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PubMed Journals Articles About "Tracking Clarifying Differential Traits Classical Atypical Type Bovine" - Page: 20 RSS

19:01 EDT 19th July 2019 | BioPortfolio

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Showing "Tracking clarifying differential traits classical atypical type bovine" PubMed Articles 476–500 of 19,000+

Patient-reported study of the impact of pediatric-onset myotonic dystrophy.

The prevalence and impact of symptoms affecting individuals with pediatric forms of myotonic dystrophy type-1 (DM1) are not well understood.


Characterization of gut microbiota, bile acid metabolism, and cytokines in intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC), a type of bile duct cancer, has a high mortality rate. Gut microbiota, bile acid metabolism, and cytokines have not been characterized in patients with ICC, and better noninvasive diagnostic approaches for ICC are essential to be established. Accordingly, in this study, we aimed to improve our understanding of changes in gut microbiota, bile acid metabolism, and cytokines in patients with ICC. We found that the α- and β-diversities of ICC were highest and that the ab...

Topical hydrogels with escin β-sitosterol phytosome and escin: Formulation development and in vivo assessment of antihyperalgesic activity.

The physicochemical properties, stability, in vivo antihyperalgesic activity, and skin irritation potential of the carbomer hydrogels with the new chemical entity escin β-sitosterol (ES) phytosome were characterized and compared with those containing escin. Physicochemical characterization of the hydrogels (performed 48 hr after preparation) included organoleptic examination, pH measurement, light microscopy, differential scanning calorimetry analysis and rheological tests. The obtained results showed th...


Methotrexate anti-cancer drug delivery to breast cancer cell lines by iron oxide magnetic based nano carrier.

In the present study, we have achieved to provide an efficient method for production of iron oxide magnetic nanoparticles with arginine capping using in situ and one-pot co-precipitation method. As a novel drug delivery system, methotrexate (MTX) was conjugated to the obtained nanoparticles. These magnetic nanoparticles conjugate can potentially use in controlled drug delivery as carrier, and in magnetic resonance imaging as a contrast agent. Also, these nanoparticles can serve as a target in cancer therapy...

Heritability estimation of dichotomous phenotypes using a liability threshold model on ascertained family-based samples.

Numerous methods for estimating heritability have been proposed; however, unlike quantitative phenotypes, heritability estimation for dichotomous phenotypes is computationally and statistically complex, and the use of heritability is infrequent. In this study, we developed a statistical method to estimate heritability of dichotomous phenotypes using a liability threshold model in the context of ascertained family-based samples. This model assumes that dichotomous phenotypes are determined by unobserved late...

Novel multicomponent organic-inorganic WPI/gelatin/CaP hydrogel composites for bone tissue engineering.

The present work focuses on the development of novel multicomponent organic-inorganic hydrogel composites for bone tissue engineering. For the first time, combination of the organic components commonly used in food industry, namely whey protein isolate (WPI) and gelatin from bovine skin, as well as inorganic material commonly used as a major component of hydraulic bone cements, namely α-TCP in various concentrations (0-70 wt.%) was proposed. The results showed that α-TCP underwent incomplete transformatio...

Prevalence and characteristics of pregnancy- and lactation-related calls to the National Poison Centre in Belgium: A retrospective analysis of calls from 2012 to 2017.

In the absence of a Teratology Information Service in Belgium, the National Poison Centre might act as a substitute centre for answering pregnancy- and lactation-related questions regarding medication use. The aim of this study was to define the prevalence and characteristics of pregnancy- and lactation-related calls to the National Poison Centre in Belgium, as well as the type of health products involved during these calls.

Concise Review: Beta-cell dedifferentiation in type 2 diabetes.

Type 2 diabetes (T2D) is caused by an inherited predisposition to pancreatic islet β-cell failure, which is manifested under cellular stress induced by metabolic overload. The decrease in the functional β-cell mass associated with T2D has been attributed primarily to β-cell death; however, studies in recent years suggested that β-cell dedifferentiation may contribute to this decline. The mechanisms linking genetic factors and cellular stress to β-cell dedifferentiation remain largely unknown. Here I ev...

The Role of Amino Acids in the Amplification and Quality of DNA Vectors for Industrial Applications.

