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Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc articles that have been published worldwide.
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Dehydrogenative C-H arylations of 1,2,3-triazoles were accomplished with the aid of a reusable palladium catalyst in PEG. The widely applicable oxidative palladium-catalysis enabled the synthesis of fully decorated 1,2,3-triazoles with a broad functional group tolerance and ample substrate scope. The sustainability of the aerobic C-H arylation was reflected by the use of PEG as green reaction medium and demonstrated by recycling studies of the catalyst and the reaction medium.
Molecular organic radicals were intensively studied in the last decades, due to their interesting optical, magnetic and redox properties. Here we report the synthesis and characterization of persistent organic radicals from one-electron oxidation of redox-active azines (RAAs), composed of two guanidinyl or related groups. By connecting two different groups together, asymmetric compounds result. In this way a series of compounds with varying redox potential is obtained, that could be oxidized reversibly to t...
The lipopolysaccharide (LPS) of Vibrio cholerae O139, strain CIRS245, was isolated conventionally, and the lipid A was removed by mild acid hydrolysis (0.1 M NaOAc buffer containing 1% SDS, pH 4.2, 95°C, 8 h). The crude product was a complex mixture consisting mainly of constituent fragments of the O-specific polysaccharide-core (OSPc). The OSPc was only a minor component in the mixture. Two-stage purification of the crude OSPc by HPLC gave pure OSPc fragment of the LPS, as shown by NMR spectroscopy, analy...
Engineered heme proteins and biomimetic iron porphyrins have been found to possess excellent catalytic properties for numerous carbene transfer reactions. Computational studies including the use of density functional theory (DFT) calculations and molecular dynamics (MD) simulations have been employed to help understand some important mechanistic aspects of heme carbene transfer reactions. This review summarizes the advances of the computational results published in the following two areas: 1) heme carbenes'...
Psoriasis impacts the quality of life by disrupting overall health and social life. Thus, the use of a quality of life evaluation item is crucial in assessing a therapeutic regimen. Also, faster improvements in quality of life lead to better patient compliance, but very few studies compare psoriasis traditional and biologic therapies timing. To evaluate how much different systemic therapies improve disease severity and quality of life, a retrospective analysis was performed on 56 patients. Subjects were adm...
Previous work has demonstrated that patients with cartilage defects of the knee benefit from arthroscopic transplantation of autologous synovial mesenchymal stem cells (MSCs) in terms of magnetic resonance imaging (MRI), qualitative histologic findings, and Lysholm score. However, the effectiveness was limited by the number of cells obtained, so large-sized defects (>500 mm) were not investigated. The use of MSC aggregates may enable treatment of larger defects by increasing the number of MSCs adhering to t...
Purpose This investigation was designed to provide interrater reliability data for the Apraxia of Speech Rating Scale 3.0 (ASRS 3.0; Strand, Duffy, Clark, & Josephs, 2014 ). Importantly, ratings were completed by investigators who were not involved with the ASRS development. Another aim was to evaluate the relationship of the ASRS 3.0 total score to word intelligibility. Method Two investigators independently completed ASRS 3.0 ratings for 28 participants with chronic apraxia of speech and aphasia. Intellig...
Allogeneic Hematopoietic Cell Transplantation (HCT) has been shown to restore normal hematopoiesis in Fanconi anemia (FA) patients with excellent results in matched related donor HCT; outcomes of alternative donor HCT are less favorable. In non-FA patients, several reports documented stable engraftment/low risk of graft-versus-host disease (GVHD) using unmanipulated HLA-mismatched related donors and post HCT cyclophosphamide (PT-CY) for GVHD prophylaxis. In FA patients, data on using this approach are scarc...
Most of the meningiomas are classified as WHO grade I and adjuvant radiation therapy (RT) is commonly recommended for subtotal resections with documented progressive regrowth of lesions with venous sinus involvement. We investigated if recurrence of grade I meningiomas was influenced by adjuvant RT.
