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PubMed Journals Articles About "Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated" - Page: 5 RSS

06:08 EST 16th February 2019 | BioPortfolio

Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated articles that have been published worldwide.

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Showing "Bacterial Efflux Pump Inhibitors Pipeline Insights 2017 Updated" PubMed Articles 101–125 of 15,000+

20 Armoured Infantry Brigade downgrade study: epidemiology of principal conditions and plugging leaks in the rehabilitation pipeline.

In April 2017, 22% of Army Full-time Trade Trained Strength was downgraded, reducing fully deployable strength to 60 546, against a target of 82 000. In June 2017, Commander 20 Armoured Infantry Brigade (20 AI Bde) initiated a study to look at the principal conditions causing medical downgrading, as a stepping stone to finding ways of reducing injury, enhancing rehabilitation and improving deployability.


Mechanisms of glutathione-conjugate efflux from the brain into blood: Involvement of multiple transporters in the course.

Accumulation of detrimental glutathione-conjugated metabolites in the brain potentially causes neurological disorders, and must therefore be exported from the brain. However, in vivo mechanisms of glutathione-conjugates efflux from the brain remain unknown. We investigated the involvement of transporters in glutathione-conjugates efflux using 6-bromo-7-[C]methylpurine ([C]1), which enters the brain and is converted into its glutathione conjugate, S-(7-[C]methylpurin-6-yl)glutathione ([C]2). In mice of contr...

Molecular characterization of two novel atypical porcine pestivirus (APPV) strains from piglets with congenital tremor in China.

As one of emerging porcine viruses, atypical porcine pestivirus (APPV) was found in three continents since it emerged in 2015. It is now thought as the causative agent for congenital tremor type A-II in piglets. At the end of 2017, two APPV strains were identified from piglets with congenital tremor in Guangxi and Yunnan, China. The genome of APPV GX04/2017 strain was so far determined to be 11,534 nucleotides (nt) in length and contains a single open reading frame (ORF) encoding a polyprotein comprising 3,...


Cigarette smoke condensate alters Saccharomyces cerevisiae efflux transporter mRNA and activity and increases caffeine toxicity.

In animals, cigarette smoke may alter pharmacokinetics by altering activity and expression of ABC drug transporters. We previously demonstrated that cigarette smoke condensate (CSC) impairs activity and expression of several hepatic ABC drug transporters which mediate toxicant efflux. However, CSC effects on efflux transporters are still unknown in Saccharomyces cerevisiae which resists diverse chemical stresses, by inducing pleiotropic drug resistance (PDR) genes among others. The yeast ABC transporters ar...

A self-sufficient pressure pump using latex balloons for microfluidic applications.

Here, we demonstrate a self-sufficient, inexpensive and disposable pressure pump using commercially available latex balloons. The versatility of the pump is demonstrated against various microfluidic structures, liquid viscosities, and ambient temperatures. The flow rate of the pump can be controlled by varying the size and thickness of the balloon. Importantly, the soft structure of the balloon allows for almost instantaneous change of the flow rate upon manual squeezing of the balloon. This feature has bee...

Identifying Bacterial Strains from Sequencing Data.

Environmental and clinical settings can host a wide variety of both bacterial species and strains in a single colony but accurate identification of the organisms is difficult. We describe BIB, a probabilistic method for estimating the relative abundances of species or strains contained in mixed samples analyzed by short read high-throughput sequencing. By grouping closely related strains together in clusters, the BIB pipeline is capable of estimating the relative abundances of the clusters contained in a se...

Change in the antimicrobial resistance profile of Pseudomonas aeruginosa from soil after exposure to herbicides.

The extensive use of pesticides represents a risk to human health and to the environment. This study aimed to investigate if the exposure to atrazine and diuron, two herbicides widely used in Brazil, could induce changes in the susceptibility profile to aztreonam, colistin and polymyxin B antimicrobials in isolates of P. aeruginosa obtained from soil samples by using the determination of minimum inhibitory concentration (MIC) test. Three isolates had an increase of MIC to aztreonam after exposure to both he...

Discovery of NDM-1 inhibitors from natural products.

