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PubMed Journals Articles About "Craving Manipulation Cocaine Placebo Cocaine Unspecified" - Page: 3 RSS

07:25 EDT 20th July 2019 | BioPortfolio

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Showing "Craving Manipulation Cocaine Placebo Cocaine Unspecified" PubMed Articles 51–75 of 1,800+

The Efficacy and Safety of Xinmailong Injection in Patients with Chronic Heart Failure: A Multicenter Randomized Double-Blind Placebo-Controlled Trial.

Chronic heart failure (CHF) is a chronic and progressive disease with high incidence. The aim of this study was to evaluate the effectiveness and safety of Xinmailong injection (XI) on CHF patients with B-type natriuretic peptide (BNP) ≥200 ng/mL and left ventricular ejection fraction (LVEF) of ≤45%. This is a randomized double-blind placebo-controlled trial. Hospitals. One hundred patients with CHF were randomly divided into XI ( = 50) and control groups ( = 50). The XI group was treated ...


Comparing alcohol cue-reactivity in treatment-seekers versus non-treatment-seekers with alcohol use disorder.

: Recent studies have examined the distinction between treatment-seekers and non-treatment-seekers with alcohol use disorder (AUD) with a focus on treatment development. : To advance our understanding of treatment-seeking in clinical research for AUD, this study compares treatment-seekers to non-treatment-seekers with AUD on alcohol cue-reactivity (CR). : A community sample ( = 65, 40% female) of treatment-seeking ( = 32, 40.6% female) and non-treatment-seeking individuals ( = 33, 39.4% female) with a d...

Opioid, cocaine, and amphetamine use disorders are associated with higher30-day inpatient readmission rates in the United States.

Patients with substance use disorders (SUDs) are more likely to experience serious health problems, high healthcare utilization, and premature death. However, little is known about the contribution of SUDs to medical 30-day readmission risk. We examined the association between SUDs and 30-day all cause readmission among non-pregnant adult in-patients in the US. We conducted a retrospective study using 2010-2014 data from the Nationwide Readmissions Database. Our primary focus was on opioid use compared to ...


Dynamics of the power-duration relationship during prolonged endurance exercise and influence of carbohydrate ingestion.

We tested the hypotheses that the parameters of the power-duration relationship, estimated as the end-test power (EP) and work done above EP (WEP) during a 3-min all out exercise test (3MT), would be reduced progressively following 40 min, 80 min and 2 h of heavy-intensity cycling, and that carbohydrate (CHO) ingestion would attenuate the reduction in EP and WEP. Sixteen participants completed a 3MT without prior exercise (control), immediately after 40 min, 80 min and 2-h of heavy-intensity exercise while ...

Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study.

Prokinetics are considered the preferred treatment option for gastroparesis, but evidence of their efficacy is scarce. Prucalopride, a selective 5-hydroxytryptamine 4 receptor agonist used in the treatment of constipation, is able to enhance the gastric emptying rate. In a double-blind, randomized, placebo-controlled crossover study, we evaluated the efficacy of prucalopride to improve the gastric emptying rate and symptoms in patients with gastroparesis.

A new toolkit for gene tagging in Candida albicans containing recyclable markers.

Gene manipulation and epitope tagging are essential tools for understanding the molecular function of specific genes. The opportunistic human pathogen Candida albicans is a diploid fungus that utilizes a non-canonical genetic code. Since selection markers available in this organism are scarce, several tools based on recyclable markers have been developed for gene disruption, such as the Clox system. This system relies on the Cre recombinase, which recycles selection markers flanked by loxP sites with high e...

Cost-effectiveness analysis of empagliflozin treatment in people with Type 2 diabetes and established cardiovascular disease in the EMPA-REG OUTCOME trial.

In the EMPA-REG OUTCOME trial, empagliflozin therapy reduced cardiovascular death by 38% compared with placebo when added to standard of care. Using the trial results, we created a discrete-event simulation model to assess lifetime health economic outcomes in people with Type 2 diabetes and established cardiovascular disease.

Uniaxial Alignment of a Monolayer of Flat-on Free-Base Porphyrins on an Exfoliable Insulating Substrate.

Porphyrins are an extremely valuable class of molecules engaged in a variety of roles spanning from biology to optoelectronics. Manipulation of the chemical and physical properties of the inner cavity of porphyrins has been recognized crucial for the exploitation of these systems in organic devices, particularly when porphyrins self-organize at the interface with flat-on orientation of the macrocycle. Such orientation has been mostly observed on metallic surfaces. Unfortunately, the physical-chemical proper...

