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PubMed Journals Articles About "Steps Editors Calling" - Page: 20 RSS

08:19 EST 17th December 2018 | BioPortfolio

Steps Editors Calling PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Steps Editors Calling articles that have been published worldwide.

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Showing "Steps Editors Calling" PubMed Articles 476–500 of 1,700+

Improving the calling of non-invasive prenatal testing on 13-/18-/21-trisomy by support vector machine discrimination.

With the advance of next-generation sequencing (NGS) technologies, non-invasive prenatal testing (NIPT) has been developed and employed in fetal aneuploidy screening on 13-/18-/21-trisomies through detecting cell-free fetal DNA (cffDNA) in maternal blood. Although Z-test is widely used in NIPT NGS data analysis, there is still necessity to improve its accuracy for reducing a) false negatives and false positives, and b) the ratio of unclassified data, so as to lower the potential harm to patients as well as ...


Asymmetric Synthesis of Chiral Spiroketal Bisphosphine Ligands and Their Application in Enantioselective Olefin Hydrogenation.

A series of chiral spiroketal bisphosphine ligands containing 1,1'-spirobi(3H,3'H)isobenzofuran backbones was accessed through asymmetric synthesis and subsequently tested in enantioselective Rh-catalyzed hydrogenation of α-dehydroamino acid esters. The ligand providing the highest enantioselectivity (up to 99.5%) was obtained in seven steps in an overall 38% yield. The synthesis could be performed on gram-scale and no kinetic resolution of enantiomers is required. Overall, the developed ligand provides an...

Convenient synthesis of the immunogenic glycolipid BbGL1.

A simple and efficient method to synthesize the immunogenic glycolipid BbGL1 is introduced. Two simple steps were required to obtain the desired product in good yield. First, a highly efficient glycosylation of cholesterol using galactosyl trichloroacetimidate as a donor was performed to produce cholesteryl-β-D-galactoside. Finally, an efficient palmitoylation on the C6-OH of the galactose of the synthesized saponin using sym-collidine and acyl chloride under microwave heating that produced BbGL1 in good y...


Dermatoses caused by cultural practices: Cosmetic cultural practices.

The second article in this continuing medical education series discusses cosmetic practices associated with cultural dermatoses, including hair care, traditional clothing, and skin decorations. Often, the steps individuals take to enhance their physical appearance are determined by cultural perceptions of beauty. Without awareness of cultural practices, a multitude of cutaneous dermatoses may be missed by the dermatologist. Recognition and understanding of patients' cultural backgrounds and habits will allo...

Insight into the mechanism of decarbonylation of methanol by ruthenium complexes; a deuterium labelling study.

In the reaction of [RuHClP3] (P = PPh3) with NaOMe in methanol, the product is [RuH2(CO)P3]. Short reaction times show that the final product is formed through [RuH4P3] as the major intermediate. Using NaOCD3 in CD3OD, the first formed product is [RuH4P'3] (P' is PPh3 partially deuterated in the ortho positions of the aromatic rings). Further reaction leads to a mixture of [RuHnD2-n(CO)P3] (n = 0, 22%; n = 1, 2 isomers each 28%; n = 2, 22%). Mechanistic aspects of both steps of the reaction are explored and...

RNA-seq: Basic Bioinformatics Analysis.

Quantitative analysis of gene expression is crucial for understanding the molecular mechanisms underlying genome regulation. RNA-seq is a powerful platform for comprehensive investigation of the transcriptome. In this unit, we present a general bioinformatics workflow for the quantitative analysis of RNA-seq data and describe a few current publicly available computational tools applicable at various steps of this workflow. These tools comprise a pipeline for quality assessment and quantitation of RNA-seq da...

Differentiated laboratory diagnostics of rheumatic diseases.

Laboratory diagnostics of rheumatic diseases include examinations to confirm the diagnosis, estimate prognosis, assess disease activity as well as recognition and avoidance of complications. Although detection and clinical classification of serological signs of inflammation are the first and often decisive steps in the diagnosis of inflammatory rheumatic diseases, a lack of humoral signs of inflammation does not rule out an inflammatory rheumatic disease. Rheumatological and immunological laboratory diagno...

Logistics of Lignocellulosic Feedstocks: Preprocessing as a Preferable Option.

In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed....

Shining light on plant hormones with genetically encoded biosensors.

