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PubMed Journals Articles About "GCS Ltd" - Page: 5 RSS

20:01 EDT 20th October 2018 | BioPortfolio

GCS Ltd PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest GCS Ltd articles that have been published worldwide.

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Showing PubMed Articles 101–125 of 1,000,000+

Contact resistance in ambipolar organic field-effect transistors measured by confocal photoluminescence electro-modulation microscopy.

While it is theoretically expected that all organic semiconductors support ambipolar charge transport, most organic transistors either transport holes or electrons effectively. Single-layer ambipolar organic field-effect transistors enable the investigation of the different mechanisms in hole and electron transport in a single device since the device architecture provides a controllable planar pn-junction within the transistor channel. However, a direct comparison of the injection barriers and of the channe...


Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants.

The influenza M2 proton channel is a major drug target, but unfortunately, the acquisition of resistance mutations greatly reduces the functional life-span of a drug in influenza treatment. New M2 inhibitors have been reported that inhibit mutant M2 channels otherwise resistant to the early adamantine-based drugs, but it remains unclear whether and how easy resistance could arise to such inhibitors. We have combined a newly developed proton conduction assay with an established method for selection and scree...

Paving the way for K-ion batteries: role of the electrolyte reactivity through the example of Sb-based electrodes.

Developing potassium-ion batteries remains a challenge so far due to the lack of efficient electrolytes. Moreover, the high reactivity of K metal and the use of half-cells may greatly alter both the electrochemical performance and the solid electrolyte interphase formation. Here, it is showed that, in K metal/Sb half-cells, coulombic efficiency improvement is achieved by the addition of FEC + VC to PC, the replacement of PC by EC:DEC and the replacement of KPF by KFSI. Surprisingly, however, storage of cell...


Maintenance DNA methyltransferase activity in the presence of oxidized forms of 5-methylcytosine: Structural basis for TET-mediated DNA demethylation.

A precise balance of DNA methylation and demethylation is required for epigenetic control of cell identity, development, and growth. DNA methylation marks are introduced by de novo DNA methyltransferases DNMT3a/b and are maintained throughout cell divisions by DNA methyltransferase 1 (DNMT1), which adds methyl groups to hemimethylated CpG dinucleotides generated during DNA replication. Ten Eleven Translocation (TET) dioxygenases oxidize 5-methylcytosine (mC) to 5-hydroxymethylcytosine (hmC), 5-formylcytosin...

Ligand Impact on Monolayer Electrochromic Materials Properties.

In this study, we present a range of efficient highly-durable electrochromic materials that demonstrate excellent redox and lifetime stability, sufficient coloration contrast ratios, and the best in their class electron transfer constants. The materials were formed by anchoring as little as a monolayer of pre-defined iron complexes on a surface-enhanced conductive solid support. The thickness of the substrate was optimized to maximize the change in optical density. We demonstrate that even a slight change i...

A robust proton flux (pHlux) assay for studying function and inhibition of the Influenza A M2 proton channel.

The M2 protein is an important target for drugs in the fight against the influenza virus. Due to the emergence of resistance against antivirals directed towards the M2 proton channel, the search for new drugs against resistant M2 variants is of high importance. Robust and sensitive assays to test potential drug compounds on different M2 variants are valuable tools in this search for new inhibitors. In the present work, we describe a fluorescence-sensor-based assay, which we termed 'pHlux', that measures pro...

Essential Role of Spinel ZnFe2O4 Surfaces during Lithiation.

Spinel zinc ferrite (ZnFe2O4) is a well-known anode material in lithium ion batteries (LIBs) due to its large theoretical capacity. However, the high potentials at the initial stage of lithiation observed cannot be captured using a model of Li+ intercalation into the stoichiometric ZnFe2O4 bulk. Here, using density functional theory (DFT) we report for the first time that the ZnFe2O4 surfaces is responsible for the measured initial potentials. Among the three identified stable surfaces, ZnFeO2-terminated Zn...

Robust and High Spatial Resolution Light Addressable Electrochemistry Using Hematite (α-FeO) Photoanodes.

Light addressable/activated electrochemistry (LAE) has recently attracted attention as it can provide spatially resolved electrochemical information without using pre-patterned electrodes whose sizes and positions are unchangeable. Here, we propose hematite (α-FeO) as the photoanode for LAE, which does not require any sort of surface modification for protection or facilitating charge transfer. As experimentally confirmed with various redox species, hematite is stable enough to be used for repetitive electr...

Multifunctional Epoxy-Based Solid Polymer Electrolytes for Solid-State Supercapacitors.

