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PubMed Journals Articles About "M*Modal Inc." - Page: 4 RSS

13:19 EDT 15th August 2018 | BioPortfolio

M*Modal Inc. PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest M*Modal Inc. articles that have been published worldwide.

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Showing "Modal" PubMed Articles 76–100 of 211

Two-pore channels and disease.

Two-pore channels (TPCs) are Ca-permeable endo-lysosomal ion channels subject to multi-modal regulation. They mediate their physiological effects through releasing Ca from acidic organelles in response to cues such as the second messenger, NAADP. Here, we review emerging evidence linking TPCs to disease. We discuss how perturbing both local and global Ca changes mediated by TPCs through chemical and/or molecular manipulations can induce or reverse disease phenotypes. We cover evidence from models of Parkins...


Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome.

Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies. The discovery of ALK activating mutations opened the way to precision treatment in a subset of these patients. Previously, we investigated the transcriptional effects of pharmacological ALK inhibition on neuroblastoma cell lines, six hours after TAE684 administration, resulting in ...

Evaluation of a Multi-modal, Direct-to-Patient Educational Intervention Targeting Barriers to Osteoporosis: A Randomized Clinical Trial.

Osteoporosis treatment rates are declining, even among those with past fractures. Novel, low-cost approaches are needed to improve osteoporosis care. We conducted a parallel group, controlled, randomized clinical trial evaluating a behavioral intervention for improving osteoporosis medication use. A total of 2,684 women with self-reported fracture history after age 45 not using osteoporosis therapy from U.S. Global Longitudinal study of Osteoporosis in Women (GLOW) sites were randomized 1:1 to receive a mul...


Influence of Selected Factors on the Relationship between the Dynamic Elastic Modulus and Compressive Strength of Concrete.

In this paper, the relationship between the static and dynamic elastic modulus of concrete and the relationship between the static elastic modulus and compressive strength of concrete have been formulated. These relationships are based on investigations of different types of concrete and take into account the type and amount of aggregate and binder used. The dynamic elastic modulus of concrete was tested using impulse excitation of vibration and the modal analysis method. This method could be used as a non-...

Phase sensitive imaging of 10 GHz vibrations in an AlN microdisk resonator.

We demonstrate a high frequency phase-sensitive heterodyne vibrometer, operating up to 10 GHz. Using this heterodyne vibrometer, the amplitude and phase fields of the fundamental thickness mode, the radial fundamental, and the 2nd-order modes of an AlN optomechanical microdisk resonator are mapped with a displacement sensitivity of around 0.36pm/Hz. The simultaneous amplitude and phase measurement allow precise mode identification and characterization. The recorded modal frequencies and profiles are consist...

Dendritic Ca2+ dynamics and multi-modal processing in a cricket antennal interneuron.

The integration of stimuli of different modalities is fundamental to information processing within the nervous system. A descending interneuron in the cricket brain, with prominent dendrites in the deutocerebrum, receives input from three sensory modalities: touch of the antennal flagellum, strain of the antennal base, and visual stimulation. Using calcium imaging, we demonstrate that each modality drives a Ca2+ increase in a different dendritic region. Moreover, touch of the flagellum is represented in a t...

Interplay of Kerr and Raman beam cleaning with a multimode microstructure fiber.

We experimentally study the competition between Kerr beam self-cleaning and Raman beam cleanup in a multimode air-silica microstructure optical fiber. Kerr beam self-cleaning of the pump is observed for a certain range of input powers only. Stokes Raman beam generation and cleanup lead to both depletion and degradation of beam quality for the pump. The interplay of modal four-wave mixing and Raman scattering in the infrared domain leads to the generation of a multimode supercontinuum ranging from 500 nm up...

A multi-modal recruitment strategy using social media and internet-mediated methods to recruit a multidisciplinary, international sample of clinicians to an online research study.

Challenges exist in recruiting an international sample of clinicians and researchers to an online survey. Traditional recruitment methods remain relevant but issues such as narrow geographical reach, high cost and time intensity limit what can be achieved when aiming to recruit an international, multi-disciplinary sample. Internet-mediated and social media approaches to recruitment and engagement offer new, untested ways of capitalizing upon existing professional networks.

