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PubMed Journals Articles About "Indivior Warns Potential Loss This Year Star Drug" - Page: 3 RSS

11:52 EDT 21st October 2019 | BioPortfolio

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Showing "Indivior warns potential loss this year star drug" PubMed Articles 51–75 of 42,000+

What Is New in Recurrent Pregnancy Loss?: Best Articles From the Past Year.

This month we focus on current research in recurrent pregnancy loss. Dr. Ros discusses four recent publications, which are concluded with a "bottom-line" that is the take-home message. A complete reference for each can be found on Box 1 on this page along with direct links to abstracts.


A rare case of clomiphene-induced leukocytoclastic vasculitis.

Clomiphene citrate is a first-line drug for the induction of ovulation in infertility cases. Leukocytoclastic vasculitis (LCV) is an extremely rare serious adverse drug reaction to clomiphene. We report here the case of a 30-year-old Indian female patient who presented with generalized petechiae and palpable purpura without fever and sparing the mucosa, temporally related to clomiphene intake and consistent with LCV histologically. Clomiphene was stopped and the patient was treated symptomatically with pred...

Efficacy and safety of prolonged-release tacrolimus in stable pediatric allograft recipients converted from immediate-release tacrolimus.

There are limited clinical data regarding prolonged-release tacrolimus (PR-T) use in pediatric transplant recipients. This Phase 2 study assessed the efficacy and safety of PR-T in stable pediatric kidney, liver, and heart transplant recipients (aged ≥5-≤16 years) over 1 year following conversion from immediate-release tacrolimus (IR-T), on a 1:1 mg total-daily-dose basis. Endpoints included the incidence of acute rejection (AR), a composite endpoint of efficacy failure (death, graft loss, biopsy-confir...


Drug stabilization in the gastrointestinal tract and potential applications in the colonic delivery of oral zein-based formulations.

In recent years, various oral dosage forms using biomaterials have been developed to deliver drugs to the colon for therapy due to the advantages of local treatment and its ideal location for drug delivery. To achieve site-specific delivery, the complete drug should be released in the colon, while the drug must be protected or their delivery minimized in the stomach and small intestine. The use of natural or synthetic polymers has been reported for these purposes. The roles of zein in drug delivery have bee...

Clinical Practice Guideline: Sudden Hearing Loss (Update).

Sudden hearing loss is a frightening symptom that often prompts an urgent or emergent visit to a health care provider. It is frequently but not universally accompanied by tinnitus and/or vertigo. Sudden sensorineural hearing loss affects 5 to 27 per 100,000 people annually, with about 66,000 new cases per year in the United States. This guideline update provides evidence-based recommendations for the diagnosis, management, and follow-up of patients who present with sudden hearing loss. It focuses on sudden ...

Will 2019 kick off a new era in person-centered care?

Medicare's star rating system for Medicare Advantage health plans is a powerful tool for driving plan behavior and, beginning in 2019, CMS is providing new weight to patient access and experience measures. As the shift begins, a recent analysis of person-centered care measures in the star rating system conducted by the Center for Consumer Engagement in Health Innovation found ample room for improving both plan performance and how the ratings measure patient-centeredness. Although from 2010 to 2017, plans pe...

Clinical Practice Guideline: Sudden Hearing Loss (Update) Executive Summary.

Sudden hearing loss is a frightening symptom that often prompts an urgent or emergent visit to a health care provider. It is frequently, but not universally, accompanied by tinnitus and/or vertigo. Sudden sensorineural hearing loss affects 5 to 27 per 100,000 people annually, with about 66,000 new cases per year in the United States. This guideline update provides evidence-based recommendations for the diagnosis, management, and follow-up of patients who present with sudden hearing loss. It focuses on sudde...

Topological Design of Star Glycopolymers for Controlling the Interaction with the Influenza Virus.

The precise design of synthetic polymer ligands using controlled polymerization techniques provides advantage for the field of nanoscience. We report the topological design of glyco-ligands based on synthetic polymers for targeting hemagglutinin (HA, lectin on the influenza virus). To achieve precise arrangement of the glycounits toward the sugar-binding pockets of HA, triarm star glycopolymers were synthesized. The interaction of the star glycopolymers with HA was found to depend on the length of the polym...

