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PubMed Journals Articles About "Regenxbio Inks Viral Vector Rights Deal With Pfizer" - Page: 20 RSS

07:39 EST 20th November 2019 | BioPortfolio

Regenxbio Inks Viral Vector Rights Deal With Pfizer PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Regenxbio Inks Viral Vector Rights Deal With Pfizer articles that have been published worldwide.

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Showing "Regenxbio inks viral vector rights deal with Pfizer" PubMed Articles 476–500 of 9,000+

Dynamics of Liquid Transfer from Nanoporous Stamps in High-Resolution Flexographic Printing.

Printing of ultrathin layers of polymeric and colloidal inks is critical for the manufacturing of electronics on non-conventional substrates such as paper and polymer films. Recently, we found that nanoporous stamps overcome key limitations of traditional polymer stamps in flexographic printing, namely enabling the printing of ultrathin nanoparticle films with micron-scale lateral precision. Here, we study the dynamics of liquid transfer between nanoporous stamps and solid substrates. The stamps comprise a ...


Kaposi's sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression.

Kaposi's sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) belongs to the subfamily of Gammaherpesvirinae and is the etiological agent of Kaposi's sarcoma as well as of two lymphoproliferative diseases: primary effusion lymphoma and multicentric Castleman disease. The KSHV life cycle is divided into a latent and a lytic phase and is highly regulated by viral immunomodulatory proteins which control the host antiviral immune response. Among them is a group of proteins with homology to cellular interf...

Zika virus: Molecular responses and tissue tropism in the mammalian host.

Zika virus (ZIKV) outbreaks have raised alarm because of reports of congenital Zika virus syndrome in infants. The virus is also known to cause the debilitating Guillain-Barré syndrome in adults. As a result, extensive research has been carried out on the virus over the past few years. To study the molecular responses of viral infectivity in mammals, in vitro two-dimensional and three-dimensional cellular models have been employed. The in vivo models of mouse, pig, chicken, and nonhuman primates are primar...


Vector Mosquito Surveillance Using Centers For Disease Control and Prevention Autocidal Gravid Ovitraps In San Antonio, Texas.

Mosquito surveillance in large urban areas of the southern USA that border Mexico has become increasingly important due to recent transmission of Zika virus and chikungunya virus in the Americas as well as the continued threat of dengue and West Nile viruses. The vectors of these viruses, , , and , co-occur in residential areas, requiring vector control entities to deploy several different trap types, often expensive and labor-intensive, to surveil these ecologically different species. We evaluated the use ...

Shortened nuclear matrix attachment regions are sufficient for replication and maintenance of episomes in mammalian cells.

Matrix attachment regions (MARs) can mediate the replication of vector episomes in mammalian cells; however, the molecular mode of action remains unclear. Here, we assessed the characteristics of MARs and the mechanism that mediates episomal vector replication in mammalian cells. Five shortened sub-fragments of β-interferon MAR fragments were cloned and transferred into Chinese hamster ovary (CHO) cells and transgene expression levels, presence of the gene, and the episomal maintenance mechanism were deter...

Potential impact of the antirheumatic agent auranofin on proviral HIV-1 DNA in individuals under intensified antiretroviral therapy: results from a randomized clinical trial.

Antiretroviral therapy (ART) is typically composed of a combination of three antiretroviral drugs, and is the treatment of choice for people with HIV-1/AIDS. It is, however, unable to impact on the viral reservoirs, which harbor latent HIV-1 genomes that are able to reignite the infection upon treatment suspension. The aim of the study is to provide an estimate of the safety of the disease-modifying antirheumatic agent auranofin and its impact on the HIV-1 reservoir in humans under intensified ART. For this...

"adaptatiVe Endovascular strategy to the CloT MRI in large intracranial vessel Occlusion" (VECTOR): study protocol of a randomized control trial.

A correlation between the susceptibility vessel sign (SVS) and red thrombi has been identified in MRI. We hypothesized that the Embotrap allow better retrieving of SVS+ thrombi. The AdaptatiVe Endovascular strategy to the CloT MRI in large intracranial vessel Occlusion (VECTOR) trial is a multicenter, prospective and randomized study designed to compare a first line strategy combining Embotrap added to contact aspiration (CA) versus CA alone in patients with SVS+ occlusions.

Ni-base superalloy single crystal (SX) mosaicity characterized by the Rotation Vector Base Line Electron Back Scatter Diffraction (RVB-EBSD) method.

