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PubMed Journals Articles About "Brown Shoe Company" - Page: 3 RSS

19:12 EDT 22nd September 2018 | BioPortfolio

Brown Shoe Company PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Brown Shoe Company articles that have been published worldwide.

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Showing "Brown Shoe Company" PubMed Articles 51–75 of 499

Mortality of Little Brown Bats ( Myotis lucifugus carissima) Naturally Exposed to Microcystin-LR.

We describe a die-off of little brown bats ( Myotis lucifugus carissima) associated with acute intoxication with microcystin-LR in 2016 at Scofield Reservoir in Utah. High levels of this cyanotoxin in water from the reservoir and gastrointestinal content of bats supported this diagnosis.


Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) α1.

Development of brown and beige/brite adipocytes increases thermogenesis and helps to reduce obesity and metabolic syndrome. Our previous study suggests that dietary raspberry can ameliorate metabolic syndromes in diet-induced obese mice. Here, we further evaluated the effects of raspberry on energy expenditure and adaptive thermogenesis and determined whether these effects were mediated by AMP-activated protein kinase (AMPK). Mice deficient in the catalytic subunit of AMPKα1 and wild-type (WT) mice were fe...

Role of ABC transporters White, Scarlet and Brown in brown planthopper eye pigmentation.

The brown planthopper ATP-binding cassette (ABC) proteins White (W), Scarlet (St) and Brown (Bw) belong to the ABC transporter superfamily and are responsible for the transportation of guanine and tryptophan precursors of eye pigments. In the present study, the brown planthopper White (NlW), S t(NlSt) and Bw (NlBw) genes were cloned, and subsequent phylogenetic analysis showed that these genes are clustered with their respective homologues, with a genetic relationship observed between NlW and its Bemisia ta...


Canine Adenovirus type 1 (CAdV-1) in free-ranging European brown-bear (Ursus arctos arctos): a threat for Cantabrian population?

Canine adenovirus type 1 (CAdV-1) is responsible for infectious canine hepatitis. The disease has been described in captive American black bear (Ursus americanus) and European brown bear (Ursus arctos arctos), with just one recently reported case in a cub of a free-ranging brown bear (Ursus arctos horribilis) from Alaska. The aim of this work is to summarize findings related to presence and associated mortality of CAdV-1 in twenty-one free-ranging Cantabrian brown bears (Ursus arctos arctos) submitted to ne...

Effects of α-(prazosin and yohimbine) and β-receptors activity on cAMP generation and UCP1 gene expression in brown adipocytes.

Brown adipose tissue (BAT) contains both α- and β-adrenergic receptors. In the literature, the activity of α-adrenoreceptors is less documented, and their functions still remain puzzling. The present investigation has been undertaken to understand α-adrenoreceptors' activity and their relation between uncoupling protein 1 (UCP1) mRNA expression and cyclic AMP (cAMP) generation in BAT.

Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation.

Pseudomonas aeruginosa is an opportunistic pathogen with a relatively large genome, and has been shown to routinely lose genomic fragments during environmental selection. However, the underlying molecular mechanisms that promote chromosomal deletion are still poorly understood. In a recent study, we showed that by deleting a large chromosomal fragment containing two closely situated genes, hmgA and galU, P. aeruginosa was able to form 'brown mutants', bacteriophage (phage) resistant mutants with a brown col...

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation.

Activation of brown adipose tissue (BAT) contributes to total body energy expenditure through energy dissipation as heat. Activated BAT increases the clearance of lipids and glucose from the circulation, but how BAT accommodates large influx of multiple substrates is not well defined. The purpose of this work was to assess the metabolic fluxes in brown adipocytes during β3-adrenergic receptor (β3-AR) activation.T37i murine preadipocytes were differentiated into brown adipocytes and we used Seahorse respir...

Discovery and screening of novel metagenome-derived GH107 enzymes targeting sulfated fucans from brown algae.

Sulfated fucans, often denoted fucoidans, are highly variable cell wall polysaccharides of brown algae, which possess a wide range of bioactive properties with potential pharmaceutical applications. Due to their complex architecture, the structures of algal fucans have until now only been partly determined. Enzymes capable of hydrolyzing sulfated fucans may allow specific release of defined bioactive oligosaccharides and may serve as a tool for structural elucidation of algal walls. Currently, such enzymes ...

