PubMed Journals Articles About "Bioverativ Taps Manufacturer Steps Biogen Shadow" - Page: 5 RSS

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Showing "Bioverativ taps manufacturer steps Biogen shadow" PubMed Articles 101–125 of 1,600+

10 Ways to Build Effective Community Relations. There are many simple steps your agency can take to develop trust and foster respect.

Protein-Polymer Delivery: Chemistry from the Cold Chain to the Clinic.

Drug delivery is commonly thought of as the performance of a drug in vivo. Rather, the process of drug delivery can comprise of the journey of the drug from manufacturer to clinic, clinic to patient, patient to disease. Each step of the journey includes hurdles that must be overcome for the therapeutic to be successful. Recent developments in proteinaceous therapeutics have made the success-ful completion of this journey even more important because of the relatively fragile nature of proteins in a drug deli...

Key phosphorylation events in Spc29 and Spc42 guide multiple steps of yeast centrosome duplication.

Phosphorylation modulates many cellular processes during cell cycle progression. The yeast centrosome (called the spindle pole body, SPB) is regulated by the protein kinases Mps1 and Cdc28/Cdk1 as it nucleates microtubules to separate chromosomes during mitosis. Previously we completed an SPB phosphoproteome, identifying 297 sites on 17 of the 18 SPB components. Here we describe mutagenic analysis of phosphorylation events on Spc29 and Spc42, two SPB core components that were shown in the phosphoproteome to...

Concrete Steps for Empowering Learners to Create a Feedback Environment.

Absorption of Unconjugated Bile Acids from the Perfused Jejunum of the Anesthetized Rat: Structure-Activity Relationships and Rate-Limiting Steps.

Inducible Protein Production in 293 Cells Using the piggyBac Transposon System.

Recombinant proteins are widely used to study various pathophysiological processes. Nevertheless, the establishment of the desired protein-producing stable mammalian cell lines using traditional methods is hampered by multiple laborious steps. In this chapter, we describe a simple and robust system that allows for the derivation of stable transgenic cell lines in 293 cells, yielding high protein expression levels, in a short time period. This methodology is based on the piggyBac transposon system and, nota...

A wavelet based time frequency analysis of electromyograms to group steps of runners into clusters that contain similar muscle activation patterns.

To wavelet transform the electromyograms of the vastii muscles and generate wavelet intensity patterns (WIP) of runners. Test the hypotheses: 1) The WIP of the vastus medialis (VM) and vastus lateralis (VL) of one step are more similar than the WIPs of these two muscles, offset by one step. 2) The WIPs within one muscle differ by having maximal intensities in specific frequency bands and these intensities are not always occurring at the same time after heel strike. 3) The WIPs that were recorded form one mu...

P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities.

Leinamycin (LNM) is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140. Both in vivo and in vitro characterization of the LNM biosynthetic machinery have established the formation of the 18-membered macrolactam backbone and the C-3 alkyl branch; the nascent product, LNM E1, of the hybrid nonribosomal peptide synthetase (NRPS)-acyltransferase (AT)-less type I polyketide synthase (PKS); and the generation of the thiol moiety at C-3 of LNM E1. However, the tailoring steps converting LNM...

A Key Factor Dominating the Competition between Photolysis and Photoracemization of Ru(bipy) and Ru(phen) Complexes.

Photolysis and photoracemization are two important photochemical phenomena of the prototype complexes [Ru(bipy)] and [Ru(phen)] (bipy = 2,2'-bipyridine, phen = 1,10-phenanthroline), but little is known about their relations. To solve this issue, the photoinduced chiral inversion Δ⇌Λ of the complexes was analyzed theoretically. The results indicated that the photoracemization reaction proceeds on the lowest triplet potential energy surface in three steps CT↔MC, MC↔MC, and MC↔CT (CT = charge transfe...


: Minimally invasive fetal therapeutic procedures reduce the morbidity and mortality in monochorionic (MC) twins and in fetuses with congenital diaphragmatic hernia (CDH). MC pregnancies share their blood systems due to communicating vessels over their single placenta and may develop specific complications: Twin-to-Twin transfusion syndrome (TTTS), Selective intrauterine growth restriction (sIUGR), Twin Anemia-Polycythemia Sequence (TAPS), Twin Reverse Arterial Perfusion Syndrome (TRAP) or anomalies in one....