Broadband TE-pass slot waveguide polarizer using an asymmetrical directional coupler.

A compact TE-pass polarizer for silicon-based slot waveguides is numerically proposed based on a directional coupler where an asymmetrical slot waveguide (ASW) and hybrid plasmonic waveguide (HPW) are involved. The input section is linearly tapered to an ASW to markedly enlarge the modal birefringence. Beneficially, only the TM mode can be coupled into the adjacent HPW and attenuated while the injected TE mode just passes through the slot waveguide without coupling by properly choosing the dimensions. As a ...

Comprehensive, multi-modal characterization of an imiquimod-induced human skin inflammation model for drug development.

Imiquimod (IMQ) is often used as topical challenge agent to provoke local skin inflammation. The objective of this study was to develop and refine a rapid, temporary and reversible human skin inflammation model with IMQ for application in clinical drug development. A randomized, vehicle-controlled, open-label, dose-ranging study was conducted in 16 healthy male subjects. IMQ (5 mg) was applied once daily for 72h under occlusion to intact skin (n = 8) or tape stripped (TS) skin (n = 8). Although IMQ alone in...

Optimal model-based sensorless adaptive optics for epifluorescence microscopy.

We report on a universal sample-independent sensorless adaptive optics method, based on modal optimization of the second moment of the fluorescence emission from a point-like excitation. Our method employs a sample-independent precalibration, performed only once for the particular system, to establish the direct relation between the image quality and the aberration. The method is potentially applicable to any form of microscopy with epifluorescence detection, including the practically important case of inco...

Broadband and low-loss mode scramblers using CO-laser inscribed long-period gratings.

We demonstrate broadband and low-loss three-mode and six-mode scramblers employing CO-laser inscribed long-period gratings (LPGs) for space-division multiplexing. Step-index (SI) few-mode fibers are used to avoid mode coupling to the cladding modes. We characterize the mode scramblers using a swept-wavelength interferometer. Mode-dependent loss (MDL) and modal transfer matrices over the C+L band are presented. Demonstrated LPGs with negligible MDL and low insertion loss contributed to high-performance CO-la...

Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model.

Targeting of vascular endothelial growth factor receptors (VEGFRs) has potential anti-angiogenic effects because VEGFR-2 is the major signaling regulator of VEGF/VEGFR pathways. We aimed to elucidate the drug mechanism and anti-tumor efficacy of TTAC-0001, a novel, fully human anti-VEGFR-2/KDR monoclonal antibody, in mouse orthotopic breast cancer model using multi-modal bioimaging.

Multi-wavelength add-drop filter with phase-modulated shifted Bragg grating.

We present, for the first time to the best of our knowledge, a multichannel add-drop operation with a phase-modulated shifted Bragg grating based filter. The device is realized in a silicon-on-insulator waveguide platform with TiO as a coating material to reduce the refractive index contrast. The operation is shown for three and five wavelength channels within the telecom C-band. A line width of 0.6 nm with an extinction ratio of 20 dB is achieved. The shifted Bragg grating is modulated maintaining a moda...

Audiovisual perception in amblyopia: A review and synthesis.

Amblyopia is a common developmental sensory disorder that has been extensively and systematically investigated as a unisensory visual impairment. However, its effects are increasingly recognized to extend beyond vision to the multisensory domain. Indeed, amblyopia is associated with altered cross-modal interactions in audiovisual temporal perception, audiovisual spatial and motion perception, and audiovisual speech perception. Furthermore, although the visual impairment in amblyopia is typically unilateral,...

Ultra-broadband tunable single- and double-mode InAs/InP quantum dot external-cavity laser emitting around 1.65  μm.

We report an ultra-wide tunable single- and double-mode InAs/InP quantum dot (QD) external-cavity (EC) laser in a Littrow configuration. By combining the high modal gain of the QD material in the long wavelength range and an anti-reflection/high-reflection facet coating, the entire single-mode tuning range was increased up to 190 nm under a relatively low constant pulsed injection current. Furthermore, the tunable range was further increased to 230 nm at different bias currents. In addition, a mode spacin...

Goos-Hänchen and Imbert-Fedorov shifts: relation with the irradiance moments of a beam.