In the present work we present the Rotation Vector Base Line Electron Back Scatter Diffraction (RVB-EBSD) method, a new correlative orientation imaging method for scanning electron microscopy (OIM/SEM). The RVB-EBSD method was developed to study crystal mosaicity in as-cast Ni-base superalloy single crystals (SX). The technique allows to quantify small crystallographic deviation angles between individual dendrites and to interpret associated accommodation processes in terms of geometrically necessary disloc...

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.

Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV latent and lytic transcripts. Furthermore, m6A modification demonstrated a functional role in regulation of the stability of viral transcripts. The methyltransferase METTL14 was induced at the transcript and protein levels, ...

Evaluation of antiviral passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.

Chronic Hepatitis B (CHB) remains a major problem for global public health. Viral persistence and immune defects are the two major reasons for CHB, and it was hypothesized that based on a transient clearance of serum viral DNA and HBsAg "window stage", active immunization against hepatitis B virus (HBV) might initiate effective host immune responses versus HBV to achieve functional cure of CHB.

Learning a Functional Grammar of Protein Domains using Natural Language Word Embedding Techniques.

In this paper, using word2vec, a widely-used natural language processing method, we demonstrate that proteins domains may have a learnable implicit semantic "meaning" in the context of their functional contributions to multi-domain proteins in which they are found. Word2vec is a group of models which can be used to produce semantically meaningful embeddings of words or tokens in a fixed-dimension vector space. In this work, we treat multi-domain proteins as "sentences" where domain identifiers are tokens wh...

A new strategy of using satellite RNA to control viral plant diseases: Post-inoculation with satellite RNA attenuates symptoms derived from pre-infection with its helper virus.

Satellite RNA (satRNA) is the supernumerary RNA of some viruses. It typically shares no nucleotide homology with its helper virus and depends on its helper virus for replication and encapsidation (Simon et al. 2004). The presence of satRNA sometimes interferes with the replication and symptom expression of its helper virus. Satellite RNA can have neutral, attenuated, or intensified effects on the virulence of its helper virus owing to complicated interactions among satRNA variants, helper viruses, and host...

The evolution of a super-swarm of foot-and-mouth disease virus in cattle.

Foot-and-mouth disease (FMD) is a highly contagious viral disease that severely impacts global food security and is one of the greatest constraints on international trade of animal products. Extensive viral population diversity and rapid, continuous mutation of circulating FMD viruses (FMDVs) pose significant obstacles to the control and ultimate eradication of this important transboundary pathogen. The current study investigated mechanisms contributing to within-host evolution of FMDV in a natural host spe...

Structural puzzles in virology solved with an overarching icosahedral design principle.

Viruses have evolved protein containers with a wide spectrum of icosahedral architectures to protect their genetic material. The geometric constraints defining these container designs, and their implications for viral evolution, are open problems in virology. The principle of quasi-equivalence is currently used to predict virus architecture, but improved imaging techniques have revealed increasing numbers of viral outliers. We show that this theory is a special case of an overarching design principle for ic...

Point Set Registration With Similarity and Affine Transformations Based on Bidirectional KMPE Loss.

Robust point set registration is a challenging problem, especially in the cases of noise, outliers, and partial overlapping. Previous methods generally formulate their objective functions based on the mean-square error (MSE) loss and, hence, are only able to register point sets under predefined constraints (e.g., with Gaussian noise). This article proposes a novel objective function based on a bidirectional kernel mean p-power error (KMPE) loss, to jointly deal with the above nonideal situations. KMPE is a ...

Determination of the Scalar and Vector Polarizabilities of the Cesium 6s^{2}S_{1/2}→7s^{2}S_{1/2} Transition and Implications for Atomic Parity Nonconservation.

Using recent high-precision measurements of electric dipole matrix elements of atomic cesium, we make an improved determination of the scalar (α) and vector (β) polarizabilities of the cesium 6s^{2}S_{1/2}→7s^{2}S_{1/2} transition calculated through a sum-over-states method. We report values of α=-268.82(30)a_{0}^{3} and β=27.139(42)a_{0}^{3} with the highest precision to date. We find a discrepancy between our value of β and the past preferred value, resulting in a significant shift in the value of ...

Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation.

Although mitochondria are known to be involved in host defense against viral infection, the physiological role of mitophagy, a crucial mechanism for maintaining mitochondrial homeostasis, in antiviral immunity remains poorly defined. Here, we show that Parkin, a central player in mitophagy, has a vital function in regulating host antiviral responses. Parkin-knockout mice exhibit improved viral clearance and survival after viral infection. However, Parkin deficiency does not affect antiviral signaling and in...

