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PubMed Journals Articles About "Remote Monitoring Infantile Spasms Intractable" - Page: 20 RSS

15:05 EST 11th November 2019 | BioPortfolio

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Showing "Remote monitoring Infantile Spasms Intractable" PubMed Articles 476–500 of 5,000+

"Basicles": Microbial growth and production monitoring in giant lipid vesicles.

We present a method and protocol to encapsulate bacteria inside giant unilamellar lipid vesicles combined with a microfluidic platform for real-time monitoring of microbial growth and production. The microfluidic device allows to immobilize the lipid vesicles, and record bacterial growth and production using automated microscopy. Moreover, the lipid vesicles retain hydrophilic molecules and therefore, can be used to accumulate products of microbial biosynthesis, which we demonstrate here for a riboflavin-pr...


FERMI: A Novel Method for Sensitive Detection of Rare Mutations in Somatic Tissue.

With growing interest in monitoring mutational processes in normal tissues, tumor heterogeneity, and cancer evolution under therapy, the ability to accurately and economically detect ultra-rare mutations is becoming increasingly important. However, this capability has often been compromised by significant sequencing, PCR and DNA preparation error rates. Here, we describe FERMI (Fast Extremely Rare Mutation Identification) - a novel method designed to eliminate the majority of these sequencing and library-pr...

Hedgehog-like moustache trichomegaly during treatment with vismodegib.

Vismodegib is a Hedgehog pathway oral antagonist used to treat locally advanced and metastatic Basal Cell Carcinoma (BCC). The most frequent adverse events include muscle spasms (66%), non-scarring diffuse alopecia (62%), dysgeusia (55%) and weight loss (41%). With the increasing use of vismodegib in daily practice, characterization of new adverse events and strategies to manage them is of great interest. Here we describe a not previously reported dermatological effect related to vismodegib. A male in his 8...


Assessment of the chlorine demand and disinfection byproduct formation potential of surface waters via satellite remote sensing.

The ability of satellites to assess surface water quality indicators such as colored dissolved organic matter (CDOM) suggests that remote sensing could be a useful tool for evaluating water treatability metrics in considering potential drinking water supplies. To explore this possibility, 24 surface water samples were collected throughout Minnesota, USA with wide ranging values of CDOM (a; 0.41-27.9 m), dissolved organic carbon (DOC; 5.5-47.6 mg/L) and specific ultraviolet absorbance at 254 nm (SUVA; ...

Monitoring Heterogeneously Catalyzed Hydrogenation Reactions at Elevated Pressures Using In-Line Flow NMR.

We present a novel setup that can be used for the in-line monitoring of solid-catalyzed gas-liquid reactions. The method combines the high sensitivity and resolution of a stripline NMR detector with a microfluidic network that can withstand elevated pressures. In our setup we dissolve hydrogen gas in the solvent, then flow it with the added substrate through a catalyst cartridge and finally flow the reaction mixture directly through the stripline NMR detector. The method is quantitative and can be used to d...

Therapeutic Drug Monitoring to Guide Clinical Decision Making in Inflammatory Bowel Disease Patients with Loss of Response to Anti-TNF: A Delphi Technique-Based Consensus.

Loss of response is frequently encountered in patients with inflammatory bowel disease (IBD) treated with antitumor necrosis factor (TNF) agents. Therapeutic drug monitoring (TDM) and antidrug antibody measurement are increasingly used in this setting.

A comparative study of detection of myocarditis induced by clozapine: With and without cardiac monitoring.

The aim of this study was to investigate and compare the incidence of suspected or definite cases of clozapine induced myocarditis (SDM) and clinical factors which could influence its onset in two different time periods, defined by pre- and post-cardiac monitoring at an inpatient setting, during the initiation phase of clozapine treatment. Hospital records of patients started on clozapine in the inpatient unit between 2011 and 2018 were investigated. Eight in 38 patients (11.3%) were classified as SDM after...

Laboratory Monitoring in Emicizumab-Treated Persons with Hemophilia A.

