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Showing "Global Chinese 5BisTrifluoromethylBenzyl Amine Industry 2017 Market Research" PubMed Articles 51–75 of 33,000+

The European Virus Archive goes global: A growing resource for research.

The European Virus Archive (EVA) was created in 2008 with funding from the FP7-EU Infrastructure Programme, in response to the need for a coordinated and readily accessible collection of viruses that could be made available to academia, public health organisations and industry. Within three years, it developed from a consortium of nine European laboratories to encompass associated partners in Africa, Russia, China, Turkey, Germany and Italy. In 2014, the H2020 Research and Innovation Framework Programme (IN...

Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods...

Prioritizing research for patients requiring surgery in low- and middle-income countries.

The National Institute for Health Research Global Health Research Unit on Global Surgery is establishing research Hubs in low- and middle-income countries (LMICs). The aim of this study was for the Hubs to prioritize future research into areas of unmet clinical need for patients in LMICs requiring surgery.

Naval Medicine's Involvement in Global Health: The Participation of Women's Healthcare Providers in Continuing Promise 2017.

This is a retrospective review of information collected during operation Continuing Promise 2017 from the Wayuu population in Colombia, South America.

Orphan drugs: major development challenges at the clinical stage.

Biotechnology has provided powerful tools to assist in research and development (R&D) for rare diseases. However, orphan drug development presents several major challenges and obstacles, such as low disease prevalence, disease severity, small and heterogeneous patient populations, difficulties in patient recruitment, and limited knowledge of the natural history of disease, among others. Several strategies can be used to plan for and overcome these clinical and regulatory challenges, namely improved clinical...

Pharmaceutical cocrystals: from serendipity to design to application.

The field of pharmaceutical cocrystals has reached a tipping point, particularly because cocrystals can improve the physicochemical properties of drugs without compromising their therapeutic benefit. Accounts of cocrystal investigations in the literature started in earnest in 2003 and patent applications soon followed. The frequency of both has steadily accelerated, demonstrating an enhanced understanding of the design, characterisation, and manufacture of cocrystals and heightened interest from industry. I...

Contemporary global perspectives of medical students on research during undergraduate medical education: a systematic literature review.

The need for increased expertise in evidence-based medicine and concerns about the decreasing numbers of physician-scientists have underscored the need for promoting and encouraging research in medical education. The critical shortage of physician-scientists has assumed a dimension demanding a coordinated global response. This systematic review examined the perceptions of medical students regarding research during undergraduate medical school from a global perspective.

Copper-catalyzed tandem reactions of 2-amine-1,3,5triazines with nitriles.

Copper-catalyzed intermolecular annulation of 2-amine-[1,3,5]triazines and aryl nitriles for the synthesis of [1,2,4]triazolo [1,5-a][1,3,5]triazines is presented via the N-C bond formation and oxidative N-N coupling [oxidative 3+2 cyclization]. A wide range of aryl nitriles, including electron-rich benzonitriles, electron-poor benzonitriles, 2-cyanothiophene, and 4-cyanopyridine, are all functionalized with 2-amine-[1,3,5]triazines. Furthermore, amidation of 2-amine-[1,3,5]triazines via Cu catalyzed C-CN b...

Mainstreaming as rhetoric or reality? Gender and global health at the World Bank.

Over the past decade gender mainstreaming has gained visibility at global health organisations. The World Bank, one of the largest funders of global health activities, released two showcasing its gender policies, and recently announced a $1 billion initiative for women's entrepreneurship. However, the development of the Bank's gender policies and its financing for gender programmes have never been systematically analysed by external researchers in the context of global health. We use the Bank as a case stu...

University-industry-government relations of the Ministry of Industry and Information Technology (MIIT) universities: The perspective of the mutual information.

The Ministry of Industry and Information Technology (MIIT) universities are important bases for science and technology research and play a critical role in China's National Innovation System. Based on the Web of Science (WoS), this article analyzes the statistics of paper published by MIIT universities and universities from across China including MIIT universities. The results are as follows: (1) Both the MIIT universities and universities nationwide in China have increased their international academic publ...

Epidemiological analysis of malaria in Shandong Province in 2017.

To understand the malaria epidemiological characteristics of Shandong Province in 2017, so as to provide the evidences for formulating targeted prevention and control strategy and measures.

Nontuberculous mycobacteria strains isolated from patients between 2013 and 2017 in Poland. Our data with respect to the global trends.

During the last decades the prevalence of NTM infections has increased, especially in developed countries. The aim of the study was to provide an overview on all NTM isolated from clinical samples in Poland between 2013 and 2017.

Updated Genetic Testing of Primary Hyperoxaluria Type 1 in a Chinese Population: Results from a Single Center Study and a Systematic Review.

Primary hyperoxaluria type 1 (PH1) is a rare but devastating autosomal recessive inherited disease caused by mutations in gene AGXT. Pathogenic mutations of AGXT were mostly reported in Caucasian but infrequently in Asian, especially in Chinese. To update the genotypes of PH1 in the Chinese population, we collected and identified 7 Chinese probands with PH1 from 2013 to 2017 in our center, five of whom had delayed diagnosis and failed in kidney transplantation. Samples of peripheral blood DNA from the 7 pat...

