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PubMed Journals Articles About "Effect Of Probiotics On Lipid Management∨derfield=score∨derval=desc" - Page: 4 RSS

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Showing "Effect Probiotics Lipid Management derfield score derval desc" PubMed Articles 76–100 of 35,000+

Novel enzymatic single-nucleotide modification of DNA oligomer: prevention of incessant incorporation of nucleotidyl transferase by ribonucleotide-borate complex.

Terminal deoxynucleotidyl transferase (TdT), which mediates template-independent polymerization with low specificity for nucleotides, has been used for nucleotide extension of DNA oligomers. One concern is that it is difficult to control the number of incorporated nucleotides, which is a limitation on the use of TdT for single-nucleotide incorporation of DNA oligomers. Herein, we uncovered an interesting inhibitory effect on TdT when ribonucleotide substrates (rNTPs) were employed in a borate buffer. On the...


To the editor: In vitro and in vivo inhibitory effects of TLR4 agonist, glucopyranosyl lipid A (GLA), on allergic rhinitis caused by Japanese cedar pollen.

Long survival of patients with metastatic clear cell renal cell carcinoma. Results of real life study of 344 patients.

The treatment landscape in metastatic renal cell carcinoma has changed fundamentally over the last decade by the development of anti-angiogenic agents, mTOR inhibitors, and immunotherapy. Outside of the context of a clinical trial the treatments are used sequentially. We describe results under real life conditions of a sequential treatment strategy, before the era of immunotherapy. All patients were treated according to their prognostic score (either MSKCC or IMDC) for advanced renal cell carcinoma. A treat...


Temperature Control of Sequential Nucleation-Growth Mechanisms in Hierarchical Supramolecular Polymers.

Upon cooling in various solvents, chiral triarylamine tris-amide unimers produce organogels by stacking into helical supramolecular polymers which subsequently bundle into larger fibers. Interestingly, AFM imaging, circular dichroism, and vibrational circular dichroism of the chiral self-assemblies reveal that, while monocolumnar P-helical fibrils are formed upon fast cooling, bundled M-superhelical fibers are formed upon slow cooling. The mechanistic study of this structural bifurcation demonstrate the pre...

Ligand Effect in Alkali Metal-Catalyzed Transfer Hydrogenation of Ketones Iryna D. Alshakova, Hayden C. Foy, Travis Dudding, and Georgii I. Nikonov*a.

This paper unveils the reactivity patterns, as well as ligand and additive effect on alkali metal base catalyzed transfer hydrogenation of ketones. Crucially to this reactivity is the presence of a Lewis acid (alkali cation), as opposed to a simple base effect. With aryl ketones, the observed reactivity order is Na+ > Li+ > K+, whereas for aliphatic substrates it follows the expected Lewis acidity, Li+ > Na+ > K+. Importantly, the reactivity pattern can be drastically changed by adding ligands and additives...

A systematic review of non-invasive and invasive sialorrhoea management.

To review published literature pertaining to the management of sialorrhoea while also highlighting the significance of the multidisciplinary approach.

Changing incidence of obstetric anal sphincter injuries- what lesson can be learned?

There has been significant discussion in recent years about the conduct of delivery (especially operative vaginal delivery) and the recognition and management of obstetric anal sphincter injuries (OASIS). The true magnitude of OASIS is not clear, however the estimation of an incidence of 5% or higher in women who gave birth vaginally is probably more accurate than lower numbers that likely represent under-diagnosis by obstetrical staff. We read the study by Jangö et al. with great interest. This article is...

Angioedema Associated With Thrombolysis For Ischemic Stroke: Analysis Of A Case-Control Study.

Bradykinin-mediated angioedema is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknow and management is discussed.

Interest of plasma microvesicles to monitor pancreatic islet graft dysfunction: beta cell- and leukocyte-derived microvesicles as specific features in a pilot longitudinal study.

Markers of early pancreatic islet graft dysfunction and its causes are lacking. We monitored 19 T1D islet-transplanted patients for up to 36 months following last islet injection. Patients were categorized as Partial (PS) or complete (S) Success, or Graft Failure (F), using the β-score as an indicator of graft function. F was the subset reference of maximum worsened graft outcome. To identify the immune, pancreatic, and liver contribution to the graft dysfunction, the cell origin and concentration of circu...

