Topics

PubMed Journals Articles About "PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc" - Page: 20 RSS

18:23 EDT 18th July 2019 | BioPortfolio

PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc articles that have been published worldwide.

More Information about "PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc" on BioPortfolio

We have published hundreds of PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc news stories on BioPortfolio along with dozens of PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc Clinical Trials and PubMed Articles about PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc Companies in our database. You can also find out about relevant PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc Drugs and Medications on this site too.

Showing "PARP Inhibition Appears Promising CRPC Questions Remain derfield" PubMed Articles 476–500 of 18,000+

Multiple factors drive the abundance and diversity of diazotrophic community in typical farmland soils of China.

Biological nitrogen fixation plays an important role in nitrogen cycling by transferring atmospheric N2 to plant available N in the soil. However, the diazotrophic activity and distribution in different types of soils remain to be further explored. In this study, 152 upland soils were sampled to examine the diazotrophic abundance, nitrogenase activity, diversity, and community composition by qPCR, acetylene reduction assay, and the MiSeq sequencing of nifH genes, respectively. The results showed that diazot...


Growth and fatty acid profiles of Halophytophthora vesicula and Salispina spinosa from Philippine mangrove leaves.

Studies on marine-sourced fatty acids have gathered significant interest recently as an important component of aquaculture feeds and of biofuel production. Of the organisms capable of producing fatty acids, marine oomycetes are promising model organisms. One group of marine oomycetes are the Halophytophthora spp. which are known to have an important role in leaf decomposition, thereby changing the plant debris into exudates which are usable to consumers in the mangrove ecosystems. This study reports the thr...

RANKL-inhibition in Fibrous Dysplasia of bone: A preclinical study in a mouse model of the human disease.

Fibrous Dysplasia of bone/McCune-Albright Syndrome (FD/MAS, OMIM#174800) is a crippling skeletal disease caused by gain-of-function mutations of G α. Enhanced bone resorption is a recurrent histological feature of FD and a major cause of fragility of affected bones. Previous work suggests that increased bone resorption in FD is driven by RANKL and some studies have shown that the anti-RANKL monoclonal antibody, denosumab, reduces bone turnover and bone pain in FD patients. However, the effect of RANKL inhi...


High Prevalence of Eczema among Preschool Children Related to Home Renovation in China: A Multi-city-based Cross-sectional Study.

We surveyed 40,010 3-6-year-old children in seven Chinese cities (Beijing, Taiyuan, Urumqi, Shanghai, Nanjing, Changsha and Chongqing) during 2010-2012 so as to investigate possible links between home renovation and childhood eczema. Their parents responded to questions on home renovation and childhood eczema. Multivariate and two-level (city-child) logistic regression analyses yielding odds ratios (OR) with 95% confidence intervals were performed. Sensitivity analyses stratifying data for region, climate a...

Blocking inflammasome activation caused by β-amyloid peptide (Aβ) and islet amyloid polypeptide (IAPP) through an IAPP mimic.

Inflammation in brain and pancreas is linked to cell degeneration and pathogenesis of both Alzheimer's-disease (AD) and type 2-diabetes. Inflammatory cascades in both tissues are triggered by the uptake of β-amyloid-peptide (Aβ) or islet-amyloid-polypeptide (IAPP) aggregates by microglial-cells (AD) or macrophages (T2D) and their insufficient lysosomal degradation. This results in lysosomal damage, caspase-1/NLRP3-inflammasome activation and release of interleukin-1β (IL-1β), a key proinflammatory cytok...

Anion-Regulated Molecular Rotor Crystal: The First Case of Stator-Rotator Double Switch with Relaxation Behavior.

Molecular rotational motion occupies crucial status in artificial molecular machines, has expected to be the great significance for the development of electronic-information molecular machine as mentioned in 2016 Nobel Prize. However, there is a huge challenge to control the multiple motor modes. Here, we reported a case that structural phase transition effectively triggers multiple motor modes by regulating the rotational speed of the cation/anion. A novel switchable crystalline supramolecular rotor, [(cyc...

Twenty-Four-Hour Urinary Sodium and Potassium Excretion in China: A Systematic Review and Meta-Analysis.

Background In China, high sodium and low potassium intakes result in elevated blood pressure, a major cause of cardiovascular disease, yet the intake estimates lack accuracy and nutritional strategies remain limited. Methods and Results We aimed to determine sodium and potassium intake by systematically searching for and quantitatively summarizing all published 24-hour urinary sodium and potassium data (ie, the most accurate method). MEDLINE , EMBASE , Scopus, China National Knowledge Infrastructure, and Wa...

