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PubMed Journals Articles About "Quercetin Derivative Modulate Chromatin Dynamics Adipogenesis Prevents Obesity" - Page: 4 RSS

11:02 EDT 21st July 2019 | BioPortfolio

Quercetin Derivative Modulate Chromatin Dynamics Adipogenesis Prevents Obesity PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Quercetin Derivative Modulate Chromatin Dynamics Adipogenesis Prevents Obesity articles that have been published worldwide.

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Showing "Quercetin derivative modulate chromatin dynamics adipogenesis prevents obesity" PubMed Articles 76–100 of 10,000+

Does diversifying crop rotations suppress weeds? A meta-analysis.

Over the past half-century, crop rotations have become increasingly simplified, with whole regions producing only one or two crops in succession. Simplification is problematic from a weed management perspective, because it results in weeds' repeated exposure to the same set of ecological and agronomic conditions. This can exacerbate weed infestations and promote the evolution of herbicide resistance. Diversifying crop rotations through addition of crop species and their associated managements may suppress w...


Sequencing and analysis of globally obtained human parainfluenza viruses 1 and 3 genomes.

Human Parainfluenza viruses (HPIV) type 1 and 3 are important causes of respiratory tract infections in young children globally. HPIV infections do not confer complete protective immunity so reinfections occur throughout life. Since no effective vaccine is available for the two virus subtypes, comprehensive understanding of HPIV-1 and HPIV-3 genetic and epidemic features is important for diagnosis, prevention, and treatment of HPIV-1 and HPIV-3 infections. Relatively few whole genome sequences are available...

Mutant p53 - a potential player in shaping the tumor-stroma crosstalk.

A plethora of studies suggest that the non-transformed cellular and non-cellular components of the tumor, collectively known as the tumor microenvironment, have a significant impact on the tumorigenic process. It was suggested that the microenvironment, which initially restricts tumor development, is recruited by the tumor and maintains a crosstalk that further promotes cancer progression. Indeed, many of the molecules that participate in the tumor-stroma crosstalk have been characterized. However, the cruc...


Parallel G-triplexes and G-hairpins as potential transitory ensembles in the folding of parallel-stranded DNA G-Quadruplexes.

Guanine quadruplexes (G4s) are non-canonical nucleic acids structures common in important genomic regions. Parallel-stranded G4 folds are the most abundant, but their folding mechanism is not fully understood. Recent research highlighted that G4 DNA molecules fold via kinetic partitioning mechanism dominated by competition amongst diverse long-living G4 folds. The role of other intermediate species such as parallel G-triplexes and G-hairpins in the folding process has been a matter of debate. Here, we use s...

Immunohistochemical assessment of chromatin licensing and DNA replication factor 1, geminin, and γ H2A.X in oral epithelial precursor lesions and squamous cell carcinoma.

Carcinogenesis occurs when the cell cycle is compromised. Chromatin licensing and DNA replication factor 1, geminin, and γH2A histone family member X are expressed in cells in G phase, S/G /M phases, and apoptosis, respectively, and these three markers may be useful for histological evaluation of malignant lesions. Here, we aimed to identify cell cycle phases and apoptosis using immunohistochemistry in oral epithelial precursor lesions and oral squamous cell carcinoma.

Quercetin potentiates meropenem activity among pathogenic carbapenem resistant Pseudomonas aeruginosa and Acinetobacter baumannii.

Global spread of Carbapenem Resistant Pseudomonas aeruginosa (CRPsA) and Acinetobacter baumannii (CRAB) is an emerging clinical problem. Since, quercetin is a well-known antibacterial agent; it would be relevant to demonstrate synergy between quercetin and meropenem and elucidate molecular basis of effective bactericidal activity of quercetin-meropenem against CRPsA and CRAB.

Genomic analysis unveils important aspects of population structure, virulence, and antimicrobial resistance in Klebsiella aerogenes.

Klebsiella aerogenes is an important pathogen in healthcare-associated infections. Nevertheless, in comparison to other clinically important pathogens, K. aerogenes population structure, genetic diversity, and pathogenicity remain poorly understood. Here, we elucidate K. aerogenes clonal complexes (CCs) and genomic features associated with resistance and virulence. We present a detailed description of the population structure of K. aerogenes based on 97 publicly available genomes by using both multilocus se...

Recent Developments in the Design of Mn- and Ru-based Hybrid CO-Releasing Molecules (HYCOs).

