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PubMed Journals Articles About "Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc" - Page: 3 RSS

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Showing "Adalimumab biosimilar Idacio launched Germany derfield score derval" PubMed Articles 51–75 of 4,300+

A π-conjugated, covalent phosphinine framework.

Structural modularity of polymer frameworks is a key advantage of covalent organic polymers, however, only C, N, O, Si and S have found their way into their building blocks so far. Here, we expand the toolbox available to polymer and materials chemists by one additional nonmetal, phosphorus. Starting with a building block that contains a λ⁵-phosphinine (C₅P) moiety, we evaluate a number of polymerisation protocols, finally obtaining a π-conjugated, covalent phosphinine-based framework (CPF-1) via Suzu...


Design of a highly active Pd Catalyst with P,N Hemilabile Ligands for alkoxycarbonylation of alkynes and allenes: a density functional theory study.

In palladium-catalysed methoxycarbonylation of technical propyne, the presence of propadiene poisons the hemilabile Pd(P,N) catalyst. According to density functional theory calculations (B3PW91-D3/PCM level), a highly stable π-allyl intermediate is the reason for this catalyst poisoning. Predicted regioselectivities suggest that at least 11% of propadiene should yield this allyl intermediate, where the reaction gets stalled under the turnover conditions due to an insurmountable methanolysis barrier of 25.8...

A Germylene Supported by Two 2-Pyrrolylphosphane Groups as Precursor to PGeP Pincer Square-Planar Group 10 Metal(II) and T-Shaped Gold(I) Complexes.

An efficient synthesis of 2-ditertbutylphosphanylmethylpyrrole (HpyrmPtBu2), by reacting 2-dimethylaminomethylpyrrole (HpyrmNMe2) with tBu2PH at 135 oC in the absence of any solvent, has allowed the preparation of the new PGeP germylene Ge(pyrmPtBu2)2 (1), by treating GeCl2(dioxane) with LipyrmPtBu2, in which the Ge atom is stabilized by intramolecular interactions with one (solid state) or both (solution) of its phosphane groups. Reactions of germylene 1 with Group 10 metal dichlorido complexes containing ...


The Chiral Twist-Bend Nematic Phase (N*TB).

The twist-bend nematic, NTB, phase has been observed for chiral material in which chirality is introduced through a branched 2-methylbutyl terminal tail. The chiral twist-bend nematic phase, N*TB, is completely miscible with the NTB phase of the standard achiral material, CB6OCB. The N*TB phase exhibits optical textures with lower birefringence than those observed for the achiral NTB phase, suggesting an additional mechanism of averaging molecular orientations. The N*-N*TB transition temperatures for the ch...

A molecular tool targeting the base flipping activity of human UHRF1.

During DNA replication, Ubiquitin-like, containing PHD and RING fingers domains 1 (UHRF1) plays key roles in the inheritance of methylation patterns to daughter strands by recognizing through its SET and RING-associated domain (SRA) the methylated CpGs and recruiting DNA methyltransferase 1 (DNMT1). Herein, our goal is to identify UHRF1 inhibitors targeting the 5'-methylcytosine (5mC) binding pocket of the SRA domain to prevent the recognition and flipping of 5mC and determine the molecular and cellular con...

Metformin reduces risk of varicose veins in type 2 diabetes patients.

This population-based retrospective cohort study compared the incidence of varicose veins in an unmatched cohort and a cohort of 1:1 propensity score (PS)-matched pairs of ever and never users of metformin in type 2 diabetes patients.

Atomic-Layer Deposition-Assisted Double-Side Interfacial Engineering for High-Performance Flexible and Stable CsPbBr Perovskite Photodetectors toward Visible Light Communication Applications.

Self-powered photodetectors (PDs) based on inorganic metal halide perovskites are regarded as promising alternatives for the next generation of photodetectors. However, uncontrollable film growth and sluggish charge extraction at interfaces directly limit the sensitivity and response speed of perovskite-based photodetectors. Herein, by assistance of an atomic layer deposition (ALD) technique, CsPbBr perovskite thin films with preferred orientation and enlarged grain size are obtained on predeposited interfa...

