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PubMed Journals Articles About "Separations" - Page: 4 RSS

10:19 EST 13th November 2019 | BioPortfolio

Separations PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Separations articles that have been published worldwide.

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Showing "Separations" PubMed Articles 76–100 of 102

Design and optimization of a fused-silica microfluidic device for separation of trivalent lanthanides by isotachophoresis.

Elemental analysis of rare earth elements is essential in a variety of fields including environmental monitoring and nuclear safeguards; however, current techniques are often labor intensive, time consuming and/or costly to perform. The difficulty arises in preparing samples, which requires separating the chemically and physically similar lanthanides. However, by transitioning these separations to the microscale, the speed, cost, and simplicity of sample preparation can be drastically improved. Here, all fo...


Fast analytical evaluation of intermolecular electrostatic interaction energies using the pseudoatom representation of the electron density. II. The Fourier transform method.

The Fourier transform method for analytical determination of the two-center Coulomb integrals needed for evaluation of the electrostatic interaction energies between pseudoatom-based charge distributions is presented, and its Fortran-based implementation using the 128-bit floating-point arithmetic in the XDPROP module of the XD software is described. In combination with mathematical libraries included in the Lahey/Fujitsu LF64 Linux compiler, the new implementation outperforms the previously reported Löwdi...

Simultaneous determination of chiral and achiral impurities of ivabradine on a cellulose tris(3-chloro-4-methylphenylcarbamate) chiral column using polar organic mode.

A high performance liquid chromatographic method was developed for the simultaneous determination of the related substances (R-ivabradine, dehydro-S-ivabradine, N-demethyl-S-ivabradine, ((S)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-yl-methyl)-methyl-amine) and 1-(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepine-2-on-3-yl)-3-chloro-propane) of the heart-rate lowering drug, ivabradine. The separation capability of seven different polysaccharide-type chiral columns (Lux Amylose-1, Lux i-Amylose-1, Lux ...


Preparation and characterization of micro-bore wall-coated open-tubular capillaries with low phase ratios for fast-gas chromatography-mass spectrometry: Application to ignitable liquids and fire debris.

Fast Gas Chromatography (GC) allows for analysis times that are a fraction of those seen in traditional capillary GC. Key modifications in fast GC include using narrow, highly efficient columns that can resolve mixtures using a shorter column length. Hence, a typical fast GC column has an inner diameter of 100-180 μm. However, to maintain phase ratios that are consistent with typical GC columns, the film thickness of fast GC stationary phases are also low (e.g., 0.1-0.18 μm). Unfortunately, decreased ...

Interfacial Junctions Control Electrolyte Transport Through Charge-Patterned Membranes.

Distinct transport mechanisms emerge when nanostructured substrates are patterned with multiple chemistries. For example, charge-patterned mosaic membranes possess surfaces functionalized with discrete domains of both positive and negative charge. These oppositely-charged domains provide pathways for both the cation and anion from a dissolved salt to permeate through the membrane without violating the macroscopic constraint of electroneutrality. Here, by systematically varying the geometry and size of the c...

A Combined Screening and In Silico Strategy for the Rapid Design of Integrated Downstream Processes for Process and Product-Related Impurity Removal.

Integrated designs of chromatographic processes for purification of biopharmaceuticals provides potential gains in operational efficiency and reductions of costs and material requirements. We describe a combined method using screening and in silico algorithms for ranking chromatographic steps to rapidly design orthogonally selective integrated processes for purifying protein therapeutics from both process- and product-related impurities. IFN-α2b produced in Pichia pastoris containing a significant product ...

Neural correlates of explicit and implicit memory at encoding and retrieval: A unified framework and meta-analysis of functional neuroimaging studies.

The extent to which explicit memory (EM) and implicit memory (IM) involve similar or differential neural substrates remains unclear. To address this issue, this study provides a direct, meta-analytic comparison of functional neuroimaging studies involving EM and IM tasks. The meta-analysis comprised two separate meta-analytic comparisons. First, to compare EM and IM in terms of encoding activity, subsequent memory effects (remembered>forgotten) and repetition suppression effects (first>repeated) were direct...

Risk profiling using metabolomic characteristics for susceptible individuals of drug-induced liver injury caused by Polygonum multiflorum.

Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug reaction. To date, identifying individuals at risk for IDILI remains challenging. This is a prospective study, where a nested case-control (1:5) design was adopted. For six patients who had abnormalities in liver function test after Polygonum multiflorum Thunb. (PM) ingestion (susceptible group), 30 patients with normal liver function were matched (tolerant group). Based on liquid chromatography-mass spectrometry, ...

Synergistic effect of band edge potentials on BiFeO/VO composite: Enhanced photo catalytic activity.

