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The light-harvesting 1 reaction center (LH1-RC) complex from Thermochromatium ( Tch.) tepidum exhibits a largely red-shifted LH1 Q absorption at 915 nm due to binding of Ca, resulting in an "uphill" energy transfer from LH1 to RC. In a recent study, we developed a heterologous expression system (strain TS2) to construct a functional hybrid LH1-RC with the LH1 from Tch. tepidum and the RC from Rhodobacter ( Rba.) sphaeroides ( Proc. Natl. Acad. Sci. USA 114, 10906; 2017). Here, we present detailed characteri...
The centriole in eukaryotes functions as the cell's microtubule-organizing center (MTOC) to nucleate spindle assembly. The evolutionarily conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. Microsporidia possess the spindle plaque instead of centriole as their MTOC to nucleate spindle assembly. However, little is known about the components of spindle plaques in microsporidia. In our present study, we identified a SAS-6 protein in the ...
To report a single center experience with carotid body paraganglioma cases that were treated by the same surgeon in a city with high prevalence of paragangliomas due to high altitude.
To describe the prevalence, clinical presentation, and management of rheumatic immune-related adverse effects (Rh-irAEs) from immune checkpoint inhibitor therapy.
The aim of this study was to learn about the users' perceptions concerning the case-resolving capacity of dental care in the Unified Health System and to analyze the associations between solving capacity and both sociodemographic characteristics and access to the service. This was a cross-sectional study with a quantitative approach, in which 461 users responded to individual interviews. The outcome variable was the case-resolving capacity of dental care, obtained through the question: "In your opinion, is ...
Arthur Jay Moss MD PhD: The cardiology world has again lost one of its most respected and worldwide-honoured scholars and experienced clinician. Born 21 June 1931, Professor of Medicine and Cardiology at Rochester University Medical Center, Rochester, NY, Arthur passed away on 14 February 2018 at the age of 86.
To better understand the nature of periocular dermatitis (PD) patient presentation, treatment, time-to-cure, and referral pattern for allergy testing in an ophthalmic academic center.
The International Prognostic Index for Patients with Chronic Lymphocytic Leukemia Has the Higher Value in Predicting Overall Outcome Compared with the Barcelona-Brno Biomarkers Only Prognostic Model and the MD Anderson Cancer Center Prognostic Index.
In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-international prognostic index (CLL-IPI), and the Barcelona-Brno biomarkers only prognostic model. The aim of this study is to compare the utility of these PIs in a cohort of Spanish patients. A retrospective analysis of 696 unselected CLL patients newly diagnosed a...
To demonstrate that use of a minimally invasive catheter reduces endotracheal tube (ETT) malposition rate after intubation.
To present single center experience of urolithiasis management in anomalous kidneys, highlighting the need for algorithm-based approach in deciding the modality to be used in treatment planning.
To demonstrate the long term outcome of a contemporary series of 64 children who underwent CPRE in a single tertiary referral center.
To evaluate the management and outcomes of naïve bilateral retinoblastoma treated at a single-center over a 5-year period during the era of ophthalmic artery chemosurgery (OAC) and intravitreous chemotherapy.
Eosinophilic esophagitis (EoE) is increasingly common, but data on phenotypic aspects are still incomplete.
To evaluate the nutritional profile of the population assisted at a reference center for cystic fibrosis treatment.
No-till and increased cropping intensity (CI) can increase yield and soil organic C (SOC) in the US Great Plains compared with traditional wheat ( L.)-fallow management. However, gains in SOC and other C pools may not be permanent. Increasing frequency of drought may reduce C inputs and potentially reverse gains accrued during wetter periods. This study examined the effect of drought on the persistence of SOC with two objectives: (i) to determine soil C pools (0-20 cm) after 24 yr in no-till as influenced b...
In 30-50% of patients with fever of unknown origin (IUO) no explanation for the fever can be found. Prognosis and effects of empirical treatment of these patients are largely unknown.With this retrospective, questionnaire based corort study in all unexplained FUO patients in an expert center between 2003 and 2014 we studied mortality and outcome.In 131 of 274 FUO patients, FUO remained unexplained. Ninety-nine of them responded to the long-term follow up questionnaire. Adter a median duration of follow-up o...
We investigated interfacial processes affecting metal mobility by wood ash under laboratory-controlled conditions using aqueous chemistry, microscopy, and spectroscopy. The Valles Caldera National Preserve in New Mexico experiences catastrophic wildfires of devastating effects. Wood samples of Ponderosa Pine, Colorado Blue Spruce, and Quaking Aspen collected from this site were exposed to temperatures of 60, 350, and 550 °C. The 350 °C Pine ash had the highest content of Cu (4997 ± 262 mg kg), Cr (543 ±...
Approximately five to 10% of all melanomas occur in families with hereditary predisposition and the main high-risk melanoma susceptibility gene is the CDKN2A.
The movement to legalize and regulate retail marijuana is growing. We examined legislation and regulations in the first 4 states to legalize recreational marijuana (Colorado, Washington, Oregon, and Alaska) to analyze whether public health best practices from tobacco and alcohol control to reduce population-level demand were being followed. Only between 34% and 51% of policies followed best practices. Marijuana regulations generally followed US alcohol policy regarding conflict of interest, taxation, educat...
The purpose of this study was to analyze the results of patients with ruptured aneurysms who were treated with a specific microstent in the acute phase of subarachnoid hemorrhage.
Consumers have questions about their medication but the nature of these concerns and how they reflect medication use is unknown.
The approach to the clinical management of Graves' disease (GD) is debatable. This study aimed to identify predictors of remission in pediatric GD.
We investigated the association between reproductive history and mortality from all and major causes among Japanese women.
Members of the Acyl-CoA dehydrogenase (ACADs) family of enzymes play a crucial role in cholesterol and steroid catabolism and are widely studied in the oldest known human pathogen, Mycobacterium tuberculosis (Mtb). However, there is a paucity of information on ACADs involved in branched chain amino acid catabolism. Here we characterized one of the putative ACAD enzyme, fadE9, as "Isobutyryl CoA Dehydrogenase (IBDH)" using a combined computational and experimental approach, guided by homology modeled structu...
The aim of this study was to identify differences in proteome profiles of diffuse large B-cell lymphoma (DLBCL) of nongerminal center (non-GC) versus GC type in the search for new markers and drug targets.