Insecticide toxicity associated with detoxification enzymes and genes related to transcription of cuticular melanization among color morphs of Asian citrus psyllid.

The Asian citrus psyllid (Diaphorina citri Kuwayama) is known to exhibit abdominal color polymorphisms. In the current study, susceptibility to four insecticides was compared among orange/yellow, blue/green and gray/brown color morphs of field collected D. citri. The LDvalues and 95% fiducial limits were quantified for each insecticide and color morph combination and ranged between 0.32 ng/μL (0.18-0.56) and 6.16 ng/μL (3.30-12.50). Second, we measured the detoxification enzyme activity levels of orange/y...

Brown and beige fat: From molecules to physiology and pathophysiology.

The adipose organ portrays adipocytes of diverse tones: white, brown and beige, each type with distinct functions. Adipocytes orchestrate their adaptation and expansion to provide storage to excess nutrients, the quick mobilisation of fuel to supply peripheral functional demands, insulation, and, in their thermogenic form, heat generation to maintain core body temperature. Thermogenic adipocytes could be targets for anti-obesity and anti-diabetic therapeutic approaches aiming to restore adipose tissue funct...

Predictive framework for codend size selection of brown shrimp (Crangon crangon) in the North Sea beam-trawl fishery.

The brown shrimp (Crangon crangon) fishery is of great socio-economic importance to coastal communities on the North Sea. The fishery is exploited by beam trawlers often using codends with very small mesh sizes, leading to concerns about catch rates of undersized shrimp. However, little information is available on codend size selection, making it difficult to provide scientifically based advice on alternative codend designs. Therefore, this study establishes a predictive framework for codend size selection ...

Height Error Correction for Shoe-Mounted Inertial Sensors Exploiting Foot Dynamics.

Shoe-mounted inertial sensors are widespread deployed in satellite-denied scenarios because of the possibility to re-calibrate stepwise the estimated position. These re-calibrations, known as zero-velocity corrections, prevent an accumulated positioning error growth over time caused by the noise of current medium- and low-cost sensors. However, the error accumulated over time in the height estimation is still an issue under study. The objective of this article is to propose a height correction that is based...

Emission of volatile halogenated compounds, speciation and localization of bromine and iodine in the brown algal genome model Ectocarpus siliculosus.

This study explores key features of bromine and iodine metabolism in the filamentous brown alga and genomics model Ectocarpus siliculosus. Both elements are accumulated in Ectocarpus, albeit at much lower concentration factors (2-3 orders of magnitude for iodine, and

Effects of Dissolved Organic Matter Fractions Extracted from Humus Soil on Sorption of Benzotriazole in Brown Soil and Black Soil.

Dissolved organic matter (DOM) affects the sorption behavior of organic pollutants in soils. In this study, bulk DOM (marked as DOM) was extracted from natural humus soil and divided into five individual fractions by XAD-8 resin and anion/cation exchange resins based on their hydrophobicity-hydrophilicity. The isolated DOM fractions were characterized by FTIR, elemental analysis, UV spectrophotometer and potentiometric titration. Batch experiments were conducted to investigate the effects of different fract...

Brown eggshell fading with layer ageing: dynamic change in the content of protoporphyrin IX.

The dynamic change in brown eggshell color as hens age has been observed, but much uncertainty still exists. We aimed to analyze the depth of eggshell color and quantity of protoporphyrin ΙΧ throughout the laying period to explore the reasons for color variation. In this study, 120 Rhode Island Red hens were used, and two eggs were collected from each individual at 26, 34, 42, 50, 60, and 70 wk of age. The eggshell color (L*, a*, b*), egg weight, eggshell dry weight, and protoporphyrin ΙΧ quantity in eg...

Accurately Determining Proper Shoe Size in Patients With Rheumatoid Arthritis.

The aim of this descriptive study was to determine whether people with rheumatoid arthritis (RA) wear adequately fitting footwear.

Contrast-dependent red-green balance shifts depend on S-cone activity.

Previous research from our lab has established that red-green-balanced yellow targets become greenish-brown as surround luminance increases, while red-green-balanced brown targets become reddish-yellow as surround luminance decreases. To help assess the generality and underlying processes of this contrast-dependent red-green hue shift, we investigated red-green hue shifts for target stimuli that appeared achromatic or blue as well as yellow/brown. Results confirmed that the red-green hue shift was largest f...

