PubMed Journals Articles About "Pharvaris Gets 66mm Series" - Page: 20 RSS

15:23 EST 11th November 2019 | BioPortfolio

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Showing "Pharvaris gets 66mm Series" PubMed Articles 476–500 of 4,200+

Effectiveness of Knowledge Translation Strategies in Audiovisual Language Compared With Other Languages to Improve Health Outcomes in Individuals and the General Population: Systematic Review.

Knowledge translation (KT) not only encompasses a series of final actions in areas of dissemination, but also the identification of strategies for the implementation of this process.

Time series classification using a modified LSTM approach from accelerometer-based data: A comparative study for gait cycle detection.

Gait event detection (GED) is an important aspect in identifying and interpret a user's gait to assess gait abnormalities and design intelligent assistive devices.

Value-Driven Care in Developmental-Behavioral Pediatrics, Part 2: Measuring Quality and Meeting the Challenge.

The drive to improve quality and reduce cost of health care is leading to a value-driven transformation of the US health care landscape. This is the second of a 2-part series on value-driven care and its implications for developmental-behavioral pediatrics (DBP). Part 1 addressed costs of care and enhancing value of care, with a particular focus on the value proposition of the field of DBP. This study begins with a discussion of the Donabedian's model of quality, including structure, process, patient satisf...

Orbital mycoses in a pediatric subtropical population: a case series.

To report our experience in the diagnosis and management of invasive fungal infections with orbital involvement in children from a subtropical population.

Time series of hexabromocyclododecane transfers from flame-retarded curtains to attached dust.

While the production and new use of hexabromocyclododecane (HBCD) mostly ceased after being listed as a persistent organic pollutant under the Stockholm Convention in 2013, its emission from treated products in use to indoor environments still deserves attention. To examine the transfer of HBCD diastereomers to dust on the surface of flame-retarded curtains and to better characterize the potential of treated fabrics to be sources of HBCD in dust, we carried out a series of 196-day experiments using two type...

QSAR Analysis of a Series of Hydantoin-based Androgen Receptor Modulators and Corresponding Binding Affinities.

Androgen receptor (AR), a member of the nuclear hormone receptor superfamily of intracellular ligand-dependent transcription factors, plays an indispensable role in normal male development through the regulation of androgen through the binding with endogenous androgens. Inappropriate amounts of androgens have a severe adverse effect on men. Excessive androgen may contribute to accelerate prostatic hypertrophy, even prostate cancer, while the absence of androgen may result in reduced muscle mass and strength...

Discriminative Ratio of Spectral Power and Relative Power Features Derived via Frequency-Domain Model Ratio (FDMR) with Application to Seizure Prediction.

The ratio of spectral power in two different bands and relative band power have been shown to be sometimes more discriminative features than the spectral power in a specific band for binary classification of a time-series for seizure prediction. Using auto-regressive modeling, this paper, for the first time, theoretically explains that, for high signal-to-noise ratio (SNR) cases, the ratio features may sometimes amplify the discriminability of one of the two states in a time-series as compared to a band pow...

Cryopreserved Umbilical Cord Allograft for Root Coverage of Gingival Recession Defects: A Case Series.

Gingival recession is a component of periodontal disease that leads to exposure of the root surface, root hypersensitivity, and esthetic concerns. Treatment of these cases is typically performed with autologous grafts harvested from the palate. However, this is associated with a second surgical site that increases surgical time and patient morbidity. A potential alternative is the use of cryopreserved umbilical-cord allografts, which are known to contain anti-inflammatory properties and have been used clini...

Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases.

With the aim to discover novel, efficient and selective inhibitors of human alkaline phosphatase and nucleotide pyrophosphatase enzymes, two new series of pyrazolyl pyrimidinetriones (PPTs) (6a-g) and thioxopyrimidinediones (PTPs) (6h-n) were synthesized in good chemical yields using Knoevenagel condensation reaction between pyrazole carbaldehydes (4a-g) and pharmacologically active N-alkylated pyrimidinetrione (5a) and thioxopyrimidinedione (5b). The inhibition potential of the synthesized hybrid compounds...

Clinical impact of an educational antimicrobial stewardship program associated with Infectious Diseases consultation targeting patients with cancer: results of a 9-year quasi-experimental study with an interrupted time-series analysis.

Antibiotic stewardship programs (ASP) have already demonstrated clinical benefits. However, their effectiveness or safety in immunocompromised hosts needs to be proved.

Thioether-based 2-aminobenzamide derivatives: Novel HDAC inhibitors with potent in vitro and in vivo antitumor activity.

Previously, we focused on a series of 2-aminobenzamide-based histone deacetylase (HDAC) inhibitors, compound 9 of which displayed potent HDAC inhibitory activity against HDAC1 and HDAC2, and moderate anti-proliferative activity against several cancer cell lines. In the current study, we have designed and synthesized a series of novel HDAC inhibitors based on thioether moiety with 9 as a lead compound. Representative compounds12 g and 12 h showed apparently potent anti-proliferative activities against fi...

Leg restlessness preceding the onset of motor symptoms of Parkinson disease: A case series of 5 patients.

