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PubMed Journals Articles About "Scientists Take First Step Towards Digital Channels Brain" - Page: 20 RSS

04:15 EDT 23rd October 2019 | BioPortfolio

Scientists Take First Step Towards Digital Channels Brain PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Scientists Take First Step Towards Digital Channels Brain articles that have been published worldwide.

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Showing "Scientists take first step towards digital channels brain" PubMed Articles 476–500 of 14,000+

Prognostic Value of Brain Metastasis Free Interval in Patients with Breast Cancer Brain Metastases.

In patients with breast cancer brain metastases (BCBM), time between primary tumor diagnosis and appearance of brain metastases varies widely. Despite being a readily available clinical parameter, it remains unclear whether brain metastasis free interval (BMFI) carries prognostic value among breast cancer patients. The aim of this study was to compare characteristics and overall survival among patients with varying BMFIs and to assess the prognostic role, if any, for BMFI.


Estradiol Protects Neuropeptide Y/Agouti-related Peptide Neurons against Insulin Resistance in Females.

With obesity men exhibit a higher incidence of metabolic syndrome than women in early adult life, but this sex advantage wanes in postmenopausal women. A key diagnostic of the metabolic syndrome is insulin resistance in both peripheral tissues and brain, especially in the hypothalamus. Since the anorexigenic hormone 17β-estradiol (E2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, we hypothesized that E2 would prote...

Is Surgical Treatment Based on One-Step or Two-Step Protocol Effective in Managing the Odontogenic Keratocyst?


Subject-specific EEG channel selection using non-negative matrix factorization for lower-limb motor imagery recognition.

Objective- This study aims to propose and validate a subject-specific approach to recognize two different cognitive neural states (relax and pedaling motor imagery (MI)) by selecting the relevant electroencephalogram (EEG) channels. The main aims of the proposed work are: (i) to reduce the computational complexity of the BCI systems during MI detection by selecting the relevant EEG channels, (ii) to reduce the amount of data overfitting that may arise due to unnecessary channels and redundant features, and ...

Grina/TMBIM3 modulates voltage-gated Ca2.2 Ca channels in a G-protein-like manner.

Grina/TMBIM3 is a poorly characterized transmembrane protein with a broad expression pattern in mammals and with a very ancient origin within eukaryotes. Although initially characterized as an NMDA-receptor associated subunit, there is increasing evidence that Grina/TMBIM3 is involved in the unfolded protein response and controls apoptosis via regulation of Ca homeostasis. Here, we investigate a putative direct interaction of Grina/TMBIM3 with voltage gated Ca channels, in particular with the Ca2.2 α1-subu...

Quercetin depletes intracellular Ca stores and blunts ATP-triggered Ca signaling in bEND.3 endothelial cells.

Quercetin is a flavonol polyphenol widely found in many vegetables, grains and fruits. Quercetin has been shown to inhibit proliferation and invasion of various glioma cells, and is regarded as a potential anticancer agent against glioma. However, whether and how this drug could affect brain blood vessels and endothelial cells are less understood. Further, there is hitherto no report on how quercetin affects brain endothelial cell (EC) Ca homeostasis. In this report we investigated the effects of quercetin ...

Investigation of the source-detector separation in near infrared spectroscopy for healthy and clinical applications.

Understanding near infrared light propagation in tissue is vital for designing next generation optical brain imaging devices. Monte Carlo (MC) simulations provide a controlled mechanism to characterize and evaluate contributions of diverse near infrared spectroscopy (NIRS) sensor configurations and parameters. In this study, we developed a multi-layer adult digital head model under both healthy and clinical settings and assessed light-tissue interaction through MC simulations in terms of partial differentia...

Diagnostic accuracy of droplet digital PCR analysis of cerebrospinal fluid for tuberculous meningitis in adult patients.

Tuberculous meningitis (TBM) is still difficult to diagnose. Digital PCR (dPCR) is a novel method which can quantify trace nucleic acids. This study sought to evaluate the diagnostic accuracy of dPCR analysis of cerebrospinal fluid (CSF) for TBM.

