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PubMed Journals Articles About "Ganaxolone Phase Data Supports Progressing Phase Patients With" - Page: 3 RSS

17:58 EDT 21st June 2018 | BioPortfolio

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Showing "Ganaxolone Phase Data Supports Progressing Phase Patients with" PubMed Articles 51–75 of 58,000+

Ferromagnetic Phase in Nonequilibrium Quantum Dots.

By nonperturbatively solving the nonequilibrium Anderson two-impurity model with the hierarchical equations of motion approach, we report a robust ferromagnetic (FM) phase in series-coupled double quantum dots, which can suppress the antiferromagnetic (AFM) phase and dominate the phase diagram at finite bias and detuning energy in the strongly correlated limit. The FM exchange interaction origins from the passive parallel spin arrangement caused by the Pauli exclusion principle during the electrons transpor...


Apalutamide: The established and emerging roles in the treatment of advanced prostate cancer.

Prostate cancer (PCa) is the most common cancer in elderly males. Androgen deprivation therapy (ADT) is still the cornerstone of initial treatment, however the vast majority of patients develop castration resistant prostate cancer (CRPC). Several studies with numerous androgen receptor (AR)-directed agents have emerged since the approval of abiraterone acetate and enzalutamide. One of these agents is apalutamide, which seems to be a promising AR antagonist for the treatment of CRPC. Areas covered: The autho...

Encoding and immediate retrieval tasks in patients with epilepsy: a functional MRI study of verbal and visual memory.

Medial lobe temporal structures and more specifically the hippocampus play a decisive role in episodic memory. Most of the memory functional magnetic resonance imaging (fMRI) studies evaluate the encoding phase; the retrieval phase being performed outside the MRI. We aimed to determine the ability to reveal greater hippocampal fMRI activations during retrieval phase.


Babinet-bilayered geometric phase optical elements.

Geometric phase optical elements based on structured anisotropy are widely used for phase shaping via their orientational degree of freedom. To date, amplitude shaping via space-variant retardance is much less investigated, a practical reason being that the spin-orbit interaction of light couples retardance with the dynamic part of the optical phase. Inspired by the complementary diffractive elements associated with Babinet's principle, a bilayered subwavelength grating design is proposed in order to cancel...

Interim Results of a Phase II Study of Hypofractionated Radiotherapy with Concurrent Temozolomide Followed by Adjuvant Temozolomide in Patients over 70 Years Old with Newly Diagnosed Glioblastoma.

In this phase II study, we investigate clinical outcomes and tolerability of hypofractionated radiotherapy (HRT) combined with temozolomide (TMZ) to treat elderly patients with glioblastoma (GBM).

Phase unwrapping algorithm using polynomial phase approximation and linear Kalman filter.

A noise-robust phase unwrapping algorithm is proposed based on state space analysis and polynomial phase approximation using wrapped phase measurement. The true phase is approximated as a two-dimensional first order polynomial function within a small sized window around each pixel. The estimates of polynomial coefficients provide the measurement of phase and local fringe frequencies. A state space representation of spatial phase evolution and the wrapped phase measurement is considered with the state vector...

Rapid construction of Fe-Co-Ni composition-phase map by combinatorial materials chip approach.

100 nm thick Fe-Co-Ni materials chips were prepared and isothermally annealed at 500, 600 and 700oC, respectively. Pixel-by-pixel composition and structural mapping was performed by micro-beam X-ray at synchrotron light source. Diffraction images were recorded at a rate of 1 pattern/s. The XRD patterns were automatically processed, phase-identified and categorized by hierarchical clustering algorithm to construct the composition-phase map. The resulting maps are consistent with corresponding isothermal sect...

How to define pathologic pelvic floor descent in MR defecography during defecation?

To assess the extents of pelvic floor descent both during the maximal straining phase and the defecation phase in healthy volunteers and in patients with pelvic floor disorders, studied with MR defecography (MRD), and to define specific threshold values for pelvic floor descent during the defecation phase.

Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer.

Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older.

Interlocking Kerr-microresonator frequency combs for microwave to optical synthesis.