Patients with Parkinson disease (PD) often show restless legs syndrome (RLS), leg motor restlessness (LMR) and other leg restlessness (OLR) related to sensorimotor symptoms.Here, we describe 5 patients who presented with leg restlessness as an early manifestation of PD.In case 1, the patient had leg restlessness that was not LMR or RLS and preceded the onset of motor symptoms by 1 year. In case 2, LMR preceded motor symptoms by 2 years. Case 3 had unilateral RLS symptoms on the left side of the body for 33 ...

Low short-wavelength loss fiber Bragg gratings inscribed in a small-core fiber by femtosecond laser point-by-point technology.

A femtosecond-laser-induced fiber Bragg grating (FBG) usually has a higher insertion loss at the shorter wavelength than at the reflection wavelength, i.e., so-called short-wavelength loss. High-quality FBGs are inscribed in different types of small-core single-mode fibers (SMFs) by the use of femtosecond laser point-by-point technology in order to investigate the effect of the fiber core diameter on the grating inscription efficiency and on the short-wavelength loss. A lower laser pulse energy is required ...

miR-5195-3p Suppresses Cell Proliferation and Induces Apoptosis by Directly Targeting NEDD9 in Osteosarcoma.

Aberrantly expressed microRNAs (miRs) have associated with the development and progression of osteosarcoma (OS). In this study, the authors aimed to investigate the biological function of miR-5195-3p and the underlying mechanisms. Quantitative real-time polymerase chain reaction analysis was performed to determine the expression of miR-5195-3p in OS tissues and cell lines. Then, two OS cell lines (MG-63 and U2OS) were transfected with miR-5195-3p mimics to obtain stably miR-5195-3p overexpression cell line...

Holoprosencephaly: A case series from an area with high mining-related pollution.

The extraction and processing of copper and cobalt in the African Copperbelt in the Democratic Republic of Congo have led to substantial environmental pollution, causing concerns about possible adverse effects on human health, including birth defects.

In situ synthesis of biocompatible imidazolium salt hydrogels with antimicrobial activity.

Infection with antibiotic-resistant bacteria is becoming a significant public health risk. In this study, we synthesized a series of imidazolium salt (IMS)-containing polymers and hydrogels and tested their antimicrobial properties against both gram-positive (Staphylococcus aureus and MRSA) and gram-negative (Escherichia coli and PA01) bacteria. IMSs were either grafted as side chains or functionalized in the main chain of linear polymers, which demonstrated antimicrobial properties with minimum inhibitory ...

Cutaneous nontuberculous mycobacteria infections: A retrospective case series of 78 patients from the Texas Gulf Coast region.

The incidence of cutaneous nontuberculous mycobacteria (NTM) infections is increasing. These infections are a diagnostic and therapeutic challenge.

Education and cognitive decline: An integrative analysis of global longitudinal studies of cognitive aging.

The objective of this study was to examine the association between education and incidence of accelerated cognitive decline.

Nanosecond Laser Treatment in Chorioretinopathia Centralis Serosa without RPE Defects: A Retrospective Case Series.

Chorioretinopathia centralis serosa (CCS) is a uni- or bilateral disease of the macula which is characterized by detachment of the neuro-sensory retina. The spontaneous resolution rate is 68% after four months and 84% after six months.

Same day discharge after robotic radical prostatectomy.

The typical mean length of stay (LOS) following robotic-assisted laparoscopic prostatectomy (RALP) is 24-48hrs. We began routinely offering same day discharge (SDD) after RALP and evaluate the success rate, safety and cost implications in the only large series of SDD to date.

Morbidly adherent placenta: One-year case series in a tertiary hospital.

To analyse the clinical characteristics of patients with morbidly adherent placenta (MAP). Findings of this study will be used to identify patients at risk of MAP and to outline the best management strategy to deal with this devastating condition.

The Outcomes Assessment of the Plasma Blade Technology in Upper Blepharoplasties: A Prospective Study on a Series of 25 Patients.

The Dermo Ablation Surgery (DAS) Medical® (Technolux, Italy) device is a plasma blade which induces a plasma voltaic arc causing a retraction in the epidermis and superficial dermis.

Design, Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-reperfusion Injury.

The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia reperfusion injury (CIRI). Piperlongumine (PL) is a kind of natural product which has a great potential as neuroprotective agents, but it also has obvious neurotoxicity. Moreover, its neuroprotective effects remain to be improved. In this study, a series of novel PL analogs were designed on the foundation of the screened low-toxic diketene skeleton with antioxidat...

Visual Impairment and Frailty: Examining an understudied relationship.

Older adults with visual impairments are at increased risk of negative health outcomes. Here, we investigate the association between visual impairment and frailty.

Objective evaluation of healing and esthetic outcome of root coverage procedure using chorion membrane: a case series.

The ultimate goal of any periodontal plastic surgery aimed to treat gingival recession is predictable recession coverage and esthetic outcome. Due to the post-operative morbidity and discomfort related to subepithelial connective tissue graft, various other methods have been introduced including the use of fetal membranes. The fetal membranes have shown promising results in medicine and recently in the field of regenerative dentistry and could possibly become a viable alternative to autogenous grafts. This ...

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