PubMed Journals Articles About "French Industry Welcomes Moves Speed Access Innovative Drugs" - Page: 5 RSS

05:10 EST 19th January 2019 | BioPortfolio

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Showing "French Industry Welcomes Moves Speed Access Innovative Drugs" PubMed Articles 101–125 of 12,000+

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer.

Pancreatic cancer is a deadly disease with a very low 5-year patient survival rate of 6-8%. The major challenges of eliminating pancreatic cancer are treatment resistance and stromal barriers to optimal drug access within the tumor. Therefore, effective molecular targeting drugs with high intra-tumor access and retention are urgently needed for managing this devastating disease in the clinic.

Speed but not amplitude of visual feedback exacerbates force variability in older adults.

Magnification of visual feedback (VF) impairs force control in older adults. In this study, we aimed to determine whether the age-associated increase in force variability with magnification of visual feedback is a consequence of increased amplitude or speed of visual feedback. Seventeen young and 18 older adults performed a constant isometric force task with the index finger at 5% of MVC. We manipulated the vertical (force gain) and horizontal (time gain) aspect of the visual feedback so participants perfor...

The influence of gait and speed on the dynamic navicular drop - A cross sectional study on healthy subjects.

Variations of gait speed influence kinematic variables that may have an effect on dynamic foot deformation. The influence of gait speed on the navicular drop has not yet been investigated.

Evaluation of Digital Breast Tomosynthesis as Replacement of Full-Field Digital Mammography Using an In Silico Imaging Trial.

Expensive and lengthy clinical trials can delay regulatory evaluation of innovative technologies, affecting patient access to high-quality medical products. Simulation is increasingly being used in product development but rarely in regulatory applications.

Variations in the breast reconstruction rate in France: A nationwide study of 19,466 patients based on the French medico-administrative database.

Access to breast reconstruction (BR) surgery after a mastectomy remains limited, with a large degree of national and international variation despite its known psychological benefits and impact on quality of life. The aim of this study was to investigate the factors influencing breast reconstruction in France where cancer-related healthcare costs are fully reimbursed.

Prediction of vascular access stenosis: Blood temperature monitoring with the Twister versus static intra-access pressure ratio.

The Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines recommend intra-access flow (Qa) measurement as the preferred vascular access surveillance method over static intra-access pressure ratio (SIAPR). Recently, it has become possible to perform Qa measurement during hemodialysis using thermodilution method called blood temperature monitoring (BTM) with the Twister device. The aim of this study was to investigate the correlation between Qa by BTM and SIAPR and to compare the performance of two te...

Transnational access to large prospective cohorts in Europe: current trends and unmet needs.

Biobank samples and data from studies of large prospective cohorts (LPC) represent an invaluable resource for health research. Efficient sharing and pooling of samples and data is a central pre-requisite for new advances in biomedical science. This requirement, however, is not compatible with the present scattered and traditional access governance structures, where legal and ethical frameworks often form an obstacle for effective sharing. Moreover, the EU General Data Protection Regulation (GDPR) is demandi...

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). II. Drugs in more advanced clinical development.

The Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV) took place in Madrid, Spain, on May 13-16, 2018 and was attended by 168 delegates from 28 countries. The conference provided a forum for professionals involved in basic science, clinical research, regulatory affairs, and clinical care to meet and discuss the latest advances related to discovery and development of drugs and devices aimed at improving the management of people with epilepsy. This progress report provides a summa...

Electric-Field Driven Translocation of ssDNA Through Hydrophobic Nanopores.

The accurate sequencing of DNA using nanopores requires control over the speed of DNA translocation through the pores and also of the DNA conformation. Our studies show that ssDNA translo-cates through hour-glass shaped pores with hydrophobic constriction regions when an electric field is applied. The constriction provides a barrier to translocation and thereby slows down DNA movement through the pore compared to pores without the constriction. We show that ssDNA moves through these hydrophobic pores in an ...

Anaerobic Speed Reserve: A Key Component of Elite Male 800m Running.

In recent years (2011-2016), men's 800m championship running performances have required greater speed than previous eras (2000-2009). The "Anaerobic speed reserve" (ASR) may be a key differentiator of this performance, but profiles of elite 800m runners and its relationship to performance time have yet to be determined.

Investigational small molecules in phase II clinical trials for the treatment of epilepsy: cannabidivarin, selurampanel (BGG492) and ganaxolone.

Epilepsy is a neurological disorder that significantly impacts the quality of life of the affected person and affects approximately 70 million people globally. Despite advances in research, nearly a third of patients have refractory or pharmacoresistant epilepsy. Even though numerous antiepileptic drugs (AEDs) have been approved over the past decade, there are no agents that halt the development of epilepsy. Thus, new and improved AEDs to prevent refractory seizures and modify the disease are necessary. Are...

Percutaneous neonatal carotid access for interventional catheterization.

Neonatal percutaneous carotid access is a safe technique that compares favorably to neonatal surgical carotid access. Mid-term ultrasound and angiographic follow after percutaneous carotid access shows 100% vessel patency rate with no severe stenoses or aneurysms detected. Mild stenosis (

Pancreatic cancer: French clinical practice guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC).

This document is a summary of the French intergroup guidelines regarding the management of pancreatic adenocarcinoma (PA), updated in July 2018.