Visual pollution is a relatively new concern amidst the existing plethora of mainstream environmental pollution, recommending the necessity for research to conceptualize, formalize, quantify and assess it from different dimensions. The purpose of this study is to create a new field of automated visual pollutant classification, harnessing the technological prowess of the 21 century for applications in environmental management. From the wide range of visual pollutants, four categories have been considered viz...
Polygenic risk score (PRS) analyses have become an integral part of biomedical research, exploited to gain insights into shared aetiology among traits, to control for genomic profile in experimental studies, and to strengthen causal inference, among a range of applications. Substantial efforts are now devoted to biobank projects to collect large genetic and phenotypic data, providing unprecedented opportunity for genetic discovery and applications. To process the large-scale data provided by such biobank re...
As indicated by Groose et al article1, patients with advanced ESLD and high MELD score appear to be at risk of developing ICT. Higher MELD indicates a coagulation imbalance which can trigger unpredictably ICT. Under those circumstances, a prophylactic dose of heparin appears protective against ICT. This article is protected by copyright. All rights reserved.
Sex hormones influence the prevalence and the outcome of heart diseases. The conversion of testosterone to its more active metabolite dihydrotestosterone drives cardiac growth and dysfunction, while inhibition of this step by the anti-androgenic drug finasteride counteracts these pathological processes in preclinical models. In this retrospective, observational study, we aim to investigate whether finasteride, which is in clinical use mainly for prostate disease, might ameliorate cardiac hypertrophy and hea...
In Germany people over 65 years old are treated in hospital almost twice as often as younger people. Special attention needs to be paid to the transition from inpatient to outpatient care. In recent years, volunteers have been increasingly involved in the care of older patients during and after the hospitalization phase.
The working and continued training conditions of assistant physicians in urology in Germany have already been analyzed. But what about senior urologists in Germany? Under which conditions do they have to work? As far as we know no published data currently exist which illuminate the conditions of this special urological professional group, therefore, the results of this survey are presented.
Although gambling disorder (GD) criteria do not explicitly address craving, it has received increased attention because it has been found to be a significant predictor of gambling severity. Furthermore, recent findings have suggested that both alcohol consumption and maladaptive personality traits may be risk factors among adult GD. To date, no study has evaluated the relative contribution of these factors in adolescent gambling behavior. Consequently, the present study investigated the relationship between...
To assess the utility of continuous metabolic syndrome score (cMetS) for predicting metabolic syndrome (MS) and determine the cut-off values in overweight and obese children.
Ventilator-associated pneumonia (VAP) is one of the most severe complications in patients with traumatic brain injury (TBI) and is considered a risk factor for poor outcomes. However, the incidence of VAP among patients with TBI reported in studies varies widely. What is more, the risk factors and outcomes of VAP are controversial. This study estimates the incidence, risk factors, and outcomes of VAP in patients with TBI and provides evidence for prevention and treatment. PubMed, EMBASE, Cochrane Library, a...
AbataCepT In rOutiNe clinical practice (ACTION; NCT02109666) was an observational study of patients with rheumatoid arthritis who initiated intravenous abatacept in clinical practice. We aimed to compare abatacept retention rates and clinical outcomes in patients from Germany versus other countries.
Attitudes of the general public may be an influencing factor for low surgery rates: When skepticism is high, support for individuals wanting or needing to undergo surgery may diminish. This study assesses the relevance of barriers to metabolic surgery.
This study aims to explore the safety and efficacy of growth hormone (GH) therapy by retrospectively analyzing the changes of insulin-like growth factor-1 (IGF-1) Z-scores in children with short stature after treatment with GH.
There are no evidence-based data how to predict response to therapy in patients with alopecia areata.
Despite high hepatitis C virus (HCV) treatment rates, HCV incidence among HIV-positive men who have sex with men (HIV+ MSM) in Germany rose prior to HCV direct-acting antivirals (DAAs). We model what intervention can achieve the World Health Organization (WHO) elimination target of 80% incidence reduction by 2030 among HIV+ MSM in Berlin.
The aim of the study was to confirm the value of the VALID-cardiac resynchronization therapy (CRT) risk score in predicting outcome and to assess its association with clinical response (CR) in an unselected real-world CRT population.