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PubMed Journals Articles About "Cell Design Labs Appoints Chief Medical Officer" - Page: 5 RSS

15:58 EDT 26th May 2018 | BioPortfolio

Cell Design Labs Appoints Chief Medical Officer PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Cell Design Labs Appoints Chief Medical Officer articles that have been published worldwide.

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Showing "Cell Design Labs Appoints Chief Medical Officer" PubMed Articles 101–125 of 39,000+

Data Handling in NMR Facilities and Assignment of NMR Spectra in Synthetic Chemistry Labs: Why Electronic Structure Validation should become Part of the Routine.


The Retinal Pigment Epithelial Cell Line (ARPE-19) Displays Mosaic Structural Chromosomal Aberrations.

The retinal pigment epithelial cell line ARPE-19 was established in 1996 and remains widely used today for biomedical and in particular ophthalmology research. We have analyzed the chromosomes of the ARPE-19 cell line and found cultured cells exist as a heterogeneous mixture having both normal karyotypes and chromosomal rearrangements. In ARPE-19 cells, we observed metaphases with a single translocation t(15;19) and metaphases with two translocations t(5;15) and t(15;19) and a derivative chromosome 9. Aneup...

Closing the Gap: Executives and Student Perceptions of Leadership Characteristics for Health Care Managers.

A study was recently conducted to determine the perceptions of undergraduate health care management students regarding leadership characteristics that health care managers should possess to be successful. The results were then compared with a study that was conducted in 2012 of chief executive officers regarding their perceptions of the same leadership characteristics. The comparison of the studies was used to determine if the perceptions of the students and chief executive officers were similar or if the s...


Bedside Assessment of the Necessity of Daily Lab Testing for Patients Nearing Discharge.

As part of the Choosing Wisely® campaign, the Society of Hospital Medicine recommends against performing "repetitive complete blood count chemistry testing in the face of clinical and lab stability." With this recommendation as a framework, we targeted 2 hospitalist-run inpatient medicine units that employed bedside, scripted, interdisciplinary rounds. Our multifaceted intervention included prompting the hospitalist to identify clinically stable patients for next-day discharge and to discontinue labs when ...

Medical specialty preferences in early medical school training in Canada.

To understand what medical students consider when choosing their specialty, prior to significant clinical exposure to develop strategies to provide adequate career counseling.

Solid-phase supported design of carriers for therapeutic nucleic acid delivery.

Nucleic acid molecules are important therapeutic agents in the field of antisense oligonucleotide, RNA interference and gene therapies. Since nucleic acids are not able to cross cell membranes and enter efficiently into cells on their own, the development of efficient, safe and precise delivery systems is the crucial challenge for development of nucleic acid therapeutics. For the delivery of nucleic acids to their intracellular site of action, either the cytosol or the nucleus, several extracellular and int...

The Influence of New Medium with RGD on Cell Growth,Cell Fusion and Expression of Exogenous Gene.

To investigate the influence of a new culture medium added with RGD on cell growth,cell fusion and expression of exogenous gene.

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design.

Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative appro...

Protocols for the Design of Kinase-Focused Compound Libraries.

Protocols for the design of kinase-focused compound libraries are presented. Kinase-focused compound libraries can be differentiated based on the design goal. Depending on whether the library should be a discovery library specific for one particular kinase, a general discovery library for multiple distinct kinase projects, or even phenotypic screening, there exists today a variety of in silico methods to design candidate compound libraries. We address the following scenarios: 1) Datamining of SAR databases ...

A review on current status of antiviral siRNA.

Viral diseases like influenza, AIDS, hepatitis, and Ebola cause severe epidemics worldwide. Along with their resistant strains, new pathogenic viruses continue to be discovered so creating an ongoing need for new antiviral treatments. RNA interference is a cellular gene-silencing phenomenon in which sequence-specific degradation of target mRNA is achieved by means of complementary short interfering RNA (siRNA) molecules. Short interfering RNA technology affords a potential tractable strategy to combat viral...

Effects of miR-155 on proliferation and apoptosis by regulating FoxO3a/BIM in liver cancer cell line HCCLM3.

MiR-155 has been shown to be up-regulated in hepatocellular carcinoma (HCC) patients. B-cell lymphoma-2 (Bcl-2) interacting mediator of cell death (BIM) regulates cell proliferation and apoptosis, as its down-regulation is involved in HCC onset. Transcriptional factor FoxO3a mediates BIM expression and is related to HCC pathogenesis. Bioinformatics analysis showed targeted regulation of FoxO3a by miR-155. This study aims to investigate whether miR-155 plays a role in mediating FoxO3a/BIM signal pathway and ...

The Factors Affecting Teaching and Learning Professionalism Among Medical Teachers.

Given the special importance of medical professionalism, a successful faculty development strategy not only teaches professionalism in cognitive domain but also creates practical instructors who can act as role models for students. This study proposed to identify themes that can explain effective factors in teaching and learning professionalism among medical teachers. The study was qualitative. Twenty-four experts in medical education participated in the study from all medical universities of Iran. Data gat...

