Topics

PubMed Journals Articles About "PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc" - Page: 4 RSS

00:12 EDT 19th July 2019 | BioPortfolio

PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc articles that have been published worldwide.

More Information about "PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc" on BioPortfolio

We have published hundreds of PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc news stories on BioPortfolio along with dozens of PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc Clinical Trials and PubMed Articles about PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc Companies in our database. You can also find out about relevant PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=desc Drugs and Medications on this site too.

Showing "PARP Inhibition Appears Promising CRPC Questions Remain derfield" PubMed Articles 76–100 of 18,000+

Analysis of genetic recombination and the pan-genome of a highly recombinogenic bacteriophage species.

Bacteriophages are the most prevalent biological entities impacting on the ecosystem and are characterized by their extensive diversity. However, there are two aspects of phages that have remained largely unexplored: genetic flux by recombination between phage populations and characterization of specific phages in terms of the pan-genome. Here, we examined the recombination and pan-genome in Helicobacter pylori prophages at both the genome and gene level. In the genome-level analysis, we applied, for the fi...


Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology.

Delivery of native or chemically modified recombinant proteins into mammalian cells shows promise for functional investigations and various technological applications, but concerns that sub-cellular localization and functional integrity of delivered proteins may be affected remain high. Here, we surveyed batch electroporation as a delivery tool for single polypeptides and multi-subunit protein assemblies of the kinetochore, a spatially confined and well-studied subcellular structure. After electroporation i...

First-in-man randomized comparison of the Angiolite® durable fluoro-acrylate polymer-based sirolimus-eluting stent versus durable fluoropolymer-based everolimus eluting stent in patients with coronary artery disease: The ANGIOLITE trial.

The durable fluoro-acrylate polymer-based sirolimus-eluting stent (Angiolite®SES) has shown promising preclinical and clinical results regarding inflammatory vascular reaction and neointimal healing. We aimed to compare performance between SES and everolimus-eluting (EES) stents in patients with coronary artery disease.


Cr(pincer) as an electron shuttle for reductively promoted hydrazine disproportionation.

We describe here delivery of hydrazine to a reducing, low oxidation state chromium bound to a proton responsive ligand which has already been deprotonated. Reaction of PhHNNH2 at a 4 : 1 mole ratio with the bis-(pyrazolate)pyridyl pincer ligated reducing agent [CrIIL]2 gives prompt conversion to [CrIII2L2(PhNH2)2(μ-PhHNN)], with release of NH3 and C6H6, a new disproportionation of the hydrazine, with trapping of PhHNN as its dianion, bridging the two chromium centers. The redox balance of the reaction ...

Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial.

The effects of intensive care unit (ICU) visiting hours remain uncertain.

A perspective on risk factors for esophageal adenocarcinoma: emphasis on Helicobacter pylori infection.

Gastroesophageal reflux disease (GERD) and the increasing rate of its associated complications, including esophageal adenocarcinoma (EAC), has stimulated a plethora of studies attempting to evaluate provocative and protective factors. Helicobacter pylori (Hp) infection (Hp-I) was initially considered as a beneficial condition in GERD management based on rather limited data. Large-scale regional studies revealed an alternative approach, by suggesting a positive relationship between Hp-I and EAC development. ...

Things not to ask an editor.

We are both editors and we are both involved in providing training in writing for publication in academic journals. We work in different countries, different cultures and even in different languages. However, we find a range of common and frequent questions from our audiences and, among these-many of which are excellent and which we are only too pleased to answer-we find questions which are increasingly unacceptable, unnecessary and which, we consider, are incompatible with good scholarly and publishing pra...

Association between abdominal aortic calcification, bone mineral density and fracture in older women.

Although a relationship between vascular disease and osteoporosis has been recognized, its clinical importance for fracture risk evaluation remains uncertain. Abdominal aortic calcification (AAC), a recognized measure of vascular disease detected on single-energy images performed for vertebral fracture assessment, may also identify increased osteoporosis risk. In a prospective 10-year study of 1,024 older predominantly Caucasian women (mean age 75.0±2.6 years) from the Perth Longitudinal Study of Aging coh...

Impact of length of replication competent genome of hepatitis B virus over the differential antigenic secretion.