Evaluation of aqueous extracts of Cistanche deserticola as a polysaccharide adjuvant for seasonal influenza vaccine in young adult mice.

Adjuvants can improve the efficacy of influenza vaccines and are still a hot spot in the study and development of influenza vaccines. In this report, the effects of aqueous extracts of Cistanche deserticola (AECD) as a polysaccharide adjuvant on seasonal influenza vaccines (IVV) were explored. The experimental data of anti-IVV IgG and IgG as well as hemagglutinin inhibition (HI) titers in young adult mice indicated that IVV intramuscularly co-injected with AECD was significantly more immunogenic than alum-a...

Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats.

Reperfusion exceeded time window may induce ischemia/reperfusion injury, increase hemorrhagic transformation, and deteriorate neurological outcomes in ischemic stroke models. However, the increasing clinical evidences supported that reperfusion even within 6-24 h may salvage ischemic tissue and improve neurological outcomes in selected large vessel occlusion patients, without inducing serious ischemia/reperfusion injury and hemorrhagic transformation. The underlying molecular mechanisms are less clear. In...

Psycho-physiological responses to perceptually-regulated interval runs in hypoxia and normoxia.

We investigated whether perceptually-regulated high-intensity intervals in hypoxia are associated with slower running velocities versus normoxia, when physiological responses and exercise-related sensations remain the same. Nineteen trained runners (33.4 ± 9.1 years) completed a high-intensity interval running protocol (4 × 4-min intervals at a clamped perceived rating exertion of 16 on the 6-20 Borg scale, 3-min passive recoveries) in either hypoxic (HYP; FiO 15.0%) or normoxic (NOR; FiO 20.9%)...

Physiological and biochemical responses to thermal stress vary among genotypes in the parasitic wasp Nasonia vitripennis.

In ectotherm species such as insects, thermal fluctuations represent a major environmental factor driving development, survival and reproduction of individuals. Reproductive traits are particularly sensitive to heat stress that can induce a permanent sterility, or at least hypofertility, of adult males. This study aims to compare physiological and biochemical responses associated to male performances to an exposure of 24h to moderately high temperature (36 °C) among three inbred lines of N. vitripennis (As...

KSK19 - novel histamine H3 receptor ligand reduces body weight in diet induced obese mice.

Histamine H receptors ligands act anorectic by blocking the H autoreceptors in the CNS, that results in increased synthesis and disinhibition of histamine release. Histamine further influencing H receptors participates in the leptin-dependent inhibition of food intake. It also affects the peripheral metabolism by increasing white adipose tissue lipolysis. Thus, ligands such as KSK19 with significant antagonistic properties at the H receptor might serve as an useful treatment for obesity.

CRISPR-Cas9 system: A new-fangled dawn in gene editing.

Till date, only three techniques namely Zinc Finger Nuclease (ZFN), Transcription-Activator Like Effector Molecules (TALEN) and Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-Associated 9 (CRISPR-Cas9) are available for targeted genome editing. CRISPR-Cas system is very efficient, fast, easy and cheap technique for achieving knock-out gene in the cell. CRISPR-Cas9 system refurbishes the targeted genome editing approach into a more expedient and competent way, thus facilitating proficient g...

Insights into the transport side of the human SLC38A9 transceptor.

The lysosomal amino acid transporter SLC38A9 is referred to as transceptor, i.e. a transporter with a receptor function. The protein is responsible for coupling amino acid transport across the lysosomal membrane according to the substrate availability to mTORC1 signal transduction. This process allows cells to sense amino acid level responding to growth stimuli in physiological and pathological conditions triggering mTOR regulation. The main substrates underlying this function are glutamine and arginine. Th...

Exploring the influence of brilliant blue G on amyloid fibril formation of lysozyme.

Evidence suggests that amyloid fibril mitigation/inhibition is considered a promising approach toward treating amyloid diseases. In this work, we first examined how amyloid fibrillogenesis of lysozyme was affected by BBG, a safe triphenylmethane compound with nice blood-brain-barrier-permeability, and found that shorter fibrillar species were formed in the lysozyme samples treated with BBG. Next, alterations in the features including the secondary as well as tertiary structure, extent of aggregation, and mo...

Effect of glow discharge plasma on surface modification of chitosan film.

Glow discharge plasma (GDP) was used to modify chitosan films to obtain desirable properties. The chitosan films were treated with GDP of 0-800 W for 1 min, respectively. The molecular structure of chitosan films changed under GDP treatment. Chitosan films showed an enhancement of crystallinity with the increasing power of GDP, and the GDP treatment provided them with higher thermal stability, manifested as the exothermic peaks shifted from 291.5 °C (0 W) to 294.1 °C (800 W). Scanning electron...