Star-shaped plasmonic nanostructures: New, simply synthetized materials for Raman analysis of surfaces.

In this contribution we show that star-shaped gold nanoparticles and star-shaped nanostructures containing a gold core (Au@SiO, Au@Ag, and Au@Ag@SiO) can be used as very efficient, easy to produce and reproducible electromagnetic nanoresonators for the Raman analysis of surfaces, especially for shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) measurements. The "one pot" procedure used in this work for synthesizing star-shaped gold nanoparticles (a reduction of chloroauric anions by hydrogen...

Use and 1-year outcomes with conventional and drug-coated balloon angioplasty in patients with lower extremity peripheral artery disease.

With the growing use of drug-coated balloons for the treatment of peripheral artery disease, information regarding the safety and effectiveness of drug-coated balloons in current practice is needed. We examined patient, physician, and procedural characteristics as well as cardiovascular and limb events in patients who underwent peripheral vascular intervention with drug-coated balloons.

Rotational and Rotational-Vibrational Raman Spectroscopy of Air to Characterize Astronomical Spectrographs.

Raman scattering enables unforeseen uses for the laser guide-star system of the Very Large Telescope. Here, we present the observation of one up-link sodium laser beam acquired with the ESPRESSO spectrograph at a resolution λ/Δλ∼140 000. In 900 s on source, we detect the pure rotational Raman lines of ^{16}O_{2}, ^{14}N_{2}, and ^{14}N^{15}N (tentatively) up to rotational quantum numbers J of 27, 24, and 9, respectively. We detect the ^{16}O_{2} fine-structure lines induced by the interaction of the...

Augmented Reality as a Medium for Improved Telementoring.

Combat trauma injuries require urgent and specialized care. When patient evacuation is infeasible, critical life-saving care must be given at the point of injury in real-time and under austere conditions associated to forward operating bases. Surgical telementoring allows local generalists to receive remote instruction from specialists thousands of miles away. However, current telementoring systems have limited annotation capabilities and lack of direct visualization of the future result of the surgical act...

Estradiol and follicle stimulating hormone as predictors of onset of menopause transition-related bone loss in pre- and perimenopausal women.

The menopause transition (MT) may be an opportunity for early intervention to prevent rapid bone loss. In order to intervene early, we need to be able to prospectively identify pre- and perimenopausal women who are beginning to lose bone. This study examined whether estradiol (E2), or follicle stimulating hormone (FSH), measured in pre- and perimenopausal women, can predict significant bone loss by the next year. Bone loss was considered significant if BMD decline at the lumbar spine (LS) or femoral neck (F...

Current small animal models for LASV hearing loss.

Lassa virus (LASV) is endemic in West Africa, causing an estimated 100000-300000 new infections and up to 5000-10000 deaths yearly. There are no vaccines and therapeutics are extremely limited. Typical case fatality rates are ∼1%, although a recent 2018 Nigerian outbreak featured an unprecedented 25.4% case fatality rate. Survivors of infection suffer a lifetime of sequelae with sudden onset sensorineural hearing loss (SNHL) being the most prevalent. The cause of this hearing loss remains unknown, and the...

Targeting the transferrin receptor for brain drug delivery.

Obtaining efficient drug delivery to the brain remains the biggest challenge for the development of therapeutics to treat diseases of the central nervous system. The main obstacle is the blood-brain barrier (BBB), which impedes the entrance of most molecules present in the systemic circulation, especially large molecule drugs and nanomedicines. To overcome this obstacle, targeting strategies binding to nutrient receptors present at the luminal membrane of the BBB are frequently employed. Amongst the numerou...

The Impact of HIV-1 Drug Escape on the Global Treatment Landscape.

The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (ART) by the year 2020. HIVDR has implications for the persistence of HIV, the selection of current and future ART drug regimens, and strategies of vaccine and cure development. Focusing on drug classes that are in...

Employing virtual screening and molecular dynamics simulations for identifying hits against the active cholera toxin.