We report accurate phase stabilization of an interlocking pair of Kerr-microresonator frequency combs. The two combs, one based on silicon nitride and one on silica, feature nearly harmonic repetition frequencies and can be generated with one laser. The silicon-nitride comb supports an ultrafast-laser regime with three-optical-cycle, 1-picosecond-period soliton pulses and a total dispersive-wave-enhanced bandwidth of 170 THz, while providing a stable phase-link between optical and microwave frequencies. We...

Physical significance of backscattering phase measurements.

Quantitative phase imaging of transparent objects in transmission allows for a direct interpretation of the results: the phase shift measured is linear in the refractive index contrast and object thickness. However, the same measurement in a backscattering geometry yields fundamentally different results, because the incident field component is absent from the detected field. As a result, the relationship between the measured phase and object properties is obscure. We derived analytical expressions for the p...

The Phase diagram of symmetric electron-hole bilayer system : A variational Monte Carlo study.

We study the phase diagram of symmetric electron-hole bilayer at zero temperature and zero magnetic field within quantum Monte Carlo approach. Particularly, we conduct variational Monte Carlo simulation for various phases viz. paramagnetic fluid phase, ferromagnetic fluid phase, anti-ferromagnetic Wigner crystal phase, ferromagnetic Wigner crystal phase and excitonic phase to estimate the ground-state energy at different values of inlayer density and inter-layer spacing. The Slater-Jastrow style trial ...

Final results of a phase I dose-escalation, dose-expansion study of adding disulfiram with or without copper to adjuvant temozolomide for newly diagnosed glioblastoma.

Disulfiram has shown promising activity including proteasome inhibitory properties and synergy with temozolomide in preclinical glioblastoma (GBM) models. In a phase I study for newly diagnosed GBM after chemoradiotherapy, we have previously reported our initial dose-escalation results combining disulfiram with adjuvant temozolomide and established the maximum tolerated dose (MTD) as 500 mg per day. Here we report the final results of the phase I study including an additional dose-expansion cohort of disul...

Stent-assisted treatment of ruptured intracranial aneurysms in the acute phase: A single center experience.

The purpose of this study was to analyze the results of patients with ruptured aneurysms who were treated with a specific microstent in the acute phase of subarachnoid hemorrhage.

Phase-correcting non-local means filtering for diffusion-weighted imaging of the spinal cord.

DWI suffers from low SNR when compared to anatomical MRI. To maintain reasonable SNR at relatively high spatial resolution, multiple acquisitions must be averaged. However, subject motion or involuntary physiological motion during diffusion-sensitizing gradients cause phase offsets among acquisitions. When the motion is localized to a small region, these phase offsets become particularly problematic. Complex averaging of acquisitions lead to cancellations from these phase offsets, whereas magnitude averagin...

Absolute sensitivity of phase measurement in an SU(1,1) type interferometer.

Absolute sensitivity is measured for the phase measurement in an SU(1,1) type interferometer, and the results are compared to that of a Mach-Zehnder interferometer operated under the condition of the same intra-interferometer intensity. The interferometer is phase locked to a point with the largest quantum noise cancellation, and a simulated phase modulation is added in one arm of the SU(1,1) interferometer. Both the signal and noise level are estimated at the same frequency range, and we obtained 3 dB imp...

Increasing Sexually Transmitted Infection Testing Through a Coordinated, Community-Wide Approach.

We describe the impact of the Adolescent Health Project on sexually transmitted infection (STI) testing in Omaha, NE, during phase 1 (media campaigns) and phase 2 (free STI testing). To assess the impact of each phase on STI testing, we examined monthly data from January 2013 to April 2017 via interrupted time series analyses. There was an immediate and statistically significant increase in testing during phase 2. Expanding and advertising free STI testing is a promising approach to increasing testing. (Am ...

Synthesis of 2-Alkoxy/thioalkoxy Benzodimidazoles and 2-Thione Benzodimidazoles via phase-based Chemo-Selective reaction.

