PubMed Journals Articles About "Cell Design Labs Appoints Chief Medical Officer" - Page: 3 RSS

12:08 EDT 22nd October 2018 | BioPortfolio

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Showing "Cell Design Labs Appoints Chief Medical Officer" PubMed Articles 51–75 of 39,000+

Sharing and reusing cell image data.

The rapid growth in content and complexity of cell image data creates an opportunity for synergy between experimental and computational scientists. Sharing microscopy data enables computational scientists to develop algorithms and tools for data analysis, integration, and mining. These tools can be applied by experimentalists to promote hypothesis-generation and discovery. We are now at the dawn of this revolution: infrastructure is being developed for data standardization, deposition, sharing, and analysis...

Cultural competence and curricular design: learning the hard way.

Association Networks in a Matched Case-Control Design - Co-occurrence Patterns of Preexisting Chronic Medical Conditions in Patients with Major Depression versus their Matched Controls.

We present a method for comparing association networks in a matched case-control design, which provides a high-level comparison of co-occurrence patterns of features after adjusting for confounding factors. We demonstrate this approach by examining the differential distribution of chronic medical conditions in patients with major depressive disorder (MDD) compared to the distribution of these conditions in their matched controls.

Immunity War: A Novel Therapy for Lymphoma Using T-cell Bispecific Antibodies.

The activity of T cell mediated immunotherapies in B cell lymphoma has been limited to date. The novel bi-specific antibody CD20-TCB, has a 2:1 antibody design to maximize T cell engagement, and demonstrates activity in preclinical models. This may represent a novel therapeutic approach for patients with relapsed/refractory NHL.

Expression of Concern: Knockdown of eIF3d inhibits cell proliferation through G2/M phase arrest in non-small cell lung cancer.

Immunity by Design.

One outcome of the many advances in basic sciences that have been made over the last decades is the prospect of rational vaccine design. A recent publication by Du et al. (2018) describes a screening method for selection of live-attenuated viral vaccine platforms with enhanced immune-stimulatory properties.

Design of a surrogate for evaluation of methods to predict bone bending stiffness.

The high incidence of osteoporosis and related fractures demands for the use and development of methods capable of detecting changes in bone mechanical properties. The most common clinical and laboratory methods used to detect changes in bone mechanical properties, such as stiffness, strength, or flexural rigidity, include: mechanical testing, medical imaging, medical image-based analytical calculations, and medical image-based finite element analysis. However, the innate complexity of bone makes validation...

NCRP Vision for the Future and Program Area Committee Activities in 2017.

The National Council on Radiation Protection and Measurements' (NCRP) vision for the future is to improve radiation protection for the general public and workers. This vision is embodied within NCRP's ongoing initiatives: preparedness for nuclear terrorism, increasing the number of radiation professionals critically needed for the nation, providing new guidance for radiation protection in the United States, addressing the protection issues surrounding the ever-increasing use of ionizing radiation in medicin...

Comparison of Bipolar and Unipolar Pulses in Cell Electrofusion: Simulation and Experimental Research.

Unipolar pulses have been used in cell electrofusion over the last decades. However, the problem of high mortality with unipolar pulses has not been solved effectively. The cell fusion rate is restrict by cell mortality. By using the advantages of bipolar pulses which cause less cell damage, this paper attempts to use bipolar pulses to increase the cell fusion rate.

Life Cycle Assessment of Traction Lead-acid Batteries for Electric Bikes in China.

This research undertook a life cycle assessment (LCA) for lead-acid batteries (LABs) used in electric bikes, the fastest growing LABs in China. A cradle-to-grave LCA model was established to identify the key materials or processes that contribute most to environmental impacts within the life cycle of LABs, including material production, battery manufacture, transportation, use, and end-of-life. A large amount of primary data obtained from enterprisers and a Chinese LCA database were used in this research to...

Design and Activity of Specific Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).

HIF-2α, a member of the HIF family of transcription factors, is a key oncogenic driver in cancers such as clear cell renal cell carcinoma (ccRCC). A signature feature of these cancers is the over accumulation of HIF-2α protein, often by inactivation of the E3 ligase VHL (von Hippel-Lindau). Herein we disclose our structure based drug design (SBDD) approach that culminated in the identification of PT2385, the first HIF-2α antagonist to enter clinical trials. Highlights include the use of a putative n → ...

Making a difference for the profession, the people in it and the animals.

As she steps away from the BVA officer team next month, celebrates the skills she has gained through an eclectic career and wonders what will come next.

Design and applications of cell-selective surfaces and interfaces.

Tissue regeneration involves versatile kinds of cells. The accumulation and disorganized behaviors of undesired cells impair natural healing process, leading to uncontrolled immune response, restenosis, and/or fibrosis. The cell-selective surfaces and interfaces can have specific and positive effects to the desired types of cells, allowing tissue regeneration with restored structures and functions. This review outlines the importance of surfaces and interfaces of biomaterials with cell-selective properties....