Precision Medicine Goes Microscopic: Engineering the Microbiome to Improve Drug Outcomes.

Despite the recognition, nearly a century ago, that the human microbiome plays a clinically relevant role in drug disposition, mechanistic insights, and translational applications are still limited. Here, we highlight the recent re-emergence of "pharmacomicrobiomics," which seeks to understand how inter-individual variations in the microbiome shape drug efficacy and side effect profiles. Multiple bacterial species, genes, and enzymes have already been implicated in the direct biotransformation of drugs, bot...

Comparing methods of genetic manipulation in Bacillus subtilis for expression of recombinant enzyme: Replicative or integrative (CRISPR-Cas9) plasmid?

The present study evaluated the stability of Bacillus subtilis strains transformed with a replicative or integrative plasmid (via CRISPR-Cas9) to express a recombinant phytase. Both transformation methods did not affect the growth of B. subtilis, but the stability of the construct and the enzymatic activity was reduced in the strain transformed with the replicative plasmid.

Empirical investigation of preparations produced according to the European Pharmacopoeia monograph 1038.

According to the European Pharmacopoeia monograph 1038 (Praeparationes homoeopathicae), homeopathic preparations are produced by successive dilution and succussion steps. Dilution levels beyond Avogadro's limit, however, render specific effects implausible according to standard scientific knowledge. Accordingly, we were interested in a critical empirical investigation of preparations produced according to this monograph. Within a precursor study we developed a bioassay based on a fingerprint metabolomic ana...

Effects of the synthetic cannabinoid receptor agonist JWH-018 on abuse-related effects of opioids in rhesus monkeys.

Opioid abuse remains a public health crisis despite a tremendous outpouring of resources to address the problem. One factor that might complicate this issue is polydrug abuse. While cannabis is increasingly available due to legalization by states, phytocannabinoids do not appear to alter the abuse-related effects of opioids. Synthetic cannabinoids, which are not pharmacologically identical to phytocannabinoids, are also increasingly available, and differences among cannabinoids might affect their interactio...

A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872.

Src signaling is markedly upregulated in patients with invasive glioblastoma (GBM) after the administration of bevacizumab. The Src family kinase inhibitor dasatinib has been found to effectively block bevacizumab-induced glioma invasion in preclinical models, which led to the hypothesis that combining bevacizumab with dasatinib could increase bevacizumab efficacy in patients with recurrent GBM.

Facile Actuation of Organic and Aqueous Droplets on Slippery Liquid Infused Porous Surfaces for the Application of On-Chip Polymer Synthesis and Liquid-Liquid Extraction.

Digital Microfluidics employs water repellant surfaces to exquisitely manipulate droplets of water for chemical analysis. However, the actuation and manipulation of organic droplets is still relatively unexplored as it is significantly more difficult to synthesize organic-repellent surfaces compared to water repellent surfaces. Here we present the fabrication of slippery liquid infused porous surfaces (SLIPS) based on a porous polymer monolithic approach. Synthesized SLIPS were able to repel organic liquids...

Motivation and social-cognitive abilities in older adults: Convergent evidence from self-report measures and cardiovascular reactivity.

Recently, some authors have suggested that age-related impairments in social-cognitive abilities-emotion recognition (ER) and theory of mind (ToM)-may be explained in terms of reduced motivation and effort mobilization in older adults. We examined performance on ER and ToM tasks, as well as corresponding control tasks, experimentally manipulating self-involvement. Sixty-one older adults and 57 young adults were randomly assigned to either a High or Low self-involvement condition. In the first condition, sel...

Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial.

The objective of this clinical trial was to evaluate the effectiveness of zinc supplementation on diarrhea and average daily weight gain (ADG) in pre-weaned dairy calves. A total of 1,482 healthy Holstein heifer and bull calves from a large California dairy were enrolled at 24 to 48 hours of age until hutch exit at approximately 90 days of age. Calves were block-randomized by time to one of three treatments: 1) placebo, 2) zinc methionine (ZM), or 3) zinc sulfate (ZS) administered in milk once daily for 14 ...

Clinical features and survival of patients with T-cell/histiocyte-rich large B-cell lymphoma: analysis of the National Cancer Data Base.

Using data from the National Cancer Data Base, 2010-2015, we examined characteristics and outcomes of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL,  = 622) relative to unspecified diffuse large B-cell lymphoma (DLBCL-NOS,  = 91,588) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL,  = 2240). Socio-demographic characteristics of patients with THRLBCL resembled more NLPHL than DLBCL-NOS. Five-year overall survival in THRLBCL was 66% (95% confidence interval [CI], 60-71%). Adjust...

