PubMed Journals Articles About "Regenxbio Inks Viral Vector Rights Deal With Pfizer" - Page: 4 RSS

07:03 EST 22nd November 2019 | BioPortfolio

Regenxbio Inks Viral Vector Rights Deal With Pfizer PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Regenxbio Inks Viral Vector Rights Deal With Pfizer articles that have been published worldwide.

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Showing "Regenxbio inks viral vector rights deal with Pfizer" PubMed Articles 76–100 of 9,100+

Rhinovirus-16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms.

The temporal in vivo response of epithelial cells to a viral challenge and its association with viral clearance and clinical outcomes has been largely unexplored in asthma.

Viral fitness: history and relevance for viral pathogenesis and antiviral interventions.

The quasispecies dynamics of viral populations (continuous generation of variant genomes and competition among them) has as one of its frequent consequences variations in overall multiplication capacity, a major component of viral fitness. This parameter has multiple implications for viral pathogenesis and viral disease control, some of them unveiled thanks to deep sequencing of viral populations. Darwinian fitness is an old concept whose quantification dates back to the early developments of population gen...

Detection of influenza D virus in bovine respiratory disease samples, U.K.

Influenza D is a newly described virus of cattle, pigs and small ruminants first detected in North America during 2011. Cattle have been shown to be the main viral reservoir and mounting evidence indicates that infection with influenza D may contribute to the development of bovine respiratory disease. The virus has been detected across the USA, Europe and Asia. To date, influenza D has not been reported in the UK. During the winter and spring of 2017/2018, we performed molecular testing of cattle submitted ...

Attenuated MuV-S79 as vector stably expressing foreign gene.

To describe mumps virus (MuV) used as a vector to express enhanced green fluorescent protein (EGFP) or red fluorescent protein (RFP) genes.

Entomological assessment of dengue virus transmission risk in three urban areas of Kenya.

Urbanization is one of the major drivers of dengue epidemics globally. In Kenya, an intriguing pattern of urban dengue virus epidemics has been documented in which recurrent epidemics are reported from the coastal city of Mombasa, whereas no outbreaks occur in the two major inland cities of Kisumu and Nairobi. In an attempt to understand the entomological risk factors underlying the observed urban dengue epidemic pattern in Kenya, we evaluated vector density, human feeding patterns, vector genetics, and pre...

Plant Virus Vectors 3.0: Transitioning into Synthetic Genomics.

Plant viruses were first implemented as heterologous gene expression vectors more than three decades ago. Since then, the methodology for their use has varied, but we propose it was the merging of technologies with virology tools, which occurred in three defined steps discussed here, that has driven viral vector applications to date. The first being the advent of molecular biology and reverse genetics, which enabled the cloning and manipulation of viral genomes to express genes of interest (vectors 1.0). Th...

Dynamics of IFN-β Responses During Respiratory Viral Infection: Insights for Therapeutic Strategies.

Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and COPD. IFN-β is a key component of the innate immune response to viral infection. To date studies of inhaled IFN-β treatment have not demonstrated a significant effect on asthma exacerbations.

Next-generation AAV vectors - don't judge a virus (only) by its cover.

Recombinant Adeno-associated viruses (AAV) are under intensive investigation in numerous clinical trials after they have emerged as a highly promising vector for human gene therapy. Best exemplifying their power and potential is the authorization of three gene therapy products based on wild-type AAV serotypes, comprising Glybera (AAV1), Luxturna (AAV2) and, most recently, Zolgensma (AAV9). Nonetheless, it has also become evident that the current AAV vector generation will require improvements in transductio...

Viral Infection Increases the Risk of Idiopathic Pulmonary Fibrosis: A Meta-analysis.

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with a poor prognosis. Although many factors have been identified to possibly trigger or aggravate IPF, such as viral infection, the exact etiology of IPF remains unclear. Until now, there has been no systematic review to quantitatively assess the role of viral infection in IPF.

Point-of-care HIV Viral Load in Pregnant Women Without Prenatal Care: A Cost-Effectiveness Analysis.

Routine cesarean delivery has been shown to decrease mother-to-child-transmission of HIV in women with high viral load greater than 1,000 copies/mL; however, women presenting late in pregnancy may not have viral load results before delivery.

Flow Field Reduction Via Reconstructing Vector Data From 3-D Streamlines Using Deep Learning.

We present a new approach for streamline-based flow field representation and reduction. Our method can work in the in situ visualization setting by tracing streamlines from each time step of the simulation and storing compressed streamlines for post hoc analysis where users can afford longer reconstruction time for higher reconstruction quality using decompressed streamlines. At the heart of our approach is a deep learning method for vector field reconstruction that takes the streamlines traced from the ori...

Compact, robust, and high-efficiency generator of vector optical fields.

We design and realize a generator that can convert an orbital angular momentum (OAM) state into a vector polarization state. The generator is integrated by several commonly used optical elements and easy to make or glued. Compared with traditional interferometric ways for generating the vector optical fields, this integrated generator has compact and robust advantages and especially a high-efficiency of 87%.

A parallel method for accelerating visualization and interactivity for vector tiles.

Vector tile technology is developing rapidly and has received increasing attention in recent years. Compared to the raster tile, the vector tile has shown incomparable advantages, such as flexible map styles, suitability for high-resolution screens and ease of interaction. Recent studies on vector tiles have mostly focused on improving the efficiency on the server side and have overlooked the efficiency on the client side, which affects user experience. Parallel computing provides solutions to this issue. P...

Innovative approaches to exploit host plant metabolites in malaria control.

