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PubMed Journals Articles About "Building Pipeline∨derfield=score∨derval=desc" - Page: 3 RSS

10:52 EDT 16th July 2019 | BioPortfolio

Building Pipeline∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Building Pipeline∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "building pipeline derfield score derval desc" PubMed Articles 51–75 of 4,100+

Genetic algorithms for feature selection when classifying severe chronic disorders of consciousness.

The diagnosis and prognosis of patients with severe chronic disorders of consciousness are still challenging issues and a high rate of misdiagnosis is evident. Hence, new tools are needed for an accurate diagnosis, which will also have an impact on the prognosis. In recent years, functional Magnetic Resonance Imaging (fMRI) has been gaining more and more importance when diagnosing this patient group. Especially resting state scans, i.e., an examination when the patient does not perform any task in particula...


Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum.

Intensified treatment and control efforts since the early 2000s have dramatically reduced the burden of Plasmodium falciparum malaria. However, drug resistance threatens to derail this progress. In this review, we present four antimalarial resistance case studies that differ in timeline, technical approaches, mechanisms of action, and categories of resistance: chloroquine, sulfadoxine-pyrimethamine, artemisinin, and piperaquine. Lessons learned from prior losses of treatment efficacy, drug combinations, and...

Lifetime cardiovascular risk is associated with a multimarker score of systemic oxidative status in young adults independently of traditional risk factors.

Cardiovascular risk (CVR) tends to be estimated in the short-term, which underestimates lifetime (LT)-CVR of young subjects. We determined whether LT-CVR is associated with a multimarker score of oxidative status in young adults and whether this association is independent of traditional CVR factors. Seventy-two young adults were stratified into: (1) low or (2) high LT-CVR, and (3) stable coronary artery disease (SCAD). CVR was estimated with QRisk and atherosclerotic CV disease (ASCVD) risk estimators, or s...


Psychophysiological stress response of adolescent chess players during problem-solving tasks.

The game of chess has been traditionally used to study basic cognitive processes. However, it has been poorly studied in adolescent chess players. The aim of the present study was to describe the psychophysiological response of adolescence, using electroencephalography (EEG) and heart rate variability (HRV) during problem-solving tasks. Thus, participants had to solve four chess problems with different level of difficulty (low and high). A total of 13 adolescent chess players (age: 15.45 [1.64] with a mean ...

Identification of prognostic signatures associated with long-term overall survival of thyroid cancer patients based on a competing endogenous RNA network.

Competing endogenous RNAs (ceRNAs) are considered as transcripts that can regulate each other at post-transcription level by competing for shared miRNAs. Considering the key roles of lncRNAs acting as ceRNAs in progression of solid tumors, to develop prognostic signatures in thyroid cancer (THCA), patients with corresponding clinical data were selected and two ceRNA networks were constructed using online databases. Two prognostic signatures (Lnc5m4 and Lnc2mi1m2) were found to be more efficient in predictin...

Functional annotation of noncoding causal variants in autoimmune diseases.

Interpretation of noncoding disease variants, which comprise the vast majority of Genome-wide association studies (GWAS) hits, remains a momentous challenge due to haplotype structure and our limited understanding of the mechanisms and physiological contexts of noncoding elements. GWAS have identified loci underlying human diseases, but assigning the causal nucleotide changes still remain a controversial issue. Here we addressed these issues through the combination of high-density genotyping and epigenomic ...

Monte Carlo characterization and benchmarking of extended range REM meters for its application in shielding and radiation area monitoring in Compact Proton Therapy Centers (CPTC).

Compact Proton Therapy Centers, CPTC, have a single treatment room, and are technologically more affordable, smaller, advanced and easier to use. From a radiological protection point of view, the leading concern in CPTC are interactions of protons with components of the facility and patients that yield a broad emission of secondary particles, mainly high-energy neutrons, up to 230 MeV, and photons. Optimal design of shielding involves theoretical assumptions in the design phase and, consequently, experime...

Community-Delivered Heated Hatha Yoga as a Treatment for Depressive Symptoms: An Uncontrolled Pilot Study.

There are no known studies of concurrent exposure to high temperature and yoga for the treatment of depression. This study explored acceptability and feasibility of heated (Bikram) yoga as a treatment for individuals with depressive symptoms. An 8-week, open-label pilot study of heated yoga for depressive symptoms. 28 medically healthy adults (71.4% female, mean age 36 [standard deviation 13.57]) with at least mild depressive symptoms (Hamilton Rating Scale for Depression [HRSD-17] score ≥10) who attend...