Temperature controlled diffusion of hydroxide ions in 1D channels of Ni-MOF-74 for its complete conformal hydrolysis to hierarchical Ni(OH) supercapacitor electrodes.

Conformal hydrolysis of MOF precursors is a promising strategy to prepare hierarchical metal hydroxide electrode materials on a large scale with low cost and high efficiency. However, a complete transformation is challenging due to the normal "outside-in" conversion process. After studying the hydrolysis of Ni-MOF-74, which has regular 1D channels, we suggest that the transformation to Ni(OH)2 can occur simultaneously outside and within the precursor depending on the treatment temperature. Molecular dynamic...

Further studies of ion channels in the electroreceptor of the skate through deep sequencing, cloning and cross species comparisons.

Our comparative studies seek to understand the structure and function of ion channels in cartilaginous fish that can detect very low voltage gradients in seawater. The principal channels of the electroreceptor include a calcium activated K channel whose α subunit is Kcnma1, and a voltage-dependent calcium channel, Cacna1d. It has also been suggested based on physiological and pharmacological evidence that a voltage-gated K channel is present in the basal membranes of the receptor cells which modulates syna...

Short-term sleep deprivation in mice induces B cell migration to the brain compartment.

Increasing evidence highlight the involvement of immune cells in brain activity and its dysfunction. The brain's immune compartment is a dynamic ensemble of cells that can fluctuate even in naïve animals. However, the dynamics and factors that can affect the composition of immune cells in the naïve brain are largely unknown. Here we examined whether acute sleep deprivation can affect the brain's immune compartment (parenchyma, meninges and choroid plexus). Using high-dimensional mass cytometry analysis we...

Redox TRPs in diabetes and diabetic complications: mechanisms and pharmacological modulation.

Transient receptor potential (TRP) channels have shown to be involved in a wide variety of physiological functions and pathophysiological conditions. Modulation of TRP channels reported to play a major role in number of disorders starting from central nervous system related disorders to cardiovascular, inflammatory, cancer, gastrointestinal and metabolic diseases. Recently, a subset of TRP ion channels called redox TRPs gained importance on account of their ability to sense the cellular redox environment an...

A step-by-step problem-solving strategy in a patient with heart failure and cerebral aneurysm.

Left ventricular assist devices (LVAD) implantation is an established treatment for patients with end-stage heart failure. HeartMate 3 (HM3) is a continuous-flow centrifugal pump, recently introduced in the clinic, which has shown greater hemocompatibility compared to similar devices of previous generations. Nevertheless, anticoagulation is still required after HM3 implant to avoid pump dysfunction. Hereafter, we describe the case of a patient candidate to LVAD implantation for end-stage heart failure prese...

MicroRNA-mediated Downregulation of K Channels in Pulmonary Arterial Hypertension.

Downregulated expression of K channels and decreased K currents in pulmonary artery smooth muscle cells (PASMC) have been implicated in the development of sustained pulmonary vasoconstriction and vascular remodeling in patients with idiopathic pulmonary arterial hypertension (IPAH). However, it is unclear exactly how K channels are downregulated in IPAH-PASMC. MicroRNAs (miRNAs) are small noncoding RNAs that are capable of posttranscriptionally regulating gene expression by binding to the 3'-untranslated re...

Toxoplasmosis and Psychiatric and Neurological Disorders: A Step toward Understanding Parasite Pathogenesis.

Toxoplasmosis, a disease that disrupts fetal brain development and severely affects the host's brain, has been linked to many behavioral and neurological disorders. There is growing interest in how a single-celled neurotropic parasite, Toxoplasma gondii, can control or change the behavior of the host as well as how it dominates the host's neurons. Secrets beyond these could be answered by decoding the Toxoplasma gondii genome, unravelling the function of genomic sequences, and exploring epigenetics and mRNA...

Genomic analysis of claw lesions in Holstein cows: Opportunities for genomic selection, quantitative trait locus detection, and gene identification.

