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PubMed Journals Articles About "Time Limited Eating In Adolescents With Diabetes (Time LEAD): A Pilot Study∨derfield=score∨derval=desc" - Page: 4 RSS

14:15 EDT 18th July 2019 | BioPortfolio

Time Limited Eating In Adolescents With Diabetes (Time LEAD): A Pilot Study∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Time Limited Eating In Adolescents With Diabetes (Time LEAD): A Pilot Study∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "Time Limited Eating Adolescents With Diabetes Time LEAD" PubMed Articles 76–100 of 30,000+

Productivity of Neoseiulus bicaudus (Acari: Phytoseiidae) Reared on Natural Prey, Alternative Prey, and Artificial Diet.

The predatory mite, Neoseiulus bicaudus (Wainstein), is a potential biological control agent against spider mites and thrips. The objective of this experiment was to compare the effects of three diets on the life table of N. bicaudus. The three diets were 1) Tetranychus turkestani (Ugarov & Nikolskii) (Acari: Tetranychidae), the natural prey of N. bicaudus; 2) Tyrophagus putrescentiae (Schrank) (Acari: Acaridae), an alternative prey; and 3) artificial diet primarily consisting of decapsulated shrimp cysts, ...


There is value in treating elevated levels of diabetes distress: the clinical impact of targeted interventions in adults with Type 1 diabetes.

To compare the effect of targeted interventions to reduce high diabetes distress among adults with Type 1 diabetes with a comparison sample of similar but untreated individuals, and to document the stability of untreated diabetes distress over time.

Hypoxic Pulmonary Vasoconstriction Is Lacking In Rats With Type 1 Diabetes.

Hypoxic pulmonary vasoconstriction (HPV) is the most important feature of intact lung circulation that matches local blood perfusion to ventilation. The main goal of this work was to study the effects of diabetes on the HPV development in rats. The experimental design comprised diabetes mellitus induction by streptozotocin, video-morphometric measurements of the lumen area of intrapulmonary arteries (iPAs) using perfused lung tissue slices and patch-clamp techniques. It was shown that iPA lumen size was sig...


Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury.

The specific mechanisms underlying cyclin-dependent kinase 5 (Cdk5)-mediated neuropathic pain at the spinal cord level remain elusive. The aim of the present study was to explore the role of crosstalk between Cdk5/p35 and extracellular signal-regulated kinase 1/2 (ERK1/2) signalling in mediating spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury (CCI). Here, we quantified pain behaviour after CCI; detected the localization of p35, Cdk5, phosphorylated ERK1/2 (pERK...

PPARγ participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via GLT-1 in vivo and in vitro.

Glial glutamate transporter 1 (GLT-1) plays a vital role in the induction of brain ischemic tolerance (BIT) by ischemic preconditioning (IPC). However, the mechanism still needs to be further explained. The aim of this study was to investigate whether peroxisome proliferator-activated receptor gamma (PPARγ) participates in regulating GLT-1 during the acquisition of BIT induced by IPC. Initially, cerebral IPC induced BIT and enhanced PPARγ and GLT-1 expression in the CA1 hippocampus in rats. The ratio of n...

Geological gas-storage shapes deep life.

Around the world, several dozen deep sedimentary aquifers are being used for storage of natural gas. Ad-hoc studies of the microbial ecology of some of them have suggested that sulfate-reducing and methanogenic microorganisms play a key role in how these aquifers' communities function. Here, we investigate the influence of gas storage on these two metabolic groups by using high-throughput sequencing and show the importance of sulfate-reducing Desulfotomaculum and a new monophyletic methanogenic group. Aquif...

Immune landscape of hepatocellular carcinoma microenvironment: implications for prognosis and therapeutic applications.

The development of immunotherapy for solid tumors has boosted interest in the contexture of tumor immune microenvironment (TIME). Several lines of evidence indicate that the interplay between tumor cells and TIME components is a key factor for the evolution of hepatocellular carcinoma (HCC) and for the likelihood of response to immunotherapeutics. The availability of high-resolution methods will be instrumental for a better definition of the complexity and diversity of TIME with the aim of predicting diseas...

A comparison study of different decellularization treatments on bovine articular cartilage.

Previous researches have emphasized on suitability of decellularized tissues for regenerative applications. The decellularization of cartilage tissue has always been a challenge as the final product must be balanced in both immunogenic residue and mechanical properties. This study was designed to compare and optimize the efficacy of the most common chemical decellularization treatments on articular cartilage. Freeze/thaw cycles, Trypsin, ethylenediaminetetraacetic acid (EDTA), sodium dodecyl sulfate (SDS), ...

