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Showing "Ganaxolone Phase Data Supports Progressing Phase Patients with" PubMed Articles 51–75 of 59,000+

Ultrafast Control of Phase and Polarization of Light Expedited by Hot-Electron Transfer.

All-optical modulation is an entangled part of ultrafast nonlinear optics with promising impacts on tunable optical devices in the future. Current advancements in all-optical control predominantly offer modulation by means of altering light intensity, while the ultrafast manipulation of other attributes of light have yet to be further explored. Here, we demonstrate the active modulation of the phase, polarization, and amplitude of light through the nonlinear modification of the optical response of a plasmon...

P 128 - Influence of stance phase shifts in the movement analysis profile and the Gait Profile Score for cerebral palsy patients.

The Gait Profile Score (GPS) is used as a summary index to interpret gait abnormalities compared to a reference group, but stance phase shifts in gait cycles are not considered. The aim of this work is to point out, if stance phase shifts affects the GPS estimations and lead clinically relevant changes.

Assessing the pattern of recurrence in Danish stage I lung cancer patients in relation to the follow-up program: are we failing to identify patients with cerebral recurrence?

There is paucity of evidence regarding the optimal follow-up (FU) regimen for lung cancer. Consequently, FU is organized differently across countries. The Danish FU regimen has short FU intervals with a computed tomography (CT) scan of the chest and upper abdomen every three months in the early phase (first 2 years), then every six months in the late phase of FU (3rd, 5th year). Characterizing recurrences missed by the FU program in terms of site, tumor histology, department, and phase of FU, could improve ...

Increased expression of the membrane-bound CD40 ligand on peripheral CD4 T cells in the acute phase of AQP4-IgG-seropositive neuromyelitis optica spectrum disorders.

Currently, no data are available regarding the expression levels of CD40L on CD4 T cells in patients with neuromyelitis optica spectrum disorders (NMOSD). The percentage of circulating CD40LCD4 T cells was measured by flow cytometry in 23 NMOSD patients and 10 healthy controls. The ratio of CD40LCD4 to CD4 T cells in patients at acute phase (18.28 ± 15.56%) was significantly higher than that in healthy controls (7.23 ± 5.94%, P = .032) and was positively correlated with disease severity (r =...

Menstrual cycle phase predicts women's hormonal responses to sexual stimuli.

A robust body of research has demonstrated shifts in women's sexual desire and arousal across the menstrual cycle, with heightened desire and arousal coincident with heightened probability of conception (POC), and it is likely that ovarian hormones modulate these shifts. However, studies in which women are exposed to audiovisual sexual stimuli (AVSS) at high POC (mid-follicular) and low POC (luteal) phases have failed to detect significant differences in genital or subjective arousal patterns based on menst...

Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037).

Tumors may evade immunosurveillance through upregulation of the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme. Epacadostat is a potent and highly selective IDO1 enzyme inhibitor. The open-label phase I/II ECHO-202/KEYNOTE-037 trial evaluated epacadostat plus pembrolizumab, a programmed death protein 1 inhibitor, in patients with advanced solid tumors. Phase I results on maximum tolerated dose, safety, tolerability, preliminary antitumor activity, and pharmacokinetics are reported.

Apalutamide: The established and emerging roles in the treatment of advanced prostate cancer.

Prostate cancer (PCa) is the most common cancer in elderly males. Androgen deprivation therapy (ADT) is still the cornerstone of initial treatment, however the vast majority of patients develop castration resistant prostate cancer (CRPC). Several studies with numerous androgen receptor (AR)-directed agents have emerged since the approval of abiraterone acetate and enzalutamide. One of these agents is apalutamide, which seems to be a promising AR antagonist for the treatment of CRPC. Areas covered: The autho...

Efficacy of Tofacitinib for the Treatment of Psoriatic Arthritis: Pooled Analysis of Two Phase 3 Studies.

Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post hoc analysis assessed the efficacy of tofacitinib using pooled data from two phase 3 studies of patients with active PsA.

A user's guide for phase separation assays with purified proteins.

