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PubMed Journals Articles About "Oncobiologics Announces Strategic Partnership With Tenshi Holdings Limited" - Page: 20 RSS

15:35 EST 18th January 2019 | BioPortfolio

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Showing "Oncobiologics announces strategic partnership with Tenshi Holdings Limited" PubMed Articles 476–500 of 524

The driver-level crash risk associated with daily cellphone use and cellphone use while driving.

This study examined the overall prevalence of cellphone use, including the rates of calls and texts both per day and hourly while driving, and assessed whether or not individual crash risk was correlated with cellphone use. The study used data from the Second Strategic Highway Research Program Naturalistic Driving Study (SHRP 2 NDS), which had more than 3500 participants who provided up to three years of driving data. Of these participants, 620 provided cellphone records, 564 of which included both call and...


Randomized program evaluation of the Veterans Health Administration Stratification Tool for Opioid Risk Mitigation (STORM): A research and clinical operations partnership to examine effectiveness.

The United States is facing an opioid crisis in which overdose is the leading cause of injury death-misuse of opioids constitutes the vast majority of those deaths. In 2016 alone, over 42,000 people died from opioid overdose, an increase of 27% from the prior year. Deployment of the Stratification Tool for Opioid Risk Mitigation (STORM), a clinical decision support tool to improve opioid safety, is one response by the Veterans Health Administration (VHA) to the opioid crisis. STORM identifies VHA patients a...

Perceptions of climate change across the Canadian forest sector: The key factors of institutional and geographical environment.

Assessing the perception of key stakeholders within the forest sector is critical to evaluating their readiness to engage in adapting to climate change. Here, we report the results of the most comprehensive survey carried out in the Canadian forestry sector to date regarding perceptions of climate change. A total of 1158 individuals, representing a wide range of stakeholders across the five most important forestry provinces in Canada, were asked about climate change, its impact on forest ecosystems, and the...


High Genetic Diversity and No Population Structure of the New World Screwworm Fly Cochliomyia hominivorax (Diptera: Calliphoridae) on a Microgeographic Scale: Implications for Management Units.

The New World screwworm fly Cochliomyia hominivorax (Coquerel, 1858) (Diptera: Calliphoridae) is an important livestock pest endemic to the Americas that has been eradicated from North and continental Central America with a control program based on the Sterile Insect Technique (SIT). The establishment of target management units is a strategic step in the implementation of new control programs, which can be achieved using genetic studies of natural populations. Previous studies of New World screwworm fly pop...

Cytotoxic and genotoxic effects of antihypertensives distributed in Brazil by social programs: Are they safe?

Hypertension, a chronic non-transmissible multifactorial condition, it is highly frequent in Brazil, affecting about 32.5% of the population over 25 years of age. It is characterized by the sustained increase in systolic and diastolic blood pressure levels above 140 mmHg and 90 mmHg, respectively. It is the major aggravating factor in cardiovascular complications and the appearance of other comorbidities. Aiming to promote greater adherence to treatment and improve the population's access to basic medic...

Spatial Gradients of Ecosystem Health Indicators across a Human-Impacted Semiarid Savanna.

Drivers of soil organic carbon (SOC) dynamics involve a combination of edaphic, human, and climatic factors that influence and determine SOC distribution across the landscape. High-resolution maps of key indicators of ecosystem health can enable assessments of these drivers and aid in critical management decisions. This study used a systematic field-based approach coupled with statistical modeling and remote sensing to develop accurate, high-resolution maps of key indicators of ecosystem health across savan...

Standardizing the evaluation of community-based conservation success.

Community-based conservation, which strives to simultaneously improve nature conservation and alleviate poverty, must provide biological and socioeconomic benefits that are linked through effective resilience mechanisms. To date, few community-based conservation initiatives have published comprehensive assessments that track performance in these elements of success. With 45% of the world's protected areas in comanagement with local communities, standardized measures to effectively evaluate the dual goals of...

Aging effects on symbolic number comparison: No deceleration of numerical information retrieval but more conservative decision-making.

Whereas many cognitive tasks show pronounced aging effects, even in healthy older adults, other tasks seem more resilient to aging. A small number of recent studies suggests that number comparison is possibly one of the abilities that remain unaltered across the life span. We investigated the ability to compare single-digit numbers in young (19-39 years; n = 39) and healthy older (65-79 years; n = 39) adults in considerable detail, analyzing accuracy as well as mean and variance of their response time, toge...