The interest in the therapeutic effects of carbon monoxide (CO), a product of the enzyme heme oxygenase-1 (HO-1), led to the development of CO-releasing molecules (CO-RMs) for the controlled delivery of this gas in vivo. We have recently proposed to conjugate CO-RMs with Nrf2 activators, the transcription factor that regulates HO-1 expression, in order to make use of the beneficial effects of exogenous and endogenous CO. In this study we describe the preparation of hybrid molecules conjugating a fumaric aci...

Observation of Ultrafast Intersystem Crossing in Thymine by Extreme Ultraviolet Time-resolved Photoelectron Spectroscopy.

We studied the photoinduced ultrafast relaxation dynamics of the nucleobase thymine using gas-phase time-resolved photoelectron spectroscopy. By employing extreme ultraviolet pulses from high harmonic generation for photoionization, we substantially extend our spectral observation window with respect to previous studies. This enables us to follow relaxation of excited state population all the way to low-lying electronic states including the ground state. In thymine, we observe relaxation from the optically ...

Low Dimensionality, High Robustness in Neural Population Dynamics.

Neuronal populations respond within a small number of relevant dimensions. New research by Trautmann et al. (2019) shows that spike sorting is not necessary to extract the important features of this low-dimensional population signal. Combined responses of multiple neurons (multiunit activity) only generate small changes in the extracted signals.

Loss of flow responsive Tie1 results in Impaired
Aortic valve remodeling.

The mechanisms regulating endothelial cell response to hemodynamic forces required for heart valve development, especially valve remodeling, remain elusive. Tie1, an endothelial specific receptor tyrosine kinase, is up-regulated by oscillating shear stress and is required for lymphatic valve development. In this study, we demonstrate that valvular endothelial Tie1 is differentially expressed in a dynamic pattern predicted by disturbed flow during valve remodeling. Following valvular endocardial specific del...

Nicorandil prevents doxorubicin-induced human umbilical vein endothelial cell apoptosis.

Nicorandil is an adenosine triphosphate-sensitive potassium channel opener with additional antioxidant properties. Doxorubicin (DOX) is an anticancer drug that exerts oxidation-mediated adverse cardiovascular effects. This study examined the effects of nicorandil on DOX-induced cytotoxicity in human umbilical vein endothelial cells (HUVECs) and underlying intracellular signaling mechanisms. Cultured HUVECs were pretreated with nicorandil (0.1, 0.3, 1, 3, and 10 μM) for 12 h and then treated with DOX (1...

Delivery nanosystems based on sterically hindered phenol derivatives containing a quaternary ammonium moiety: Synthesis, cholinesterase inhibition and antioxidant activity.

Multitarget ligands (MTL) based on sterically hindered phenol and containing a quaternary ammonium moiety (SHP-n-Q) were synthesized. These compounds are inhibitors of cholinesterases with antioxidant properties. The inhibitory selectivity is 10-fold potent for BChE than for AChE. IC of SHP-n-Q for BChE is 20 μM. SHP-n-Q and their nanosystems exhibit more pronounced antioxidant properties than the synthetic antioxidant (hindered phenol, butylated hydroxytoluene). These compounds display a low hemolytic a...

6'-O-acetyl mangiferin from Iris rossii Baker inhibits lipid accumulation partly via AMPK activation in adipogenesis.

Effective control of white adipose tissue accumulation would provide a therapeutic strategy for obesity, which poses a growing global problem. The plant chemical mangiferin stimulates adenosine monophosphate-activated protein kinase (AMPK), which inhibits adipogenesis and has therefore been considered a therapeutic target for obesity and related diseases. We previously reported the anti-inflammatory properties of 6'-O-acetyl mangiferin (OAM). In this study, we evaluated the potential of OAM as an AMPK activ...

Updating gender differences in the control of homeostatic and hedonic food intake: Implications for binge eating disorder.

In an obesity pandemic context, eating disorders (ED) have arisen as serious illnesses associated with severe disturbances and has a clear gender dependent bias. In this manuscript, we provide an overview of the oestrogen role in the homeostatic and hedonic control of food intake. We draw attention to the role of oestrogens in the various reward processes and their possible implication in the development of ED, a condition much more common in women. In here, we have summarized the most relevant studies cond...

Acetylation modulates thyroid hormone receptor intracellular localization and intranuclear mobility.

The thyroid hormone receptor (TR) undergoes nucleocytoplasmic shuttling, but is primarily nuclear-localized and mediates expression of genes involved in development and homeostasis. Given the proximity of TR acetylation and sumoylation sites to nuclear localization (NLS) and nuclear export signals, we investigated their role in regulating intracellular localization. The nuclear/cytosolic fluorescence ratio (N/C) of fluorescent protein-tagged acetylation mimic, nonacetylation mimic, and sumoylation-deficient...