In this study, we have demonstrated that the type and feeding regimen of amino acids have a significant impact on the quality as well as the quantity of DNA vectors produced. Nutrient pool and factorial design experiments were carried out in order to identify the amino acids involved in increased biomass and induction of plasmid amplification. Leucine, glycine, and histidine were responsible for increased biomass and leucine starvation in the presence of histidine was implicated in plasmid amplification. Su...

High-performance n-type carbon nanotubes composites: Improved power factor by optimizing the acridine scaffold and tailoring the side chains.

Single-walled carbon nanotubes (SWCNTs)/organic small molecules (OSMs) are promising candidates for application in thermoelectric (TE) modules; however, the development of n-type SWCNT/OSMs with high performance is lagging behind. Only a few structure-activity relationships of OSMs on SWCNT composites have been reported. Recently, we find that the n-type acridone/SWCNT composites display high power factor (PF) value at high temperature, but suffer from a low PF at room temperature. Here, the performance of ...

Fullerene Active Layers for N-Type Organic Electrochemical Transistors.

Organic electrochemical transistors (OECTs) are currently being developed for applications ranging from bioelectronics to neuromorphic computing. We show that fullerene derivatives with glycolated side chains can serve as n-type active layers for OECTs with figures of merit exceeding the best reported conjugated-polymer-based n-type OECTs. By comparing two different fullerene derivatives, [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and 2-(2,3,4-tris(methoxtriglycol) phenyl) [60]fulleropyrrolidine (C60...

An isoform-selective PTP1B inhibitor derived from nitrogen-atom augmentation of radicicol.

A library of natural products and their derivatives was screened for inhibition of protein tyrosine phosphatase (PTP) 1B, which is a validated drug target for the treatment of obesity and type II diabetes. Of those active in the preliminary assay, the most promising was compound 2 containing a novel pyrrolopyrazoloisoquinolone scaffold derived by treating radicicol (1) with hydrazine. This nitrogen-atom augmented radicicol derivative was found to be PTP1B selective relative to other highly homologous non-re...

Quantitative Kinetic Models from Intravital Microcopy: A Case Study Using Hepatic Transport.

The liver performs critical physiological functions, including metabolizing and removing substances, such as toxins and drugs, from the bloodstream. Hepatotoxicity itself is intimately linked to abnormal hepatic transport and hepatotoxicity remains the primary reason drugs in development fail and approved drugs are withdrawn from the market. For this reason, we propose to analyze, across liver compartments, the transport kinetics of fluorescein--a fluorescent marker used as a proxy for drug molecules--using...

Numerical Simulation of Jumping-Droplet Condensation.

Jumping-droplet condensation has been shown to enhance the heat transfer performance (≈100%) when compared to dropwise condensation by reducing the time-averaged droplet size (≈ 10 μm) on the condensing surface. Here, we develop a rigorous, three dimensional numerical simulation of jumping-droplet condensation in order to compute the steady-state time-averaged droplet size distribution. In order to characterize the criteria for achieving steady-state, we use maximum radii (R_max) tracking on the surfac...

Direct Observation of Corner States in Second-Order Topological Photonic Crystal Slabs.

Recently, higher-order topological phases that do not obey the usual bulk-edge correspondence principle have been introduced in electronic insulators and brought into classical systems, featuring in-gap corner or hinge states. In this Letter, using near-field scanning measurements, we show the direct observation of corner states in second-order topological photonic crystal slabs consisting of periodic dielectric rods on a perfect electric conductor. Based on the generalized two-dimensional Su-Schrieffer-Hee...

Topological Phase Transition in non-Hermitian Quasicrystals.

The discovery of topological phases in non-Hermitian open classical and quantum systems challenges our current understanding of topological order. Non-Hermitian systems exhibit unique features with no counterparts in topological Hermitian models, such as failure of the conventional bulk-boundary correspondence and non-Hermitian skin effect. Advances in the understanding of the topological properties of non-Hermitian lattices with translational invariance have been reported in several recent studies; however...

Constraining the Neutron Star Compactness: Extraction of the ^{23}Al(p,γ) Reaction Rate for the rp Process.

The ^{23}Al(p,γ)^{24}Si reaction is among the most important reactions driving the energy generation in type-I x-ray bursts. However, the present reaction-rate uncertainty limits constraints on neutron star properties that can be achieved with burst model-observation comparisons. Here, we present a novel technique for constraining this important reaction by combining the GRETINA array with the neutron detector LENDA coupled to the S800 spectrograph at the National Superconducting Cyclotron Laboratory. The ...