2-Alkoxy/thioalkoxy benzo[d]imidazole and 2-thione benzo[d]imidazole library were constructed in solution-phase and on solid-phase, respectively. The key step in this work is reaction phase-based chemo-selective reaction of 2-mercapto benzo[d]imidazole intermediate with benzyl chloride (solution-phase) and Merrifield resin (solid-phase). In the case of solution-phase, benzyl chloride reacted with thiol group of 2-mercapto benzo[d]imidazole whereas, in the case of solid-phase, Merrifield resin was introduced...

Perianal Infections in the Phase before Engraftment after Allogeneic Hematopoietic Stem Cell Transplantations: A Study of the Incidence, Risk Factors, and Clinical Outcomes.

In this study, we aimed to investigate the incidence, risk factors, and clinical outcomes of perianal infections during the pre-engraftment phase after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Consecutive patients who underwent non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology from January 1 to December 31, 2016 were enrolled (n = 646). Ninety-nine patients were found to have perianal infections during the pre-engraftment phase, and 80 were found to have n...

Phase II trial of ipilimumab in melanoma patients with preexisting humoural immune response to NY-ESO-1.

Immune checkpoint therapy has dramatically changed treatment options in patients with metastatic melanoma. However, a relevant part of patients still does not respond to treatment. Data regarding the prognostic or predictive significance of preexisting immune responses against tumour antigens are conflicting. Retrospective data suggested a higher clinical benefit of ipilimumab in melanoma patients with preexisting NY-ESO-1-specific immunity.

PHASE DEPENDENT OPTICALLY STIMULATED LUMINESCENCE IN CU-DOPED Sr4Si3O8Cl4.

Phase dependent optically stimulated luminescence (OSL) is studied in Cu-doped Sr4Si3O8Cl4. The Study shows that samples in which amount of contributing strontium metasilicate phase in Cu-doped Sr4Si3O8Cl4 is less, show intense OSL while those samples in which strontium metasilicate phase is more show weak OSL. The observed Cu luminescence is also found to be phase dependent. Sample in which Sr4Si3O8Cl4 phase is dominant, the observed Cu luminescence is around 350 nm whereas an additional longer wavelength ...

Phase transitions in small isotropic bicelles.

Isotropic phospholipid bicelles are one of the most prospective membrane mimetics for the structural studies of membrane proteins in solution. Recent works provided an almost full set of data regarding the properties of isotropic bicelles, however, one major aspect of their behavior is still under consideration: the possible mixing between the lipid and detergent in the bilayer area. This problem may be resolved by studying the lipid phase transitions in bicelle particles. In the present work, we investigat...

Microfluidic Droplet-Based Tool to Determine Phase Behavior of a Fluid System with High Composition Resolution.

The goal of this work is to develop a simple microfluidic approach to characterizing liquid-liquid phase behavior in complex aqueous mixtures of organics and salts. We take advantage of the permeability of inexpensive microfluidic devices to concentrate aqueous solutions on chip. We demonstrate a technique that allows phase boundaries to be identified with high compositional resolution and small sample volumes. Droplets of single phase samples are produced on-chip and concentrated in the device beyond the p...

Origin of distorted 1T-phase ReS: first-principles study.

Group-VIIB transition metal dichalcogenides (TMDCs) are known to be stabilized solely in a distorted 1T phase termed as 1T″ phase, which is compared to many stable or metastable phases in other TMDCs. Using first-principles calculations, we study the structural origin of 1T″ phase group-VIIB TMDCs. We find that quasi 1D Peierls-like instability is responsible for the transition to the 1T″ phase ReSmonolayer from the 1T' phase, another distorted 1T phase. Two half-filled bands in 1T'-ReSmake sharp peak...

Phase Stochastic Resonance in a Forced Nanoelectromechanical Membrane.

Stochastic resonance is a general phenomenon usually observed in one-dimensional, amplitude modulated, bistable systems. We show experimentally the emergence of phase stochastic resonance in the bidimensional response of a forced nanoelectromechanical membrane by evidencing the enhancement of a weak phase modulated signal thanks to the addition of phase noise. Based on a general forced Duffing oscillator model, we demonstrate experimentally and theoretically that phase noise acts multiplicatively, inducing ...


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