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PubMed Journals Articles About "Craving Manipulation Cocaine Placebo Cocaine Unspecified" - Page: 4 RSS

16:56 EDT 16th July 2019 | BioPortfolio

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Showing "Craving Manipulation Cocaine Placebo Cocaine Unspecified" PubMed Articles 76–100 of 1,800+

Effects of hydrocortisone on autobiographical memory retrieval in patients with posttraumatic stress disorder and borderline personality disorder: the role of childhood trauma.

In a previous study, we found that patients with posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD) showed better autobiographical memory (AM) retrieval after hydrocortisone administration than after placebo administration. Here we investigate the neural correlates of AM retrieval after hydrocortisone administration in patients with PTSD or BPD. We recruited 78 female participants for this placebo-controlled crossover study: 40 healthy controls, 20 patients with PTSD, and 18 pati...


Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

Clinical efficacy of a new Cetyl Pyridinium Chloride-Hyaluronic Acid based mouthrinse compared to Chlorhexidine and placebo mouthrinses - A 21 days randomised clinical trial.

To compare the effectiveness of a novel Cetylpyridinium Chloride (CPC)-Hyaluronic Acid (HA) based mouthrinse with Chlorhexidine (CHX) and placebo mouthrinses in preventing plaque and gingivitis. The secondary outcomes were calculus, extrinsic stains, oral malodor and occurrence of adverse events.


Genetically Encoded Fluorescence/Bioluminescence Bimodal Indicators for Ca Imaging.

Fluorescent and bioluminescent genetically encoded Ca indicators (GECIs) are an indispensable tool for monitoring Ca dynamics in numerous cellular events. Although fluorescent GECIs have a high spatiotemporal resolution, their application is often confined to short-term imaging due to the external illumination that causes phototoxicity and autofluorescence from specimens. Bioluminescent GECIs overcome these pitfalls with enhanced compatibility to optogenetic manipulation and photophysiological processes; ho...

Acute alcohol effects on conditioned pain modulation, but not temporal summation of pain.

Although pain reduction after alcohol administration has repeatedly been demonstrated, alcohol effects on advanced and clinically relevant dynamic pain paradigms are still unknown. As such, temporal summation of pain (TSP) and conditioned pain modulation (CPM) indicate mechanisms of endogenous pain modulation and involve certain neurotransmitter systems crucially influenced by alcohol. Our study is the first to investigate acute alcohol effects on TSP and CPM. We investigated 39 healthy subjects in a placeb...

Engineering of bio-mimetic substratum topographies for enhanced early colonization of filamentous algae.

This work reveals a set of surface topography parameters that are significant for algal attachment to natural rock substrata. Topography analysis of rock surfaces from a stream identifies three descriptive areal parameters (Smr, Sv, and Sa) that correlate with the presence of natural periphyton community. A method was developed and validated to reverse engineer and manufacture artificial substrata with topographic complexity defined by these parameters, using computational modeling and additive manufacturin...

Speech-accompanying gestures are not processed by the language-processing mechanisms.

Speech-accompanying gestures constitute one information channel during communication. Some have argued that processing gestures engages the brain regions that support language comprehension. However, studies that have been used as evidence for shared mechanisms suffer from one or more of the following limitations: they a) have not directly compared activations for gesture and language processing in the same study and relied on the fallacious reverse inference (Poldrack, 2006) for interpretation, b) relied o...

Cocaine treatment before pregnancy differentially affects the anxiety and brain glucose metabolism of lactating rats if performed during adulthood or adolescence.

Cocaine exposure disrupts the maternal behavior of lactating rats, yet it is less known whether it alters the affective changes that accompany motherhood. As the long-term action of cocaine on anxiety varies according to the developmental stage of the individuals, this study aimed to compare the effect of a chronic treatment with cocaine to adult and adolescent non-pregnant females on their anxiety-like behavior and basal brain metabolic activity during lactation. Thus, adult and adolescent virgin rats were...

Reprogramming lymphocytes for the treatment of melanoma: From biology to therapy.

This decade has introduced drastic changes in melanoma therapy, predominantly due to the materialization of the long promise of immunotherapy. Cytotoxic T cells are the chief component of the immune system, which are targeted by different strategies aimed to increase their capacity against melanoma cells. To this end, reprogramming of T cells occurs by T cell centered manipulation, targeting the immunosuppressive tumor microenvironment or altering the whole patient. These are enabled by delivery of small mo...