We present closed and simple expressions of the spatial and angular Goos-Hänchen and Imbert-Fedorov shifts in terms of the second-order irradiance moments of a beam. Our results are applicable to a general totally polarized partially coherent beam. One of the main advantages of this formalism is that it can be applied directly from the knowledge of the cross-spectral density function and the polarization state without using any modal beam expansion. The obtained expressions allow understanding of the relat...

Tackling delirium: a crucial target for improving clinical outcomes.

Delirium is a common and debilitating syndrome in hospitalized patients, and its impact on mortality, morbidity and duration of hospital admission is increasingly apparent. Delirium is a complex phenomenon, for which there is no specific treatment, but research over the last decade has revealed contributing factors, many of which are modifiable, and preventative strategies have demonstrated benefit. This review highlights the importance of reducing the impact of delirium on hospitalized patients, and summar...

Energy exchanges at contact events guide sensorimotor integration across intermodal delays.

The brain must consider the arm's inertia to predict the arm's movements elicited by commands impressed upon the muscles. Here, we present evidence suggesting that the integration of sensory information leading to the representation of the arm's inertia does not take place continuously in time but only at discrete transient events, in which kinetic energy is exchanged between the arm and the environment. We used a visuomotor delay to induce cross-modal variations in state feedback and uncovered that the dif...

Ultra-broadband and compact graphene-on-silicon integrated waveguide mode filters.

Increasing bandwidth demands in optical communications necessitates the introduction of mode-division multiplexing (MDM) on top of the existing wavelength-division multiplexing (WDM) systems. Simultaneous management of both multiplexing systems will be a complex task, and there is the possibility of signal degradation through modal crosstalk. Here, we propose graphene-on-silicon (GOS) integrated waveguide mode filters to suppress the propagation of spurious waveguide modes at the telecommunications waveleng...

Mechanisms of active control of sound radiation from an opening with boundary installed secondary sources.

Previous work has demonstrated that installing secondary sources at the edge of a cavity opening can reduce sound radiation through it, but the mechanisms are not clear, which is investigated in this paper by using the modal decomposition method. It is found that a double layer edge system achieves better performance than a single layer system because secondary sources at the edge of the same layer cannot excite some modes effectively and those at different heights compensate this. There exists an upper lim...

A General Analytical Formulation for the Motional Parameters of Piezoelectric MEMS Resonators.

This paper reports on a general analytical expression for the motional resistance ( ) of an arbitrary mode in a piezoelectric microelectromechanical system resonator with parallel plate electrode geometry. After applying simplifying assumptions and using analytical modes shapes, expressions for the of modes with out-of-plane flexure as the primary displacement are presented. These modes include free-free transverse beam flexure (TBF), unclamped disk flexure resonators (DFRs), and antisymmetric Lamb modes. F...

Dancing with Gravity-Why the Sense of Balance Is (the) Fundamental.

The sense of balance, which is usually barely noticeable in the background of each of our movements, only becomes manifest in its function during intense stimulation or in the event of illness, which may quite literally turn your world upside down. While it is true that balance is becoming a bigger issue, that is mainly because people are losing it more frequently. So why is balance not as commonly talked about in psychology, medicine or the arts as the other five traditional senses? This is partly due to i...

Surgical management of female stress urinary incontinence.

Stress urinary incontinence in women is a common problem in Germany, with approx. 5 million women suffering from incontinence symptoms. These numbers are increasing, due to demographic changes; the suspected numbers are even higher. Prior to treatment, an extended diagnostic approach - including urodynamics and cystoscopy when necessary - is essential for optimal treatment selection.Primary treatment should be conservative, with pelvic floor training as an essential part of a multi-modal treatment concept. ...

Design and Realization of 3D Printed AFM Probes.

Atomic force microscope (AFM) probes and AFM imaging by extension are the product of exceptionally refined silicon micromachining, but are also restricted by the limitations of these fabrication techniques. Here, the nanoscale additive manufacturing technique direct laser writing is explored as a method to print monolithic cantilevered probes for AFM. Not only are 3D printed probes found to function effectively for AFM, but they also confer several advantages, most notably the ability to image in intermitte...


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