Development of Computational Model for Cell Dose and DNA Damage Quantification of Multicellular System.

The aim of this study is to build a computational model to investigate the cell dose and cell DNA damage distribution of a multicellular tissue system under the irradiation. In this work we developed a computational model for quantifying cell dose and Double-Strand Break (DSB) number in a multicellular system by simulating the radiation transport in 2D and 3D cell culture. The model was based on an open-source radiation transport package, Geant4 with Geant4-DNA physics. Firstly, the computational multicell...

The Effectiveness of Mediterranean Diet in Nonalcoholic Fatty Liver Disease Clinical Course: An Intervention Study.

Diet is a modifiable key factor targeted in prevention and management of nonalcoholic fatty liver disease (NAFLD). The aim was to study the effect of Mediterranean Diet (MedDiet) on clinical, biochemical, and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of signal transducer and activator of transcription 3 (STAT3) rs2293152 genotype to diet composition and patients' profile were investigated. In this nonrandomized, open-label, 24-week prospective intervention study, 4...

MemBlob database and server for identifying transmembrane regions using cryo-EM maps.

The identification of transmembrane helices in transmembrane proteins is crucial, not only to understand their mechanism of action, but also to develop new therapies. While experimental data on the boundaries of membrane-embedded regions is sparse, this information is present in cryo-electron microscopy (cryo-EM) density maps and it has not been utilized yet for determining membrane regions. We developed a computational pipeline, where the inputs of a cryo-EM map, the corresponding atomistic structure, and ...

Diagnostic Roles of Urinary Kidney Injury Molecule 1 and Soluble C5b-9 in Acute Tubulointerstitial Nephritis.

Acute tubulointerstitial nephritis (ATIN) is a common cause of acute kidney injury characterized by inflammatory cells infiltrating in the interstitium. The current study aimed to explore non-invasive biomarkers that might indicate activity of pathological injuries and help direct treatment. Fifty-four patients with clinical-pathologically diagnosed ATIN from January 1, 2014 to June 30, 2016 at Peking University First Hospital were enrolled. Urine samples were collected on the morning of renal biopsy and de...

Diagnostic value of chest ultrasound in children with cystic fibrosis - Pilot study.

Cystic fibrosis (CF) is one of the most common genetic disorders among the White population. The disease has a progressive course and leads to a reduction in the quality of life and of life expectancy. Standard diagnostic procedures used in the monitoring of CF patients include methods which expose patients to ionizing radiation. With increasing life expectancy in CF the cumulative dose of ionising radiation increases, prompting clinicians' search for safer imaging studies. Despite its safety and availabili...

Caribbean climate change vulnerability: Lessons from an aggregate index approach.

The study examines the potential influence of sub-regional variations in climate, and specifically heavy rain events, in determining relative vulnerabilities of locations in twelve Caribbean countries. An aggregate vulnerability index, referred to as the Caribbean Vulnerability Score (CVS), is created using historical demographic and socioeconomic data and climate data representing extreme rain events. Four scenarios are explored. Firstly, comparative vulnerabilities are determined when heavy rainfall is in...

Assessment of quality of life (QoL) in breast cancer patients by using EORTC QLQ-C30 and BR-23 questionnaires: A tertiary care center survey in the western region of Saudi Arabia.

This cross-sectional study is aimed at assessing the quality of life in a cohort of breast cancer patients at the Oncology Department, King Abdulaziz University Hospital (KAUH), King Abdulaziz University (KAU), Jeddah, Saudi Arabia (SA), and to differentiate QoL among different groups. Mean time since diagnosis was 3.97±1.90 years. European Organization for Research and Treatment of Cancer Quality of Life Questionnaires-Core30 and BR23 (EORTC QLQ-C30 & BR23) were used to assess QoL in breast cancer survivo...

The proteome of extracellular vesicles released by clastic cells differs based on their substrate.

Extracellular vesicles (EVs) from osteoclasts are important regulators in intercellular communication. Here, we investigated the proteome of EVs from clastic cells plated on plastic (clasts), bone (osteoclasts) and dentin (odontoclasts) by two-dimensional high performance liquid chromatography mass spectrometry seeking differences attributable to distinct mineralized matrices. A total of 1,952 proteins were identified. Of the 500 most abundant proteins in EVs, osteoclast and odontoclast EVs were 83.3% ident...