STEPS: an efficient prospective likelihood approach to genetic association analyses of secondary traits in extreme phenotype sequencing.

It has been well acknowledged that methods for secondary trait (ST) association analyses under a case-control design (ST$_{\text{CC}}$) should carefully consider the sampling process to avoid biased risk estimates. A similar situation also exists in the extreme phenotype sequencing (EPS) designs, which is to select subjects with extreme values of continuous primary phenotype for sequencing. EPS designs are commonly used in modern epidemiological and clinical studies such as the well-known National Heart, Lu...

Response of Letter to Editor: Macro textured breast implants with defined steps to minimize bacterial contamination around the device.

Easier Seen Than Done: Merely Watching Others Perform Can Foster an Illusion of Skill Acquisition.

Modern technologies such as YouTube afford unprecedented access to the skilled performances of other people. Six experiments ( N = 2,225) reveal that repeatedly watching others can foster an illusion of skill acquisition. The more people merely watch others perform (without actually practicing themselves), the more they nonetheless believe they could perform the skill, too (Experiment 1). However, people's actual abilities-from throwing darts and doing the moonwalk to playing an online game-do not improve a...

Steps forward reduction of environmental impact on children's health.

Core outcome sets in dermatology: next steps.

SILAC-MS profiling of reconstituted human chromatin platforms for the study of transcription and RNA regulation.

DNA packaged into chromatin is the core structure of the human genome. Nearly all eukaryotic genome regulation must interface with this genomic structure and modification to the chromatin can influence molecular mechanisms that regulate the underlying DNA. Many processes are governed by regulated step-wise assembly mechanisms that build complex machinery on chromatin to license a specific activity such as transcription. Transcriptional activators drive the initial steps of gene expression, regulated in part...

Professor Ruth Sonntag Nussenzweig (1928-2018) First steps towards a successful anti-sporozoite vaccine against malaria.

Making a difference for the profession, the people in it and the animals.

As she steps away from the BVA officer team next month, celebrates the skills she has gained through an eclectic career and wonders what will come next.

All-sense-all networks are suboptimal for sensorimotor synchronization.

In human groups that seek to synchronize to a common steady beat, every member can typically perceive every other member. We question whether this naturally occurring all-sense-all condition is optimal for temporal coordination. We consider alternative configurations represented by directed graphs, in which individuals can only hear or see a subset of others. We identify a trade-off in the topology of such networks: While denser graphs provide stronger coupling, improving synchrony, density increases sensit...

Major structural rearrangements of the canonical eukaryotic translation initiation complex.

Translation initiation in eukaryotes is a complex multistep process that requires the interplay of over a dozen protein factors together with the small ribosomal subunit (SSU) and the mRNA. During all these steps, the SSU serves as a platform for attachment, displacement and release of different molecules. In recent years, the great number of high-resolution X-ray and cryo-EM structures provided unprecedented insights into the molecular mechanism of this important process in eukaryotes. More specifically, c...

Designing inhaled protein therapeutics for topical lung delivery: what are the next steps?

Nuclear magnetic resonance spectroscopy and infrared spectroscopy analysis of precipitate formed after mixing sodium hypochlorite and QMix 2in1.

Mixing sodium hypochlorite (NaOCl) with chlorhexidine (CHX) forms a brown precipitate. QMix-2in1 (QMix) was introduced as a final irrigant. Manufacturer recommends interim flushing with saline between the application of NaOCl and QMix to prevent formation of precipitation. This study assessed whether para-chloroaniline (PCA) is formed after mixing NaOCl with QMix.

Phenotyping Crop Root Crowns: General Guidance and Specific Protocols for Maize, Wheat, and Soybean.

Root crown phenotyping allows measuring many parameters that describe the top portion of crop root systems and can be used for the basis of genome-wide association studies, QTL analysis, and physiology studies. Root crown phenotyping is a relatively simple process, with the major steps being excavation, transport, soil removal, and measurements. On the other hand, all steps require substantial manual labor and occur outside in challenging environments, and many factors influence the ultimate success of app...

Reply: "Macrotextured Breast Implants with Defined Steps to Minimize Bacterial Contamination around the Device. Experience in 42,000 Implants".

Reply: Macrotextured Breast Implants with Defined Steps to Minimize Bacterial Contamination around the Device. Experience in 42,000 Implants.

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