The formation of membrane-less organelles and compartments by protein phase separation is an important way in which cells organize their cytoplasm and nucleoplasm. In vitro phase separation assays with purified proteins have become the standard way to investigate proteins that form membrane-less compartments. By now, various proteins have been purified and tested for their ability to phase separate and form liquid condensates in vitro. However, phase-separating proteins are often aggregation-prone and diffi...

Babinet-bilayered geometric phase optical elements.

Geometric phase optical elements based on structured anisotropy are widely used for phase shaping via their orientational degree of freedom. To date, amplitude shaping via space-variant retardance is much less investigated, a practical reason being that the spin-orbit interaction of light couples retardance with the dynamic part of the optical phase. Inspired by the complementary diffractive elements associated with Babinet's principle, a bilayered subwavelength grating design is proposed in order to cancel...

Phase shift invariant imaging of coherent sources (PSIICOS) from MEG data.

Increasing evidence suggests that neuronal communication is a defining property of functionally specialized brain networks and that it is implemented through synchronization between population activities of distinct brain areas. The detection of long-range coupling in electroencephalography (EEG) and magentoencephalography (MEG) data using conventional metrics (such as coherence or phase-locking value) is by definition contaminated by spatial leakage. Methods such as imaginary coherence, phase-lag index or ...

Simultaneous measurement of phase transmission and birefringence of an object under test.

This paper presents a novel interferometric method for the simultaneous spatially resolved analysis of an object under test regarding the phase transmission function and the magnitude and orientation of the (uniaxial) birefringence. The measurement strategy is based on variations of the phase and polarization and processing the interference patterns so obtained. With this method, which is very similar to the classical phase-shifting interferometry, a complete analysis of birefringent properties of the objec...

How to define pathologic pelvic floor descent in MR defecography during defecation?

To assess the extents of pelvic floor descent both during the maximal straining phase and the defecation phase in healthy volunteers and in patients with pelvic floor disorders, studied with MR defecography (MRD), and to define specific threshold values for pelvic floor descent during the defecation phase.

Geriatric analysis from PRODIGE 20 randomized phase II trial evaluating bevacizumab + chemotherapy versus chemotherapy alone in older patients with untreated metastatic colorectal cancer.

Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older.

Addressing heterogeneity in the design of phase II clinical trials in geriatric oncology.

Cancer in the elderly is a major public issue. However, older patients have long been debarred from clinical trials. There is a high unmet medical need for specific trials addressing oncology strategies adapted to older patients' conditions. While randomised phase III trials remain the gold standard, they usually require large numbers of patients. In this perspective, late single-arm phase II trials assessing treatment feasibility might prove a good alternative. However, it is essential to take into account...

First-Phase Ejection Fraction Is a Powerful Predictor of Adverse Events in Asymptomatic Patients With Aortic Stenosis and Preserved Total Ejection Fraction.

This study investigated the prognostic value of first-phase ejection fraction (EF1) in patients with aortic stenosis (AS), a condition in which left ventricular dysfunction as measured by conventional indices is an indication for valve replacement.

Sensorimotor Oscillatory Phase-Power Interaction Gates Resting Human Corticospinal Output.

Oscillatory activity within sensorimotor networks is characterized by time-varying changes in phase and power. The influence of interactions between sensorimotor oscillatory phase and power on human motor function, like corticospinal output, is unknown. We addressed this gap in knowledge by delivering transcranial magnetic stimulation (TMS) to the human motor cortex during electroencephalography recordings in 20 healthy participants. Motor evoked potentials, a measure of corticospinal excitability, were cat...

Extracorporeal Treatments In Poisonings From Four Non-Traditionally Dialyzed Toxins (Acetaminophen, Digoxin, Opioids, and Tricyclic Antidepressants): A Combined Single-Centre and National Study.

The use of extracorporeal treatments (ECTRs) for poisonings with four non-traditionally dialyzed toxins (NTDTs) is increasing in the United States. This study evaluated whether ECTRs are prescribed for toxin removal or the treatment of other medical illnesses or complications. We performed a Phase 2 retrospective analysis evaluating the main indication for ECTRs in patients with: poisoning with a NTDT (defined for this study as: acetaminophen, opioids, tricyclic antidepressants (TCAs) or digoxin) and ECTR. ...