Human health is seriously threatened by metallo-beta-lactamase(MBL)-mediated bacterial resistance. Among them, the New Delhi metallo-beta-lactamase-1(NDM-1) has received great attention due to its extensive substrate specificity and high lateral gene transfer. Currently there is no inhibitor of NDM-1 available in clinical therapy, thus making an argent need for the research and development of novel NDM-1 inhibitors.

Diets Low in Saturated Fat with Different Unsaturated Fatty Acid Profiles Similarly Increase Serum-Mediated Cholesterol Efflux from THP-1 Macrophages in a Population with or at Risk for Metabolic Syndrome: The Canola Oil Multicenter Intervention Trial.

Cholesterol efflux plays an important role in preventing atherosclerosis progression. Vegetable oils with varying unsaturated fatty acid profiles favorably affect multiple cardiovascular disease risk factors; however, their effects on cholesterol efflux remain unclear.

Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.

The use of kinase-directed precision medicine has been heavily pursued since the discovery and development of imatinib. Annually, it is estimated that around ~20,000 new cases of TRK cancers are diagnosed, with the majority of cases exhibiting a TRK genomic rearrangement. In this perspective article, we discuss the opportunities and challenges for the development of TRK precision medicine by providing the following: (1) The biological background and significance of the TRK kinase family, (2) A compilation o...

A Novel Framework to Compare the Effectiveness of β-lactamase Inhibitors against Extended-Spectrum β-lactamase-producing Enterobacteriaceae.

Extended-spectrum β-lactamases (ESBLs) present a serious challenge in the treatment of Gram-negative bacterial infections. ESBLs mediate resistance to most β-lactams, which may be reversed with the addition of an active β-lactamase inhibitor (such as tazobactam, relebactam and avibactam). However, various ESBLs may exhibit different susceptibilities to these inhibitors, which could impact efficacy. We proposed a framework for comparing efficacy of these inhibitors when combined with the same β-lactam.

Variable response to low-dose naltrexone in patients with Darier disease: a case series.

Darier disease is a rare autosomal-dominant genodermatosis with a loss of function of a Ca -ATPase pump (SERCA2-pump). Clinically, the disease is characterized by red-brown keratotic papules mainly in seborrheic areas and has only limited and unsatisfactory treatment options. Previously, low-dose naltrexone was described as a successful treatment option in Hailey-Hailey-disease, a genodermatosis with a genetic mutation coding for a similar loss of function of a Ca -ATPase pump (hSPCA1-pump).

Immediate-hypersensitivity reactions to proton pump inhibitors - experience in a medical department.

Fragment-to-Lead Medicinal Chemistry Publications in 2017.

This Miniperspective is the third in a series reviewing fragment-to-lead publications from a given year. Following our reviews for 2015 and 2016, this Miniperspective provides tabulated summaries of relevant articles published in 2017 along with some general observations. In addition, we discuss insights obtained from analysis of the combined data set of 85 examples from all three years of publications.

Variability of stem CO2 efflux response to temperature over the diel period.

This study presents results from continuous measurements of stem CO2 efflux carried out for seven growing seasons in a young Norway spruce forest. The objective of the study was to determine differences in temperature sensitivity of stem CO2 efflux (Q10) during night (when sap flow is zero or nearly zero), during early afternoon (when the maximum rate of sap flow occurs) and during two transition periods between the aforementioned periods. The highest Q10 was recorded during the period of zero sap flow, whi...

HDL impairs osteoclastogenesis and induces osteoclast apoptosis via upregulation of ABCG1 expression.

Cholesterol is one of the major components of biological membranes and has an important function in osteoclast formation and survival. It has been reported that high-density lipoprotein (HDL) promotes cholesterol efflux from osteoclasts and induces their apoptosis, but the underlying mechanisms are unclear. In this study, we investigated how HDL promotes osteoclast cholesterol efflux and explored its effect on osteoclast formation and survival. Our results showed that the maximum diameter and fusion index o...

Effects of proton pump inhibitor co-administration on the plasma concentration of erlotinib in patients with non-small cell lung cancer.

Erlotinib is used for treating non-small cell lung cancer (NSCLC). Intestinal absorption of erlotinib is impaired under gastric pH elevation, therefore, co-administration of gastric acid suppressants may provide lower blood concentration of erlotinib. We investigated the effects of erlotinib co-administration with proton pump inhibitors (PPI) and histamine H2 receptor blockers (H2RB) on the plasma concentration of erlotinib and erlotinib-induced adverse reaction in NSCLC patients.

