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PubMed Journals Articles About "Quercetin Derivative Modulate Chromatin Dynamics Adipogenesis Prevents Obesity" - Page: 3 RSS

11:53 EDT 21st July 2019 | BioPortfolio

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Showing "Quercetin derivative modulate chromatin dynamics adipogenesis prevents obesity" PubMed Articles 51–75 of 10,000+

Stabilization of carbon sequestration in a Chinese desert steppe benefits from increased temperatures and from precipitation outside the growing season.

The carbon (C) dynamics of desert steppes play an important role in the C budget of temperate steppes. Using the Terrestrial Ecosystem Regional model (TECO-R) model for desert steppes, we examined the dynamics and potential driving mechanisms for C stocks at different temporal and spatial scales from 2000 to 2017 in northern China. The ecosystem C density averaged 2.73 kg C m and soil organic C accounted for 91.6%. The grassland biome stored 2.85 kg C m, which is higher than the shrub biome (2.19 kg C...


Quantity and quality variations of dissolved organic matter (DOM) in column leaching process from agricultural soil: Hydrochemical effects and DOM fractionation.

Leaching dynamics of dissolved organic matter (DOM) from agricultural soil are influenced by the chemistry of irrigation water. This study used multiple spectroscopy methods to investigate the dynamics of DOM in column leaching process by utilizing selected solutions. DOC was leached out by Na solutions more effectively than by Ca, despite the additional contributions of the ligand exchange of SO and the hydrolysis of HCO. The concentration ranking corresponding to solutions is NaSO > NaHCO > NaCl...

Noncoding RNA in Liver Regeneration-From Molecular Mechanisms to Clinical Implications.

The unique ability of the adult liver to regenerate after injury is the basis for efficient surgical resection and liver transplantation and provides solutions for the treatment of liver cancer and acute liver failure. Current success in surgical treatments could be enhanced by directed regulation of liver regeneration. A number of small molecules and growth factors have been tested in mice models to improve liver regeneration. Noncoding ribonucleic acids (ncRNA) are less studied regulators of various cellu...


Behavioral Predictors of Weight Regain in Postmenopausal Women: Exploratory Results From the Breast Cancer and Exercise Trial in Alberta.

This secondary analysis assessed associations between changes in energy balance and sleep behaviors and the risk of weight regain following exercise-induced weight loss.

BMI, Waist Circumference, and Risk of Incident Vertebral Fracture in Women.

The study aimed to investigate the association between BMI, waist circumference, and vertebral fracture (VF) risk in women.

Ultrafast, Stable Ionic and Molecular Sieving through Functionalized Boron Nitride Membranes.

Porous membranes play an important role in the separation technologies such as gas purification, solutes nanofiltration and desalination. An ideal membrane should be thin to maximize permeation speed, have optimum pore sizes to maximise selectivity and be stable in various harsh conditions. Here, we show that the nanometer-thick membrane prepared by means of filtration of functionalized boron nitride (FBN) water suspensions can block solutes with hydrated radii larger than 4.3 angstroms (Å) in water. The F...

1-D Chain Tungstotellurate Hybrids Constructed from Organic-Ligand-Connecting Iron-Lanthanide Heterometal Encapsulated Tetrameric Polyoxotungstate Units.

A family of inorganic-organic hybrid one-dimensional (1-D) chain iron-lanthanide (Ln) heterometal encapsulated tungstotellurates [HN(CH)]KNa[Ln(Ac)(HO)Fe(Hpdca)(B-β-TeWO)][Ln(HO)Fe(Hpdca)(B-β-TeWO)]·50HO [Ln = Eu (), Tb (), Dy (), Er (), HAc = acetate acid, Hpdca = 2,5-pyridinedicarboxylic acid] were prepared using a facile "one-pot" reaction. The molecular structures of - consist of an intriguing organic-ligand-connecting Fe-Ln heterometal inserted tetrameric unit [Ln(Ac)(HO)Fe(Hpdca)(B-β-TeWO)][Ln(HO)...

Probing the Differential Dynamics of the Monomeric and Dimeric Insulin from Amide-I IR Spectroscopy.