Infectious Canine Hepatitis in a Brown Bear ( Ursus arctos horribilis) from Alaska.

We diagnosed infectious canine hepatitis in a free-ranging brown bear ( Ursus arctos horribilis) cub from Alaska, US, found dead in October 2015. Intranuclear inclusion bodies were present in hepatocytes, and immunohistochemistry showed reactivity to adenoviral antigens. Sequencing of the hexon protein of adenovirus showed 100% identity to canine adenovirus 1.

Perception of facial profile attractiveness of a brown subject displaying different degrees of lip projection or retrusion, in the city of Salvador/Bahia.

The attractiveness and facial aesthetics are commonly defined by the media in modern society and the number of patients seeking for changes in the facial appearance is progressively increasing. Augmented face convexity is believed to be non aesthetic and among the treatments available for its correction, the extraction of premolars followed by anterior teeth retraction produces a significant effect. However, it is questionable whether the procedure is reasonable in brown and black patients, since dental pro...

Distribution of metals and metalloids in dried seaweeds and health risk to population in southeastern China.

Concern about metals and metalloids, especially heavy metals in seaweeds has risen due to potential health risk. This study investigated the distribution of 10 metals and metalloids in 295 dried seaweeds (brown and red) and estimated the possible health risk via hazard index (HI). Elements in seaweeds can be sequenced in descending order by mean values: Al > Mn > As > Cu > Cr > Ni > Cd > Se > Pb > Hg. The levels of Cd, Cu, Mn and Ni in red seaweeds were significantly high...

Reverse dichromatism in gem andalusite related to total pleochroism of the Fe-Ti IVCT.

We document a dichromatism effect in gem andalusite that shifts from light brownish pink at low thickness to medium green at high thickness. This is roughly reverse to that usually observed in other dichromatic materials. We show that this is due to a very strong pleochroism in andalusite, when dichromatism in other materials is due to an alexandrite effect. Here, colors varies from a strongly absorbing orangey-brown in the c direction to much less absorbing medium green in a and b directions. The brown abs...

HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression.

Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshivering thermogenesis in brown adipose tissue (BAT). UCP1 increases the conductance of the inner mitochondrial membrane (IMM) for protons to make BAT mitochondria generate heat rather than ATP. HDAC6 is a cytosolic deacetylase for non-histone substrates to regulate various cellular processes, including mitochondrial quality control and dynamics. Here, we showed that the body temperature of HDAC6 knockout mice is slightly decreased in normal h...

Identification of an optimal threshold for detecting human brown adipose tissue using receiver operating characteristic analysis of IDEAL MRI fat fraction maps.

Lower fat fraction (FF) in brown adipose tissue (BAT) than white adipose tissue (WAT) has been exploited using Dixon-based Magnetic Resonance Imaging (MRI) to differentiate these tissues in rodents, human infants and adults. We aimed to determine whether an optimal FF threshold could be determined to differentiate between BAT and WAT in adult humans in vivo.

Ablation of DJ-1 impairs brown fat function in diet-induced obese mice.

This study was conducted to investigate the effects of DJ-1 deficiency on brown adipose tissue (BAT) function in mice. DJ-1 knockout (KO) mouse models and wild-type littermates placed on normal diet or high-fat diet were utilized to demonstrate the direct consequences of DJ-1 deletion on BAT characteristics, thermogenic ability, lipid metabolism, and microenvironment regulation. Global DJ-1 KO mice had defective brown adipose tissue (BAT) activity culminating in a profound whitening of BAT. Despite aberrati...

Metformin Targets Brown Adipose Tissue in vivo and Reduces Oxygen Consumption in vitro.

Metformin is the most widely prescribed oral antidiabetic drug worldwide. Despite well-documented beneficial effects on health outcomes in diabetic patients, the target organs that mediate the effects of metformin remain to be established. In adult humans, brown adipose tissue (BAT) can influence basic metabolic rate, making BAT an attractive target for treatment of type 2 diabetes. Under the hypothesis that BAT is a metformin target tissue, we investigated in vivo uptake of [ C]-metformin tracer in mice an...


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