A Time-Programmed Release of Dual Drugs from an Implantable Trilayer Structured Fiber Device for Synergistic Treatment of Breast Cancer.

Combination chemotherapy with time-programmed administration of multiple drugs is a promising method for cancer treatment. However, realizing time-programmed release of combined drugs from a single carrier is still a great challenge in enhanced cancer therapy. Here, an implantable trilayer structured fiber device is developed to achieve time-programmed release of combined drugs for synergistic treatment of breast cancer. The fiber device is prepared by a modified microfluidic-electrospinning technique. The ...

Chitosan and Oregano Oil Treatments, Individually or in Combination, Used To Increase the Shelf Life of Vacuum-Packaged, Refrigerated European Eel () Fillets.

We investigated the impact of chitosan and oregano essential oil (EO) individually or in combination on the quality of eel fillets in vacuum packaging (VP) and stored under refrigeration (4°C). Treatments studied were (i) control eel fillets stored in VP (E), (ii) eel fillets treated with 0.3% (v/w) oregano EO and stored in VP (E-OR), (iii) eel fillets treated with 2.0% (w/v) chitosan and stored in VP (E-CH), and (iv) eel fillets treated with 2.0% (w/v) chitosan and 0.3% (v/w) oregano EO and stored in VP (...

The day after: correlates of patient-reported outcomes with actigraphy-assessed sleep in cancer patients at home (inCASA project).

Subjective sleep assessment in cancer patients poorly correlates with actigraphy parameters that usually encompass multiple nights. We aimed to determine the objective actigraphy measures that best correlated with subjective sleep ratings on a night-by-night basis in cancer patients. Thirty-one cancer patients daily self-rated sleep disturbances using the single dedicated item of the MD Anderson Symptom Inventory (0-10 scale) with 18 other items, and continuously wore a wrist actigraph for 30 days. Objectiv...

Development of a measure of genome sequencing knowledge for young people: the kids-KOGS.

Genome sequencing is increasingly being used to diagnose rare diseases in paediatric patients, however, no measures exist to evaluate their knowledge of this technology. We aimed to develop a robust measure of knowledge about genome sequencing (the kids-KOGS') suitable for use in the paediatric setting as well as for general public education. The target age was 11 to 15 year olds. An iterative process involving six sequential stages was conducted to develop a set of draft true/false items. These were then a...

Cholinergic Pruritus responding to Omalizumab: a case report.

Cholinergic pruritus is a rare condition characterised by generalised itch provoked by sweating without an associated rash. It is exacerbated by heat, exercise, emotion or activities of daily living.(1) The pruritus can be severe and have a considerable impact on the patient's life. A 60 year old gentleman presented to our clinic in 2012 with a 9-month history of severe pruritus and a burning sensation that was induced by exercise and heat and relieved by cooling. The symptoms were not associated with a ski...

A Prolonged Air Leak Score for Lung Cancer Resection: An Analysis of the STS GTSD.

The objective of this study was to create a simple preoperative tool to assess the risk of prolonged air leak (PAL) using the Society of Thoracic Surgeons General Thoracic Surgery Database (STS GTSD).

Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases.

Traditional methods for chemical risk assessment are too time-consuming and resource-intensive to characterize either the diversity of chemicals to which humans are exposed or how that diversity may manifest in population susceptibility differences. The advent of novel toxicological data sources and their integration with bioinformatic databases affords opportunities for modern approaches that consider gene-environment (GxE) interactions in population risk assessment. Here, we present an approach that syste...

Resistance training in addition to aerobic activity is associated with lower likelihood of depression and comorbid depression and anxiety symptoms: A cross sectional analysis of Australian women.

The mental health benefits of resistance training (RT) alone or beyond those provided by aerobic physical activity (PA) are unclear. This study aimed to determine the association between meeting recommendations for aerobic PA and/or RT, and symptoms of depression and/or anxiety. Participants were Australian female members of the 10,000 Steps project (n = 5180, 50.0 ± 11.5 years). Symptoms of depression and anxiety were determined using the Depression Anxiety Stress Score. Participants were groupe...