The Growing U.S. Bioeconomy: Drivers, Development and Constraints.

Bioeconomy refers to economic activities using renewable biological resources to produce energy and domestic consumables. The U.S. bioeconomy emerged in the early 2000s as a result of the societal pursuit of energy independence and security, greenhouse gas emission mitigation and sustainable development. Founded on biotechnologies and stimulated by federal policies, the U.S. bioeconomy has been growing rapidly over the past decade. Intensive research and development endeavors have been carried out to explor...

Exploiting the bioengineering versatility of lactobionic acid in targeted nanosystems and biomaterials.

Lactobionic acid (LBA) has rapidly emerged as a strategic functionalization molecule in the development of nanoparticle-based platforms and biomaterials with promising therapeutic applications. Exploiting the multi-functionality of LBA has enabled to expand the drug loading, release and selective cellular uptake capacity of hepatoma-targeting chemotherapy and nanoparticle-based theranostic systems. The high liver-specificity displayed by LBA-conjugated dendrimers, micelles and nanoparticles has indeed reinf...

Facilitators to support the implementation of injury prevention training in youth handball: A concept mapping approach.

There is a need for research to identify effective implementation strategies for injury prevention training within real-world community sports. The aim of this ecological participatory study was to identify facilitators, among stakeholders at multiple levels, that could help injury prevention training become part of regular training routines in youth team handball. Concept mapping, a mixed-method approach for qualitative data collection and quantitative data analysis, was used. Stakeholders (n=196) of two c...

Progress Toward Global Eradication of Dracunculiasis - January 2017-June 2018.

Dracunculiasis (Guinea worm disease), caused by the parasite Dracunculus medinensis, is acquired by drinking water containing copepods (water fleas) infected with its larvae. The worm typically emerges through the skin on a lower limb approximately 1 year after infection, causing pain and disability (1). The worldwide eradication campaign began at CDC in 1980. In 1986, the World Health Assembly called for dracunculiasis elimination, and the global Guinea Worm Eradication Program (GWEP), led by the Carter Ce...

Development and evaluation of two multi-antigen serological assays for the diagnosis of bovine tuberculosis in cattle.

There is currently an increased interest in the use of serological approaches in combination with traditional cell-mediated immunity-based techniques to improve the detection of tuberculosis (TB)-infected animals. In the present study, we developed and validated two different serological TB-detection assays using four antigens, MPB70, MPB83, ESAT6 and CFP10, and the tuberculin PPDb. A conventional multi-antigen TB-ELISA method and a novel TB multiplex test, based on Luminex technology, were developed to det...

Integrated perspectives on the use of bacterial endophytes in horizontal flow constructed wetlands for the treatment of liquid textile effluent: Phytoremediation advances in the field.

Constructed wetlands (CWs) have emerged as cost-effective and sustainable treatment systems for the remediation of industrial wastewaters; nevertheless, their potential has mostly been evaluated in laboratory-scale studies. Likewise, endophytic bacteria can enhance plant growth and reduce phytotoxicity under polluted conditions, but their application with pilot-scale CWs has rarely been evaluated. The present study aims to evaluate on-site performance of endophyte-assisted pilot-scale horizontal flow constr...

Predicting Caries in Medical Settings: Risk Factors in Diverse Infant Groups.

Expanded partnership with the medical community is a promising strategy for reducing disparities in dental caries among young children. However, no validated caries risk instrument exists for use in primary health care settings. To help resolve this gap, a 52-item caries risk questionnaire was developed and targeted to primary caregivers (PCGs) to test in a 3-y prospective study. To begin to understand the validity of the questionnaire items, the purpose of this study was to compare responses to the questio...

An International Perspective on the Tools and Concepts for Effluent Toxicity Assessments in the Context of Animal Alternatives: Reduction in Vertebrate Use.

Since the 1940s, effluent toxicity testing has been used to assess potential ecological impacts of effluents and help determine necessary treatment options for environmental protection prior to release. Strategic combinations of toxicity tests, analytical tools, and biological monitoring have been developed. Because the number of vertebrates utilized in effluent testing is thought to be much greater than that used for individual chemical testing, there is a new need to develop strategies to reduce the numbe...

Capacity Building for and Implementation of Policy, Systems, and Environmental Change: Results from a Survey of the National Comprehensive Cancer Control Program.