Signalling molecules are produced, degraded, modified and transported throughout the development of higher organisms. Understanding their mode of action implies understanding these dynamics in vivo and in real time. Genetically encoded biosensors are being more and more used as tools to 'follow' signalling molecules and their responses inside an organism. This is the case for plants, where important progresses have been made in the development of such biosensors. Here, we summarize the main genetically enco...

When to reveal what you feel: How emotions towards antagonistic out-group and third party audiences are expressed strategically.

In intergroup conflicts, expressed emotions influence how others see and react to those who express them. Here, we investigated whether this in turn implies that emotions may be expressed strategically. We tested whether emotion expression can differ from emotion experience, and whether emotion expression (more than emotion experience) is used to pursue specific goals. Specifically, we focused on whether support-seeking emotions (fear and sadness) are used to call for support from a powerful third party and...

Role of the Chief Nurse Officer in Ensuring Person- and Family-Centered Care.

Person- and family-centered care (PFCC) is a philosophy that has been espoused for decades and yet is rarely embedded in health care organizations. Difficulties dispelling the numerous myths about what PFCC is, as well as daunting challenges to designing and implementing it, have hindered progress. The chief nurse officer is well-positioned to assume organizational leadership in successfully navigating this effort. This article provides 9 specific steps a chief nurse officer should take to create a culture,...

A time course of prosodic modulation in phonological inferencing: The case of Korean post-obstruent tensing.

Application of a phonological rule is often conditioned by prosodic structure, which may create a potential perceptual ambiguity, calling for phonological inferencing. Three eye-tracking experiments were conducted to examine how spoken word recognition may be modulated by the interaction between the prosodically-conditioned rule application and phonological inferencing. The rule examined was post-obstruent tensing (POT) in Korean, which changes a lax consonant into a tense after an obstruent only within a p...

Genome wide analysis of rare copy number variations in alcohol abuse or dependence.

Genetics plays an important role in alcohol abuse/dependence. Its heritability has been estimated as 45-65%. Rare copy number variations (CNVs) have been confirmed as relevant genetic factors in other neuropsychiatric disorders, such as autism spectrum disorders, schizophrenia, epilepsy, or Tourette syndrome. In the present study, we analyzed the role of rare CNVs affecting exons of coding genes in a sample from Northwest Spain genotyped using the Illumina Infinium PsychArray Beadchip. After rigorous genoty...

Synthesis of the tetrasaccharide related to the repeating unit of the O-antigen from Azospirillum brasilense Jm125A2 in the form of its 2-aminoethyl glycoside.

Total chemical synthesis of the linear tetrasaccharide repeating unit β-D-Glc-(1 → 2)-α-L-Rha-(1 → 3)-α-L-Rha-(1 → 2)-α-L-Rha-CHCHNH of the O-antigen from Azospirillum brasilense Jm125A2 is accomplished through rational protecting group manipulations of commercially available monosaccharides and stereoselective glycosylations. The target tetrasaccharide in the form of its 2-aminoethyl glycoside is obtained in ∼24% yield over 10 steps following a linear strategy. The structure is part...

SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis.

Chromosome segregation errors during meiosis result in the formation of aneuploid gametes and are the leading cause of pregnancy loss and birth defects in humans. Proper chromosome segregation requires pairwise associations of maternal and paternal homologous chromosomes. Chiasmata, which are the cytological manifestations of crossovers (COs), provide a physical link that holds the homologs together as a pair, facilitating their orientation on the spindle at meiosis I. Although CO-promoting activities ensur...

Anti-D from alloimmunization versus RhIG: detective work in the blood bank and transfusion medicine services.

The blood bank and transfusion medicine services (BBTMS) engages with electronic health records (EHRs), clinicians, and outside hospitals (OHs) to obtain comprehensive patient history to optimize care. Detection of anti-D in a pregnant patient underscores this work. Differentiating passive anti-D due to RhIG administration versus alloanti-D affects clinical decision making. The objectives of this study were to identify the required steps, barriers, and outcomes of anti-D investigations in obstetric patients...

Do Exercise Trials for Hypertension Adequately Report Interventions? A Reporting Quality Study.

Non-pharmacological treatment, including exercise, is an important therapy option for patients with hypertension. The study assessed the reporting quality of exercise-based interventions included in the latest meta-analysis on that topic in order to evaluate the transferability of findings into clinical practice. Reporting quality of 24 randomised controlled trials from a meta-analysis assessing blood pressure lowering effects of endurance training in 1,195 hypertensive patients was evaluated using TIDieR (...

