PubMed Journals Articles About "GCS Ltd" - Page: 4 RSS

04:27 EST 12th December 2018 | BioPortfolio

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Showing PubMed Articles 76–100 of 1,000,000+

Somatic innervation contributes to the release of bulbourethral gland secretion in male rats.

In male rats, the bulbourethral glands (Bu-Gs) are the unique accessory sexual glands surrounded by striated musculature. However, until now the role of this musculature was unknown.

Relative and Absolute Bioavailability Study of Emicizumab to Bridge Drug Products and Subcutaneous Injection Sites in Healthy Volunteers.

Emicizumab (ACE910) is a bispecific antibody that is a novel, subcutaneously injectable treatment for patients with hemophilia A. This study assessed the relative bioavailability of emicizumab between old and new drug products (DPs) and among 3 commonly used subcutaneous injection sites (abdomen, upper arm, and thigh), together with its absolute bioavailability in healthy volunteers. Forty-eight healthy volunteers were randomized into 4 groups to receive a single subcutaneous injection of 1 mg/kg with the o...

Bleeding from Wharton's duct after fine-needle aspiration biopsy on submandibular gland.

The case of a fine-needle aspiration biopsy (FNAB) of the patient's salivary gland lesions is considered a rapid, simple, reliable, minimal invasive procedure with markedly rare complications. Herein, we report a case of bleeding from the region of the Wharton's duct after a procedure of a FNAB on the patient's submandibular gland. To our knowledge, this is the first case of bleeding from a salivary duct after a FNAB. For this reason, it is important to recognize that bleeding from the salivary duct after a...

Sequence-based searching of custom proteome and transcriptome databases.

A long-term goal in renal physiology is to understand the mechanisms involved in collecting duct function and regulation at a cellular and molecular level. The first step in modeling of these mechanisms, which can provide a guide to experimentation, is the generation of a list of model components. We have curated a list of proteins expressed in the rat renal inner medullary collecting duct (IMCD) from proteomic data from 18 different publications. The database has been posted as a public resource at https:/...

PKCα replaces AMPK to regulate mitophagy: Another PEDF role on ischaemic cardioprotection.

Both decreased autophagy positive regulator AMP activated protein kinase (AMPK) level and promoted mitophagy are observed in oxygen-glucose deprivation (OGD) cardiomyocytes treated with pigment epithelium-derived factor (PEDF). This contradictory phenomenon and its underlying mechanisms have not been thoroughly elucidated. Our previous study reveals that PEDF increases the protein kinase Cα (PKCα) and phospho-PKCα (p-PKCα) contents to promote mitophagy. Thus, we investigated the association between PKC...

Use of a Low-Cost Telecytopathology Method for Remote Assessment of Thyroid FNAs.

Rapid on-site evaluation is a great tool for optimizing the adequacy and quality of cytologic samples. The objective of the current study was to analyze a low-cost telecytopathology method for the remote assessment of thyroid fine-needle aspiration biopsies (FNABs), with comparison of the primarily rendered adequacy and diagnosis with the final conventional analysis.

Protease inhibitors: recent advancement in its usage as a potential bio-control agent for insect pest management.

Plant-derived protease inhibitors (PI) are a promising tool for crop improvement and insect pest management. Although agronomist made significant efforts in utilizing PIs for managing insect pests, the potentials of PIs are still obscured. Insect ability to compensate nutrient starvation induced by dietary PI feeding using different strategies, i.e., overexpression of PI-sensitive protease, expression of PI-insensitive proteases, degradation of PI, has made this innumerable collection of PIs worthless. A pr...

Pharmacokinetics, Excretion, and Mass Balance of C-Batefenterol Following a Single Microtracer Intravenous Dose (Concomitant to an Inhaled Dose) or Oral Dose of Batefenterol in Healthy Men.

Inhaled batefenterol is an investigational bifunctional molecule for the treatment of chronic obstructive pulmonary disease. The excretion balance and pharmacokinetics of batefenterol using [ C]-radiolabeled drug administered orally and as intravenous (IV) infusion were assessed. In this 2-period, open-label study, 6 healthy male subjects received a single IV microtracer 1-hour infusion of 4 μg [ C]-batefenterol concomitant with inhaled nonradiolabeled batefenterol (1200 μg) followed by oral [ C]-batefent...

Immunomodulatory placental-expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty.

No regenerative approach has thus far been shown to be effective in skeletal muscle injuries, despite their high frequency and associated functional deficits. We sought to address surgical trauma-related muscle injuries using local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent cells (PLX-PAD), using hip arthroplasty as a standardized injury model, because of the high regenerative and immunomodulatory potency of this cell type.

Carbon dioxide CT angiography during endovascular treatment of bilateral common iliac disease with angio-CT utilisation.

This paper presents the application of carbon dioxide for CT imaging during an endovascular procedure to help characterise unexpected bilateral common iliac artery stenosis utilising an angio-CT system, confirming its application in interventional radiology while maintaining sterility. A 78 year old male was referred to the Radiology Interventional Suite with left lower limb rest pain. On imaging via digital subtraction angiography and CT utilising both iodinated contrast and carbon-dioxide (CO ), endovasc...

Status of population-based birth defects surveillance programs before and after the Zika public health response in the United States.

The 2016 Zika public health response in the United States highlighted the need for birth defect surveillance (BDS) programs to collect population-based data on birth defects potentially related to Zika as rapidly as possible through enhanced case ascertainment and reporting. The National Birth Defects Prevention Network (NBDPN) assessed BDS program activities in the United States before and after the Zika response.