Solid polymer electrolytes (SPEs) have drawn attention for promising multifunctional electrolytes requiring high mechanical properties and ionic conductivity. To develop a safe SPE for energy storage applications, mechanically robust cross-linked epoxy matrix is combined with fast ion diffusing ionic liquid/lithium salt electrolyte (ILE) via a simple one-pot curing process. The epoxy-rich SPEs show higher Young's modulus (E) with higher glass transition temperature (T), but lower ionic conductivity (σ) wit...

Comparative Pharmacokinetics of High and Low Doses of the Herbicide Propanil in Mice.

We have documented that the herbicide propanil, is immunotoxic in mice and our in vitro tissue culture experiments largely recapitulate the in vivo studies. Laboratory studies on environmental contaminants are the most meaningful when these studies are conducted using concentrations that approximate levels in the environment. Many techniques to measure the distribution and pharmacokinetics (PK) on compounds rely on techniques, such as liquid scintillation counting (LSC) of radio-labeled starting compound re...

Polymer-Based Nanomaterials for Photothermal Therapy: From Light-Responsive to Multifunctional Nanoplatforms for Synergistically Combined Technologies.

Materials for the treatment of cancer have been studied comprehensively over the past few decades. Among the various kinds of biomaterials, polymer-based nanomaterials represent one of the most interesting research directions in nanomedicine, because their controlled synthesis and tailored designs make it possible to obtain nanostructures with biomimetic features and outstanding biocompatibility. Understanding the chemical and physical mechanisms behind the cascading stimuli-responsiveness of "smart" polyme...

Mussel-Inspired and Magnetic Co-Functionalization of Hexagonal Boron Nitride in Polyvinylidene Fluoride Composites Towards Enhanced Thermal and Mechanical Performance for Heat Exchanger.

Thermal conductive polymer composite has grown up to be a hotspot in academic and industrial field recently. Efficient heat transport and superior mechanical properties are both of critical significance for high-performance thermal conductive devices. In this paper, magnetic hexagonal boron nitride (mhBN) with excellent interfacial compatibility is successfully synthesized by dopamine and magnetic co-functionalization, and mhBN-polyvinylidene fluoride (mhBN-PVDF) composites with a combination of high therma...

Identification of the novel capecitabine metabolites in capecitabine-treated patients with hand-foot syndrome.

Hand-foot syndrome (HFS), the most common side effect of capecitabine, is a dose-limiting cutaneous toxicity with only rare therapeutic options. The causative mechanisms of HFS are still unclear. Many studies suggested that capecitabine or its metabolites caused the toxicity. This study is attempting to determine if there are any new metabolites that may be present and be linked to toxicity. For this purpose, 25 patients who ingested capecitabine orally were enrolled and divided into HFS positive and negati...

Distinct differences in structural states of conserved histidines in two related proteins: NMR studies of the chemokines CXCL1 and CXCL8 in the free form and macromolecular complexes.

Hydrogen-bonding and ionic interactions play fundamental roles in macromolecular recognition and function. In contrast to lysines and arginines, how histidines mediate these interactions is less well understood due to the unique properties of its side chain imidazole that include an aromatic ring with two titratable nitrogens, a pKa that can vary significantly, and the ability to exist in three distinct forms: protonated imidazolium and two tautomeric neutral (Nδ1 and Nε2) states. Here, we characterized t...

The formation of aluminium hydroxide-doped surface passivating layers on pyrite for acid rock drainage control.

The aim of this study was to test the performance of a novel method for acid rock drainage (ARD) control through the formation of Al(OH)-doped passivating surface layers on pyrite. At pH 2.0 and 4.0, there was no obvious inhibition of the pyrite oxidation rate on addition of 20 mg L Al (added as AlCl•6HO). In comparison, the pyrite oxidation rate at circum-neutral pH (7.4 ± 0.4) decreased with increasing added Al with ≈98% reduction in long-term (282 days) dissolution rates in the presence of 20 mg L A...

Hemiporphyrazine-Involved Sandwich Dysprosium Double-Decker Single-Ion Magnets.

Both heteroleptic (phthalocyaninato)(hemiporphyrazinato) and homoleptic bis(hemiporphyrazinato) dysprosium double-decker complexes, Dy[H(Hp)] (1) and Dy[H(Pc)(Hp)] (2) (HPc = metal-free phthalocyanine; HHp = metal-free hemiporphyrazine), were designed, synthesized, and structurally characterized. The dysprosium center in both double-deckers are octa-coordinated with a nearly ideal square-antiprismatic coordination geometry, which provides an increased molecular anisotropy for the dysprosium ion and ensures ...

Influence of Structural (Cation and Anion) Order in the Superconducting Properties of Ozone-Oxidized MoCuSrRECuO (RE = Yb, Tm, Gd, Nd, and Pr).

