PubMed Journal Database - Page: 3 RSS

13:40 EST 23rd January 2019 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.

BioPortfolio aims to cross reference relevant information on published papers, clinical trials and news associated with selected topics - speciality.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 51–75 of 1,000,000+

Statistical Analysis Plan (SAP) for "An international multicenter study of isoelectric electroencephalography (EEG) events in infants and young children during anesthesia for surgery".

This Statistical Analysis Plan (SAP) details the statistical procedures to be applied for the analysis of data for the multi-center electroencephalography (EEG) study. It consists of a basic description of the study in broad terms and separate sections that detail the methods of different aspects of the statistical analysis, summarized under the following headings 1: Background; 2: Definitions of protocol violations; 3: Definitions of objectives and other terms; 4: Variables for analyses; 5: Handling of mis...

Visible Light-driven Copper Photoredox-catalyzed Multicomponent Coupling of Arylamines, Terminal Alkynes, and Alcohols via HAT Process.

The first successful example of 3-component coupling of N-alkylanilines, terminal alkynes, and alcohols was achieved at R.T. via a visible light-mediated copper-catalyzed photoredox-hydrogen atom transfer (HAT) process. This method allows preparation of propargylamines via unique selective α-C-H bond activation of unactivated alkylalcohols. Preliminary studies indicate that a formation of α-oxy radical is operative. 53 examples were presented. This approach allows facilitates rapid access to biologically ...

Discovery of sustainable drugs for neglected tropical diseases: cashew nut shell liquid (CNSL)-based hybrids target mitochondrial function and ATP production in Trypanosoma brucei.

In a search for effective and sustainable treatments for trypanosomiasis, we developed a library of hybrid compounds by merging the structural features of a previously synthesized quinone hit (4) with those of long-chain phenolic constituents from cashew nut shell liquid (CNSL). CNSL is an agro-waste product from cashew nut processing factories with great potential as a precursor for the production of drugs. The synthesized compounds were tested against Trypanosoma brucei brucei, including three multi-drug ...

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF-1.

Bile acids are now accepted as central signaling molecules for the regulation of glucose, amino acid, and lipid metabolism. Adrenal gland cortex cells express the bile acid receptors farnesoid X receptor (FXR), the G protein-coupled bile acid receptor (TGR5), and the sphingosine-1-phosphate receptor 2 (S1PR2). We aimed to determine the effects of cholestasis and more specifically of bile acids on cortisol production.

Patient-reported outcome measures for life participation in kidney transplantation: A systematic review.

For many patients with end-stage kidney disease, transplantation improves survival and quality of life compared to dialysis. However, complications and side-effects in kidney transplant recipients can limit their ability to participate in activities of daily living including work, study and recreational activities. The aim of this study was to identify the characteristics, content and psychometric properties of the outcome measures used to assess life participation in kidney transplant recipients. We search...

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as hematologic indices of inflammatory response in ceramic workers' silicosis.

Occupational exposure to crystalline silica over time may result with silicosis: a fatal, irreversible occupational disease leading to lung function impairment. A complex inflammatory process, excessive accumulation of mesenchymal cells collagen production are the primary mechanisms underlying silicosis. Neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) have emerged as representative indices of systemic inflammation.

A critical review on solid waste derived CO2 capturing materials.

Solid sorbents are considered as promising materials for CO2 capture due to their exceptional advantages. In recent years, a lot of studies dealt worked on using solid waste as CO2 sorbents. The use of waste resource as the CO2 sorbents not only can develop relative low-cost materials, but also eliminate the waste simultaneously. Different types of waste materials from biomass, industrial waste, household waste etc. were used as CO2 sorbents with sufficient CO2 capture capacities. In this paper, the progres...

Creatinine-based estimation of glomerular filtration rate in patients with a Fontan circulation.

Patients with a Fontan circulation are at risk of renal dysfunction. We analyzed cross-sectional data in pediatric and adult Fontan patients in order to assess the accuracy of commonly used serum creatinine-based methods in estimating glomerular filtration rate (GFR).

Efficient electrocatalysis for the preparation of (hetero)aryl chlorides and vinyl chloride with 1,2-dichloroethane.

Although the application of DCE as a chlorinating reagent in organic synthesis concomitant with release of vinyl chloride as a useful byproduct is a fantastic idea, it is still a big challenge and is hardly achieved because of the harsh dehydrochlorination conditions and the inert C-H chlorination process. Here we report a bifunctional electrocatalysis strategy for catalytic dehydrochlorination of DCE at cathode simultaneously with the anodic oxidative aromatic chlorination using the released HCl as chloro-...

An undergraduate laboratory experience using CRISPR-Cas9 technology to deactivate green fluorescent protein expression in Escherichia coli.

Undergraduates learn that gene editing in diverse organisms is now possible. How targeted manipulation of genes and genomes is utilized in basic science and biomedicine to address biological questions is challenging for undergraduates to conceptualize. Thus, we developed a lab experience that would allow students to be actively engaged in the full process of design, implementation of a gene editing strategy, and interpretation of results within an 8-week lab period of a Genetics course. The laboratory exper...

Palladium-catalyzed Asymmetric Intramolecular Reductive Heck Desymmetrization of Cyclopentenes: Access to Chiral Bicyclo3.2.1octanes.

