PubMed Journals Articles About "Damon Runyon Cancer Research Foundation" - Page: 3 RSS

02:25 EST 20th January 2019 | BioPortfolio

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Showing "Damon Runyon Cancer Research Foundation" PubMed Articles 51–75 of 38,000+

Oncogene addiction as a foundation of targeted cancer therapy: the paradigm of the MET receptor tyrosine kinase.

Following nearly two decades of its conception, the phenomenon of oncogene addiction still represents a key concept of how progresses in basic research can translate to unprecedented translational breakthroughs. Coined by Bernard Weinstein, this term refers to the phenomenon by which cancer cells can exhibit dependence on a single oncogenic protein or signaling pathway for sustaining proliferation and survival, despite the wide burden of genetic lesions characterizing their genomic background, revealing thu...

A randomized trial of interpersonal psychotherapy, problem solving therapy, and supportive therapy for major depressive disorder in women with breast cancer.

Breast cancer (BC) is a risk factor for major depressive disorder (MDD), yet little research has tested the efficacy of different psychotherapies for depressed women with BC. This study, the largest to date, compared outcomes of three evidence-based, 12-week therapies in treating major depressive disorder among women with breast cancer.

Fibrosis of mesothelial cell-induced peritoneal implantation of ovarian cancer cells.

Peritoneal metastasis frequently occurs in patients with advanced ovarian cancer and is the main basis for a poor prognosis. The mechanism underlying preferential ovarian cancer spread to the peritoneum is not well understood.

Quality of diabetes care in breast, colorectal, and prostate cancer.

Overlooking other medical conditions during cancer treatment and follow-up could result in excess morbidity and mortality, thereby undermining gains associated with early detection and improved treatment of cancer. We compared the quality of care for diabetes patients subsequently diagnosed with breast, colorectal, or prostate cancer to matched, diabetic non-cancer controls.

International testicular cancer incidence rates in children, adolescents and young adults.

Testicular cancer is the most common cancer in young men in developed countries. In adults, international variation in testicular cancer incidence rates has been well-described, while previous research on pediatric and adolescent testicular cancer has been more geographically limited.

Vaccine-induced memory CD8+ T cells provide clinical benefit in HER2 expressing breast cancer: a mouse to human translational study.

Immune-based therapy for metastatic breast cancer has had limited success, particularly in molecular subtypes with low somatic mutations rates. Strategies to augment T cell infiltration of tumors include vaccines targeting established oncogenic drivers like the genomic amplification of HER2. We constructed a vaccine based on a novel alphaviral vector encoding a portion of HER2 (VRP-HER2).

Adult weight change and the risk of pre- and postmenopausal breast cancer in the Chinese Wuxi Exposure and Breast Cancer Study.

The accumulating evidence indicates that weight gain in adulthood is more predictive of breast cancer risk than absolute body weight. However, the relative impact of timing of weight gain in adulthood on breast cancer as well as other characteristics of the association between weight and breast cancer has not been well documented.

Overexpression of the cancer stem cell marker CD133 confers a poor prognosis in invasive breast cancer.

CD133/ prominin 1 is a cancer stem cell marker associated with cancer progression and patient outcome in a variety of solid tumours, but its role in invasive breast cancer (BC) remains obscure. The current study aims to assess the prognostic value of CD133 expression in early invasive BC.

Lost in Translation: Deciphering the mechanism of action of anti-human CTLA-4.

Despite a number of pre-clinical studies demonstrating that the activity of anti-CTLA-4 antibodies in murine models of cancer relies on effector T cell activation and Treg depletion, the activity of the clinical antibodies remains controversial. To decipher such mechanisms is critical to the development of novel and more potent immunotherapies.

Regulatory mechanisms of PD-L1 expression in cancer cells.

Immunotherapy targeting the PD-L1/PD-1 pathway using antibodies is effective in the clinical treatment of a multitude of cancers. This makes research of the regulatory mechanisms of PD-1 expression in cancer cells intriguing. PD-L1 expression can be categorized into inducible expression, attributed to extrinsic factors in the microenvironment, and constitutive expression, attributed to intrinsic cancer-driving gene alteration. The mechanisms of PD-L1 expression in cancer cells operate at multiple levels, in...

Primary lactase deficiency and bone mineral density in postmenopausal women.

Cancer survivorship: an integral part of Europe's research agenda.

Cancer survivorship has traditionally received little prioritisation and attention. For a long time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is time to increase the amount of attention given to patients' long-term well-being and their ability to return to a productive and good life. This article describes the current state of knowledge and identifies research areas in need of development to enable interventions for improved survivorship for all cancer patients in...

Cancer Survivorship and Employment: Intersection of Oral Agents, Changing Workforce Dynamics, and Employers' Perspectives.

The ability to continue employment during and following cancer diagnosis and treatment is critical to working-age cancer survivors. Prolonged survival combined with concerns of the financial burden associated with high-cost therapies makes the mitigation of work-related consequences all the more relevant, particularly in light of recent workforce trends and evolving employment dynamics. Research that integrates the needs of survivors, employers, and the workforce is required so that advancements are made to...

Characterization of healthy and nonmelanoma-induced mouse utilizing the Stokes-Mueller decomposition.

Skin cancer is one of the most common cancers, including melanoma and nonmelanoma cancer. Melanoma can be easily detected by the observation of abnormal moles, but nonmelanoma signs and symptoms are not apparent in the early stages. We use the Stokes-Mueller matrix decomposition method to detect nonmelanoma at the early stage by decomposing the characteristics of polarized light interacting with normal and cancerous tissues. With this decomposition method, we extract nine optical parameters from biological ...

Cancer cachexia and myopenia - Update on management strategies and the direction of future research for optimizing body composition in cancer - A narrative review.

Body composition degenerates with cancer. Optimizing body composition is rarely, if ever, undertaken. This narrative review highlights and evaluates emerging treatments that have the potential to improve outcomes for our cancer patients.

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases.

MALAT1: a potential biomarker in cancer.

The research of long non-coding RNAs (lncRNAs) has become a new passion with the discovery of abundant new lncRNAs and extensive investigation of their roles in various diseases, especially in cancers. Metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) emerges as a hotspot, which has been reported to be involved in dysregulation of cell signaling and closely correlated with cancer development, progression, and response to therapy. This review is a brief update of the current knowledge relate...

Voice Outcomes After Radiation for Early-Stage Laryngeal Cancer.

Radiation treatment for laryngeal cancer has been shown to cause tissue changes to the vocal folds, which can result in degradation of voice. Our objective in this study was to investigate changes in perceptual, acoustic, and patient-reported outcomes over an extended period of follow-up after radiation.

Mutational analysis of 472 urothelial carcinoma across grades and anatomic sites.

Characterize the mutational landscape across the spectrum of urothelial carcinoma (UC) to identify mutational features and potential therapeutic targets.

Correction: miRNA-708 Control of CD44 Prostate Cancer-Initiating Cells.

Reducing Social Inequalities in Cancer: Setting Priorities for Research.

Cancer care and public health policy evaluations in France: Usefulness of the national cancer cohort.

In the context of the national Cancer Plans of France that have changed the healthcare landscape, it has become necessary to better document and assess the related actions, and to promote research and understanding. The national cancer cohort, an exhaustive population-based cohort, was set up on the basis of the National Health Data System (SNDS) by the French National Cancer Institute.

Correction: "miR-34a Regulates Expression of the Stathmin-1 Oncoprotein and Prostate Cancer Progression".

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2018): Author Index.

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2018): Poster Abstracts.

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