Hepatitis B virus (HBV) genome consists of circular partially double stranded DNA of 3.2 kb size which gets converted into covalently closed circular DNA (cccDNA) during its life cycle. It then acts as a template for formation of pregenomicRNA (pgRNA) of 3.5 kb. Absence of appropriate animal models prompted a need to establish a better in vitro culture system to uncover the propagation and survival mechanisms of the virus. There is scarcity of data to represent the significance of varying length of repl...

Evaluation of neuroprotective activity of digoxin and semisynthetic derivatives against partial chemical ischemia.

Recently, cardiotonic steroids (CTS) have been shown to lead to the activation of Na,K-ATPase at low concentrations in brain, promoting neuroprotection against ischemia. We report here the results of the use of digoxin and its semisynthetic derivatives BD-14, BD-15, and BD-16 against partial chemical ischemic induction followed by reperfusion in murine neuroblastoma cells neuro-2a (N2a). For chemical ischemic induction, sodium azide (5 mM) was used for 5 hours, and then reperfusion was induced for 24 ...

ZnO Quantum Dots Coupled with Graphene toward Electrocatalytic N2 Reduction: Experimental and DFT Investigations.

Electrochemical reduction of N2 to NH3 offers a promising way for artificial N2 production, but requires the efficient and robust electrocatalysts to boost the N2 reduction reaction (NRR). Herein, a combination of experimental measurements and theoretical calculations revealed that the ZnO quantum dots (QDs) supported on reduced graphene oxide (ZnO/RGO) hybrid could be a highly active and stable catalyst for NRR at ambient conditions. Experimentally, the ZnO/RGO was confirmed to favor the N2 adsorption due ...

Gold-catalyzed Regiospecific Annulation of Asymmetric 1,5-Diyne for Precise Synthesis of Bispentalenes.

Precise control of the selectivity in organic synthesis is important to access desired molecule. We demonstrated a regiospecific annulation of asymmetric 1,2-di(arylethynyl)benzene derivatives for a geometry controlled synthesis of a linear bispentalene which is one of the promising structures for material science. Gold-catalyzed annulation of asymmetric 1,2-di(arylethynyl)benzene possibly produces two isomers of pentalenes, but both electronic and steric effects on the aromatics at a terminal position of a...

19F-NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition.

Bacterial production of β-lactamases with carbapenemase activity is a global health threat. The active sites of class D carbapenemases such as OXA-48, which is of major clinical importance, uniquely contain a carbamylated lysine residue which is essential for catalysis. Although there is significant interest in characterizing this post-translational modification, and it is a promising inhibition target, protein carbamylation is challenging to monitor in solution. We report the use of 19F-NMR spectroscopy t...

Goosebumps-Inspired Microgel Patterns with Switchable Adhesion and Friction.

A substrate mimicking the surface topography and temperature sensitivity of skin goosebumps is fabricated. Close-packed arrays of thermoresponsive microgel particles undergo topographical changes in response to temperature changes between 25 and 37 °C, resembling the goosebump structure that human skin develops in response to temperature changes or other circumstances. Specifically, positively charged poly[2-(methacryloyloxy)ethyltrimethylammonium chloride] (PMETAC) brushes serve as an anchoring substrate ...

Extracellular acidosis triggers a senescence-like phenotype in human melanoma cells.

Acidosis of the tumor microenvironment is a characteristic of solid tumors such as malignant melanoma. Main causes of the extracellular acidification are metabolic alterations in cancer cells. While numerous studies showed that acidosis promotes tumor invasiveness, metastasis and neoangiogenesis resulting in malignant progression, contrary data reported that acidosis induces cell apoptosis, inhibits cell proliferation and mediates cell autophagy. Here, we show that low pH (pH 6.7) induces senescent/quiescen...

Acute Kidney Injury after Cardiac Surgery: Risk Factors and Novel Biomarkers.

Acute kidney injury (AKI) is a common and severe complication after cardiac surgery. Currently, a series of novel biomarkers have favored the assessment of AKI after cardiac surgery in addition to the conventional indicators. The biomartkers, such as urinary liver fatty acid binding protein (L-FABP), urinary neutrophil gelatinase-associated lipocalin (NGAL), serum L-FABP, heart-type FABP, kidney injury molecule 1 (KIM-1), and interleukin-18 were found to be significantly higher in patients who developed AKI...