Association of cardiovascular health through early adulthood and health-related quality of life in middle age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Previous studies have linked cardiovascular health (CVH) and health-related quality of life (HRQoL), but only in cross-sectional analyses where temporality cannot be established. The aim of this study was to determine trajectories of CVH from early adulthood to middle age, and examine their association with HRQoL in middle age. This analysis, conducted in 2018, included 3275 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study who completed a year 30 follow-up exam in 2015/201...

Development of a target-free high throughput screening platform for the discovery of anti-leishmanial compounds.

Leishmania parasites are the causative agents of a wide spectrum of human diseases. The clinical manifestations of leishmaniasis range from self-healing skin lesions to fatality. The WHO has declared leishmaniasis a Category I Neglected Tropical Disease. This disease represents a major international health challenge, affecting 12 million people per year and with nearly 310 million people at risk. The first-line chemotherapies used to treat leishmaniasis are intravenous pentavalent antimonials; however, thes...

Undifferentiated connective tissue disease at risk of systemic sclerosis: A weighted score to identify patients who will evolve.

One-stage surgical resection of giant intracranial arteriovenous malformations in selected patients: a novel diffusion tenser imaging score.

Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass.

Roux-en-Y gastric bypass (RYGB) is a common surgical procedure for treatment of morbid obesity. RYGB induces considerable and sustained weight loss, and remission of obesity related-comorbidities. While studies have suggested negative effects of RYGB on bone health, long-term data are lacking. We aimed to evaluate the prevalence of aBMD below the expected range for age, osteopenia, osteoporosis and low-energy fractures in a defined patient cohort 10 years after RYGB. Secondly, we wanted to identify factor...

Acute stroke rehabilitation for gait training with cyborg type robot Hybrid Assistive Limb: A pilot study.

Robot-assisted gait training following acute stroke could allow patients with severe disability to receive a high dosage and intensity of gait training compared with conventional physical therapy (CP). However, given the limited data on gauging the efficacy of Hybrid Assistive Limb (HAL) on gait training in patients with acute stroke, we aimed to evaluate several outcome measures following gait training with HAL. Patients with first-ever stroke, who required a walking aid and were able to start gait trainin...

Problematic internet use in Bangladeshi students: The role of socio-demographic factors, depression, anxiety, and stress.

Problematic Internet Use (PIU) has become a concern for public mental health across the globe. However, there are few studies assessing PIU in Bangladesh. The present cross-sectional study estimated the prevalence rate of PIU and its associated risk factors among 405 university students in Bangladesh between June and July 2018. The measures included sociodemographic questions, internet and health-related variables, the Internet Addiction Test (IAT) and the Depression, Anxiety and Stress Scale (DASS-21). The...

Semi-quantitative analysis of morphological changes in bee tissues: A toxicological approach.

During foraging, bees are exposed to sublethal doses of insecticides, which can cause morphological changes to various organs, such as the midgut, Malpighian tubules, and mushroon body. Thus, the purpose of this study was to establish a scoring system to evaluate these alterations based on the damage caused and its reversibility. Therefore, a grade 1 score indicates a minimal and easily reversible lesion, increased apocrine secretion, increased cell elimination into the lumen, and a larger quantity of spher...

Sustainability of safe foods: Joint environmental, economic and microbial load reduction assessment of antimicrobial systems in U.S. beef processing.

Various antimicrobial interventions are applied sequentially in the beef processing industry to reduce microbial load on beef products by using intensive inputs (e.g., chemicals, energy), high strength wastewater, and potentially result in meat discoloration. This study serves as the first analysis to jointly evaluate environmental and economic assessment with its microbial load reduction of proposed antimicrobial systems in the U.S. beef processing industry to identify relatively sustainable systems that m...

Rebleeding drives poor outcome in aneurysmal subarachnoid hemorrhage independent of delayed cerebral ischemia: a propensity-score matched cohort study.

Delayed cerebral ischemia (DCI) and aneurysm rebleeding contribute to morbidity and mortality in aneurysmal subarachnoid hemorrhage (aSAH); however, the relationship between their impacts on overall functional outcome is incompletely understood.


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