The effects of acupuncture on pregnancy outcomes of in vitro fertilization with embryo transfer: An interdisciplinary systematic review.

The present systematic review is designed to summarize the evidence concerning the effect of acupuncture on pregnancy outcomes in vitro fertilization with embryo transfer (IVF-ET). We searched MEDLINE, the Wanfang Database, the China Academic Journal Electronic Full-text Database in the China National Knowledge Infrastructure, and the Index to Chinese Periodical Literature. Randomized controlled trials with intervention groups using acupuncture and control groups consisting of no acupuncture or sham (placeb...

Animal-vehicle collisions in Texas: How to protect travelers and animals on roadways.

Animal-vehicle collisions (AVCs) are a growing problem in the United States, resulting in countless loss of animal life and considerable human injury and death every year, especially to motorcyclists. Due to underreporting, collision data generally provide a very low (highly biased) estimate of actual AVC counts and often lack key details, such as the species of animals involved. However, AVC reports cover entire states and nations, and can illuminate differences in wild versus domestic animal-vehicle colli...

The role of Glucagon-Like Peptide 1 Loading on periprocedural myocardial infarction During elective PCI (GOLD-PCI study): A randomized, placebo-controlled trial.

The incretin hormone glucagon-like peptide 1 (GLP-1) has been shown to protect against lethal ischemia-reperfusion injury in animal models and against nonlethal ischemia reperfusion injury in humans. Furthermore, GLP-1 receptor agonists have been shown to reduce major adverse cardiovascular and cerebrovascular events (MACCE) in large-scale studies. We sought to investigate whether GLP-1 reduced percutaneous coronary intervention (PCI)-associated myocardial infarction (PMI) during elective PCI.

Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function.

Dopamine (DA) signaling is critical for movement, motivation, and addictive behavior. The neuronal GTPase, Rit2, is enriched in DA neurons (DANs), binds directly to the DA transporter (DAT), and is implicated in several DA-related neuropsychiatric disorders. However, it remains unknown whether Rit2 plays a role in either DAergic signaling and/or DA-dependent behaviors. Here we leveraged the TET-OFF system to conditionally silence Rit2 in Pitx3 mouse DANs. Following DAergic Rit2 knockdown (Rit2-KD), mice dis...

TCR α β /CD19 cell-depleted hematopoietic stem cell transplantation for pediatric patients.

TCR α β /CD19 cell depletion is an emerging technique for ex vivo graft manipulation in HSCT. We report 20 pediatric patients who underwent TCR α β /CD19 cell-depleted HSCT in four Australian centers. Conditioning regimen was dependent on HSCT indication, which included immunodeficiency (n = 14), Fanconi anemia (n = 3), and acute leukemia (n = 3). Donor sources were haploidentical parent (n = 17), haploidentical sibling (n = 2), or matched unrelated donor (n = 1). Mean cell dose was 8.2 ×...

Effect of supplementation with omega-3 fatty acids on hypertriglyceridemia in pediatric patients with obesity.

Background The beneficial effects of treating hypertriglyceridemic adults with omega-3 fatty acids have been reported. However, information regarding omega-3 treatment of pediatric patients is limited. Objective To evaluate the efficacy and safety of administering omega-3 fatty acids (3 g/day for 12 weeks) to children/adolescents with obesity and hypertriglyceridemia. Methods A randomized, double-blind, placebo-controlled, parallel study involving pediatric patients (10-16 years old) with obesity and hypert...

GmWRKY54 improves drought tolerance through activating genes in ABA and Ca signaling pathways in transgenic soybean.

WRKY transcription factors play important roles in response to various abiotic stresses. Previous study proved that soybean GmWRKY54 can improve stress tolerance in transgenic Arabidopsis. Here, we generated soybean transgenic plants and further investigated roles and biological mechanisms of GmWRKY54 in response to drought stress. We demonstrate that expression of GmWRKY54, driven by either a constitutive promoter (pCm) or a drought-induced promoter (RD29a), confers drought tolerance. GmWRKY54 is a transcr...

Visualizing Infralimbic Control over Incubation of Cocaine Craving.

The infralimbic prefrontal cortex serves complex roles in controlling drug-seeking behavior. In this issue of Neuron, Cameron et al. (2019) provide new insights into engagement and function of the infralimbic cortex → nucleus accumbens corticostriatal pathway in the incubation of cocaine craving.

Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence.

Drug relapse after periods of abstinence is a common feature of substance abuse. Moreover, anxiety and other mood disorders are often co-morbid with substance abuse. Cholinergic receptors in the ventral tegmental area (VTA) are known to mediate drug-seeking and anxiety-related behavior in rodent models. However, it is unclear if overlapping VTA cholinergic mechanisms mediate drug relapse and anxiety-related behaviors associated with drug abstinence. We examined the effects of VTA cholinergic receptor blocka...

Effects of probiotic supplementation of a plant-based protein diet on intestinal microbial diversity, digestive enzyme activity, intestinal structure, and immunity in olive flounder (Paralichthys olivaceus).

The aim of this study was to investigate the effects of intestinal microbial manipulation by dietary probiotic supplementation on digestive enzyme activity, immune-related gene transcription, intestinal structure alteration, and viability against pathogenic challenge in olive flounder. Similar-sized flounders (14.92 ± 0.21 g) were divided into three groups and supplemented with a control (without probiotic) or 1 × 10 CFU/g diet of each of Bacillus sp. SJ-10 (ProB) and Lactobacillus plantarum (...

Plasmonic Nano surface for neuronal differentiation and manipulation.

Neurodegenerative diseases and traumatic brain injuries can destroy neurons, resulting in sensory and motor function loss. Transplantation of differentiated neurons from stem cells could help restore such lost functions. Plasmonic gold nanorods (AuNR) were integrated in growth surfaces to stimulate and modulate neural cells in order to tune cell physiology. An AuNR nanocomposite system was fabricated, characterized, and then utilized to study the differentiation of embryonic rat neural stem cells (NSCs). Re...

Biochemical and behavioral effects induced by cocaine exposure to Daphnia magna.

Illicit drugs and their metabolites have been identified as emerging aquatic pollutants. Cocaine (COC) is one of the most used illicit drug worldwide. After human consumption, COC enters the aquatic ecosystems, where it is commonly detected in ng L concentration range. Although a number of studies have shown that the exposure to environmental concentrations of COC can induce diverse biochemical, molecular and histological effects on aquatic organisms, the information of COC-induced behavioral alterations is...

Inhaled alprazolam rapidly suppresses epileptic activity in photosensitive participants.

Treatment options for seizure clusters are limited; the need for easy-to-administer treatments remains. The Staccato system delivers drug deep into the lung via inhalation. In this phase 2a study, we investigated the ability of three different doses of Staccato alprazolam to suppress the electroencephalographic (EEG) photoparoxysmal response (PPR) compared with placebo in participants with photosensitive seizures.

Acute Negative Allosteric Modulation of M Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with no effect on Antinociception.

Opioid Use Disorder (OUD) is a debilitating neuropsychiatric condition characterized by compulsive opioid use, dependence, and repeated relapse after periods of abstinence. Given the high risk of developing OUD following prescription opioid use, the continued need for opioid-induced analgesia, and the limitations of current treatments, it is necessary to develop novel, non-opioid based treatments for OUD and decrease abuse potential of prescription opioids. Recent evidence suggests that negative allosteric ...

Controlling Crystal Texture in Programmable Atom Equivalent Thin Films.

DNA is a powerful tool in the directed assembly of nanoparticle based superlattice materials, as the predictable nature of Watson-Crick base pairing allows DNA-grafted particles to be programmably assembled into unit cells that arise from the complete control of nanoparticle coordination environment within the lattice. However, while the local environment around each nanoparticle within a superlattice can be precisely dictated, the same level of control over aspects of crystallite structure at the meso- or ...

The Novel Cyclophilin-D Interacting Protein FASTKD1 Protects Cells Against Oxidative Stress-Induced Death.

Opening of the mitochondrial permeability transition (MPT) pore leads to necrotic cell death. Excluding cyclophilin D (CypD), the makeup of the MPT pore remains conjecture. The purpose of these experiments was to identify novel MPT modulators by analyzing proteins that associate with CypD. We identified Fas-activated serine/threonine phosphoprotein kinase domain-containing protein 1 (FASTKD1) as a novel CypD interactor. Overexpression of FASTKD1 protected mouse embryonic fibroblasts (MEFs) against oxidative...


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