Hemophilia A (HA) is an X-linked hereditary bleeding disorder caused by deficiency of coagulation factor (F) VIII activity. One of the greatest complications in the treatment of HA is the development of neutralizing alloantibodies, known as FVIII inhibitors. HA patients who develop FVIII inhibitors have limited treatment options available to them and experience greater disease- and treatment-related burdens than HA patients without FVIII inhibitors. Emicizumab, a recently approved bispecific monoclonal anti...

Informing Data to Care: Contacting Persons Sampled for the Medical Monitoring Project.

Data to care (D2C) is a public health strategy that uses HIV surveillance and other data to identify persons in need of HIV medical care. The Medical Monitoring Project (MMP), which uses similar methods to contact and recruit HIV-positive persons, may inform predictors of successful contact for D2C programs.

A flood of information: Using Sentinel-3 water colour products to assure continuity in the monitoring of water quality trends in the Great Barrier Reef (Australia).

An operational method to assess trends in marine water composition and ecosystem health during flood periods has been developed for the Great Barrier Reef (GBR), Queensland, Australia. This method integrates satellite water colour data with field water quality and ecosystem monitoring data and involves the classification of Moderate-Resolution Imaging Spectroradiometer (MODIS satellite) pixels into six distinct water bodies using a "wet season" colour scale developed specifically for the GBR. Using this inf...

Twenty-Five-Fold Reduction in Measurement Uncertainty for a Molecular Line Intensity.

To accurately attribute sources and sinks of molecules like CO_{2}, remote sensing missions require line intensities (S) with relative uncertainties u_{r}(S)

The Check and Report Ebola (CARE+) Program to Monitor Travelers for Ebola After Arrival to the United States, 2014-2016.

The 2014-2016 Ebola epidemic in West Africa influenced how public health officials considered migration and emerging infectious diseases. Responding to the public's concerns, the US government introduced enhanced entry screening and post-arrival monitoring by public health authorities to reduce the risk of importation and domestic transmission of Ebola while continuing to allow travel from West Africa. This case study describes a new initiative, the Check and Report Ebola (CARE+) program that engaged travel...

A 3D-printed hand-powered centrifuge for molecular biology.

The centrifuge is an essential tool for many aspects of research and medical diagnostics. However, conventional centrifuges are often inaccessible outside of standard laboratory settings, such as remote field sites, because they require a constant external power source and can be prohibitively costly in resource-limited settings and Science, technology, engineering, and mathematics (STEM)-focused programs. Here we present the 3D-Fuge, a 3D-printed hand-powered centrifuge, as a novel alternative to standard ...

Modified Palmer Drought Severity Index: Model improvement and application.

Monitoring of droughts is the first step into human adaptation and related management of drought hazards. Therefore, drought index is critical in drought monitoring practice. However, the standing drought indices include no information about agricultural irrigation. In this case, based on the Palmer Drought Severity Index (PDSI) and the Self-Calibrating Palmer Drought Severity Index (sc-PDSI), here we proposed the Modified Palmer Drought Severity Index (MPDSI) by considering agricultural irrigation such as ...

Concurrent Use of Teneligliptin and Canagliflozin Improves Glycemic Control with Beneficial Effects on Plasma Glucagon and Glucagon-Like Peptide-1: A Single-Arm Study.

We investigated the mechanisms of the glucose-lowering effects of teneligliptin and canagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, by monitoring several gastrointestinal peptides using the most appropriate measuring methods during multiple meal tolerance tests (MTTs) and flash glucose monitoring.

Determination of the physical domain for air quality monitoring stations using the ANP-OWA method in GIS.

Air pollution is a major concern in some megacities of Iran. Specific cities in the country have reached an extremely harmful level of air pollution which poses a serious risk to the daily lives of Iranians. According to news reports, the air quality index of the city of Tehran hovers around 159, which is more than three times the World Health Organization's advised maximum. For the purpose of air pollution abatement, it is necessary to precisely know the air pollution distribution in the area. In order to ...

SPS: Understanding the complexity.