The BiFeO/VO has been successfully synthesized by simple annealing of BiFeO nanoplates and VO nanoflower. The phase, structural, optical properties and chemical state of the BiFeO, VO and different composition of BiFeO/VO samples were comparatively characterized by various spectroscopic and microscopic techniques. The prepared catalyst exhibits unique photo catalytic and post-oxidation/reduction ability for removal of various (MB, Phenol, CV, RhB) water organic pollutants. Compared to pure BiFeO and VO, the...

Discovery and Utilization of EST-SSR Marker Resource for Genetic Diversity and Population Structure Analyses of a Subtropical Bamboo, Dendrocalamus hamiltonii.

Dendrocalamus hamiltonii is a giant bamboo species native to Indian subcontinent with high economic importance. Nevertheless, highly outcross nature and flowering once in decades impose severe limitation in its propagation. Identification and mixed cultivation of genetically diverse genotypes may assist successful breeding and natural recombination of desirable traits. Characterization of existing genetic diversity and population structure are indispensable for efficient implementation of such strategies, w...

Structure determination of large isomeric oligosaccharides of natural origin through multi-pass and multi-stage cyclic traveling wave ion mobility mass spectrometry.

Carbohydrate isomers with identical atomic composition cannot be distinguished by mass spectrometry. By separating the ions according to their conformation in the gas phase, ion mobility (IM) coupled to mass spectrometry is an attractive approach to overcome this issue and extend the limits of mass spectrometry in structural glycosciences. Recent technological developments have significantly increased the resolving power of ion mobility separators. One such instrument features a cyclic traveling-wave IM sep...

Conformational dynamics and interfacial interactions of peptide-appended pillar5arene water channels in biomimetic membranes.

Peptide appended pillar[5]arene (PAP) is an artificial water channel resembling biological water channel proteins, which has shown a significant potential for designing bioinspired water purification systems. Given that PAP channels need to be incorporated at a high density in membrane matrices, it is critical to examine the role of channel-channel and channel-membrane interactions in governing the structural and functional characteristics of channels. To resolve the atomic-scale details of these interactio...

Knowledge-Driven Deep Unrolling for Robust Image Layer Separation.

Single-image layer separation targets to decompose the observed image into two independent components in terms of different application demands. It is known that many vision and multimedia applications can be (re)formulated as a separation problem. Due to the fundamentally ill-posed natural of these separations, existing methods are inclined to investigate model priors on the separated components elaborately. Nevertheless, it is knotty to optimize the cost function with complicated model regularizations. Ef...

Metabolic Profiling of Saponin-Rich Ophiopogon japonicus Roots Based on 1H NMR and HPTLC Platforms.

Ideally, metabolomics should deal with all the metabolites that are found within cells and biological systems. The most common technologies for metabolomics include mass spectrometry, and in most cases, hyphenated to chromatographic separations (liquid chromatography- or gas chromatography-mass spectrometry) and nuclear magnetic resonance spectroscopy. However, limitations such as low sensitivity and highly congested spectra in nuclear magnetic resonance spectroscopy and relatively low signal reproducibilit...

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-capillary Electrophoresis Mass Spectrometry.

New analytical methods are urgently needed to enable high-throughput, yet comprehensive drug screening, given an alarming opioid and prescription drug crisis in public health. Conventional urine drug testing based on a two-tier immunoassay screen followed by a gas chromatography-tandem mass spectrometry (GC-MS/MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS) method are expensive and prone to bias while being limited to targeted panels of known drugs of abuse (DoA). Herein, we outline an impr...

Horizontal transmission of Metarhizium anisopliae between Spoladea recurvalis (Lepidoptera: Crambidae) adults and compatibility of the fungus with the attractant phenylacetaldehyde.

The compatibility of the entomopathogenic fungus Metarhizium anisopliae ICIPE 30 which was proved to be pathogenic to adult Spoladea recurvalis, and phenylacetaldehyde (PAA) floral attractant for lepidopteran moths, was investigated under laboratory and field conditions through spatial and temporal separations. Horizontal transmission of M. anisopliae ICIPE 30 between adult S. recurvalis and the number of conidia picked up by a single moth from the autoinoculation device were also determined under laborator...

Isolation of cypress gibberellin-regulated protein: Analysis of its structural features and IgE binding competition with homologous allergens.

The presence in cypress pollen of an important allergen, belonging to the gibberellin-regulated protein (GRP) family, has been suggested for many years. However, it has never been isolated and sometimes the homologous peach allergen, Pru p 7, has been used as a surrogate to perform immunological investigations. The aim of this study has been the isolation and molecular characterization of the GRP contained in the Cupressus sempervirens pollen. This protein, named Cypmaclein, has been purified from the natur...