Medical Rehabilitation: Guidelines to Advance the Field with High-Impact Clinical Trials.

The purpose of this Special Communication is to summarize guidelines and recommendations stemming from an expert panel convened by the National Institutes of Health (NIH), National Center for Medical Rehabilitation Research (NCMRR) for a workshop entitled, The Future of Medical Rehabilitation Clinical Trials, held 29-30 September 2016 at the NCMRR offices in Bethesda, Maryland. The ultimate goal of both the workshop and this summary is to offer guidance on clinical trials design and operations to the medica...

Bribery Games on Interdependent Complex Networks.

Bribe demands present a social conflict scenario where decisions have wide-ranging economic and ethical consequences. Nevertheless, such incidents occur daily in many countries across the globe. Harassment bribery constitute a significant sub-set of such bribery incidents where a government official demands a bribe for providing a service to a citizen legally entitled to it. We employ an evolutionary game-theoretic framework to analyse the evolution of corrupt and honest strategies in structured populations...

Identification of Novel Target for Osteosarcoma by Network Analysis.

BACKGROUND Osteosarcoma (OS) is a highly complicated bone cancer involving imbalance of signaling transduction networks in cells. Development of new anti-osteosarcoma drugs is very challenging, mainly due to lack of known key targets. MATERIAL AND METHODS In this study, we attempted to reveal more promising targets for drug design by "Target-Pathway" network analysis, providing the new therapeutic strategy of osteosarcoma. The potential targets used for the treatment of OS were selected from 4 different sou...

Expanding Human Computer Interaction Methods to Understand User Needs in the Design Process of Personal Health Systems.

 To review innovative human computer interaction methods researchers utilize to identify stakeholders' needs that inform the design of personal health systems outside of clinical environments.

Data Protection Officer and Freedom of Information Act.

Computer-assisted subtyping and prognosis for non-small cell lung cancer patients with unresectable tumor.

The histological classification or subtyping of non-small cell lung cancer is essential for systematic therapy decisions. Differentiating between the two main subtypes of pulmonary adenocarcinoma and squamous cell carcinoma highlights the considerable differences that exist in the prognosis of patient outcomes. Physicians rely on a pathological analysis to reveal these phenotypic variations that requires invasive methods, such as biopsy and resection sample, but almost 70% of tumors are unresectable at the ...

Design and synthesis of aminocoumarin derivatives as DPP-IV inhibitors and anticancer agents.

DPP-IV "a moonlighting protein" has immerged as promising pathway to control Type 2 diabetes as well as found to play key role in earlier stages of cancer. Here we have reported design, synthesis and applications of aminocoumarin derivatives as DPP-IV inhibitors. Compounds have been synthesized and studied for their DPP-IV inhibition activity. Three compounds have shown moderate inhibition at 100 µM concentration. All compounds were also screened for their anticancer activity against A549 (Lung cancer ce...

Sources of Safety Data and Statistical Strategies for Design and Analysis: Postmarket Surveillance.

Safety data are continuously evaluated throughout the life cycle of a medical product to accurately assess and characterize the risks associated with the product. The knowledge about a medical product's safety profile continually evolves as safety data accumulate.

Medical and non-medical marijuana use in depression: Longitudinal associations with suicidal ideation, everyday functioning, and psychiatry service utilization.

Marijuana use is clinically problematic in depression, and non-medical and medical use may both contribute to barriers to care in this population. Among outpatients with depression, we examined the differential impact of medical or non-medical marijuana use, relative to no-use, on psychopathology and service use over time.

Feasibility of controlling CD38-CAR T cell activity with a Tet-on inducible CAR design.

Recent clinical advances with chimeric antigen receptor (CAR) T cells have led to the accelerated clinical approval of CD19-CARs to treat acute lymphoblastic leukemia. The CAR T cell therapy is nevertheless associated with toxicities, especially if the CARs are not entirely tumor-specific. Therefore, strategies for controlling the CAR T cell activity are required to improve their safety profile. Here, by using the multiple myeloma (MM)-associated CD38 molecule as target molecule, we tested the feasibility a...

CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges.

The California Institute for Regenerative Medicine (CIRM) Alpha Stem Cell Clinic (ASCC) Network was launched in 2015 to address a compelling unmet medical need for rigorous, FDA-regulated, stem cell-related clinical trials for patients with challenging, incurable diseases. Here, we describe our multi-center experiences addressing current and future challenges.

MiR-448 downregulates CTTN to inhibit cell proliferation and promote apoptosis in glioma.

miRNAs have been confirmed to be related to cell proliferation and apoptosis. In this study, we detected the potential effect of miR-448 on glioma cell proliferation and apoptosis.

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