Sensorimotor Gating in Cocaine-Related Disorder with Comorbid Schizophrenia or Antisocial Personality Disorder.

Schizophrenia, cocaine-related disorder, antisocial personality disorder, and psychopathy share biological bases, but few studies discriminate between these disorders by means of prepulse inhibition. This work studies the phenotype of patients with cocaine-related disorders who are vulnerable to presenting a dual diagnosis of schizophrenia or antisocial personality disorder, by evaluating their prepulse inhibition, impulsivity and psychopathy personality traits. The sample ( = 38) was divided into thre...

Report on the AASLD/EASL Joint Workshop on Clinical Trial Endpoints in NAFLD.

Nonalcoholic fatty liver disease (NAFLD) is a global public health concern. Its natural history, the development of nonalcoholic steatohepatitis (NASH) and fibrosis, is highly variable, prone to endogenous (e.g., genetics, microbiota) and exogenous (e.g., nutrition, alcohol, physical activity) disease modifiers, and can fluctuate over time. The complexity of its pathophysiology is reflected by the multitude of pharmacological targets in development. NASH clinical trials have provided valuable insight that i...

Low thermal conductivity and optimized thermoelectric properties of p-type Te-Sb2Se3: synergistic effect of doping and defect engineering.

Elemental tellurium has been exhibited a promising thermoelectric performance, largely due to the optimization of carrier concentration stemming from the effective chemical doping. In this study, we demonstrate a novel approach to realize the collaborative manipulation of the electrical and thermal transport properties in Te system via introduction of Sb2Se3. A series of p-type Te1-x(Sb2Se3)x (0 ≤ x ≤ 0.2) samples were fabricated through the melting method followed by spark plasma sintering (SPS). Elect...

From Monomers to a Lasagna-Like Aerogel Monolith: An Assembling Strategy for Aramid Nanofibers.

The manipulation of nano-building blocks into a 3D macroscopic monolith with ordered hierarchical structures has been much desired for broad and large-scale practical applications of nano architectures. In this paper, we demonstrate a fully bottom-up strategy for the preparation of aramid aerogel monoliths. The process starts from the synthesis of poly (p-phenylene terephthalamide) (PPTA) through the polycondensation of p-phenylenediamine and terephthaloyl chloride, with the assistance of a non-reactive dis...

Effect of acupressure on post tonsillectomy pain in adolescents: a randomized, single-blind, placebo-controlled trial study.

Introduction Tonsillectomy is one of the most common pediatric surgeries in the world and pain control following tonsillectomy is very important. Objective The aim of this study is to investigate the effect of acupressure on the amount of pain following tonsillectomy in children. Method One hundred and forty-four children aged 5-12 years old were assigned into one of three groups: interventions, control and placebo. In the intervention group, acupressure was applied at three acupoints and in the placebo gro...

The face-in-the-crowd effect: Threat detection versus iso-feature suppression and collinear facilitation.

Are people biologically prepared for the rapid detection of threat posed by an angry facial expression, even when it is conveyed in the form of a schematic line drawing? Based on visual search times, the current literature would suggest that the answer is yes. But are there low-level explanations for this effect? Here, we present visual search results for schematic faces using current best practice, based on a concentric search array and set size manipulation. Using this approach, we replicate the classic s...

Placental Bed Research: 2. Functional and Immunological Nvestigations of the Placental Bed.

Research on the placenta as the interface between the mother and the fetus has been undertaken for some 150 years and in two subsequent reviews, we attempted to summarize the situation. In the first part, we described the discovery of unique physiological modifications of uteroplacental spiral arteries enabling them to cope with a major increase in blood-flow necessary to ensure proper growth of the fetus. These consist of an invasion of the arterial walls by trophoblast and a progressive disappearance of i...

Evaluation of the effect of three constituent metals of monazita on the radiosensibility of human osteoblasts.

Thorium has gained notoriety in recent years, as a potential source of nuclear energy, substituting uranium in power plants. Monazite is an important source of thorium, as well of uranium and rare earths elements. Workers involved in the extraction and manipulation of this mineral are occupationally exposed to a range of metal mixtures containing thorium and to ionizing radiation. As an osteotropic substance, thorium is mostly deposited in bone tissue and may interfere in cellular radiosensitivity. A human ...


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