2D Crystal Engineering of Nanosheets Assembled from Helical Peptide Building Blocks.

The successful integration of 2D nanomaterials into functional devices hinges on developing fabrication methods that afford hierarchical control across length-scales of the entire assembly. Here, we demonstrate structural control over a class of crystalline 2D nanosheets assembled from collagen triple helices. By lengthening the triple helix unit via sequential additions of Pro-Hyp-Gly triads, we impart sub-angstrom tuning over the 2D lattice. These subtle changes influence the overall nanosheet size, which...

Reduction in Aortic Pulse Wave Velocity Is Associated with a Short-Term Reduction in Dual-Energy X-Ray Absorptiometry Lumbar Spine Bone Mineral Density T Score.

Increased vascular stiffness is a risk factor for mortality. We wished to determine whether changes in vascular stiffness are associated with changes in bone mineral density (BMD) in peritoneal dialysis patients.

Adropin: Connection between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease.

We read the article entitled "Serum Adropin Levels Are Reduced in Adult Patients with Nonalcoholic Fatty Liver Disease." with interest [1]. The authors evaluated serum adropin levels among patients with nonalcoholic fatty liver disease (NAFLD). The authors showed evidence that association of serum levels of adropin with insulin resistance and NAFLD in adult patients. Low serum adropin level is associated with reduced nitric oxide (NO) bioavailability in the endothelium. Reduced NO bioavailability is a major...

Full-Squat as a Determinant of Performance in CrossFit.

This study analyzed the relationship between CrossFit performance and power and strength variables measured in the full-squat exercise. Twenty male trained subjects (33±7 years) performed an incremental load full-squat test for assessment of the 1-repetition maximum (1RM) and the mean (Pmean) and peak (Ppeak) power. Performance in 5 different Workouts of the Day (WODs) was measured on different days, and overall CrossFit performance was determined as the sum of the scores obtained in these WODs. Athletes w...

Flexible Metal-Organic Frameworks for Light-Switchable CO Sorption Using an Auxiliary Ligand Strategy.

We report the synthesis and characterization of two photoactive metal-organic frameworks (MOFs), and . The compounds were synthesized by incorporating 4,4'-azopyridine auxiliary ligands into -type scaffolds that are composed of dinuclear copper(II) "paddle-wheel"-based secondary building units and flexible, acetylene-extended, tritopic benzoate linkers. Room temperature CO sorption of the MOFs was studied, and UV-light irradiation is shown to result in reduced CO adsorption under static conditions. reveal...

Equilibrium Model for Supramolecular Copolymerizations.

The coassembly of different building blocks into supramolecular copolymers provides a promising avenue to control their properties and to thereby expand the potential of supramolecular polymers in applications. However, contrary to covalent copolymerization which nowadays can be well controlled, the control over sequence, polymer length, and morphology in supramolecular copolymers is to date less developed, and their structures are more determined by the delicate balance in binding free energies between the...

Muscle performance and fatigue in compensated chronic liver disease.

A common and debilitating symptom in patients with chronic liver disease is fatigue (CLD). Muscle dysfunction has been suggested to be a key mechanism of fatigue in CLD. We aimed to evaluate fatigue and the potential association with muscle performance and physical activity in outpatients with CLD. Two-hundred seventy outpatients with CLD were included, (52 ± 15 years, mean ± SD; 151 females) with autoimmune hepatitis ( = 49), primary biliary cholangitis ( = 45), primary sclerosing chol...

Neuropsychological impact of white matter hyperintensities in older adults without dementia.

The purpose of this study was to determine (a) if simple clinical judgements of white matter hyperintensities (WMH) on imaging are associated with measurable cognitive impacts in otherwise cognitively normal older adults, (b) if neuropsychological measures can predict those with WMH, and (c) the frequency of low cognitive scores in those with WMH on a battery of measures. Forty-four individuals judged free of other cognitive disorders despite moderate to extensive WMH were compared with 50 individuals match...

Family Caregiver Perspectives on End-of-Life Dreams and Visions during Bereavement: A Mixed Methods Approach.

End-of-life dreams and visions (ELDVs) are prevalent experiences that provide comfort and meaning to dying individuals. Limited research has examined the impact of ELDVs on the bereaved. This study aimed to explore differences in self-reported grief for people whose loved ones shared ELDVs and those who did not, and to describe the role of ELDVs in the grieving process. Mixed-methods cross-sectional survey. A total of 228 bereaved family caregivers (FCGs) of patients who died while under the care of a co...


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