecitabine alone in patients with advanced breast cancer previously treated with an anthracycline and resistant to taxane.

Capecitabine is an approved standard therapy for anthracycline- and taxane-pretreated locally advanced or metastatic breast cancer (BC). Vinflunine has demonstrated single-agent activity in phase II studies in this setting, and activity and tolerability when combined with capecitabine. We compared the combination of vinflunine plus capecitabine (VC) with single-agent capecitabine.

Dynamic joint stiffness of the ankle in healthy and rheumatoid arthritis post-menopausal women.

The purpose of this study was to compare rheumatoid arthritis post-menopausal women (RAPW) with pathological involvement of the lower limb joints and age-matched healthy post-menopausal women (AHPW) in regard to the dynamic joint stiffness of the ankle (DJSankle) during the stance phase of gait. Data were collected from 18 RAPW and 18 AHPW. Gait was assessed by a three-dimensional motion analysis system synchronised with a force plate. Subjects walked barefoot at natural and self-selected speed, performing ...

Soft X-ray spectroscopy as a probe for gas-phase protein structure: electron impact ionization from within.

Preservation of protein conformation upon transfer into the gas-phase is key for structure determination of free single molecules, e.g. using X-ray free-electron lasers. In the gas phase, the helicity of melittin decreases strongly as the protein's protonation state increases. We demonstrate the sensitivity of soft X-ray spectroscopy to the gas phase conformation of melittin cations ([melittin+qH]q+, q=2-4) in a cryogenic linear radiofrequency ion trap. With increasing helicity we observe a decrease of the ...

Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins.

Liquid-liquid phase separation resulting in formation of colloidal droplets has recently attracted attention as a mechanism for rapid and transient assembly of intracellular macromolecules into functional units. Phase separation also appears to be a widespread and evolutionarily ancient mechanism for organization of proteins of the extracellular matrix into fibrillar, polymeric assemblies. Elastin, which provides the physical properties of extensibility and elastic recoil to large arteries, lungs and other ...

Binocular contrast-gain control for natural scenes: image structure and phase alignment.

In the context of natural scenes, we applied the pattern-masking paradigm to investigate how image structure and phase alignment affect contrast-gain control in binocular vision. We measured the discrimination thresholds of bandpass-filtered natural-scene images (targets) under various types of pedestals. our first experiment had four pedestal types: bandpass-filtered pedestals, unfiltered pedestals, notch-filtered pedestals (which enabled removal of the spatial frequency), and misaligned pedestals (which i...

Imprinted naked Pt nanoparticles on N-doped carbon supports: A synergistic effect between catalyst and support.

A synergistic effect resulting from the interaction of small (2.4-3.1 nm) naked Pt nanoparticles (NPs) imprinted on N-doped carbon supports is evidenced by structural, electronic and electrochemical characterization. The size and distribution of the sputtered Pt NPs are found to be related to the nature of the support, as Pt NPs are preferentially located at Ngraphitic sites. In addition, Rutherford backscattering shows that a deeper penetration of the Pt NPs is obtained in the N-doped carbon support with l...

Transplant conditioning with Treosulfan/Fludarabine with or without TBI. A randomized phase II trial in patients with MDS and AML.

In this prospective randomized phase II "pick the winner" trial we assessed the efficacy of transplant conditioning with treosulfan/fludarabine ± 2 Gy total body irradiation (TBI) in reducing post-transplant relapse in 100 patients, 2-70 (median 57) years of age, with myelodysplastic syndrome/chronic myelomonocytic leukemia (MDS/CMML; n=51) or acute myeloid leukemia (AML; n=49). Patients received intravenous (IV) treosulfan, 14 g/m2/day on days -6 to -4 and IV fludarabine, 30 mg/m2/day on days -6 to -2, al...

Gapless Spin Excitations in the Field-Induced Quantum Spin Liquid Phase of α-RuCl_{3}.