Preparation of a new benzylureido-β-cyclodextrin-based column and its application for the determination of phenylmercapturic acid and benzylmercapturic acid enantiomers in human urine by LC/MS/MS.

A benzylureido-β-cyclodextrin was synthesized by the reaction of 6-amino-β-cyclodextrin with an active benzyl isocyanate. Then, it was bonded to silica gel by a thiol-ene addition reaction, obtaining a new benzylureido-β-cyclodextrin-based chiral stationary phase (BzCDP). Its chemical structure was characterized by infrared spectroscopy, elemental analysis, and solid-state nuclear magnetic resonance spectroscopy. The BzCDP was successfully used to separate phenylmercapturic acid (PMA) and benzylmercaptur...

Binary Assembly of PbS and Au Nanocrystals: Patchy PbS Surface Ligand Coverage Stabilizes the CuAu Superlattice.

Self-assembly of two sizes of nearly-spherical colloidal nanocrystals (NCs) capped with hydrocarbon surface ligands has been shown to produce more than twenty distinct phases of binary nanocrystal superlattices (BNSLs). Such structural diversity, in striking contrast to binary systems of micron-sized colloidal beads, cannot be rationalized by models assuming entropy-driven crystallization of simple spheres. In this work, we show that the PbS ligand binding equilibrium controls the relative stability of two ...

Modulation of electroosmotic flow in capillary electrophoresis by plant polyphenol-inspired gallic acid/polyethyleneimine coatings: Analysis of small molecules.

Plant polyphenols can form functional coatings on various materials through self-polymerization. In this paper, a series of modified capillary columns, which possess diversity of charge characteristics for modulating electroosmotic flow (EOF), were prepared by one-step co-deposition of gallic acid (GA), a plant-derived polyphenol monomer, and branched polyethyleneimine (PEI). The physicochemical properties of the prepared columns were characterized by Fourier transform infrared spectroscopy (FT-IR), UV-Vis ...

Aggregation of plate-like colloids induced by charged polymer chains: organisation at the nanometer scale tuned by polymer charge density.

We study the aggregation of charged plate-like colloids, Na-montmorillonite clays, in the presence of ionenes, oppositely charged polymer chains. The choice of the charged polymer allows tuning its linear charge density to match/mismatch the average charge separation on the clay surfaces. We assess the nanoscale structure of the aggregates formed by small angle X-ray and neutron scattering (SAXS, SANS). The nanoscale features of the formed clay aggregates are dominated by the presence of a stacking peak, gi...

Influence of Water on Structure, Dynamics and Electrostatics of Hydrophilic and Hydrophobic Ionic Liquids in Charged and Hydrophilic Confinement between Mica Surfaces.

Water is ubiquitous in the environment and the origin for operational constraints in ionic-liquid based electrolytes for supercapacitors. In this study, the influence of water on the interfacial behavior of hydrophilic (1-ethyl-3-methylimidazolium ethylsulphate, abbr. [EMIM][EtSO4] and hydrophobic (1-ethyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate and 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, abbr. [EMIM][FAP] and [EMIM][TFSI], respectively) ionic liquids (ILs) confin...

Agro-environmental impacts, carbon sequestration and profit analysis of blended biochar pellet application in the paddy soil-water system.

The application of biochar pellet blended with pig manure compost was investigated to estimate its agro-environmental impacts and to evaluate its soil carbon sequestration and profit analysis during rice cultivation. The experiment consisted of four different treatments such as control as pig manure compost only, pig manure compost pellet (PMCP), biochar pellet blended with biochar and pig manure compost (4: 6 ratios, BCP), and slow release fertilizer (SRF). The application of chemical fertilizer and pig ma...

ENEA, a peach and apricot IgE-binding protein cross-reacting with the latex major allergen Hev b 5.

Peach and apricot can cause allergic reactions with symptoms ranging from mild to very severe, including anaphylaxis. Sometimes subjects allergic to fruits of the Prunus genus have been reported to be also allergic to rubber latex products. The objective of this study is the characterization of a newly identified peach and apricot protein showing similarities with the allergens Hev b 5 from rubber latex and Man e 5 from manioc. This protein has been named ENEA on the basis of the single letter amino acid co...

High throughput screening of serum γ-glutamyl dipeptides for risk assessment of nonalcoholic steatohepatitis with impaired glutathione salvage pathway.

Non-alcoholic fatty liver disease (NAFLD) is the most common preventable chronic liver disorder in developed countries, the prevalence of which is increasing worldwide due to its association with obesity, and type 2 diabetes. However, the exact mechanisms of NAFLD pathophysiology remain poorly understood, including its progression to the more severe non-alcoholic steatohepatitis (NASH). New advances for early detection and monitoring of NASH progression are limited due to the lack of specific blood biomarke...


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