Early ALT response to corticosteroid treatment distinguishes idiosyncratic Drug-induced Liver Injury from Autoimmune Hepatitis.

Drug-induced liver injury (DILI) and idiopathic autoimmune hepatitis (AIH) are competing diagnoses in patients with acute liver injury and drug intake. In absence of unequivocal markers, scores like RUCAM and the AIH score are used to distinguish both entities. However, in some cases the diagnosis remains ambiguous. Our aim was to identify a simple parameter to discriminate DILI and AIH shortly after starting corticosteroid treatment.

Trapping and Characterization of Non-Toxic Aβ42 Aggregation Intermediates.

Amyloid β (Aβ) 42 is an aggregation-prone peptide and the believed seminal etiological agent of Alzheimer's Disease (AD). Intermediates of Aβ42 aggregation, commonly referred to as diffusible oligomers, are considered to be among the most toxic forms of the peptide. Here we studied the effect of the age-related epimerization of Ser26 (i.e. S26s chiral edit) in Aβ42, and discovered that this subtle molecular change led to reduced fibril formation propensity. Surprisingly, the resultant soluble aggregates...

Hydroxamate titanium-organic frameworks and the effect of siderophore-type linkers over their photocatalytic activity.

The chemistry of Metal-Organic Frameworks (MOFs) relies on the controlled linking of organic molecules and inorganic secondary building units to assemble an unlimited number of reticular frameworks. However, the design of porous solids with chemical stability remains still limited to carboxylate or azolate groups. There is a timely opportunity to develop new synthetic platforms that make use of unexplored metal binding groups to produce metal-linker joints with hydrolytical stability. Living organisms use s...

Chronic Cannabis Use and Circulating Biomarkers of Neural Health, Stress, and Inflammation in Physically Active Individuals.

Previous research has associated cannabis use with altered circulating neurotrophins and biomarkers of immune health, but these relationships have yet to be fully explored in physically active individuals. The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically act...

Effect of CCT137690 on long non-coding RNA expression profiles in MCF-7 and MDA-MB-231 cell lines.

Long non-coding RNAs (lncRNAs) are involved in a range of biological processes, such as cellular differentiation, migration, apoptosis, invasion, proliferation, and transcriptional regulation. The aberrant expression of lncRNAs plays a significant role in several cancer types. Aurora kinases are increasingly expressed in various malignancies; accordingly, the inhibition of these enzymes may represent a novel approach for the treatment of various cancers. CCT137690, an Aurora kinase inhibitor, displays an an...

A lipid-structured model for macrophage populations in atherosclerotic plaques.

Atherosclerosis is a chronic inflammatory disease driven by the accumulation of pro-inflammatory, lipid-loaded macrophages at sites inside artery walls. These accumulations lead to the development of atherosclerotic plaques. The rupture of plaques that contain lipid-rich necrotic cores can trigger heart attacks and strokes via occlusion of blood vessels. We construct and analyse a system of partial integro-differential equations that model lipid accumulation by macrophages, the generation of apoptotic cells...

Comparison of Three Anxiety Management Protocols for Extraction of Third Molars With the Use of Midazolam, Diazepam, and Nitrous Oxide: A Randomized Clinical Trial.

The objective of the present study was to compare 3 sedation protocols using diazepam, midazolam, and nitrous oxide.

Anesthetic Management of a Cardiac Transplant Patient After Extensive Facial Trauma Caused by a Pit Bull Attack.

A 72-year-old male cardiac transplant patient presented after sustaining facial and extremity trauma caused by a pit bull dog attack. The case was further complicated by the duration of the surgery, bleeding, infection risk, intraoperative hypothermia, immunosuppression, and the risk of sepsis. His anesthetic management required careful coordination with his transplant team. We also sought the expertise of the in-house pharmacist to obtain the appropriate administration strategies for the patient's immunosu...

Autophagy inhibition exerts neuroprotection on white matter ischemic damage after chronic cerebral hypoperfusion in mice.

