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PubMed Journals Articles About "Tracking Clarifying Differential Traits Classical Atypical Type Bovine" - Page: 4 RSS

00:20 EDT 24th July 2019 | BioPortfolio

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Showing "Tracking clarifying differential traits classical atypical type bovine" PubMed Articles 76–100 of 19,000+

Nanoparticulate delivery of potent microtubule inhibitor for metastatic melanoma treatment.

Melanoma is the most aggressive type of skin cancer, which readily metastasizes through lymph nodes to the lungs, liver, and brain. Since the repeated administration of most chemotherapeutic drugs develops chemoresistance and severe systemic toxicities, herein we synthesized 2-(4-hydroxy-1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) methanone (abbreviated as QW-296), a novel tubulin destabilizing agent with little susceptible to transporter-mediated drug resistance. QW-296 disturbed the microtubu...


Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions.

Endothelial cells represent the first biological barrier for compounds, including nanoparticles, administered via the intravascular route. In the case of ischemic stroke and other vascular diseases, the endothelium overexpresses specific markers, which can be used as molecular targets to facilitate drug delivery and imaging. However, targeting these markers can be quite challenging due to the presence of blood flow and the associated hydrodynamic forces, reducing the likelihood of adhesion to the vessel wal...

Long non-coding RNA SNHG1 functions as a competitive endogenous RNA to regulate PDCD4 expression by sponging miR-195-5p in hepatocellular carcinoma.

Long non-coding RNA (lncRNA) potentially regulates tumorigenesis. LncRNA small nucleolar RNA host gene 1 (SNHG1) expression remains high in hepatocellular carcinoma cells; however, its biological mechanism in hepatocellular carcinoma remains unknown. In this study, SNHG1 expression in hepatocellular carcinoma cells was detected by qRT-PCR. Proliferative and migratory potentials of hepatocellular carcinoma cells were determined by CCK-8 and Transwell assay, respectively. Then, the nude mice model of xenograf...


Treatment with fibrates is associated with higher LAL activity in dyslipidemic patients.

Lysosomal acid lipase (LAL) is responsible for the hydrolysis of cholesteryl esters (CE) and triglycerides (TG) within the lysosomes; generated cholesterol and free fatty acids (FFA) are released in the cytosol where they can regulate their own synthesis and metabolism. When LAL is not active, as in case of genetic mutations, CE and TG accumulate in the lysosomal compartment, while the lack of release of cholesterol and FFA in the cytosol leads to an upregulation of their synthesis. Thus, LAL plays a centra...

Comparative analysis of shrimp (Penaeus vannamei) miRNAs expression profiles during WSSV infection under experimental conditions and in pond culture.

In recent years, the importance of viral and host microRNAs (miRNAs) in mediating viral replication and control of host cellular machinery, has been realised and increasing efforts have been taken in order to understand the interactions of miRNAs from host and pathogen during infection. However, all existing studies has thus far been conducted in controlled experimental conditions and the veracity of these data for field conditions has yet to be established. In this framework, small RNA sequencing was perfo...

Treatment of olive processing wastewater by electrocoagulation: An effectiveness and economic assessment.

In the present study, the technique of electrocoagulation (EC) followed by filtration was explored at the laboratory scale for the removal of organic compounds from olive debittering wastewater (ODW). Different parameters such as electrode type and distance as well as sample pH, current density, and electrolysis time were investigated in batch experiments with identical electrode geometries. Our results showed that highest pollutant removal efficiency and lowest operational cost were achieved using two Al e...

Highly sensitive HPLC-MS/MS assay for the quantitation of ondansetron in rat plasma and rat brain tissue homogenate following administration of a very low subcutaneous dose.

Ondansetron is a highly selective 5-hydroxytryptamine type 3 (5-HT) receptor antagonist that is well tolerated in the clinic. Pre-clinical studies in rats have shown interesting effects of small doses of ondansetron on cognition, behavioural sensitisation and epilepsy. However, the pharmacokinetic profile at a very low dose has not been reported, possibly because currently, there are no published analytical methods capable of quantifying trace levels of ondansetron in plasma or brain. The objective of this ...

Terminologia Histologica after more than 10 years: disputable terms which need a wide scientific discussion and recent developments.