Cholera is a major global threat, affecting millions each year. The ADP ribosyltransferase activity of the active cholera toxin catalyses the massive loss of water and electrolytes during cholera infections. The active toxin heterodimer comprises the A1 subunit from Vibrio cholerae and ARF (ADP Ribosylation Factor) from the human host. Although the active toxin is a potential target for drug discovery against cholera, it has been scarcely targeted to date. The A1-ARF interface contains a potential druggable...

Maternal short and medium chain fatty acids supply during early pregnancy improves embryo survival through enhancing progesterone synthesis in rats.

Exploring strategies to prevent miscarriage in women or early pregnancy loss in mammals is of great importance. Manipulating maternal lipid metabolism to maintain sufficient progesterone level is an effective way. To investigated the embryo loss and progesterone synthesis impacts of short and medium chain fatty acids on the lipid metabolism, pregnancy outcome and embryo implantation were investigated in rats fed the pregnancy diets supplemented without or with 0.1% sodium butyrate (SB), 0.1% sodium hexanoat...

Pharmacokinetics and pharmacodynamics of cytochrome P450 inhibitors for HIV treatment.

Drugs used in HIV treatment; all protease inhibitors, some non-nucleoside reverse transcriptase inhibitors, and pharmacoenhancers ritonavir and cobicistat can inhibit cytochrome P450 (CYP) enzymes. CYP inhibition can cause clinically significant drug-drug interactions (DDI), leading to increased drug exposure and potential toxicity. Areas covered: A complete understanding of pharmacodynamics and CYP-mediated DDI is crucial to prevent adverse side effects and to achieve optimal efficacy. We summarized the ph...

CHILDHOOD NEGATIVE DENTAL EXPERIENCES AND TOOTH LOSS IN LATER LIFE: A 25-YEAR LONGITUDINAL STUDY IN SWEDEN.

To explore the association between childhood NDEs and changes in tooth loss over 25 years among Swedish older adults, and the role of dental visits in explaining such an association.

Toward a repositioning of the antibacterial drug nifuroxazide for cancer treatment.

Nifuroxazide (NFX) is a broad-spectrum antibacterial drug that has been used for the treatment of infectious diarrhoea since 1966. In 2008, the discovery of potent inhibition of the transcription factor signal transducer and activator of transcription (STAT)3 by NFX prompted studies as a potential anticancer agent. Subsequently, it was shown that NFX induces cancer cell apoptosis and inhibits tumour growth. Recently, NFX was identified as a potent inhibitor of aldehyde dehydrogenase (ALDH)1 that selectively...

Antibacterial activity study of 1,2,4-triazole derivatives.

Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. More effecti...

Reducing blood loss in pediatric craniosynostosis surgery by use of tranexamic acid.

Craniosysnostosis surgical corrections are routine procedures in the pediatric neurosurgical field. However, these procedures result in significant blood loss. Tranexamic acid (TXA) is an antifibrinolytic drug which has demonstrated a significant reduction in perioperative blood loss in many pediatric surgical procedures such as cardiac surgery and scoliosis surgery. We conducted a systematic review to evaluate protocols of TXA use in pediatric craniosynostosis procedures and its effect on intra-operative b...

Black-Hole Remnants from Black-Hole-Neutron-Star Mergers.

Observations of gravitational waves and their electromagnetic counterparts may soon uncover the existence of coalescing compact binary systems formed by a stellar-mass black hole and a neutron star. These mergers result in a remnant black hole, possibly surrounded by an accretion disk. The mass and spin of the remnant black hole depend on the properties of the coalescing binary. We construct a map from the binary components to the remnant black hole using a sample of numerical-relativity simulations of diff...

The Centers For Medicare And Medicaid Services Hospital Ratings: Pitfalls Of Grading On A Single Curve.

The star rating system for hospitals of the Centers for Medicare and Medicaid Services (CMS) pools all hospitals together and awards each institution one to five stars for quality, despite variation across hospitals in the numbers and types of measures they report. Thus, hospitals essentially are being evaluated differently, which affects the validity of quality comparisons. We considered the number and types of measures reported and the size of measure denominators to represent different forms of a "test,"...


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