Claw lesions are the third most important health issue in dairy cattle, after mastitis and reproductive disorders, and genomic selection is a key component for long-term improvement of claw health. The objectives of this study were to assess the feasibility of a genomic evaluation for claw health in French Holstein cows, explore possibilities to increase evaluation accuracy, and gain a better understanding of the genetic determinism of claw health traits. The data set consisted of 48,685 trimmed Holstein co...

Brain metastasis from nasopharyngeal carcinoma treated with stereotactic radiosurgery.

Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, and is associated with high recurrence and low survival rates; however, distant brain metastasis from NPC is rare. The authors report 3 cases of brain metastasis from NPC treated with stereotactic radiosurgery (SRS). A 49-year-old woman presented was diagnosed with brain metastasis from NPC, which occurred 53 months after initial diagnosis of NPC. Brain magnetic resonance imaging (MRI) revealed a well-enhanced large tumor on th...

Mid-sagittal plane detection for advanced physiological measurements in brain scans.

The diagnostic process of many neurodegenerative diseases, such as Parkinson, Progressive Supranuclear Palsy, etc., involves the study of brain MRI scans in order to individuate morphological markers that can highlight on the healthy status of the subject. A fundamental step in the pre-processing and analysis of MRI is the identification of the Mid-Sagittal Plane, which corresponds to the mid-brain and allows a coordinate reference system for the whole MRI scans set. To improve the identification of the Mid...

Mathematical model of Na-K-Cl homeostasis in ictal and interictal discharges.

Despite big experimental data on the phenomena and mechanisms of the generation of ictal and interictal discharges (IDs and IIDs), mathematical models that can describe the synaptic interactions of neurons and the ionic dynamics in biophysical detail are not well-established. Based on experimental recordings of combined hippocampal-entorhinal cortex slices from rats in a high-potassium and a low-magnesium solution containing 4-aminopyridine as well as previous observations of similar experimental models, th...

A Consensus Community-Based Particle Swarm Optimization for Dynamic Community Detection.

The community detection in dynamic networks is essential for important applications such as social network analysis. Such detection requires simultaneous maximization of the clustering accuracy at the current time step while minimization of the clustering drift between two successive time steps. In most situations, such objectives are often in conflict with each other. This article proposes the concept of consensus community. Knowledge from the previous step is obtained by extracting the intrapopulation con...

Health Data in Dentistry: An Attempt to Master the Digital Challenge.

Biomedical research has recently moved through three stages in digital healthcare: (1) data collection; (2) data sharing; and (3) data analytics. With the explosion of stored health data (HD), dental medicine is edging into its fourth stage of digitization using artificial intelligence (AI). This narrative literature review outlines the challenge of managing HD and anticipating the potential of AI in oral healthcare and dental research by summarizing the current literature.

Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system.

As an alternative to advection, solute transport by shear-augmented dispersion within oscillatory cerebrospinal fluid flow was investigated in small channels representing the basement membranes located between cerebral arterial smooth muscle cells, the paraarterial space surrounding the vessel wall and in large channels modeling the spinal subarachnoid space (SSS).

Effect of coded healing abutment height and position on the trueness of digital intraoral implant scans.

Information regarding the effect of the height and position of a coded healing abutment (CHA) on the trueness of intraoral digital scans is lacking.

Cell numbers, distribution, shape, and regional variation throughout the murine hippocampal formation from the adult brain Allen Reference Atlas.

Quantifying the distribution of cells in every brain region is fundamental to attaining a comprehensive census of distinct neuronal and glial types. Until recently, estimating neuron numbers involved time-consuming procedures that were practically limited to stereological sampling. Progress in open-source image recognition software, growth in computing power, and unprecedented neuroinformatics developments now offer the potentially paradigm-shifting alternative of comprehensive cell-by-cell analysis in an e...

Biophysics at the coffee shop: lessons learned working with George Oster.

Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous research accomplishments, but also through the many students and postdocs he mentored over his long career. Those of us fortunate enough to have worked with George agree that ...


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