Formation of Metal-Organic Frameworks on Metal Ion-Doped Polymer Substrate: In-Depth Time-Course Analysis using Scanning Electron Microscopy.

The growth of metal-organic frameworks (MOFs) on a metal ion-doped polymer as a precursor and support substrate was investigated based on mechanistic and kinetic analyses. The studies were performed by varying the reaction temperature and the concentrations of the organic ligand and nucleation-promoted additive. Using the NH2-MIL-53 (Al) framework as a model system, a systematic study of the mechanism of formation of tetragonal- and rod-shaped NH2-MIL-53 (Al) crystals on the substrate was performed. The nuc...

Gadofullerene Nanoparticles Reverse Dysfunctions of Pancreas and Improve Hepatic Insulin Resistance for Type 2 Diabetes Mellitus Treatment.

Type 2 diabetes mellitus (T2DM) has been one of the most prevalent metabolic disorders. Nonetheless, the commonly used anti-T2DM drugs failed to substantially treat T2DM, which always rapidly rebound in blood glucose when withdrawal. Here we put forward a superior and sustainable anti-diabetic strategy using intraperitoneal (i.p.) administration of amino acid functionalized gadofullerene nanoparticles (GFNPs) in db/db diabetic mice. Highly accumulated into pancreas and liver, GFNPs could prominently decreas...

An update on the, routine application of maldi-tof ms, in clinical microbiology.

: Within less than a decade, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has entered clinical diagnostics and is today a generally accepted and appreciated integral part of the workflow for microbial identification. MALDI-TOF MS identification systems received approval from national and international institutions, such as the USA FDA, and are continuously improved and adopted to other fields like veterinary and industrial microbiology. At this stage, the quest...

10-year results of the Nesovic procedure combined with adductor release for groin pain in 33 competitive athletes.

The authors present a 10-year review of the postoperative bilateral release of the adductor brevis and gracilis muscles combined with a bilateral abdominal myo-fascio-plasty according to Nesovic for groin pain in competitive athletes. We present the 10 years results of 33 patients operated on between April 2002 and May 2006 diagnosed with a "sports hernia". The injury was treated with a bilateral abdominal procedure according to Nesovic combined with a bilateral adductor release after unsuccessful conservat...

Proximal femoral nail anti-rotation (PFNA) and hemi-arthroplasty in the treatment of elderly intertrochanteric fractures.

To determine reasonable treatment of intertrochanteric fractures with proximal femoral nail anti-rotation (PFNA) or hemi-arthroplasty (HA) in elderly patients. Between January 2009 and June 2013, a total of 367 patients were admitted to the Orthopedics Department of The Second Affiliated Hospital of Soochow University. Patient data were retrospectively analyzed and included 160 males and 207 females. The ages of the patients were between 60 and 97 years and the average age was 72 +/- 3.9 years. According to...

Plate augmentation combined with bone grafting for aseptic non-union of femoral shaft fractures following interlocking nails.

TThe aim of this study was to evaluate plate augmentation over previously inserted interlocking nails, combined with iliac bone grafting in treating aseptic femoral shaft non-unions. The research was conducted prospectively on 34 patients. A narrow dynamic compression plate was placed while the nail was retained. All the screws were directed posterior to the nail. There were 25 males and 9 females with mean age of 36.6 years old. The mean operative time was 95 minutes with 320ml blood loss. 28 patients show...

Minimally Invasive Plate Osteosynthesis (MIPO) technique for complex tibial shaft fracture.

TTo evaluate the clinical and radiological results of the treatment of complex tibial shaft fracture (AO/OTA type 42-C) with minimally invasive plate osteosynthesis(MIPO). Twenty patients diagnosed with complex tibial shaft fracture without extension to the articular surface and treated with MIPO, including 9 cases of AO/OTA type 42-C2 and 11 cases of AO/OTA type 42-C3, 6 of which were open fractures. External fixation was used for open fractures until the soft tissue damage had healed; then, 2nd stage oper...

A strand-specific real-time quantitative RT-PCR assay for distinguishing the genomic and antigenomic RNAs of Rift Valley fever Phlebovirus.

Rift Valley Fever Phlebovirus (RVFV), genus Phlebovirus, family Phenuiviridae, order Bunyavirales, has a single-stranded, negative-sense RNA genome, consisting of L, M and S segments. Here, we report the establishment of a strand-specific, quantitative reverse transcription (RT)-PCR assay system that can selectively distinguish between the genomic and antigenomic RNAs of each of the three viral RNA segments produced in RVFV-infected cells. To circumvent the obstacle of primer-independent cDNA synthesis duri...

