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PubMed Journals Articles About "Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated" - Page: 3 RSS

09:06 EST 18th February 2019 | BioPortfolio

Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated articles that have been published worldwide.

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Showing "Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated" PubMed Articles 51–75 of 15,000+

The impact of proton pump inhibitors on the pharmacokinetics of voriconazole in vitro and in vivo.

Voriconazole (VRC) and proton pump inhibitors (PPIs) have similar metabolic pathways. The objectives of the study are to evaluate the impact of PPIs on the pharmacokinetics of VRC. Human liver microsomes model was applied to assess the inhibitory effects of PPIs on the metabolism of VRC in vitro. A retrospective study was also carried out to explore the relationship between the plasma VRC trough concentrations and PPIs uses. Patients were divided into six groups: control (n = 166), lansoprazole (LAN, n...


Proton pump inhibitors reduce the accuracy of faecal immunochemical test for detecting advanced colorectal neoplasia in symptomatic patients.

The faecal immunochemical test (FIT) is used in colorectal cancer (CRC) screening and for the detection of advanced colorectal neoplasia (AN) in symptomatic patients, but its accuracy could be improved. Our objective was to assess the impact of proton pump inhibitors (PPI) on the accuracy of the FIT in the detection of AN, namely advanced colorectal adenoma and CRC.

Proton pump inhibitors use and risk of falls.


Proton Pump Inhibitors and Bone Health: What the Orthopaedic Surgeon Needs to Know.

Structure Based Drug Design: Clinically relevant HIV1 Integrase Inhibitors.

HIV-1 integrase, a member of a polynucleotidyl transferases superfamily, catalyze the insertion of the viral DNA into the genome of host cells. It has emerged as a potential target for developing anti-HIV agents. In last two decades, number of integrase inhibitors has been developed as potential anti-HIV therapeutics. Several integrase inhibitors have reached later stages of clinical trials including S-1360, L870,810, L870,812 and BMS-707035. Into the bargain, Raltegravir, Elvitegravir and Dolutegravir have...

Early Childhood Education Centers' Reported Readiness to Implement the Updated Child and Adult Care Food Program Meal Pattern Standards in the United States, 2017.

The Child and Adult Care Food Program (CACFP) serves nutritious meals/snacks to >3.6 million children in early childhood education (ECE) centers. This study provides a nationwide assessment of nonhome-based CACFP-participating ECE centers' awareness of and reported readiness for implementing updated CACFP standards/best practices that took effect October 1, 2017.

Laparoscopic magnetic sphincter augmentation versus double-dose proton pump inhibitors for management of moderate-to-severe regurgitation in GERD: a randomized controlled trial.

GERD patients frequently complain of regurgitation of gastric contents. Medical therapy with proton-pump inhibitors (PPIs) is frequently ineffective in alleviating regurgitation symptoms, as PPIs do nothing to restore a weak lower esophageal sphincter. Our aim was to compare effectiveness of increased PPI dosing with laparoscopic magnetic sphincter augmentation (MSA) in patients with moderate-to-severe regurgitation despite once-daily PPI therapy.

Proton pump inhibitors: Review of reported risks and controversies.

Proton pump inhibitors (PPIs) are among the most prescribed classes of drugs in this day and age. These may be beneficial to treat many gastrointestinal conditions, such as gastroesophageal reflux or Barrett's esophagus as well as laryngopharyngeal reflux. However, many reports have emerged in the literature exposing the potential association of PPIs with various risks and complications such as bone fracture, infection, myocardial infarction, renal disease, and dementia. This review highlights many of these...

Developing a modern data workflow for regularly updated data.

Over the past decade, biology has undergone a data revolution in how researchers collect data and the amount of data being collected. An emerging challenge that has received limited attention in biology is managing, working with, and providing access to data under continual active collection. Regularly updated data present unique challenges in quality assurance and control, data publication, archiving, and reproducibility. We developed a workflow for a long-term ecological study that addresses many of the c...

Letter: proton pump inhibitors and the risk of hepatocellular carcinoma.

Editorial: proton pump inhibitors (PPIs) and microscopic colitis.

Glycoprotein IIb/IIIa inhibitor use in patients with acute myocardial infarction undergoing PCI: Insights from the TRANSLATE ACS study.

Concomitant use of glycoprotein IIb/IIIa inhibitors (GPI) and P2Y inhibitors increases bleeding risk. How GPIs are being used with faster onset, higher potency P2Y inhibitors are unclear.

Quorum sensing inhibitors as antipathogens: biotechnological applications.

