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PubMed Journals Articles About "Indinavir Sulfate Abacavir Sulfate Amprenavir Nelfinavir Mesylate Efavirenz" - Page: 3 RSS

11:59 EST 20th January 2019 | BioPortfolio

Indinavir Sulfate Abacavir Sulfate Amprenavir Nelfinavir Mesylate Efavirenz PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Indinavir Sulfate Abacavir Sulfate Amprenavir Nelfinavir Mesylate Efavirenz articles that have been published worldwide.

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Showing "Indinavir sulfate Abacavir sulfate Amprenavir Nelfinavir mesylate Efavirenz" PubMed Articles 51–75 of 852

Structure characterization of low molecular weight sulfate Ulva polysaccharide and the effect of its derivative on iron deficiency anemia.

Sulfate Ulva polysaccharide with low molecular weight was prepared by enzymatic method and name SUE. The structural characterization of SUE and the effect of its derivative SUE-iron (III) on iron deficiency anemia were studied. Results showed SUE with molecular weight of 178 kDa were consisted of 57.9% rhamnose, 12.1% glucose, 16.3% glucuronic acid, and 13.7% xylose. The backbone contained (1 → 3, 4)-linked rhamnose, (1 → 4)-linked xylose, (1 → 6)-linked glucose and sulfate substitution ...


Chemical synthesis of 4-azido-β-galactosamine derivatives for inhibitors of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase.

Chondroitin sulfate E (CS-E) plays a crucial role in diverse processes ranging from viral infection to neuroregeneration. Its regiospecific sulfation pattern, generated by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), is the main structural determinant of its biological activity. Inhibitors of GalNAc4S-6ST can serve as powerful tools for understanding physiological functions of CS-E and its potential therapeutic leads for human diseases. A family of new 4-acylamino-β-GalNAc derivativ...

Heparan sulfate as a regulator of inflammation and immunity.

Heparan sulfate is found on the surface of most cell types, as well as in basement membranes and extracellular matrices. Its strong anionic properties and highly variable structure enable this glycosaminoglycan to provide binding sites for numerous protein ligands, including many soluble mediators of the immune system, and may promote or inhibit their activity. The formation of ligand binding sites on heparan sulfate (HS) occurs in a tissue- and context-specific fashion through the action of several familie...


Bio-mixotrophic perchlorate reduction to control sulfate production in a step-feed sulfur-based reactor: A study of kinetics, ORP and bacterial community structure.

Excess sulfate production and low concentration of perchlorate removal are the main problems for sulfur-based perchlorate reduction reactor. In this study, the problems were firstly solved by step-feeding under mixotrophic conditions. The performances of step-feed sulfur-based reactor (SFSBR) and up-flow sulfur-based reactor (UFSBR) are compared. At perchlorate of 194 mg/L, acetate of 28.8 mg/L and hydraulic retention time of 0.9 h, the Half-order reaction rate constant and the sulfate production of S...

Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sulfate (LMW-HS) and a blend of naturally derived extracts.

Maintaining a youthful appearance is a priority for many people. Global eye rejuvenation is sought more frequently and at a younger age than other treatments. Major concerns around the eye area are periorbital hyperpigmentation, puffiness, and lines and wrinkles. Glycosaminoglycans (GAGs) are complex carbohydrates that modulate skin health, repair and renew skin's appearance. Heparan sulfate (HS) is the most biologically active GAG, although it is too large and polar to penetrate the skin. Low Molecular Wei...

Quantification of SO Oxidation on Interfacial Surfaces of Acidic Micro-Droplets: Implication for Ambient Sulfate Formation.

Sulfate formation on the surface of aqueous micro-droplets was investigated using a spray-chamber reactor coupled to an electrospray ionization mass spectrometer that was calibrated using NaSO(aq) as a function of pH. The observed formation of SO, SO, and HSO at pH < 3.5 without the additional of other oxidants indicates that an efficient oxidation pathway takes place involving direct interfacial electron transfer from SO to O on the surface of aqueous micro-droplets. Compared to the well-studied sulfate fo...

LOw dose MAGnesium sulfate versus HIgh dose in the early management of rapid atrial fibrillation: randomised controlled double blind study.

We aim to determine the benefit of two different doses magnesium sulfate (MgS) compared to placebo in rate control of rapid atrial fibrillation (AF) managed in the emergency department (ED).

Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells.

Although neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity of OH-PCBs and PCB sulfates derived from PCBs 3, 8, 11, and 52 in two neural cell lines (N27 and SH-SY5Y) and an hepatic cell line (HepG2). With the exception of a similar toxicity seen for N27 ...

Cation exchange reactions in layered double hydroxides intercalated with sulfate and alkaline cations (A(H2O)6)M+26Al3(OH)18(SO4)2.6H2O (M+2= Mn, Mg, Zn; A+= Li, Na, K).

Layered double hydroxides (LDHs) with similar compositions to the minerals Shigaite, Natroglaucocerinite and Motukoreaite were synthesized by coprecipitation with increasing pH and characterized by several instrumental techniques. These minerals have previously been described to occur only with sodium and sulfate (Na(H2O)6)[M+26Al3(OH)18(SO4)2].6H2O (M+2= Mn, Mg and Zn). These phases were synthesized successfully along with others containing lithium and potassium. Cation exchange reactions were performed in...

Risk of Cardiovascular Disease Associated With Exposure To Abacavir Among Individuals With HIV: A Systematic Review And Meta-analyses Of Results From Seventeen Epidemiologic Studies.

Abacavir's potential to cause cardiovascular disease (CVD) among people living with HIV (PLWH) is debated. We conduct a systematic review and meta-analyses to assess CVD risk from recent and cumulative abacavir exposure.

Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells.

The emergence of multidrug resistance (MDR) caused by P-glycoprotein (P-gp) overexpression is a serious obstacle to the treatment of chronic myelocytic leukemia. In recent years, some clinical trials have shown that nelfinavir (NFV), a traditional anti-HIV drug, has anti-cancer effects. Some researchers have also shown NFV might be a potential P-gp inhibitor. This study is aimed at investigating whether nelfinavir can act as an MDR-reversal drug and to clarify its molecular mechanism as well.

Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial.

Appropriate pain relief enhances patient satisfaction and reduces patient anxiety. This study aimed to compare oral oxycodone with intravenous (IV) morphine sulfate (MS) in pain management of acute limb trauma.

Semisynthesis of Chondroitin Sulfate E Tetrasaccharide from Hyaluronic Acid.

Chondroitin sulfate (CS) is crucial glycosaminoglycan that regulates key functions of the nervous system. CS-E is one of the key CS subtypes that modulates the biological function of CS. Herein, N-protecting-group-free semisynthesis of CS-E tetrasaccharide is reported using hyaluronic acid as a readily available starting material. The synthetic process utilizes the enzymatic degradation and selective C4 hydroxyl group conversion as key approaches for direct construction of the CS tetrasaccharide precursor, ...

Effects of mercury addition on microbial community composition and nitrate removal inside permeable reactive barriers.

Permeable reactive barriers (PRBs) remove nitrogen from groundwater by enhancing microbial denitrification. The PRBs consist of woodchips that provide carbon for denitrifiers, but these woodchips also support other anaerobic microbes, including sulfate-reducing bacteria. Some of these anaerobes have the ability to methylate inorganic mercury present in groundwater. Methylmercury is hazardous to human health, so it is essential to understand whether PRBs promote mercury methylation. We examined microbial com...

Proteoglycan-substrate gel zymography for the detection of chondroitin sulfate-degrading enzymes.

Chondroitin sulfate (CS), a linear polysaccharide, is a major component of the cartilage matrix. Although CS plays various roles in several biological and pathological processes, most details regarding its metabolism are still poorly understood. Some CS-degrading enzymes have been identified in mammals, but their expression patterns and localizations remain unclear. Here we present a simple zymography procedure to detect CS-degrading enzymes using salmon nasal cartilage proteoglycans as substrates. This met...

Geographical pattern of methanogenesis in paddy and wetland soils across eastern China.

Large variation of CH emissions from paddy and wetland ecosystems exists across different geographical locations in China. To obtain mechanistic understanding of this variation, we investigated the dynamics of methanogenesis over the course of glucose degradation in fourteen paddy field soils and five wetland soils collected from different regions of China. The results revealed that the maximal rate (2-3 mM per day) and the total amount (25-30 mM) of CH produced were similar across soil samples. The...

Selective Uptake of Third Hand Tobacco Smoke Components to Inorganic and Organic Aerosol Particles.