Robust microfluidic construction of konjac glucomannan-based micro-films for active food packaging.

The objective of this study was to develop a novel active food packaging with high performance by using natural active compound. Here, a facile and green strategy was employed to construct the konjac glucomannan/polylactic acid/trans-cinnamic acid micro-films (KPTMF) via microfluidic spinning technology (MST). MST, a mild preparation approach, could remain the activities of natural compound during processing. Konjac glucomannan could drive the release of trans-cinnamic by using its hydrophilicity under our ...

Mussel-inspired antibacterial polydopamine/chitosan/temperature-responsive hydrogels for rapid hemostasis.

The aim of this study was to develop an effective wound dressing using a temperature-responsive hydroxybutyl chitosan (HBC) based hydrogel. The HBC - chitosan (CS) - dopamine (HCS-DOPA) composite hydrogels were prepared by the dopamine self-polymerization at different concentrations (0, 0.5, 1.0 and 2.0 mg/mL), termed as HCS, HCS-DOPA-0.5, HCS-DOPA-1 and HCS-DOPA-2, respectively. The gelling characteristic of HBC hydrogel was not influenced by composite CS and DOPA. The HCS-DOPA composite hydrogels were n...

Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells.

Calcium influx via store-operated calcium entry (SOCE) has an important role for regulation of vast majority of cellular physiological events. MAPK signalling is also another pivotal modulator of many cellular functions. However, the relationship between SOCE and MAPK is not well understood. In this study, we elucidated the involvement of SOCE in Gα protein-mediated activation of p38 MAPK in an intestinal epithelial cell line HT-29/B6. In this cell line, we previously showed that the stimulation of M3 musc...

Dual effects of the novel ingenol derivatives on the acute and latent HIV-1 infections.

The latent reservoir of HIV-1 in resting memory CD4 T cells serves as a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 is proposed as a promising strategy for the clearance of the viral reservoirs. Because of the limitations of current latency reversal agents (LRAs), identification of new LRAs is urgently required. Here, we analyzed Euphorbia kansui extracts and obtained three ingenol derivative compounds named EK-1A, EK-5A and EK-15A. We found that ingenol derivatives can effectively...

Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging.

The preclinical landscape of photoacoustic imaging has experienced tremendous growth in the past decade. This non-invasive imaging modality augments the spatiotemporal capabilities of ultrasound with optical contrast. While it has principally been investigated for diagnostic applications, many recent reports have described theranostic delivery systems and drug monitoring strategies using photoacoustics. Here, we provide an overview of the of the progress to date while highlighting work in three specific are...

Synthesis of carboxymethylated nanocellulose fabricated ciprofloxacine - montmorillonite composite for sustained delivery of antibiotics.

Montmorillonite(MMT) is a highly promising material for use in drug delivery due to its high drug loading capacity and controlled drug release properties. MMT protects drug molecules between layered structure; however, drug release from MMT is sustained less than 6 h, which is insufficient for the release of antibiotics. This study sought to synthesize an antibiotic delivery material with more sustained release properties. A ciprofloxacin(CIP)-MMT composite was fabricated using carboxymethylated nanocellulo...

Enzyme responsive drug delivery systems in cancer treatment.

Recent technological approaches in drug delivery have attracted scientist interest for improving therapeutic index of medicines and drug compliance. One of the powerful strategies to control the transportation of drugs is implementation of intelligent stimuli-responsive drug delivery system (DDS). In this regard, tumor tissues with unique characteristics including leaky vasculature and diverse enzyme expression profiles facilitate the development of efficient enzyme-responsive nanoscale delivery systems. Ba...

Dynamically enhancing plaque targeting via a positive feedback loop using multifunctional biomimetic nanoparticles for plaque regression.

A paradigm shift from preventive therapy to aggressive plaque regression and eventual eradication is much needed to address increasing atherosclerotic burden and risks. Herein, we report a biologically inspired dual-targeting multifunctional recombinant high-density lipoprotein (rHDL)-mimicking core-shell nanoplatform. It is composed of an ATP-responsive ternary polyplexes core for SR-A siRNA and catalase complexation, and a phosphatidylserine-modified rHDL-based outer shell for SR-BI and CD36 targeting, in...

Functional annotation of noncoding causal variants in autoimmune diseases.

Interpretation of noncoding disease variants, which comprise the vast majority of Genome-wide association studies (GWAS) hits, remains a momentous challenge due to haplotype structure and our limited understanding of the mechanisms and physiological contexts of noncoding elements. GWAS have identified loci underlying human diseases, but assigning the causal nucleotide changes still remain a controversial issue. Here we addressed these issues through the combination of high-density genotyping and epigenomic ...


Quick Search