The mechanisms through which microbes communicate using signal molecules has inspired a great deal of research. Microbes use this exchange of information, known as quorum sensing (QS), to initiate and perpetuate infectious diseases in eukaryotic organisms, evading the eukaryotic defense system by multiplying and expressing their pathogenicity through QS regulation. The major issue to arise from such networks is increased bacterial resistance to antibiotics, resulting from QS-dependent mediation of the forma...

Efflux Pump Substrates Shuttled to Cytosolic or Vesicular Compartments Exhibit Different Permeability in a Quantitative Human Blood-Brain Barrier Model.

Representative in vitro blood-brain barrier (BBB) models can support the development of strategies to efficiently deliver therapeutic drugs to the brain by aiding the characterization of their internalization, trafficking, and subsequent transport across the BBB. A collagen type I (COL1) hydrogel-based in vitro BBB model was developed to enable the simultaneous characterization of drug transport and intracellular processing using confocal microscopy, in a way that traditional insert-based in vitro BBB model...

Off-Pump versus On-Pump Impact: Diabetic Patient Five-Year Coronary Artery Bypass Clinical Outcomes.

For diabetic patients requiring coronary artery bypass graft (CABG) surgery, controversy persists whether an off-pump or an on-pump approach may be advantageous. As the first US-based, multi-center, randomized, controlled trial, this Department of Veterans Affairs "Randomization On versus Off Bypass Follow-up Study" compared diabetic patients' five-year off-pump versus on-pump clinical outcomes.

Passing the "Acid Test": Do Proton Pump Inhibitors Affect the Composition of the Microbiome?

A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma.

The treatment of melanoma patients has been revolutionized by the development of targeted therapies such as BRAF and MEK inhibitors which have achieved response rates above 50% and median overall survival of more than 12 months. Similarly, immunotherapies such as checkpoint inhibitors have been used to obtain response rates of up to 70%, with a proportion of patients having long-term durable responses (Luke et al., 2017). Despite these advances, the majority of melanoma patients cannot be cured with availa...

Patients' Perceptions of Proton Pump Inhibitor Risks and Attempts at Discontinuation: A National Survey.

Little is known about how reports on the adverse effects of proton pump inhibitors (PPIs) impact patients' perceptions of these drugs and medication use. We sought to determine patients' level of concern about PPI adverse effects and its association with attempts to discontinue these drugs.

Letter: association between proton pump inhibitors and the risk of hepatocellular carcinoma-authors' reply.

Acute toxicity of selenate and selenite and their impacts on oxidative status, efflux pump activity, cellular and genetic parameters in earthworm Eisenia andrei.

Selenium (Se) is an essential element for humans, animals, and certain lower plants, but can be toxic at high concentration. Even though Se is potentially toxic, little information is available about the effects of Se on soil animals. The aim of this study was to assess the impact of different concentrations of two Se forms, selenate and selenite, on earthworm Eisenia andrei. In order to obtain comprehensive overview on the Se effects, different parameters were measured. Namely, acute toxicity, apoptosis, e...

Comparing Two Classification Schemes for Seizures and Epilepsy in Rural China.

The International League Against Epilepsy (ILAE) updated the classifications of seizures and epilepsies in 2017. We compared the 2017 classifications with the 1980's classifications in rural China.

Size-dependent effects of polystyrene microplastics on cytotoxicity and efflux pump inhibition in human Caco-2 cells.

Microplastics in the environment may gain entry the human gastrointestinal tract through the food chain. However, information on different adverse effects of microplastics at nanometer or micrometer scales in human intestine cells is limited. This study compared the cytotoxicity and efflux pump inhibition ability of 0.1 μm and 5 μm polystyrene microplastics (PS-MPs) in the human colon adenocarcinoma Caco-2 cells. Both PS-MP sizes exhibited low toxicity on cell viability, oxidative stress, and membra...

Letter: proton pump inhibitors use and risk of hepatocellular carcinoma: A meta-analysis of observational studies.

Costs Five Years after Off-Pump or On-pump Coronary Artery Bypass Surgery.

Coronary artery bypass surgery (CABG) is a common surgical treatment for ischemic heart disease. Little is known about the long-term costs of conducting the surgery on-pump or off-pump.

Antibacterial and anti-PmrA activity of plant essential oils against fluoroquinolone resistant Streptococcus pneumoniae clinical isolates.

Streptococcus pneumoniae (pneumococcus) is recognized as one of the major cause of infections in communities and hospitals. In this study, anti-pneumococcal and anti-efflux pump activity of two medicinal plants (Thymus daenensis and Origanum vulgare) essential oils were evaluated. Checkerboard assay test was performed for investigation of the effects of selected EOs on ciprofloxacin and ethidium bromide uptake in pmrA overexpressed fluoroquinolone resistant pneumococcus. Using quantitative real-time RT-PCR ...


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