Reflections from participants in the chief registrar scheme.

Why Owners Choose an Orthosis Over Stifle Surgery for Canine Cranial Cruciate Ligament Deficiency.

The objective of this study was to describe the patient population of dogs with cranial cruciate ligament (CrCL) deficiency that were prescribed a stifle orthosis. A total of 215 client-owned dogs with previously diagnosed CrCL deficiency were prescribed a stifle orthosis at a veterinary pain management and mobility clinic. Patient intake data collected included dog signalment, chief medical complaint, home environment and activity description, medical and surgical history, and diagnosing veterinarian. An o...

On the Design of Combination Cancer Therapy.

Combination therapy programs are the hallmark of the successful treatment of all forms of human malignancies. In this issue of Cell, Palmer and Sorger present data suggesting that cell culture results indicative of synergistic anticancer drug interactions rarely translate clinically and that the results of combination therapies in mouse models or human clinical trials, even if successful, are best explained by the independent activities of the individually administered drugs.

A sweet embrace: Control of protein-protein interactions by O-linked β-N-acetylglucosamine.

O-linked β-N-acetylglucosamine (O-GlcNAc) is a critical post-translational modification (PTM) of thousands of intracellular proteins. Reversible O-GlcNAcylation governs many aspects of cell physiology and is dysregulated in numerous human diseases. Despite this broad pathophysiological significance, major aspects of O-GlcNAc signaling remain poorly understood, including the biochemical mechanisms through which O-GlcNAc transduces information. Recent work from many labs, including our own, has revealed that...

Design, Synthesis and Anticancer Evaluation of Fangchinoline Derivatives.

Twenty fangchinoline derivatives were synthesized from the natural product fangchinoline, and their anticancer activities on human breast cancer MDA-MB-231 cell line, human prostate cancer PC3 cell line, human melanoma WM9 cell line and human leukaemia HEL and K562 cell lines were evaluated. The biological result showed that those derivatives exhibited potent activities on inhibiting cancer cell growth, and the structure-activity relationships were investigated. Among them, compound 4g, which was protected ...

Strategies for enhancing medical student resilience: student and faculty member perspectives.

To improve programs aimed to enhance medical student resiliency, we examined both medical student and faculty advisor perspectives on resiliency-building in an Asian medical school.

Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior.

The neuroendocrine brain or hypothalamus has emerged as one of the most highly sexually dimorphic brain regions in mammals, and specifically in rodents. It is not surprising that hypothalamic nuclei play a pivotal role in controlling sex-dependent physiology. This brain region functions as a chief executive officer or master regulator of homeostatic physiological systems to integrate both external and internal signals. In this review, we describe sex differences in energy homeostasis that arise in one area ...

Improving medical students' confidence with supplemental training programs: a medical student's view.

An insider's view on how Ki-67, the bright beacon of cell proliferation, became very popular.A tribute to Johannes Gerdes (1950 - 2016).

In July 2016 Johannes Gerdes passed away, 25 years after the Journal of Pathology published a groundbreaking paper on Ki-67. The manuscript has been quoted nearly 1400 times since then.Thomas Scholzen, Christiane Gerlach and Giorgio Cattoretti, former coworkers, collaborators and friends of Hannes present a reconstruction of the scientific ambience of the field in the world and in their labs, anecdoctes of the discovery and a very brief summary of published and unpublished research on Ki-67 as a tribute to ...

Creating a Faculty Publications Database Using Sci-Matetm.

Faculty publication are reflection of research activity at a medical school and are thus very important. When a more organized and detailed record of faculty productivity was desired at the University of Nevada School of Medicine, manual methods as well as generic database manger were seen as too cumbersome. Instead, automating the collection using Sci-Mate, tm since it will accept downloaded citations, was seen as the more efficient solution to producing and keeping eh list up-to-date. This article will di...

The Suffering Medical Students Attribute to Their Undergraduate Medical Education.

The purpose of this study was to explore medical student perceptions of their medical school teaching and learning about human suffering and their recommendations for teaching about suffering. During data collection, students also shared their percerptions of personal suffering which they attributed to their medical education.

Modulator Dynamics Shape the Design Space for Stepwise-Elution Simulated Moving Bed Chromatographic Separations.

For proteins and other biological macromolecules, SMB chromatography is best operated non-isocratically. However, traditional modes of non-isocratic SMB operation generate significant mobile-phase modulator dynamics. The mechanisms by which these modulator dynamics affect a separation's success, and thus frame the design space, have yet to be explained quantitatively. Here, the dynamics of the modulator (e.g. salts in ion exchange and hydrophobic interaction chromatography) are explicitly accounted for. Thi...

Establishment and analysis of the prediction model for cervical squamous cell carcinoma.

This study aimed to construct a prediction model for cervical squamous cell carcinoma and evaluate its accuracy in diagnosing cervical squamous cell carcinoma.


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