One-Step Photochemical Generation of Biofunctionalized Hydrogel Particles via Two Phase Flow.

Biofunctional hydrogel particles become increasingly popular in medical diagnostics, however, their generation is time consuming and typically requires several process steps. We report on a new method for the simple, fast, and reproducible one-step generation of monodisperse hydrogel particles equipped with biofunctional molecules such as proteins or DNA. Key to the approach is the simultaneous photo crosslinking of the polymer chains and covalent binding of proteins or DNA through a C,H insertion reaction ...

Cascade Reactions in Tunable Lamellar Micro-Mesopores for C=C Bond Coupling and Hydrocarbon Synthesis.

Two-dimensional MFI zeolite nanosheets (2D-MFI) contain Brønsted acid sites partially confined at the intercept between micro- and meso-pores (Hpc+). These acid sites exhibit exceptional reactivities and stabilities for C=C bond coupling and ring closure reactions that transform light aldehydes to aromatics. These sites are much more effective than those confined within the micropores of MFI crystallites and those unconfined on H4SiW12O40 clusters or mesoporous aluminosilicate Al-MCM-41. The partially conf...

Hydrogen Sulfide: A Reagent for pH-Driven Bioinspired 1,2-Diol Mono-deoxygenation and Carbonyl Reduction in Water.

Hydrogen sulfide (HS) was evaluated for its peculiar sulfur radical species generated at different pHs and was used under photolytical conditions in aqueous medium for the reduction of 1,2-diols to alcohols. The conversion steps of 1,2-cyclopentanediol to cyclopentanol via cyclopentanone were analyzed, and it was proven that the reaction proceeds via a dual catalytic/radical chain mechanism. This approach was successfully adapted to the reduction of a variety of carbonyl compounds using HS at pH 9 in water...

The Association of Statin Therapy with Incident Diabetes: Evidence, Mechanisms, and Recommendations.

Recent studies have demonstrated a higher risk of incident diabetes associated with statin use, causing concern among patients and clinicians. In this review, we will assess the evidence and proposed mechanisms behind statin therapy and its association with incident diabetes. We will then review the current recommendations for statin use in light of this association and suggest next steps for clinicians managing these patients and researchers exploring this phenomenon.

Widened Dorsum: Bony and Cartilaginous Contributions.

Creation of a pleasing dorsal nasal profile in the anterior and lateral views requires proper analysis and planning to determine the required series of steps to accomplish the desired outcome. The widened nasal dorsum is a common esthetic complaint of the patient seeking rhinoplasty. Often patients seek an unrealistic result that, if accomplished, would leave them with a restricted nasal vault and nasal airway compromise. Nasal function must be balanced with the patient and surgeon's desire to narrow the na...

Protecting-Group-Free Total Synthesis and Biological Evaluation of 3-Methylkealiiquinone and Structural Analogues.

The modular protecting-group-free total synthesis of 3-methylkealiiquinone, an analogue of the marine alkaloid kealiiquinone, was accomplished in seven steps. A regioselectively-constructed functionalized arylbenzimidazolone moiety and dimethyl squarate were used as the only two building blocks. A thermal ring expansion via 6π-conrotatory ring closure to build the quinone fragment gave rise to the desired linear analogue of the natural compound along with a non-described structurally attractive angular nap...

Towards a Fuller Assessment of Gastric Motility in Patients With Upper GI Dyspepsia: Time to Accommodate!

There is increasing recognition of the importance of assessing patients with unexplained upper gastrointestinal symptoms for impaired gastric accommodation. New therapeutic approaches to treat impaired accommodation are being developed. This increasing interest in diagnosing and treating impaired gastric accommodation emphasizes the need to have a clinically available method to measure the gastric accommodation response. In this editorial, gastric accommodation is discussed along with the currently availabl...

Too stiff, too late…Timing is everything in anti-angiogenic treatment of liver fibrosis.

Despite recent advances and ongoing intensive research, no antifibrotic treatment has been approved for liver fibrosis. Elucidation of the key steps in fibrogenesis may pave the road towards effective drugs. However, pathophysiological mechanisms are complex and severity of fibrosis may affect the efficacy of antifibrotic compounds. Earlier treatment may be more effective, (1) although reasons for the stage-dependent effectiveness of antifibrotic treatment are not entirely clear. For more than a decade, ang...


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