A palladium-catalyzed asymmetric reductive Heck reaction of unactivated aliphatic alkenes with eliminable β-H has been realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing a chiral quaternary and a tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibiting good functional group tolerance and scalability. Moreover, the deuterated optically active bicyclo[3.2.1]octanes could also be obtained in high efficiency.

Nursing students' perceptions of a silent mentor program in an anatomy course.

Anatomy is a core course in undergraduate nursing curriculum. In today's nursing profession, the integration of biosciences and humanities is increasingly emphasized. Anatomy is considered one of the most essential bioscience subjects for nursing practice. Thus, integrating a silent mentor program into the anatomy course can enrich the knowledge of undergraduate nursing students regarding biosciences and humanities and enhance their future patient-centered care competencies. This paper aimed to understand s...

Size-control by anion templating in mechanochemical synthesis of hemicucurbiturils in the solid state.

Self-organization is one of the most intriguing phenomena of chemical matter. While the self-assembly of macrocycles and cages in dilute solutions has been extensively studied, it remains poorly understood in solvent-free environments. We provide the first example of using anionic templates to achieve selective assembly of differently-sized macrocycles in a solvent-free system. Using acid-catalyzed synthesis of cyclohexanohemicucurbiturils as a model, we demonstrate size-controlled, quantitative synthesis o...

Molecular Nutrition-From Gut Microbiota to Metabolomics and Inter-Individual Nutrition.

An Atypical Case of Kleine-Levin Syndrome.

Withdrawal-Emergent Dyskinesia Following Abrupt Discontinuation of Desvenlafaxine.

Encephalitis with anti-NMDA receptor antibodies: paraneoplastic or non-paraneoplastic?

We report the case of an encephalitis patient with anti-N-methyl-D-aspartate receptor (NMDAR) antibody positivity. Anti-NMDAR encephalitis is a relatively rare autoimmune disease. In our patient, the diagnosis of anti-NMDAR encephalitis was established as late as several months after the first manifestations of the condition. Further development demonstrated that the patient probably suffered from a paraneoplastic form of the disease, although the presence of an underlying tumour was not detected by the ava...

Insulin resistance - "the good or the bad and ugly".

Insulin resistance (IR) is a state of decreased sensitivity or responsiveness of target tissues to metabolic actions of circulating insulin. IR can be selective, involving only certain aspects of insulin action, i.e. only its impact on hepatic glucose disposal. Plasma insulin concentration is a continuous variable, dependent upon several physiological stimuli, thus the thresholds used to diagnose IR are arbitrary. Insulin resistance (impaired insulin action) may occur due to derangements on three levels: pr...

Mu Opioid Receptor Regulation of Gonadotropin-Releasing Hormone-Luteinizing Hormone Axis during Short-Term Food Deprivation: Role of Alpha1-Adrenoreceptor Signaling.

Brain bio-energetic stability is required for optimal gonadal steroid positive-feedback activation of the gonadotropin-releasing hormone-I (GnRH-I)-pituitary luteinizing hormone (LH) neuroendocrine axis. Caudal hindbrain metabolic-sensory noradrenergic neurons counter energy deficiency by curtailing the mid-cycle LH surge. Central mu opioid receptors (mu-R) impose inhibitory effects of diverse physiological stimuli, including stress, on LH.

Sequencing of the insulin receptor (INSR) gene reveals association between gene variants in exon and intron 13 and schizoaffective disorder.

From the hypothesis that an impaired insulin and insulin-like growth factor cellular signalling in brain and body might result in the development of schizophrenia or related psychoses, I in this study chose to thoroughly investigate the insulin receptor gene in patients with schizophrenia or schizoaffective disorder and controls.

Accumulation of selected metals pollution in aquatic ecosystems in the Smeda river (Czech republic).

Biomonitoring of some slelected heavy metals in the Smeda river (Czech Republic) was carried out during 2015-2016 to assess the extent of environmental pollution. Attempts were also made to map the intensity of bioaccumulation in brown trout which was used as an indicator species. Monitoring of the environmental pollution of the Smeda river was carried in 2016.

Comparison of gait kinematics between professional ballet dancers and non-dancers.

The aims of the study were to assess the kinematics of the lower limbs and pelvis during normal walking in professional ballet dancers and to investigate relationships between movements of segments of the lower limbs and pelvis.

Mathematical evaluation of melatonin secretion in hypoxic ischemic encephalopathy.

The aims of the study were to assess the kinematics of the lower limbs and pelvis during normal walking in professional ballet dancers and to investigate relationships between movements of segments of the lower limbs and pelvis.

Assessing the awareness of Czechs, age 40+, on the link between lifestyle choices and risk factors for cardiovascular diseases.

Cardiovascular diseases constitute the main cause of disability and premature death worldwide. Those diseases will continue to endanger health unless the public understands clearly and completely which risk factors contribute to the development of these diseases and what they can do to avoid these risks. This article assesses the understanding of risk factors that can lead to the development of heart and vessel diseases.

Selected bisphenols and phthalates screened for estrogen and androgen disruption by in silico and in vitro methods.

The aim of this study was to detect endocrine disruption potential of selected bisphenols and phthalates, compare in silico prediction with results from two in vitro methods and bring up-to-date information on development of EU legislation, available in vitro methods and biomechanisms involved in endocrine disruption.

Quick Search