A Surfactant-Free Direct Access to Porphyrin-Crosslinked Nanogels for Photodynamic and Photothermal Therapy.

Photosensitizing nanogels were obtained through a surfactant free single step protocol by using a porphyrin based crosslinker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photo-induced killing efficiency was tested against three cells lines: human breast adenocarcinoma (MDA-MB-...

Exploring the impacts of speed variances on safety performance of urban elevated expressways using GPS data.

Speed variation on urban expressways has been frequently noted as a key factor associated with high crash risk. However, it was often difficult to capture the safety impact of speed variance with spaced sensor measurements. As an alternative, this paper aims to leverage the use of the floating car data (FCD) to capture the speed variance in a morning rush hour on urban elevated expressways and examine its effect on safety. A semi-automatic filtering process was introduced to distinguish taxi GPS data points...

Integrative literature review: access to primary healthcare services.

Analyze the scientific production that describes the type of access to primary healthcare services and identify specific populations that have differentiated access to health services.

Internal validity of the French version of the Family Coping Questionnaire (FCQ): A confirmatory factor analysis.

Family members of patients with schizophrenia, especially when they assume caregivers' positions, experience difficulties to adapt to the situation. To gain insight into these caregivers' coping style is a challenge to decrease the stress of family members, and in this way, improve patient related outcome. The FCQ (Family Coping Questionnaire) is an adapted clinical assessment tool that focuses on specific ways to cope with dysfunction that characterize the psychotic pathology. The goal of this study was to...

Psychometric Analysis of the SPEED Questionnaire and CLDEQ-8.

This study reports on the ability of the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire to detect dry eye (DE) symptoms in contact lens (CL) and non-CL wearers.

Simulation and experimental study on control strategy of zero-speed fin stabilizer based on disturbance and compensation.

Zero-speed fin stabilizer is applied to reduce the roll motion of ships at zero speed. This paper aims to explore the control strategy of zero-speed fin stabilizer through a composite method of theoretical analysis, simulations and tank tests. The hydrodynamic force model is established using analytical approach and a simplified model is obtained by fitting the CFD simulation data. The control strategy of zero-speed fin stabilizer is obtained based on disturbance and compensation by analyzing the phase matc...

Marin Cureau de La Chambre (1594-1669), a 17th-century pioneer in neuropsychology.

Marin Cureau de La Chambre (1594-1669) was a physician from Le Mans who advised and treated two French Kings, Louis XIII and Louis XIV, as well as his patron, Chancellor Pierre Séguier. As both a physician and a philosopher, he was among the first members of the Académie Française and the Académie des Sciences. His key role in dethroning Latin and using French in its place would have sufficed to ensure his notoriety, as French then became a vehicle for disseminating the sciences throughout Europe. Howev...

Fascial suture technique versus open femoral access for thoracic endovascular aortic repair.

Fascial suture technique (FST) has proved to be a safe and effective access closure technique after endovascular repair of the abdominal aorta. FST has not yet been investigated for closure of large-bore access after thoracic endovascular aortic repair (TEVAR). The aim of this study was to compare FST with open femoral access in terms of access safety, hemostasis efficacy, and reintervention rate after TEVAR.

Simultaneous chiral separation of tramadol and methadone in tablets, human urine, and plasma by capillary electrophoresis using maltodextrin as the chiral selector.

The stereoselective analysis and separation of racemic drugs play an important role in pharmaceutical industry to eliminate the unwanted isomer and find the right therapeutic control for the patient. Present study suggests a maltodextrin-modified capillary electrophoresis method for a single-run chiral separation of two closely similar opiate pain relief drugs: tramadol (TRA) and methadone (MET). The best separation method possible for the both enantiomers was achieved on an uncoated fused-silica capillary ...

The GBA p.Trp378Gly mutation is a probable French-Canadian founder mutation causing Gaucher disease and synucleinopathies.

Biallelic GBA mutations cause Gaucher disease (GD), and heterozygous carriers are at risk for synucleinopathies. No founder GBA mutations in French-Canadians are known. GBA was fully sequenced using targeted next generation and Sanger sequencing in French-Canadian Parkinson disease (PD) patients (n=436), REM-sleep behavior disorder (RBD) patients (n=189) and controls (n=891). Haplotype, identity by descent (IBD) and principal component analyses (PCA) were performed using SNP-chip data. Data on GD patients f...

Prevalence and predictors of penile nodules in French Guiana's sole prison facility.

Penile implants or nodules are objects inserted beneath the skin of the penis mostly for erotic purposes. The procedure is painful and there may be complications. It is often associated with prison. Our objectives were to describe the prevalence of penile nodules among inmates in French Guiana, and to study factors associated with this practice, notably psychiatric diagnoses.

Repurposing old drugs in oncology: Opportunities with clinical and regulatory challenges ahead.

In order to expedite the availability of drugs to treat cancers in a cost-effective manner, repurposing of old drugs for oncological indications is gathering momentum. Revolutionary advances in pharmacology and genomics have demonstrated many old drugs to have activity at novel antioncogenic pharmacological targets. We decided to investigate whether prospective studies support the promises of nonclinical and retrospective clinical studies on repurposing three old drugs, namely metformin, valproate and astem...

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