Postfusion structure of human-infecting Bourbon virus envelope glycoprotein.

Thogotoviruses are important zoonotic viruses infecting a variety of domestic animals, as well as humans. Among these viruses, Bourbon virus (BRBV) is one of the several human-infecting members, which emerged in the US in recent years and caused human deaths. Here, we report the crystal structure of the BRBV envelope glycoprotein in the postfusion conformation. The structure adopts the typical fold of a class III viral fusion protein and displays an extensive positively charged electrostatic potential patte...

Health Knowledge and Adherence as Predictors of Viral Burden and CD4+ T-Cell Count in Youth and Young Adults Living With HIV.

Health literacy influences HIV treatment for youth and, thus, is a research priority. We explored health knowledge and self-reported adherence, as indicators of health literacy, among youth living with HIV (YLWH) and the association between health literacy and health outcomes. A total of 102 YLWH ages 13-25 years participated in the study. Participants completed the Brief Estimate of Health Knowledge and Action-HIV Version; CD4 T-cell counts and viral loads were extracted from participant medical records. P...

Analysis in a murine model points to IgG responses against the 34k2 salivary proteins from Aedes albopictus and Aedes aegypti as novel promising candidate markers of host exposure to Aedes mosquitoes.

Aedes mosquitoes are vectors of arboviral diseases of great relevance for public health. The recent outbreaks of dengue, Zika, chikungunya and the rapid worldwide spreading of Aedes albopictus emphasize the need for improvement of vector surveillance and control. Host antibody response to mosquito salivary antigens is emerging as a relevant additional tool to directly assess vector-host contact, monitor efficacy of control interventions and evaluate risk of arboviral transmission.

Current observer-based online open-switch fault diagnosis for voltage-source inverter.

In order to guarantee the system reliability and enhance post-fault maintenance efficiency of inverters, this paper presents an current observer-based online open-switch fault diagnosis method for the voltage-source inverters (VSI). Analyzing the state space model of VSI when fault occurs, a state observer of the system is built to estimate phase currents. Once the open-switch fault occurs, the current residual vector between the estimated currents on observer and the measured currents, and fault diagnosis ...

Identification of Beclin-1 from orange-spotted grouper (Epinephelus coioides) involved in viral infection.

Beclin-1 is an essential autophagic regulator that plays diverse roles in physiology and disease. However, reports about the function of fish Beclin-1 during pathogen infection are still very limited. In this study, a Beclin-1 homolog (EcBeclin-1) from orange-spotted grouper (Epinephelus coioides) was identified and its roles in viral infection were investigated. EcBeclin-1 encoded 447amino acids protein with a BH3 domain, a CCD domain and an ECD domain, which shared high identities (97%-82%) with reported ...

Arginine Enveloped Virus Inactivation and Potential Mechanisms.

Arginine synergistically inactivates enveloped viruses at a pH or temperature that do little harm to proteins, making it a desired process for therapeutic protein manufacturing. However, the mechanisms and optimal conditions for inactivation are not fully understood, and therefore, arginine viral inactivation is not used industrially. Optimal solution conditions for arginine viral inactivation found in the literature are high arginine concentrations (0.7-1 M), a time of 60 minutes, and a synergistic factor ...

Human bocavirus infection in Belgian children with respiratory tract disease.

Human bocavirus (HBoV) has been detected primarily in children with acute lower respiratory tract disease (LRTD), but its occurrence, clinical profile, and role as a causative agent of RTD are not clear. The aim of this study was to investigate the prevalence and the potential clinical relevance of HBoV. Using molecular tests, we tested 1352 nasopharyngeal samples obtained between October 1, 2017 and April 30, 2018 from children up to the age of 16 with RTD for the presence of HBoV DNA and 20 other respirat...

Neuroinvasion and cognitive impairment in comorbid alcohol dependence and chronic viral infection: An initial investigation.

Viruses that invade the central nervous system (CNS) can cause neuropsychiatric impairments. Similarly, chronic alcohol exposure can induce inflammatory responses that alter brain function. However, the effects of a chronic viral infection and comorbid alcohol use on neuroinflammation and behavior are not well-defined. We investigated the role of heavy alcohol intake in regulating inflammatory responses and behavioral signs of cognitive impairments in mice infected with lymphocytic choriomeningitis virus (L...


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