Malaria is the most important vector borne disease in sub-Saharan Africa (SSA). Recent reports indicate that the levels of malaria associated mortality and morbidity in SSA have remained the same. Malaria vectors have modified their feeding behavior in response to the selective pressure from indoor-based interventions, and there is emerging malaria parasite resistance to artemisinin-based combination therapies. These challenges have created an altered malaria landscape, especially within local scales in som...

Aedes albopictus is a competent vector of Zika virus: A meta-analysis.

Much work has been done in recent years to determine the vector competence of Aedes albopictus (Skuse) for Zika virus (ZIKV). If competent, Ae. albopictus could become an important vector in the spread of ZIKV to areas which until now have been considered safe from the virus. Despite much speculation about Ae. albopictus' competence for ZIKV, there have been, to date, no quantitative syntheses of Ae. albopictus' competence, nor have the potentially confounding differences between studies been addressed.

High mortality from viral pneumonia in patients with cancer.

With the advancement of diagnostic methods, a viral infection is increasingly recognized in adult patients with pneumonia and the outcomes can be fatal especially in high-risk patients. We aimed to examine the clinical characteristics of adults with viral pneumonia and also to determine the associated factors with short-term mortality in those patients.

Spatial Models of Vector-Host Epidemics with Directed Movement of Vectors Over Long Distances.

We investigate a time-dependent spatial vector-host epidemic model with non-coincident domains for the vector and host populations. The host population resides in small non-overlapping sub-regions, while the vector population resides throughout a much larger region. The dynamics of the populations are modeled by a reaction-diffusion-advection compartmental system of partial differential equations. The disease is transmitted through vector and host populations in criss-cross fashion. We establish global well...

Cation exchange chromatography performed in overloaded mode is effective in removing viruses during the manufacturing of monoclonal antibodies.

Viral safety is a critical concern with regard to monoclonal antibody (mAb) products produced in mammalian cells such as Chinese hamster ovary cells. Manufacturers are required to ensure the safety of such products by validating the clearance of viruses in downstream purification steps. Cation exchange (CEX) chromatography is widely used in bind/elute mode as a polishing step in mAb purification. However, bind/elute modes require a large volume of expensive resin. To reduce the production cost, the use of C...

Recombinant live attenuated influenza vaccine viruses carrying CD8 T-cell epitopes of respiratory syncytial virus protect mice against both pathogens without inflammatory disease.

Respiratory syncytial virus (RSV) is the most common cause of lower respiratory disease in young children, elderly and immunocompromised adults. There is no licensed vaccine against RSV although development of an effective and safe RSV vaccine has been a high priority for several decades. Among the various vaccine platforms, the viral-vectored RSV vaccines based on licensed cold-adapted live attenuated influenza vaccine (LAIV) might offer an advantage of inducing adequate mucosal CD8 T cell immunity at the ...

Host-feeding patterns of Aedes (Aedimorphus) vexans arabiensis, a Rift Valley Fever virus vector in the Ferlo pastoral ecosystem of Senegal.

Host-vector contact is a key factor in vectorial capacity assessment and thus the transmission of mosquito-borne viruses such as Rift Valley Fever (RVF), an emerging zoonotic disease of interest in West Africa. The knowledge of the host-feeding patterns of vector species constitutes a key element in the assessment of their epidemiological importance in a given environment. The aim of this work was to identify the blood meal origins of the mosquito Aedes vexans arabiensis, the main vector of RVF virus in the...

Comparing deep belief networks with support vector machines for classifying gene expression data from complex disorders.

Genomics data provide great opportunities for translational research and the clinical practice, e.g., for predicting disease stages. However, the classification of such data is a challenging task due to their high dimensionality, noise and heterogeneity. In recent years, deep learning classifiers generated much interest but due to their complexity, so far, little is known about the utility of this method for genomics. In this paper, we address this problem by studying a computational diagnostics task by cla...

Two mutations in viral protein enhance the adaptation of waterfowl-origin H3N2 virus in murine model.

After serial passage of a waterfowl-origin H3N2 subtype avian influenza virus in BALB/c mice, we obtained H3N2 mouse-adapted variants and identified eight amino acid substitutions in five viral proteins in our previous study. Here, we analyze the key mutations determining viral pathogenicity in mammals. We found that both PB2-D701 N mutation and M1-M192 V mutation were implicated in the viral pathogenic phenotypic variation of H3N2 avian influenza virus in mice. Furthermore, we found that PB2-D701 N c...

Environmental methods for dengue vector control - A systematic review and meta-analysis.

Vector control remains the primary method to prevent dengue infections. Environmental interventions represent sustainable and safe methods as there are limited risks of environmental contamination and toxicity. The objective of this study is to perform a systematic review and meta-analysis of the effectiveness of the following environmental methods for dengue vector control.

Elective egg freezing - better younger but effective enough?

We read with interest the correspondence commenting on our review on fertility preservation without medical indications by Levin and Rottenstreich. The purpose of our manuscript was to summarise the highlights of social freezing regarding chances of success, safety, costs and socio/ethical issues. The authors claimed limits of studies that deal with the issue on optimal timing of oocyte cryopreservation, concluding that eggs freezing should be performed as early as possible. This article is protected by cop...

Cytomegalovirus reactivation: another reason to minimize graft ischemia/reperfusion.

Despite advances in viral monitoring, pharmacologic antiviral agents and strategies that include prophylaxis and preemptive therapy, cytomegalovirus (CMV) reactivation remains a significant problem in solid organ transplantation. It has been recently suggested that CMV latency is influenced by three main forces; inflammation, CMV specific immunity, and epigenetic regulation of the viral promoter. If true, then allogeneic transplantation may contribute to reactivation in multiple ways, including inflammation...

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