Autophagy plays vital roles in the pathophysiology of many central nervous system diseases. Emerging evidence indicates that autophagy has both detrimental and protective effects in ischemic cerebral injury. This study aimed to investigate the temporal pattern of autophagy activation in the white matter of bilateral common carotid artery stenosis (BCAS) mouse model by immunofluorescence and western blotting. The effect of wortmannin, an autophagy inhibitor, against hypoperfusion induced white matter injury ...

Assessment of lipid peroxidation and artificial neural network models in early Alzheimer Disease diagnosis.

Lipid peroxidation constitutes a molecular mechanism involved in early Alzheimer Disease (AD) stages, and artificial neural network (ANN) analysis is a promising non-linear regression model, characterized by its high flexibility and utility in clinical diagnosis. ANN simulates neuron learning procedures and it could provide good diagnostic performances in this complex and heterogeneous disease compared with linear regression analysis.

Increased immunomodulatory capacity of human amniotic cells after activation by pro-inflammatory chemokines.

Human amniotic cells (hAC) possess multiple unique immunomodulatory properties. They are believed to be a very appealing and safe material for clinical applications. Primary hAC have been proposed as an efficient source of immunomodulatory factors that could be used as alternative or supporting to classical drug immunosuppression. The aim of this study was to evaluate hAC immunomodulatory properties post-activation by inflammatory cytokines as Interleukin 1β and Interferon γ. hAC were isolated and charact...

Ginsenoside Rb1 inhibits vascular calcification as a selective androgen receptor modulator.

Ginsenoside Rb1 (Rb1), a major component of ginseng, has a steroidal chemical structure, implying that it exerts sex hormone-like actions. Recent studies have been suggested cardioprotective actions of Rb1. However, the actions of Rb1 in vascular calcification, one of the significant pathological features associated with aging and atherosclerosis, have not been examined. In the present study, we examined the effects of Rb1 on vascular calcification, focusing on its androgen-like actions. Using inorganic pho...

Subcutaneous brompheniramine for cutaneous analgesia in rats.

Brompheniramine as an antihistamine blocked sodium channels, and local anesthetics by blocking sodium channels produced the local anesthetic effects. The authors aimed to assess local anesthetic quality and duration of brompheniramine when compared to the local anesthetic mepivacaine. After rats were shaved and injected subcutaneously on the dorsal skin, the panniculus reflex, induced via applying a noxious pinprick to the skin (injected area), was scored. The dose-response curve and nociceptive block durat...

Osteogenic stimulatory effect of heraclenin purified from bael in mouse mesenchymal stem cells in vitro.

Osteoporosis is a major health concern occurring to the aging adult population across the globe. Currently, there is an increasing demand for treatment of osteoporosis with plant-based medicines. In the present study, we report that heraclenin was extracted and purified from unripe fruit portion of Bael (Aegle marmelos Corr.) using silica gel column chromatography. The identification and characterization of heraclenin were carried out by UV-Vis, HPLC, LC-MS, NMR, FT-IR, and XRD analyses. The standardized pu...

6'-O-acetyl mangiferin from Iris rossii Baker inhibits lipid accumulation partly via AMPK activation in adipogenesis.

Effective control of white adipose tissue accumulation would provide a therapeutic strategy for obesity, which poses a growing global problem. The plant chemical mangiferin stimulates adenosine monophosphate-activated protein kinase (AMPK), which inhibits adipogenesis and has therefore been considered a therapeutic target for obesity and related diseases. We previously reported the anti-inflammatory properties of 6'-O-acetyl mangiferin (OAM). In this study, we evaluated the potential of OAM as an AMPK activ...

Kir7.1 inwardly rectifying K channel is expressed in ciliary body non pigment epithelial cells and might contribute to intraocular pressure regulation.

Inwardly rectifying K channel Kir7.1 is expressed in epithelia where it shares membrane localisation with the Na/K-pump. The ciliary body epithelium (CBE) of the eye is a determinant of intraocular pressure (IOP) through NaCl-driven fluid secretion of aqueous humour. In the present study we explored the presence Kir7.1 in this epithelium in the mouse and its possible functional role in the generation of IOP. Use heterozygous animals for total Kir7.1 knockout expressing β-galactosidase under the control of ...


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