Thermoelectric Property in Orthorhombic-Domained SnSe Film.

Single-crystal SnSe exhibits extremely high thermoelectric properties, and fabrication of SnSe films is promising for practical application and basic research on properties. However, the high thermoelectric properties have not yet been reported in SnSe films and their thermoelectric properties and nanostructure have not yet been analyzed in detail. In the present study, -axis-oriented epitaxial SnSe films were prepared to discuss the thermoelectric properties of the SnSe films. While the electrical conducti...

Energy Dependent Z-Scheme via Metal Interfacing Two-Dimensional p-type and n-type Semiconductor Layers for Efficient Opto-Electronic Conversion.

Hybrid heterostructures are a promising type of materials framework for opto-electronic conversion. Herein, we designed ternary energy dependent thin layer of CuS-Pt-WO (p-type-metal-n-type) heterojunction to explore an alternative way of realizing efficient charge separation. First principle calculations showed that Fermi level of the whole system is lined up via the mediation of Pt metal, which fosters the combination of holes in CuS and electrons in WO, and keeps electrons in CuS and holes in WO well sep...

Functionalization of Sulfonamide-Containing Peptides through Late-Stage Palladium-Catalyzed C(sp)-H Arylation.

Bioactive peptides are emerging as promising candidates of clinic therapeutics. Here, we report a method for late-stage functionalization of sulfonamide-containing peptides through Pd-catalyzed C(sp)-H arylation. In this protocol, the backbones of -sulfonated peptides act as directing groups, which allows site-specific arylation of benzylsulfonamide moiety. This chemistry exhibits broad substrate scope and can be utilized to synthesize peptide-peptide and peptide-amino acid conjugates. Our results highlight...

Non-Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Cancer and Atrial Fibrillation: A Systematic Review and Meta-Analysis.

Background Several studies have investigated the effect of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with cancer, but the results remain controversial. Therefore, we conducted a meta-analysis to compare the efficacy and safety of NOACs versus warfarin in this population. Methods and Results We systematically searched the PubMed and Embase databases until February 16, 2019 for studies comparing the effect of NOACs with warfarin in AF patients with cancer. Risk ...

Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage.

Prostate cancer (PC) is initially dependent on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leading to PC growth inhibition. We sought to discern the mechanisms by which SPA inhibits PC and to determine if molecular context associates with anti-tumor activity. SPA produced an AR-mediated, dose-dependent ...

Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential.

The dynamics of tumor progression is driven by multiple factors, which can be exogenous to the tumor (microenvironment) or intrinsic (genetic, epigenetic or due to intercellular interactions). While tumor heterogeneity has been extensively studied on the level of cell genetic profiles or cellular composition, tumor morphological diversity has not been given as much attention. The limited analysis of tumor morphophenotypes may be attributed to the lack of accurate models, both experimental and computational,...

Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks.

Once biological systems are modeled by regulatory networks, the next step is to include external stimuli, which model the experimental possibilities to affect the activity level of certain network's nodes, in a mathematical framework. Then, this framework can be interpreted as a mathematical optimal control framework such that optimization algorithms can be used to determine external stimuli which cause a desired switch from an initial state of the network to another final state. These external stimuli are ...

Osteoporosis prevention: Where are the barriers to improvement in French general practitioners? A qualitative study.

Osteoporosis prevention, diagnosis and treatment remain suboptimal.

Resveratrol induced premature senescence and inhibited epithelial-mesenchymal transition of cancer cells via induction of tumor suppressor Rad9.

Resveratrol (RSV) has been reported to influence many biological processes, including the stimulation of cellular senescence and inhibition of epithelial-mesenchymal transition (EMT). In this research, we explored the mechanisms of RSV on EMT and cellular senescence through the expression of a DNA damage response (DDR) protein, Rad9, in breast and lung cancer cell lines. Upon treating breast and lung cancer cell lines with RSV at the concentrations of 10-50 μM, Rad9 expression was increased at both transcr...


Quick Search