The monomer-dimer equilibrium for insulin is one of the essential steps in forming the receptor-binding competent monomeric form of the hormone. Despite this importance, the thermodynamic stability, in particular for modified insulins, is quite poorly understood, in part, due to experimental difficulties. This work explores one- and two-dimensional infrared spectroscopy in the range of the amide-I band for the hydrated monomeric and dimeric wild-type hormone. It is found that for the monomer the frequency f...

An Efficient Implementation of the Second-Order Quasidegenerate Perturbation Theory with Density-Fitting and Cholesky Decomposition Approximations: Is It Possible to Use Hartree-Fock Orbitals for a Multiconfigurational Perturbation Theory?

The high cost of common multireference second-order perturbation theory (MRPT2) methods compared with the single-reference variant (MP2) arises from the expensive complete active space self-consistent field (CASSCF) orbital optimization step. Furthermore, the use of conventional four-index electron repulsion integrals (ERIs) prevents their application to larger molecular systems due to expensive I/O procedures. To address these bottlenecks of the multiconfigurational second-order quasidegenerate perturbatio...

Toward Efficient Calculations Using Numerical Atomic Orbitals: Benchmarking and Application to Molecular Dynamics Simulations.

The use of atomic orbitals in Hedin's approximation provides, in principle, an inexpensive alternative to plane-wave basis sets, especially when modeling large molecules. However, benchmarking of the algorithms and basis sets is essential for a careful balance between cost and accuracy. In this paper, we present an implementation of the approximation using numerical atomic orbitals and a pseudopotential treatment of core electrons. The combination of a contour deformation technique with a one-shot extract...

Car-Parrinello Monitor for more robust Born-Oppenheimer molecular dynamics.

Born-Oppenheimer molecular dynamics (BOMD) is a promising simulation method for exploring the possible reaction pathways of a chemical system, but one significant challenge is the increased difficulty of converging the self-consistent field (SCF) calculation that often accompanies the breaking and forming of chemical bonds. To address this challenge, we developed an enhancement to the BOMD simulation method called the Car-Parrinello monitor (CPMonitor) that uses Car-Parrinello molecular dynamics (CPMD) to r...

3D-Micromachined Polyimide Mixing Devices for in situ X-ray Imaging of Solution-based Block Copolymer Phase Transitions.

Advances in modern interface- and material sciences often rely on the understanding of a system's structure-function relationship. Designing reproducible experiments that yield in situ time-resolved structural information at fast time scales are therefore of great interest, e.g. for better understanding the early stages of self-assembly or other phase transitions. However, it can be challenging to accurately control experimental conditions, especially when samples are only available in small amounts, prone ...

Capillary flow in open microgrooves: bifurcations and networks.

Open capillary flows are increasingly used in biotechnology, biology, thermics, and space science. So far, the dynamics of capillary flows has been studied mostly for confined channels. However, the theory of open microfluidics has considerably progressed during the last years, and an expression for the travel distance has been derived, generalizing the well-known theory of Lucas, Washburn, and Rideal. This generalization is based on the use of the average friction length and generalized Cassie angle. In th...

The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.

Sirtuins (Sirts) are implicated in regulating a myriad of biologic functions ranging from cell growth and metabolism to longevity. Here, we show that nuclear Sirt, Sirt6, and mitochondrial Sirt, Sirt3, regulate each other's activity and protect the heart from developing diabetic cardiomyopathy. We found that expression of both Sirt6 and Sirt3 was reduced in cardiomyocytes treated with palmitate and in hearts of mice fed with a high-fat, high-sucrose (HF-HS) diet to develop obesity and diabetes. Conversely, ...

Included, but Deportable: A New Public Health Approach to Policies That Criminalize and Integrate Immigrants.

There has been a burst of research on immigrant health in the United States and an increasing attention to the broad range of state and local policies that are social determinants of immigrant health. Many of these policies criminalize immigrants by regulating the "legality" of their day-to-day lives while others function to integrate immigrants through expanded rights and eligibility for health care, social services, and other resources. Research on the health impact of policies has primarily focused on th...

Computational analysis of airflow dynamics for predicting collapsible sites in the upper airways: Machine learning approach.