The influence of rare earth (RE) elements on superconducting properties of the transition element (TE)-substituted TE CuSrRECuO cuprates has not been sufficiently emphasized so far. In the case of molibdo-cuprates with the general formula MoCuSrRECuO , all the RE element containing compounds except La, Ce, and Lu can be prepared at room pressure. The influence of the crystal structure on the superconducting properties after ozone oxidation of the present system is reported selecting three groups of RE elem...

Copper-Catalyzed N-Formylation of Amines through Tandem Amination/Hydrolysis/Decarboxylation Reaction of Ethyl Bromodifluoroacetate.

Ethyl bromodifluoroacetate (BrCF2COOEt) was firstly used as the N-formylating reagent in the copper-catalyzed N-formylation of amines. A range of primary, secondary, cyclic arylamines and aliphatic amines underwent the N-formylation smoothly to furnish the N-formamides in moderate to excellent yields.

Thionoesters: A Native Chemical Ligation-Inspired Approach to Cysteine-Triggered HS Donors.

Native chemical ligation (NCL) is a simple, widely used, and powerful synthetic tool to ligate N-terminal cysteine residues and C-terminal α-thioesters via a thermodynamically stable amide bond. Building on this well-established reactivity, as well as advancing our interests in the chemical biology of reactive sulfur species including hydrogen sulfide (HS), we hypothesized that thionoesters, which are constitutional isomers of thioesters, would undergo a similar NCL reaction in the presence of cysteine to ...

Biotransformation of Artemisinin to 14-hydroxydeoxyartemisinin: C-14 hydroxylation by Aspergillus flavus.

The biotransformation of the front-line antimalarial drug, artemisinin (1) by the filamentous fungus Aspergillus flavus MTCC-9167 was investigated. Incubation of compound 1 with A. flavus afforded a new hydroxy derivative (2) along with three known metabolites (3-5). The new compound was characterized as 14-hydroxydeoxyartemisinin (2) by extensive spectroscopic data analysis (IR, 1H, 13C NMR, HSQC, HMBC, COSY, NOESY and HR-ESIMS). The known metabolites were identified as deoxyartemisinin (3), artemisinin G ...

Construction of Fully Substituted 2-Pyridone Derivatives via Four-Component Branched Domino Reaction utilizing Microwave Irradiation.

Microwave irradiation, four-component branched domino reaction of methyl acetoacetate/2,4-pentanedione, diethyl malonate, triethyl orthoformate and amines offering an extremely efficient strategy for the construction of fully substituted 2-pyridone derivatives under sustainable conditions is established. This self-sorting branched domino transformation is proposed to proceed separate through N-nucleophilic addition & imine-enamine tautomerization /condensation reaction generated from enamino ester and dieth...

Discrete and Stereospecific Oligomers Prepared by Sequential and Alternating Single Unit Monomer Insertion.

Natural biopolymers, such as DNA and proteins, have uniform microstructures with defined molecular weight, precise monomer sequence and stereoregularity along the polymer main chain that affords them unique biological functions. To reproduce such structurally perfect polymers and understand the mechanism of specific functions through chemical approaches, researchers have proposed using synthetic polymers as an alternative due to their broad chemical diversity and relatively simple manipulation. Herein, we r...

Ligand Isomerism in Coordination Cages.

Complexation reactions of palladium(II) nitrate with a set of 3-pyridyl appended nonchelating bidentate ligands possessing regioisomeric phenylene-diurea functionalities as spacers were carried out. The ligands utilized in this study are 1,1'-(1,2-phenylene)bis(3-(pyridin-3-yl)urea), L1; 1,1'-(1,3-phenylene)bis(3-(pyridin-3-yl)urea), L2; and 1,1'-(1,4-phenylene)bis(3-(pyridin-3-yl)urea), L3. The complexation reactions of the ligands (L1, L2, and L3) with palladium(II) produced single discrete isomeric cages...

High Volumetric Hydrogen Adsorption in a Porous Anthracene-Decorated Metal-Organic Framework.

We report an unprecedented ligand-based binding domain for D within a porous metal-organic framework (MOF) material as confirmed by neutron powder diffraction studies of D-loaded MFM-132a. A tight pocket of 6 Å diameter is formed by the close packing of three anthracene panels, and it is here rather than the open metal sites where D binds preferentially. As a result, MFM-132a shows exceptional volumetric hydrogen adsorption (52 g L at 60 bar and 77 K) and the highest density of adsorbed H within its pores ...

Addition to "Reactions of Chemically Activated Formic Acid Formed via HĊO + ȮH".


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