α-RuCl_{3} is a leading candidate material for the observation of physics related to the Kitaev quantum spin liquid (QSL). By combined susceptibility, specific-heat, and nuclear-magnetic-resonance measurements, we demonstrate that α-RuCl_{3} undergoes a quantum phase transition to a QSL in a magnetic field of 7.5 T applied in the ab plane. We show further that this high-field QSL phase has gapless spin excitations over a field range up to 16 T. This highly unconventional result, unknown in either Heisen...

Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates.

Faithful DNA replication is challenged by stalling of replication forks during S phase. Replication stress is further increased in cancer cells or in response to genotoxic insults. Using live single-cell image analysis, we found that CDK2 activity fluctuates throughout an unperturbed S phase. We show that CDK2 fluctuations result from transient ATR signals triggered by stochastic replication stress events. In turn, fluctuating endogenous CDK2 activity causes corresponding decreases and increases in DNA sy...

A phase II trial of gemcitabine, S-1 and LV combination (GSL) neoadjuvant chemotherapy for patients with borderline resectable and locally advanced pancreatic cancer.

There has been a pressing need to develop optimal regimen for neoadjuvant chemotherapy (NAC) for pancreatic cancer (PC). The safety and efficacy of gemcitabine, S-1, and LV combination (GSL) therapy as NAC for borderline resectable (BR) and locally advanced (LA) PC was evaluated in this phase II study. Patients with pathologically proven BR or LA PC were enrolled and gemcitabine 1000 mg/m by 30-min infusion on day 1, S-1 40 mg/m orally twice daily, and LV 25 mg orally twice daily on days 1-7 every 2 week...

Nanoscale tilt measurement using a cyclic interferometer with polarization phase stepping and multiple reflections.

High-accuracy tilt or roll angle measurement is required for a variety of engineering and scientific applications. A cyclic interferometer with multiple reflections has been developed to measure small tilt angles. To accomplish this task, a novel and simple method, phase shift by polarization, was developed. The results of these studies show that the multiple reflection cyclic interferometers can be used to measure object tilts on the order of 0.2 nano-radians. We develop the theory for polarization phase s...

Characteristic phase distribution in the white matter of infants on phase difference enhanced imaging.

The infantile brain is continuously undergoing development. Non-invasive methods to assess the neurological development of infants are important for the early detection of abnormalities. Some microstructures in the brain have been demonstrated via phase difference-enhanced imaging (PADRE), which may reflect myelin-related microstructures. We aimed to assess the white matter (WM) signal distribution in infants using PADRE and compared it with that using T1-weighted images (T1WI) and diffusion tensor imaging ...

The Temporal Regulation of S Phase Proteins During G1.

Successful DNA replication requires intimate coordination with cell-cycle progression. Prior to DNA replication initiation in S phase, a series of essential preparatory events in G1 phase ensures timely, complete, and precise genome duplication. Among the essential molecular processes are regulated transcriptional upregulation of genes that encode replication proteins, appropriate post-transcriptional control of replication factor abundance and activity, and assembly of DNA-loaded protein complexes to licen...

The role of multimodal treatment in patients with advanced lung neuroendocrine tumors.

Lung neuroendocrine tumors (NETs) comprise typical (TC) and atypical carcinoids (AC). They represent the well differentiated (WD) or low/intermediate grade forms of lung neuroendocrine neoplasms (NENs). Unlike the lung poorly differentiated NENs, that are usually treated with chemotherapy, lung NETs can be managed with several different therapies, making a multidisciplinary interaction a key point. We critically discussed the multimodal clinical management of patients with advanced lung NETs. Provided that ...

Solid-Phase Synthesis of Pyrrole Derivatives through a Multicomponent Reaction Involving Lys Containing Peptides.

The synthesis of pyrroles has received considerable attention because of their biological and pharmaceutical activities. Herein we describe a solid-phase multicomponent reaction that utilizes Lys as a N donor, β-nitrostyrenes, 1,3-dicarbonyl compounds, and FeCl3 as an easily accessible catalyst under microwave irradiation affords the subsequent pyrrole derivatives in high conversions. The strategy combines three of the most powerful tools in modern synthetic chemistry: the solid-phase mode, the microwave a...


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