Obstructive sleep apnea (OSA) is a common sleep breathing disorder. Employing computational fluid dynamics (CFD), this study provides a quantitative standard for accurate diagnosis and effective surgery based on the investigation of the relationship between airway geometry and aerodynamic characteristics. Based on computed tomography data from patients having normal geometry, four major geometric parameters were selected, and a total of 160 idealized cases were modeled and simulated. We created a predictive...

Highlight: Dynamics of the Nervous System in Health and Disease.

No abstract available.

Exosome-encapsulated microRNAs as promising biomarkers for Alzheimer's disease.

Alzheimer's disease (AD) is a chronic neurodegenerative disease that locks into long clinical latency and low curative ratio. Therefore, early diagnosis before the clinical phase is quite essential and may be effective for therapeutic prevention. Peripheral blood or cerebrospinal fluid biomarkers symbolizing functional neuronal impairment are gradually applied to diagnose AD in research studies. Exosomes have generated immense interest in the diagnosis field of neurodegenerative disorders after confirmation...

Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation.

Prouroguanylin (ProUGN) in the intestine is cleaved to form uroguanylin (UGN), which stimulates guanylate cyclase C (GUCY2C), inducing cyclic guanosine monophosphate signaling. Paracrine release regulates fluid secretion, contributing to bowel function, whereas endocrine secretion evoked by eating forms a gut-brain axis, controlling appetite. Whereas hormone insufficiency contributes to hyperphagia in obesity, its contribution to the pathophysiology of constipation syndromes remains unexplored. Here, we com...

Household Chaos, Maternal Emotional Responsiveness, and Child Eating Behavior: A Moderation Analysis.

To address calls for a resilience-informed approach to understand the cause and prevention of childhood obesity, the current study aims to investigate the independent and interactive associations between household chaos, maternal emotional responsiveness, and eating behavior in early childhood.

Endothelin A and B Receptors: Potential Targets for Microcirculatory-Mitochondrial Therapy in Experimental Sepsis.

The hypoxia-sensitive endothelin (ET) system plays an important role in circulatory regulation through vasoconstrictor ETA and ETB2 and vasodilator ETB1 receptors. Sepsis progression is associated with microcirculatory and mitochondrial disturbances along with tissue hypoxia. Our aim was to investigate the consequences of treatments with the ETA receptor (ETA-R) antagonist, ETB1 receptor (ETB1-R) agonist, or their combination on oxygen dynamics, mesenteric microcirculation and mitochondrial respiration in a...

Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.

Apicomplexan parasites possess a plastid organelle called the apicoplast. Inhibitors that selectively target apicoplast housekeeping functions, including DNA replication and protein translation, are lethal for the parasite, and several (doxycycline, clindamycin, and azithromycin) are in clinical use as antimalarials. A major limitation of such drugs is that treated parasites only arrest one intraerythrocytic development cycle (approximately 48 hours) after treatment commences, a phenotype known as the 'dela...

Conditioned place avoidance using encapsulated calcium propionate as an appetite suppressant for broiler breeders.

Broiler breeders, the parent stock of meat chickens, are feed-restricted throughout the production cycle to avoid obesity-related problems in their health and reproductive performance. Broiler breeders often show signs of chronic hunger, lack of satiety and feeding frustration, and the development of alternative feeding strategies has investigated the inclusion of calcium propionate (CaP) as an appetite suppressant. The mechanisms involved in the reduction of voluntary feed intake are unknown, but are thoug...

DNA segregation under Par protein control.

The spatial organization of DNA is mediated by the Par protein system in some bacteria. ParB binds specifically to the parS sequence on DNA and orchestrates its motion by interacting with ParA bound to the nucleoid. In the case of plasmids, a single ParB bound plasmid is observed to execute oscillations between cell poles while multiple plasmids eventually settle at equal distances from each other along the cell's length. While the potential mechanism underlying the ParA-ParB interaction has been discussed,...

A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: A pilot study.

The global obesity epidemic constitutes a major cause of morbidity and mortality challenging public health care systems worldwide. Thus, a better understanding of its pathophysiology and the development of novel therapeutic options are urgently needed. Recently, alterations of the intestinal microbiome in the obese have been discussed as a promoting factor in the pathophysiology of obesity and as a contributing factor to related diseases such as type 2 diabetes and metabolic syndrome. The present pilot stud...


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