Breast Cancer Classification Based on Proteotypes Obtained by SWATH Mass Spectrometry.

Accurate classification of breast tumors is vital for patient management decisions and enables more precise cancer treatment. Here, we present a quantitative proteotyping approach based on sequential windowed acquisition of all theoretical fragment ion spectra (SWATH) mass spectrometry and establish key proteins for breast tumor classification. The study is based on 96 tissue samples representing five conventional breast cancer subtypes. SWATH proteotype patterns largely recapitulate these subtypes; however...

Inflammation within the Neurovascular Unit: Focus on Microglia for Stroke Injury and Recovery.

Neuroinflammation underlies the etiology of multiple neurodegenerative diseases and stroke. Our understanding of neuroinflammation has evolved in the last few years and major players have been identified. Microglia, the brain resident macrophages, are considered sentinels at the forefront of the neuroinflammatory response to different brain insults. Interestingly, microglia perform other physiological functions in addition to their role in neuroinflammation. Therefore, an updated approach in which modulatio...

IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation.

Gout is a paradigm of acute, self-limiting inflammation caused by the deposition of monosodium urate (MSU) crystals within intra-and/or peri-articular areas, which leads to excruciating pain, joint swelling and stiffness. The infiltration of leukocytes drives the inflammatory response and remains an attractive target for therapeutic intervention. In this context, emerging evidence support the view that systemic differentiation of Th17 cells and their in-situ infiltration as one of the potential mechanisms b...

Now Is the Time for All Good Compounders to Come to the Aid of Their Profession: What You Do Right Now to Advance Compounding's Advocacy Priorities Can Help Assure Your Profession's Future.

Development and Validation of a Stability-indicating High-performance Liquid Chromatographic Method for Quantification of Progesterone in Compounded Glycerinated Gelatin Troches.

The objective of this study was to develop a validated stability-indicating high-performance liquid chromatographic method that quantifies progesterone in compounded glycerinated gelatin troches. The mobile phase was composed of methanol and water (75:25 v/v), while the stationary phase was a Waters Nova-Pak C18 column (3.9 mm Å~ 15 cm Å~ 4.0 µm) with the column's temperature set to 40°C. The injection volume was 20 µL, while the gradient flow rate was maintained at 0.75 mL/min for a run time of 15 min...

Impacts of photon counting CT to maximum intensity projection (MIP) images of cerebral CT angiography: theoretical and experimental studies.

While CTA is an established clinical gold standard for imaging large cerebral arteries and veins, an important challenge that currently remains for CTA is its limited performance in imaging small perforating arteries with diameters below 0.5 mm. The purpose of this work was to theoretically and experimentally study the potential benefits of using photon counting detector (PCD)-based CT (PCCT) to improve the performance of CTA in imaging these small arteries. In particular, the study focused on an important ...

Single-shot phase-sensitive wideband active microrheology of viscoelastic fluids using pulse-scanned optical tweezers.

We present a fast phase sensitive active microrheology technique exploring the phase response of a microscopic probe particle trapped in a linear viscoelastic fluid using optical tweezers under an external perturbation. Thus, we experimentally
 determine the cumulative response of the probe to an entire repertoire of sinusoidal excitations simultaneously by applying a spatial square pulse as an excitation to the trapped probe. The square pulse naturally contains the fundamental sinusoidal frequency ...

Dark-field spectroscopy: development, applications and perspectives in single nanoparticle catalysis.

Dark-field microscopy (DFM) is an effective method to detect the scattering signal from single nanoparticles. This technique could break through the 200 nm limit resolution of ordinary optical microscope. It even can observe the submicron particles of 20-200 nm. Moreover, from 2000, DFM was coupled with a spectrometer to measure the scattering spectra of single silver nanoparticles. Then, dark-field spectroscopy becomes a very important plasmon spectroscopy technique for single nanoparticle. Usually, plasmo...

Dynamic beam current control for improved dose accuracy in PBS proton therapy.

The step-and-shoot method of pencil beam scanning delivers the dose on a three-dimensional grid in the target volume, with one dimension defined by the proton energy. While the dose per pencil beam may vary substantially within an iso-energy layer, the beam current typically remains constant. In this static operation mode, the inherent latency of the beam switch-off mechanism results in a lower limit for the deliverable spot dose, which may prevent the application of some of the low-weighted spots prescribe...


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