Cross-Regulation between Bacteria and Phages at a Posttranscriptional Level.

The study of bacteriophages (phages) and prophages has provided key insights into almost every cellular process as well as led to the discovery of unexpected new mechanisms and the development of valuable tools. This is exemplified for RNA-based regulation. For instance, the characterization and exploitation of the antiphage CRISPR (clustered regularly interspaced short palindromic repeat) systems is revolutionizing molecular biology. Phage-encoded proteins such as the RNA-binding MS2 protein, which is broa...

Clinical outcomes of laryngopharyngeal reflux treatment: A systematic review and meta-analysis.

To investigate the therapeutic benefit of proton pump inhibitors (PPIs) over placebo in patients with laryngopharyngeal reflux (LPR) and to analyze the epidemiological factors of heterogeneity in the literature.

Updates on the pathogenicity status of Pseudomonas aeruginosa.

Pseudomonas aeruginosa is a pathogenic bacterial species that causes infections and diseases in both plants and animals, including several human diseases, especially in immune-compromised patients, and many hospital-acquired infections. Given that P. aeruginosa is an opportunistic pathogen, the occurrence of antimicrobial resistance makes it difficult to treat and eradicate. Antimicrobial resistance in P. aeruginosa is categorized as intrinsic, acquired, or adaptive. Here, we different aspects of resistance...

CIRCpe{Piwecka, 2017 #307}dia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison.

Circular RNAs (circRNAs) from back-splicing of exon(s) have been recently identified to be broadly expressed in eukaryotes, in tissue- and species- specific manners. Although functions of most circRNAs remain elusive, some circRNAs are shown to be functional in gene expression regulation and potentially relate to diseases. Due to their stability, circRNAs can also be used as biomarkers for diagnosis. Profiling circRNAs by integrating their expression among different samples thus provides molecular basis for...

Ca efflux via plasma membrane Ca-ATPase mediates chemotaxis in ascidian sperm.

When a spermatozoon shows chemotactic behavior, transient [Ca] increases in the spermatozoon are induced by an attractant gradient. The [Ca] increase triggers a series of stereotypic responses of flagellar waveforms that comprise turning and straight-swimming. However, the molecular mechanism of [Ca] modulation controlled by the attractants is not well defined. Here, we examined receptive mechanisms for the sperm attractant, SAAF, in the ascidian, Ciona intestinalis, and identified a plasma membrane Ca-ATPa...

2017 AUA Renal Mass and Localized Renal Cancer Guidelines: Imaging Implications.

Renal cell carcinoma (RCC) is a common cancer that is increasing in incidence because of the increased prevalence of risk factors, including tobacco use, hypertension, and obesity, and the improved detection of these tumors due to increased use of imaging. Localized renal cancer now accounts for more than 60%-70% of new RCC cases. Renal masses suggestive of cancer include enhancing solid renal lesions and Bosniak III and IV complex cystic lesions. Most of these tumors are detected incidentally, and many are...

Antimicrobial Dialkylresorcins from Marine-Derived Microorganisms: Insights into Their Mode of Action and Putative Ecological Relevance.

has been reported as a seaweed-associated or marine-derived species with largely unknown secondary metabolites. The combination of bioinformatic analysis and MS- and bioactivity guided separation led to the isolation of a new antibiotically active dialkylresorcin from the marine bacterium . The antibiotic profile of the new dialkylresorcin zobelliphol ( 1: ) was investigated and compared with related and naturally occurring dialkyresorcins (i.e., stemphol ( 2: ) and 4-butyl-3,5-dihydroxybenzoic acid ( 3: ))...

HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages.

High density lipoproteins (HDL) are key components of reverse cholesterol transport pathway. HDL removes excessive cholesterol from peripheral cells, including macrophages, providing protection from cholesterol accumulation and conversion into foam cells, which is a key event in pathogenesis of atherosclerosis. The mechanism of cellular cholesterol efflux stimulation by HDL involves interaction with the ABCA1 lipid transporter and ensuing transfer of cholesterol to HDL particles. In this study, we looked fo...


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