Presence of chromosomal abnormalities in fetuses with isolated ventriculomegaly on prenatal ultrasound in China.

The purpose of our study was to compare the incidence of chromosomal abnormalities of fetuses with isolated fetal ventriculomegaly (VM) to that of fetuses with the sole risk factor of being born to mothers of advanced age.

Susceptibility of placental mitochondria to oxidative stress.

Two different mitochondrial fractions (MFs) have been characterized in the human placenta: the "light" and "heavy" fractions (LMF and HMF). Although these organelles are the main source of reactive oxygen species, an imbalance between their production and the rate of detoxification represents a serious threat to mitochondrial homeostasis and, in the case of the placenta, also to the fetus. The aim of this study was to evaluate the antioxidant capacity and susceptibility to oxidative stress in both types of ...

Road-killed mammals provide insight into tick-borne bacterial pathogen communities within urban habitats.

Small and medium-sized mammals play an important role in the life cycle of tick-borne pathogens in urban habitats. Our aim was to apply the general protocol, DAMA (documentation-assessment-monitoring-action), which is an integrated proposal to build a proactive capacity to understand, anticipate, and respond to the outcomes of accelerating environmental change. Here we tested whether road killed carcasses in urban areas are useful sources of tissue and parasite samples to investigate these species' contribu...

Novel In Situ Gelling Hydrogels Loaded with Recombinant Collagen Peptide Microspheres as a Slow-Release System Induce Ectopic Bone Formation.

New solutions for large bone defect repair are needed. Here, in situ gelling slow release systems for bone induction are assessed. Collagen-I based Recombinant Peptide (RCP) microspheres (MSs) are produced and used as a carrier for bone morphogenetic protein 2 (BMP-2). The RCP-MSs are dispersed in three hydrogels: high mannuronate (SLM) alginate, high guluronate (SLG) alginate, and thermoresponsive hyaluronan derivative (HApN). HApN+RCP-MS forms a gel structure at 32 ºC or above, while SLM+RCP-MS and SLG+R...

Practical impressions of interpretative phenomenological analysis from the novice's standpoint.

Interpretative phenomenological analysis (IPA) is an approach to qualitative analysis that has increasingly been used in health and psychology over the past 10-15 years.

Clinical epidemiology of congenital heart disease in Nigerian children, 2012-2017.

Congenital heart diseases (CHDs) affect ~1% of newborns and are a significant cause of morbidity and mortality in children. We present the clinical epidemiology of CHD as seen in a large university medical center in Nigeria.

Ambient particulate matter enhances the pulmonary allergic immune response to house dust mite in a BALB/c mouse model by augmenting Th2- and Th17-immune responses.

Ambient particulate matter (PM) exacerbates airway inflammation and hyper-reactivity in asthmatic patients. Studies show that PM has adjuvant-like properties that enhance the allergic inflammatory response; however, the mechanisms through which PM enhances these processes remain elusive. The objective of the study was to examine how ambient PM enhances the allergic immune response. Eight-week-old BALB/c mice were sensitized with house dust mite (HDM) or HDM and ambient particulate matter (PM, 2.5 μm; Sacr...

Long-term oncologic and functional outcomes after robot-assisted partial nephrectomy in elderly patients.

The aim of this study was to assess the long-term oncologic and functional outcomes in elderly patients having undergone robot-assisted partial nephrectomy (RAPN) for renal cancer (RC).

Assessment, prevention and treatment of faecal incontinence in older people.

Faecal incontinence is an impaired ability to control the passage of stool, often described as involuntary loss of solid or liquid stool, and the symptom of an underlying diagnosis. It is a common problem in older adults. Although not a life-threatening condition, it can have a significant negative effect on an individual's quality of life and adverse medical, social and economic consequences. Due to the taboo and stigmatising nature of the condition many individuals do not seek assistance. Healthcare profe...

Risk factors and prognostic implications for pathologic upstaging to T3a after partial nephrectomy.

Performing a partial nephrectomy (PN) on a cT1 tumor, which post- operatively is upgraded to pT3a can possibly lead to compromise of cancer specific mortality. We therefore aimed to identify risk factors for pathologic T3a upstaging of cT1 tumors and to analyze the association between upstaging, positive surgical margins (PSM) and overall survival (OS).

Cigarette smoking is not associated with prostate cancer diagnosis and agressiveness: a cross sectional italian study.

The aim of our study is to explore the association between cigarette smoking and the risk of prostate cancer (PCa) diagnosis as well as high grade disease in men undergoing prostate biopsies.

Adherence to hormonal deprivation therapy in prostate cancer in clinical practice: a retrospective, single-centre study.

Androgen-deprivation therapy is one of the options available for treating both advanced and metastatic prostate cancer (PCa). It is used as an adjuvant or neoadjuvant therapy, either alone or in combination with radiotherapy (RT) or surgery. The aim of this study is to appraise adherence to ADT.

Fluoroscopy-free technıque is relıable and safe in retrograde intrarenal surgery.

Traditional retrograde intrarenal surgery is performed under fluoroscopic guidance. In the present study, we assessed the efficacy and safety of retrograde intrarenal surgery without fluoroscopic guidance in selected patients with renal and proximal ureteral stone disease.

New insight in penile cancer.

Penile cancer is a rare disease. Most of penile cancer are squamous cell carcinoma. Diagnosis is based on self-examination, clinical examination and confirmatory biopsy. Several imaging technique could be used for staging purpose. However, the best modality for staging in intermediate and high risk patients is by surgical evaluation and the use of inguinal lymph node dissection, that has also a therapeutic effect. Unfortunately, inguinal lymph node dissection is underused. Penile cancer treatment may have a...

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