Polyoxazolines based mixed micelles as PEG free formulations for an effective quercetin antioxidant topical delivery.

This study aims to prove the value of the polyoxazolines polymer family as surfactant in formulations for topical application and as an alternative to PEG overuse. The amphiphilic polyoxazolines (POx) were demonstrated to have less impact on cell viability of mice fibroblasts (NIH3T3) than their PEG counterparts. Mixed micelles, made of POx and phosphatidylcholine, were manufactured using thin film and high pressure homogenizer process. The mixed micelles were optimized to produce nanosized of vesicles abou...

Climate change effects on population dynamics of three species of Amazonian lizards.

The scarcity of data on natural history and ecology of lizards still limits the understanding of population dynamics for many species. We attempt to evaluate possible effects of climate change on the population dynamics of three lizard species (Ameiva ameiva, Gonatodes humeralis and Norops fuscoauratus) in two Amazonian localities (Caxiuanã National Forest and Ducke Reserve). We calculated a tolerance index combining environmental thermal adequacy with the b-d model, which consider survival and reproductiv...

Is one dose of human papillomavirus vaccine as effective as three?: A national cohort analysis.

Prophylactic human papillomavirus (HPV) vaccines are highly effective at preventing pre-cancerous cervical lesions when given in a three-dose schedule. Some post-hoc trial data suggest that one dose prevents HPV infection. If one dose could prevent pre-cancerous cervical lesions, then global cervical cancer prevention would be greatly facilitated. We assessed the effectiveness of quadrivalent HPV vaccine by number of doses against cervical intraepithelial neoplasia (CIN) 2 or 3/adenocarcinoma-in-situ (AIS)/...

The Different Roles of miRNA-92a-2-5p and let-7b-5p in Mitochondrial Translation in db/db Mice.

Excessive reactive oxygen species (ROS) generated in mitochondria is known to be a causal event in diabetic cardiomyopathy. Recent studies suggest that microRNAs (miRNAs) are able to translocate to mitochondria to modulate mitochondrial activities, but the roles of such miRNAs in diabetic cardiomyopathy remain unclear. We observed a marked reduction of mitochondrial gene cytochrome-b (mt-Cytb) in the heart of db/db mice compared with controls. Downregulation of mt-Cytb by small interfering RNA (siRNA) recap...

GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro.

Several studies have recently revealed the regulatory mechanisms underlying female germline stem cell (FGSC) differentiation, proliferation, and apoptosis, but other biological processes such as autophagy and its mechanism in FGSCs are largely unclear. The use of small chemical compounds may be a good approach to further investigate the process and mechanism of autophagy in FGSC development. In this study, we used ZCL-082, a derivative of benzoxaboroles, to treat FGSCs. Using a cell counting kit-8 (CCK8) an...

Composition of soil organic matter drives total loss of dieldrin and dichlorodiphenyltrichloroethane in high-value pastures over thirty years.

The residues of dieldrin and dichlorodiphenyltrichloroethane (DDT), internationally-banned agricultural insecticides, continue to exceed government guidelines in some surface soils 30 years after use. Little is known regarding the soil factors and microbial community dynamics associated with the in-situ biodegradation of these organochlorine chemicals. We hypothesised that soil organic matter, a key factor affecting microbial biomass and diversity, affects the biodegradation and total loss of the pollutan...

Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents.

Among several potential applications, sigma receptors (σRs) can be used as neuroprotective agents, antiamnesic, antipsychotics and against other neurodegenerative disorders. On the other hands, antagonists of the GluN2b-subunit-containing-N-methyl-D-aspartate (NMDA) receptors are of major interest for the same purpose, being this subunit expressed in specific areas of the central nervous system and responsible for the excitatory regulation of nerve cells. Under these premises, we have synthesized and biolo...

Relating network connectivity to dynamics: opportunities and challenges for theoretical neuroscience.

We review recent work relating network connectivity to the dynamics of neural activity. While concepts stemming from network science provide a valuable starting point, the interpretation of graph-theoretic structures and measures can be highly dependent on the dynamics associated to the network. Properties that are quite meaningful for linear dynamics, such as random walk and network flow models, may be of limited relevance in the neuroscience setting. Theoretical and computational neuroscience are playing ...

A network approach to investigate the bi-hemispheric synchrony in absence epilepsy.

Our objective was to unravel the dynamics underlying spike-and-wave discharges (SWDs) characteristic for childhood absence epilepsy.


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