Extracting the Top-Quark Width from Nonresonant Production.

In the context of the standard model of particle physics, the relationship between the top-quark mass and width (Γ_{t}) has been precisely calculated. However, the uncertainty from current direct measurements of the width is nearly 50%. A new approach for directly measuring the top-quark width using events away from the resonance peak is presented. By using an orthogonal dataset to traditional top-quark width extractions, this new method may enable significant improvements in the experimental sensitivity i...

Continuous Real-Time Tracking of a Quantum Phase Below the Standard Quantum Limit.

We propose a scheme for continuously measuring the evolving quantum phase of a collective spin composed of N pseudospins. Quantum nondemolition measurements of a lossy cavity mode interacting with an atomic ensemble are used to directly probe the phase of the collective atomic spin without converting it into a population difference. Unlike traditional Ramsey measurement sequences, our scheme allows for real-time tracking of time-varying signals. As a bonus, spin-squeezed states develop naturally, providing ...

Higher-Order Quantum Ghost Imaging with Ultracold Atoms.

Ghost imaging is a quantum optics technique that uses correlations between two beams to reconstruct an image from photons that do not interact with the object being imaged. While pairwise (second-order) correlations are usually used to create the ghost image, higher-order correlations can be utilized to improve the performance. In this Letter, we demonstrate higher-order atomic ghost imaging, using entangled ultracold metastable helium atoms from an s-wave collision halo. We construct higher-order ghost ima...

Src-mediated crosstalk between FXR and YAP protects against renal fibrosis.

Renal fibrosis is the common pathway of chronic kidney disease progression. The nuclear receptor farnesoid X receptor [FXR, NR1H4 (nuclear receptor subfamily 1 group member 4)], a multifunctional transcription factor, plays a pivotal role in protecting against fibrosis. However, the mechanisms underlying these antifibrotic actions of FXR in kidney disease are largely unknown. Here, we show that agonist GW4064-mediated FXR activation inhibits the activity of the nonreceptor tyrosine kinase Src (proto-oncogen...

Production losses in laying hens during infestation with the poultry red mite .

A research centre with 30,568 laying hens kept in enriched cages and in aviaries, had become naturally infested with poultry red mites (PRM) in 32 of its 48 animal units. Therefore, at the age of 52 weeks all hens were treated with fluralaner through the drinking water. After this treatment, PRM were no longer observed. As all birds were of the same age and since production figures were measured daily in all 48 units, this offered a unique opportunity to examine how PRM had affected performance. Statistical...

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma.

The canonical complement component 5a (C5a) receptor (C5aR) 1 has well-described roles in tumorigenesis but the contribution of the second receptor, C5aR2, is unclear. The present study demonstrates that B16.F0 melanoma cells express mRNA for both and and signal through ERK and p38 MAPKs in response to C5a. Despite this, C5a had no impact on melanoma cell proliferation or migration . studies demonstrated that the growth of B16.F0 melanoma tumors was increased in C5aR2 mice but reduced in C5aR1 mice and w...

Two Novel Genomospecies in the Agrobacterium tumefaciens Species Complex Associated with Rose Crown Gall.

In this study, we explored the pathogenicity and phylogenetic position of Agrobacterium spp. strains isolated from crown gall tissues on annual, perennial and ornamental plants in Iran. Of the 43 strains studied, 10 strains were identified as Allorhizobium vitis (formerly Agrobacterium vitis) using the species-specific primer pair PGF/PGR. Thirty-three remaining strains were studied using multilocus sequence analysis of four housekeeping genes (i.e., atpD, gyrB, recA and rpoB), from which seven strains were...

Integrated tumor stromal features of hepatocellular carcinoma reveals two distinct subtypes with prognostic/predictive significance.

Current clinical classification of hepatocellular carcinoma (HCC) is unable to predict prognosis efficiently. Our aim is to classify HCC into clinically/biologically relevant subtypes according to stromal factors. We detected seven types of stromal features in tumors from 161 HCC patients by immunohistochemical staining and Hematoxylin-eosin staining. Five stromal features were selected out of seven types of stromal features to construct stromal type based on LASSO COX regression model. Then, integrating mu...


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