Third hand smoke (THS) is an emerging route of exposure to tobacco smoke in the indoor environment. Few studies have investigated the chemical behavior of THS, although initial findings suggest that semi-volatile components of THS can partition to indoor aerosol. By exposing single component particles to THS in an environmental chamber, this study demonstrates a pronounced dependence of THS uptake on aerosol composition. First, it was found that primarily reduced nitrogen compounds (that produced CHN ion si...

Viscera of fishes as raw material for extraction of glycosaminoglycans of pharmacological interest.

World fisheries and aquaculture production totaled 167 million tons in 2014. This high fish production generates a lot of waste that could be used as raw material for extraction of substances of pharmacological interest. In this work, we extract and characterize glycosaminoglycans (GAGs) present in the viscera of Nile tilapia (Oreochromis niloticus) and Pacu (Piaractus mesopotamicus), which are among the most vastly produced fishes in inland aquaculture in Brazil. Moreover, the anticoagulant activity of...

Assessing the Physicochemical Stability of a Compounded Neonatal Trace Element Solution.

Alberta Health Services (AHS) recommends the adoption of a new neonatal multi-trace element formulation containing zinc sulfate, copper sulfate, selenious acid and sodium iodide to be compounded internally in appropriate AHS pharmacies. The objective of this study was to assess the physicochemical stability of this formulation under commonly used storage conditions.

Complete dechlorination and mineralization of pentachlorophenol (PCP) in a hydrogen-based membrane biofilm reactor (MBfR).

Complete biodegradation and mineralization of pentachlorophenol (PCP), a priority pollutant in water, is challenging for water treatment. In this study, a hydrogen (H)-based membrane biofilm reactor (MBfR) was applied to treat PCP, along with nitrate and sulfate, which often coexist in contaminated groundwater. Throughout 120-days of continuous operation, almost 100% of up to 10 mg/L PCP was removed with minimal intermediate accumulation and in parallel with complete denitrification of 20 mg-N/L nitrate...

Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis.

There are known links between inflammatory bowel disease (IBD) and changes in the microbiota of the gut and inflammation and oxidative stress. In this study, a colitis model induced by dextran sodium sulfate (DSS) in mice is used to evaluate whether the presence of bioactive peptides IRW (Ile-Arg-Trp) and IQW (Ile-Gln-Trp) peptides is advantageous.

Protective effects of magnesium sulfate against doxorubicin induced cardiotoxicity in rats.

Clinical use of doxorubicin, an effective chemotherapeutic agent, has limited uses due to dose-dependent cardiac toxicity. It has been supposed that the production of free radicals and calcium ions overload can lead to cardiac toxicity. Magnesium is a cardioprotective drug which inhibits lipid peroxidation and reducing myocardial apoptosis. This study was aimed to explore the hypothesis that the cardiac toxicity induced by administration of doxorubicin is prevented or reduced by magnesium sulfate treatment ...

Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism.

Cysteine is one of the two key sulfur-containing amino acids with important functions in, redox homeostasis, protein functionality and metabolism. Cysteine is taken up by mammals via the diet, and can also be derived from methionine via the transsulfuration pathway. The cellular concentration of cysteine is kept within a narrow range by controlling its synthesis and degradation. There are two pathways for the catabolism of cysteine leading to sulfate, taurine and thiosulfate as terminal products. The oxidat...

Complete observation of all structural, conformational, and fibrillation transitions of monomeric globular proteins at submicellar sodium dodecyl sulfate concentrations.

Although considerable information is available regarding protein-sodium dodecyl sulfate (SDS) interactions, it is still unclear as to how much SDS is needed to denature proteins. The role of protein charge and micellar surfactant concentration on amyloid fibrillation is also unclear. This study reports on equilibrium measurements of SDS interaction with six model proteins and analyzes the results to obtain a general understanding of conformational breakdown, reorganization and restructuring of secondary str...

Cost Effectiveness of Dolutegravir as a First-Line Treatment Option in the HIV-1-Infected Treatment-Naive Patients in Russia.

To evaluate the cost effectiveness of dolutegravir + abacavir/lamivudine (DTG + ABC/3TC) compared with raltegravir + abacavir/lamivudine (RAL + ABC/3TC) and ritonavir-boosted darunavir + abacavir/lamivudine (DRV/r + ABC/3TC) in HIV-1-infected treatment-naive patients in Russia.


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