British rubber and cable industry cohort: 49-year mortality follow-up.

The International Agency for Research on Cancer (IARC) has determined there is sufficient evidence that working in the rubber manufacturing industry increases the risk of cancers of the stomach, lung, bladder and leukaemia and lymphoma.

Association of general and central adiposity with blood pressure among Chinese adults: results from the China National Stroke Prevention Project.

The American Heart Association concluded that waist circumference was a better predictor of blood pressure risk than BMI in Asians. However, data are inconsistent and information in Chinese, the largest global population group, is limited.

Psychometric properties of the chinese version of autism spectrum quotient-children's version: A sex-specific analysis.

A Simplified Chinese translation of the Autism Spectrum Quotient-Children's Version (AQ-C) is needed for research in mainland China. Autism Spectrum Disorder (ASD) is a condition that differs in presentation and prevalence by sex. Thus, evaluating the psychometric validity of the AQ-C in males and females is an important step in its validation. The present study aims to develop a Chinese translation of the parent-report AQ-C, and test its psychometric properties among Mandarin Chinese speaking boys and girl...

Auditory identification of frequency-modulated sweeps and reading difficulties in Chinese.

In Chinese Mandarin, lexical tones play an important role of providing contrasts in word meaning. They are pitch patterns expressed by frequency-modulated (FM) signals. Yet, few studies have looked at the relationship between low-level auditory processing of frequency signals and Chinese reading skills.

Conflict of Interest Mitigation Procedures May Have Little Influence on the Perceived Procedural Fairness of Risk-Related Research.

Two between-subject experiments explored perceived conflict of interest (COI)-operationalized as perceived procedural unfairness-in a hypothetical public-private research partnership to study the health risks of trans fats. Perceived fairness was measured as subjects' perceptions that health researchers would be willing to listen to a range of voices and minimize bias (i.e., COI) in the context of a research project. Experiment 1 (n = 1,263) randomly assigned research subjects to a partnership that included...

A 2017 global update on folic acid-preventable spina bifida and anencephaly.

Spina bifida and anencephaly are largely preventable birth defects through mandatory folic acid fortification. Our objective was to estimate the proportion of folic acid-preventable spina bifida and anencephaly (FAP SBA) prevented worldwide through mandatory fortification of wheat and/or maize flour with folic acid during the year 2017.

Chinese medicine/acupuncture: historical notes on the colonization of a body of knowledge.

Western colonialism influenced the encounter between traditional and modern knowledge from the nineteenth century onwards, resulting in the overlapping of Western medicine as a privileged form of knowledge. In 1958 the hybridization between Chinese and Western medicines became official under the name of traditional Chinese medicine and, through the development of biomedical research on acupuncture, it distanced itself from traditional knowledge. This essay presents historical changes experienced by Chinese ...

Assessing the environmental impact of the dairy processing industry in the Republic of Ireland.

This Research Communication describes the methodology used and the subsequent results obtained for an assessment of the environmental impact associated with the manufacture of dairy products in the Republic of Ireland. As the Irish dairy industry changes and grows, it is necessary to have a benchmark of the environmental performance of the sector if it is to remain sustainable in the future. In order to estimate the environmental impact, life cycle assessment has been implemented, which has been structured ...

Strategies and Research Progress of Chinese Medicine in Prevention and Treatment of Diabetic Peripheral Neuropathy.

Diabetic peripheral neuropathy (DPN) seriously affects the quality of life in patients with type 2 diabetes mellitus. This paper reviews the role of Chinese medicine in the main treatment goal of DPN, including protecting pancreatic β-cells, in the use of antioxidation therapy to delay disease progression, and in the endpoint of neural repair and regeneration. We propose that protecting the body from injury caused by high glucose and oxidative stress, and promoting repair and regeneration of nerves should ...

Rigorous control of vesicle-forming lipid pK by fluorine-conjugated bioisosteres for gene-silencing with siRNA.

While the influence of pK provided by amine-containing materials in siRNA delivery vectors for use in gene-silencing has been widely studied, there are little reports in which amine pK is controlled rigorously by using bioisosteres and its effect on gene-silencing. Here, we report that amine pK could be rigorously controlled by replacement of hydrogen atom(s) with fluorine atom(s). A series of mono- and di-amine lipids with a different number of fluorine atoms were synthesized. The pK of the polyamine lipid...

History and Current Trends in the Electronic Nicotine Delivery Systems Retail Marketplace in the United States: 2010-2016.

The US market for electronic nicotine delivery systems (ENDS) has grown rapidly in the last decade. There is limited published evidence examining changes in the ENDS marketplace prior to the US Food and Drug Administration's (FDA) deeming rule in 2016. This study describes US ENDS retail market trends from 2010 to 2016.

A niche for ecosystem multifunctionality in global change research.

Concern about human modification of Earth's ecosystems has recently motivated ecologists to address how global change drivers will impact the simultaneous provisioning of multiple functions, or ecosystem multifunctionality (EMF). However, metrics of EMF have often been applied in global change studies with little consideration of the information they provide beyond single functions, or how and why EMF may respond to global change drivers. Here, we critically review the current state of this rapidly expandin...

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