At first sight, the issue of morphological terminology may seem as "closed and changeless chapter", as many of the structures within the human body have been known for decades or even centuries. However, the exact opposite is true. The initial knowledge of the microscopic structure of the human body has been continuously broadening thanks to the development of new specialized staining techniques, discovery of the electron microscope, or later application of histochemical and immunohistochemical methods into...

DIABETES DRUGS IN THE FIGHT AGAINST ALZHEIMER'S DISEASE.

Alzheimer's disease (AD) is the most prevalent form of dementia, particularly in old age subjects. Hyperinsulinemia and insulin resistance, which are known as pathophysiological features of Type 2 Diabetes Mellitus (T2DM), have also been demonstrated to have a significant impact on cognitive impairment. Studies have shown that an altered insulin pathway may interact with amyloid-β protein deposition and tau protein phosphorylation, both leading factors for AD development. Drugs used for T2DM treatment from...

TAK1 knock-down in macrophage alleviate lung inflammation induced by black carbon and aged black carbon.

Black carbon (BC) can combine with organic matter and form secondary pollutants known as aged BC. BC and aged BC can cause respiratory system inflammation and induce lesions at relevant sites, but the underlying mechanism has remained unknown. To gain insight into the potential mechanisms, we focused on macrophages and transforming growth factor β-activated kinase 1 (TAK1) which are a crucial factor in inflammation. Our research aims to determine the role of TAK1 in macrophages in pulmonary inflammation in...

Development of a high-resolution traffic emission model: Lessons and key insights from the case of Bogotá, Colombia.

This paper presents a traffic-related air emissions inventory of a developing megacity using a traffic assignment model that results in a detailed temporal and spatial emission representation, disaggregating emissions sources by vehicle type and hour of the day, for five criteria air pollutants.

Mechanistic insight into the adsorption of diclofenac by MIL-100: Experiments and theoretical calculations.

The development of high-efficiency adsorbents and the exploration of their adsorption mechanisms are major challenges in environmental remediation. Herein, MIL-100 was prepared, characterized, and utilized for the adsorptive removal of diclofenac sodium (DCF) from aqueous solutions. A high monolayer adsorption capacity of 773 mg g was recorded. The adsorption mechanism was proposed based on different contributions of two types of pore structure of MIL-100 to the adsorption of DCF from aqueous solutions ...

Yeast cells in double layer calcium alginate-chitosan microcapsules for sparkling wine production.

This paper focuses on the use of a new type of yeast encapsulation procedure, applying the chitosan-calcium alginate double layer microcapsules, for the production of Riesling sparkling wine. Four different sparkling wines were produced by free or encapsulated yeasts. The four types of yeast used were adapted (Free EtOH-A, Encapsulated EtOH-A) and non-adapted to ethanol (Free, Encapsulated). The different yeast-inoculating formats had a significant impact on oxygen consumption and pressure increase rate in ...

Transmitted Drug Resistance in Newly Diagnosed, Treatment-Naïve, HIV Type 1-Infected Patients in Hungary.

Transmitted HIV-1 drug resistance (TDR) may affect the success of first-line antiretroviral treatment. The aim of this study was to monitor the presence of HIV-1 strains carrying transmitted drug resistance-associated mutations (TDRMs) in newly diagnosed, treatment-naïve patients in Hungary.

High molecular weight adiponectin reduces glucolipotoxicity-induced inflammation and improves lipid metabolism and insulin sensitivity via APPL1-AMPK-GLUT4 regulation in 3T3-L1 adipocytes.

Although the importance of adipokines in modulating the disease process of type 2 diabetes is well recognized, there is dearth of data on the specific role of high molecular weight adiponectin (HMW Ad) on insulin resistance and obesity. Therefore, we tested the effects of HMW Ad on glucolipotoxcity-induced inflammation and insulin resistance in 3T3-L1 adipocytes.

Microgels at fluid-fluid interfaces for food and drinks.

Various aspects of microgel adsorption at fluid-fluid interfaces of relevance to emulsion and foam stabilization have been reviewed. The emphasis is on the wider non-food literature, with a view to highlighting how this understanding can be applied to food-based systems. The various different types of microgel, their methods of formation and their fundamental behavioral traits at interfaces are covered. The latter includes aspects of microgel deformation and packing at interfaces, their deformability, size,...