Regulating Phase Conversion from Ni3Se2 to NiSe in Bifunctional Electrocatalyst for Overall Water Splitting Enhancement.

Phase engineering has been demonstrated as an efficient way to enhance the catalytic activity. Here, phase- and morphology-modulated Ni3Se2/NiSe nanorod arrays through hydrothermal process are reported. Partial phases conversion can effectively enhance the electrical conductivity and yield more active sites due to the atom rearrangement in the phase transformation progress. Quite low overpotential of 166 mV for hydrogen evolution reaction (HER) and and 370 mV oxygen evolution reaction (OER) are obtained in ...

Autocalibrated multiband CAIPIRINHA with through-time encoding: Proof of principle and application to cardiac tissue phase mapping.

In conventional multiband (MB) CAIPIRINHA, additional reference scans are acquired to allow the separation of the excited slices. In this study, an acquisition-reconstruction technique that makes use of the MB data to calculate these reference data is presented. The method was integrated into a 2D time-resolved phase-contrast MR sequence used to assess velocities of the myocardium.

Interlocking Kerr-microresonator frequency combs for microwave to optical synthesis.

We report accurate phase stabilization of an interlocking pair of Kerr-microresonator frequency combs. The two combs, one based on silicon nitride and one on silica, feature nearly harmonic repetition frequencies and can be generated with one laser. The silicon-nitride comb supports an ultrafast-laser regime with three-optical-cycle, 1-picosecond-period soliton pulses and a total dispersive-wave-enhanced bandwidth of 170 THz, while providing a stable phase-link between optical and microwave frequencies. We...

Interfacial coupling between noble metal nanoparticles and metal-organic frameworks for enhanced catalytic activity.

Metal-organic frameworks (MOFs) have great potential to become innovative heterogeneous supports for immobilizing catalytically active noble metal nanoparticles (NPs). However, unlike metal oxide supports, the interfacial interactions between noble metal NPs and MOFs are currently neglected, thus dramatically diminishing the advantage of MOFs as supports. Herein, ZIFs(Co/Zn)@M (M = Pd, Pt or Au) nanocomposites with well-defined interfaces are synthesized and used as catalysts in gas-phase CO oxidation and l...

Thermal evolution of the crystal structure and phase transitions of KNbO.

The thermal evolution of the crystal structure and phase transitions of KNbO were investigated by high-temperature powder X-ray diffraction and Rietveld refinement of the diffraction data. Two phase transitions from orthorhombic (2) to tetragonal (4) and from tetragonal to cubic ( ) were confirmed, both on heating and cooling. Both phase transitions are first order based on the observed hysteresis. The mixed displacive and order-disorder nature of the tetragonal to cubic transition is argued based on symme...

A phase I clinical trial of ruxolitinib in combination with nilotinib in chronic myeloid leukemia patients with molecular evidence of disease.

Preclinical evidence indicates that the bone marrow microenvironment provides a protective niche for leukemic stem cells, allowing them to evade the effects of BCR-ABL tyrosine kinase inhibitors (TKIs), but that targeting of the JAK-STAT pathway with the JAK2 inhibitor ruxolitinib increases TKI-induced apoptosis. A phase I clinical trial (NCT01702064) investigated the tolerability and safety of treating chronic-phase chronic myeloid leukemia patients with ruxolitinib in combination with the BCR-ABL TKI nilo...

Incorporating public values into evaluative criteria: Using crowdsourcing to identify criteria and standards.

At its core, evaluation involves the generation of value judgments. These evaluative judgments are based on comparing an evaluand's performance to what the evaluand is supposed to do (criteria) and how well it is supposed to do it (standards). The aim of this four-phase study was to test whether criteria and standards can be set via crowdsourcing, a potentially cost- and time-effective approach to collecting public opinion data. In the first three phases, participants were presented with a program descripti...

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