Policy, systems, and environmental (PSE) approaches are commonly used to improve population health. Cancer-related examples include providing data and education to stakeholders about policies that support healthy living, or health systems changes such as universal reminders about recommended cancer screening. The National Comprehensive Cancer Control Program (NCCCP) funds health departments to form cancer coalitions that develop and implement cancer plans. NCCCP initiated a demonstration program in 13 of 65...

Evaluation of the immune response against Trypanosoma cruzi cytosolic Tryparedoxin Peroxidase in human natural infection.

Trypanosoma cruzi, the etiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by its host. One of the antioxidant enzymes involved is the cytosolic tryparedoxin peroxidase (c-TXNPx) which catalyzes the reduction of hydrogen peroxide, small-chain organic hydroperoxides and peroxynitrite. This enzyme is present in all parasite stages, and its over-expression renders parasites more resistant to oxidative defenses of macrophages, favoring paras...

Inequalities in access to health and social care among adults with multiple sclerosis: A scoping review of the literature.

Variations in access to health care are known to contribute to differences in life expectancy, morbidity and health-related quality-of-life across population subgroups. We undertook a scoping review to identify what is known about in-country variations in access to services for adults with multiple sclerosis and to identify gaps in the literature to inform future research and national policies. We searched MEDLINE, CINAHL, EMBASE, PSYCHINFO, SocINDEX and Social Science Abstracts from inception to end of Dec...

Spatiotemporal diffusion of influenza A (H1N1): Starting point and risk factors.

Influenza constitutes a major challenge to world health authorities due to high transmissibility and the capacity to generate large epidemics. This study aimed to characterize the diffusion process of influenza A (H1N1) by identifying the starting point of the epidemic as well as climatic and sociodemographic factors associated with the occurrence and intensity of transmission of the disease. The study was carried out in the Brazilian state of Paraná, where H1N1 caused the largest impact. The units of spat...

NMR based metabolomics: An exquisite and facile method for evaluating therapeutic efficacy and screening drug toxicity.

Metabolomics is an analytical approach to metabolism and involves quantitative and comparative analysis of low-molecular-weight metabolites in body fluids or cellular/tissues extracts. Owing to its ability to reveal disease-specific metabolic patterns or metabolic changes produced in response to a therapeutic intervention; it is gaining widespread applications virtually in all aspects of biomedical and pharmaceutical research pertaining to human healthcare management. It has also started playing a strategic...

Habitat restoration opportunities, climatic niche contraction, and conservation biogeography in California's San Joaquin Desert.

A recent global trend toward retirement of farmland presents opportunities to reclaim habitat for threatened and endangered species. We examine habitat restoration opportunities in one of the world's most converted landscapes, California's San Joaquin Desert (SJD). Despite the presence of 35 threatened and endangered species, agricultural expansion continues to drive habitat loss in the SJD, even as marginal farmland is retired. Over the next decades a combination of factors, including salinization, climate...

Improving Health and Cancer Services in Low-Resource Countries to Attain the Sustainable Development Goals Target 3.4 for Noncommunicable Diseases.

The United Nations Sustainable Development Goals 2015 to 2030 includes a specific goal for health (Sustainable Development Goal [SDG] 3) with 13 targets, including SDG3.4 for the control and treatment of noncommunicable diseases (NCDs), namely, cardiovascular diseases, cancer, diabetes, and chronic lung disease. There is considerable concern that SDG3.4 may not be achieved. The WHO Best Buys for NCDs has emphasized prevention, and although crucial, it alone will not achieve the 30% reduction in NCDs by 2030...

Could bovine livestock intensification in Pantanal be neutral regarding enteric methane emissions?

Bovine livestock is a major anthropogenic greenhouse gas source via enteric methane. Brazilian bovine livestock is also responsible for emissions from land-use changes. In contrast, enteric emissions from extensive cattle systems in wetlands might have been overestimated. We provide scientific evidences that the human footprint of bovine products delivered by the Pantanal can be much lower. To assess this, a historical cloud-free imagery of the Landsat-5, spanning 26 years, were processed for mapping spat...

The Opioid Epidemic: Moving Toward an Integrated, Holistic Analytical Response.

In many jurisdictions, public safety and public health entities are working together to enhance the timeliness and accuracy of the analytical characterization and toxicology testing of novel synthetic opioids. The improved sharing and early detection of these analytical data are intended to inform surveillance, interdiction efforts, patient intervention and treatment, all of which are critical to curbing the opioid epidemic. Forensic practitioners working to identify novel synthetic opioids struggle to prov...


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