Pre-labelling versus direct labelling of anthrax proteins for imaging of matrix metalloproteinases activity using DOTA-GA.

Increased activity of matrix metalloproteases (MMPs) is associated with reduced survival in several cancer subtypes. Aiming to produce an MMP tumour cell-selective cytotoxin, we genetically modified both components of the AB-type lethal toxin from Bacillus anthracis. Component A, Protective Antigen (PA-WT), was re-engineered to form an oligomeric pore in cell membranes only when cleaved by MMPs (PA-L1). The pore-translocation domain (LFn - N-terminal, 30 kDa) of the Lethal Factor (LF), component B, was fu...

Nitrogen mustard gas molecules and α-arsenene nanosheet interaction studies - A DFT insight.

Bis(2-chloroethyl)ethylamine (HN-1) and Bis(2-chloroethyl)methylamine (HN-2) are two classifications under the blistering agents, which are taken as target nitrogen mustard gas in the current research. α-arsenene nanosheets in its puckered configuration, are employed as a prime material to detect the above mentioned gas molecules. The chemo-sensing nature of the base material towards the target gas is ascertained with the assistance of electronic and surface assimilating attributes with the help of density...

Strengthening child and youth programs: A look at inter-organizational mentoring strategies.

Community-based non-profit organizations rarely have access to research or evaluation evidence to inform their programs and often lack the capacity to gather or use this information independently. In 2016, Wisdom2Action-a network of knowledge mobilization (KMb) experts, policy makers and service providers across Canada-launched an inter-organizational mentorship program to facilitate the implementation and sharing of best and promising practices within community-based programs for young people. This article...

Telmisartan, an angiotensin II receptor blocker, attenuates Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages.

Telmisartan, widely prescribed for the treatment of hypertension, has an anti-inflammatory property in addition to being an angiotensin II type 1 receptor antagonist. This study was carried out to explore the influence of telmisartan upon the elaboration of inflammatory mediators in murine macrophages stimulated with lipopolysaccharide (LPS) prepared from Prevotella intermedia, a periodontal pathogen, as well as its molecular mechanisms. Telmisartan significantly inhibited LPS-induced generation of inducibl...

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review.

To better define the rare adverse event (AE) of diabetes mellitus associated with immune checkpoint inhibitors (ICI).

Visit-to-Visit B-Type Natriuretic Peptide Variability during the Previous Year Has Independent Prognostic Value in Patients with Stable Chronic Heart Failure.

There is wide variability of visit-to-visit (V2V) B-type natriuretic peptide (BNP) in patients with chronic heart failure (CHF), even when they are stable. The prognostic significance of V2V-BNP variability has not been investigated. We aimed to test whether V2V-BNP variability during the stable period of CHF has prognostic value regardless of BNP level.

Acute Type A Aortic Dissection Surgery Performed by Aortic Specialists Improves 2-Year Outcomes.

 In patients presenting with acute Type A aortic dissections (ATADs), the authors sought to evaluate whether emergent aortic operations performed by cardiac surgeons with different level of aortic surgery experience can impact perioperative outcomes and survival.

Effects of Sex on Early Outcome following Repair of Acute Type A Aortic Dissection: Results from The Nordic Consortium for Acute Type A Aortic Dissection (NORCAAD).

 Female sex is known to have increased perioperative mortality in cardiac surgery. Studies reporting effects of sex on outcome following surgical repair for acute Type A aortic dissection (ATAAD) have been limited by small cohorts of heterogeneous patient populations and have shown diverging results. This study aimed to compare perioperative characteristics, operative management, and postoperative outcome between sexes in a large and well-defined cohort of patients operated for ATAAD.

Hypogastric Artery Occlusion with Evoked Potentials Monitoring as Bailout Technique to Assess the Risk of Postoperative Spinal Cord Ischemia.

A 65-year-old man, with previous open surgical repair of an infrarenal abdominal aortic, presented with acute complicated (paraplegia) Type B aortic dissection. He successfully underwent endovascular repair of the descending thoracic and abdominal aorta. Following the procedure, the neurological manifestations resolved. As he had a concomitant aneurysm of the right hypogastric artery (HGA), we executed a 10-minute balloon occlusion of this artery with evoked potential measurements to assess the risk of spin...


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