Stiff-person syndrome (SPS), first described in 1956 by Moersch and Woltman, is a progressive autoimmune disorder with core features of chronic fluctuating progressive truncal and limb rigidity and painful muscle spasms leading to gait difficulties, falls and an appearance that resembles tin soldiers. The syndrome is a rare, highly disabling disorder of the central nervous and frequently results in significant disability. Understanding of the etiology, clinical spectrum, diagnostic workup and therapeutic mo...

Evaluation of dried blood spots for hepatitis B and D serology and nucleic acid testing.

Areas with the highest burden of hepatitis B virus (HBV) infection are often low-middle-income countries with limited access to diagnosis due to isolation, affordability and/or feasibility. Dried blood spots (DBS) provide an alternative for remote areas where collection and transportation of serum is impractical. In this study the application of DBS for serological and molecular detection of HBV and hepatitis D virus (HDV) was evaluated. HBsAg was detected in 87 of 91 (95.6%) DBS. 17/21 (81%) had detectable...

Increased arbekacin clearance in patients with febrile neutropenia.

Arbekacin (ABK) is used to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and is used widely for the treatment of febrile neutropenia (FN). As ABK has a narrow therapeutic concentration window, the dosage must be adjusted via therapeutic drug monitoring (TDM). However, the influence of the physiology of patients with FN on the pharmacokinetic (PK) parameters of ABK remains unclear. Therefore, we examined this influence on ABK PK parameters.

Application of Matrix Scoring Techniques to evaluate marine debris sources in the remote islands of the Azores Archipelago.

Three-quarters of all marine debris (MD) consists of plastic, a reflection of their worldwide use, production and waste mismanagement. Data on MD distributions can improve our ability to effectively reduce debris that escapes onto shorelines and the ocean. In this study, the Matrix Scoring Technique (Marine Strategy Framework Directive Technical Group on Marine Litter) was applied as an approach to calculate the likelihood of single debris items originating from a series of potential sources. Factors consid...

Intracellular cardiomyocytes potential recording by planar electrode array and fibroblasts co-culturing on multi-modal CMOS chip.

Intracellular action potential signals reveal enriched physiological information. Patch clamp techniques have been widely used to measure intracellular potential. Despite their high signal fidelity, they suffer from low throughput. Recently, 3D nanoelectrodes have been developed for intracellular potential recording. However, they are limited by scalability, yield, and cost, directly constraining their use in monitoring large number of cells and high throughput applications. In this paper, we demonstrate in...

Rewarding deep brain stimulation at the medial forebrain bundle favours avoidance conditioned response in a remote memory test, hinders extinction and increases neurogenesis.

Intracranial Self-Stimulation (ICSS) at the medial forebrain bundle consistently facilitates learning and memory in rats when administered post-training or when administered non-concurrent to training, but its scope regarding remote memory has not yet been studied. The present work aims to test whether the combination of these two forms of ICSS administration can cause a greater persistence of the facilitating effect on remote retention and affect neurogenesis in the dentate gyrus (DG) of the hippocampus. R...

Risk factors for unsuccessful atropine therapy in hypertrophic pyloric stenosis.

Intravenous atropine (IA) for infantile hypertrophic pyloric stenosis (IHPS) is a good alternative to pyloromyotomy but has not been broadly accepted. The lower success rate is one of the greatest disadvantages of IA. We aimed to investigate the risk factors for unsuccessful results following IA for IHPS.

Long-term renal follow-up of preterm neonates born before 35 weeks of gestation.

The hypothesis of the Developmental Origins of Health and Disease states that environmental factors during fetal and infantile life are risk factors for some chronic diseases in adulthood. However, few studies have confirmed this hypothesis early in childhood. Therefore, we aimed to assess how premature birth and low birth weight (LBW) affect the renal function of Japanese children.

Butterfly abundance declines over 20 years of systematic monitoring in Ohio, USA.

Severe insect declines make headlines, but they are rarely based on systematic monitoring outside of Europe. We estimate the rate of change in total butterfly abundance and the population trends for 81 species using 21 years of systematic monitoring in Ohio, USA. Total abundance is declining at 2% per year, resulting in a cumulative 33% reduction in butterfly abundance. Three times as many species have negative population trends compared to positive trends. The rate of total decline and the proportion of sp...


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