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PubMed Journals Articles About "Hall Joins AccessOne Senior Vice President Business Development∨derfield=score∨derval=desc" - Page: 5 RSS

00:20 EDT 19th July 2019 | BioPortfolio

Hall Joins AccessOne Senior Vice President Business Development∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Hall Joins AccessOne Senior Vice President Business Development∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "Hall Joins AccessOne Senior Vice President Business Development" PubMed Articles 101–125 of 19,000+

Efficiency of human olfactory ensheathing cell transplantation into spinal cysts to improve mobility of the hind limbs.

The pathological processes developing after spinal cord injuries often lead to the formation of cysts. Existing surgical and medical methods are insufficient for the treatment of posttraumatic spinal cord cysts. One of the emerging tools is cell therapy. The olfactory ensheathing cells are perspective cells for the cell therapy. Here, we demonstrated that the human olfactory ensheathing cell transplantation is effective in experimental spinal cysts. For our experiments, we selected animals only at the inter...


Rift Valley fever: biology and epidemiology.

Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that was first discovered in Kenya in 1930 and is now endemic throughout multiple African countries and the Arabian Peninsula. RVF virus primarily infects domestic livestock (sheep, goats, cattle) causing high rates of neonatal mortality and abortion, with human infection resulting in a wide variety of clinical outcomes, ranging from self-limiting febrile illness to life-threatening haemorrhagic diatheses, and miscarriage in pregnant women. Since it...

Vocal and locomotor coordination develops in association with arousal state.

In adult animals, movement and vocalizations are coordinated, sometimes facilitating, and at other times inhibiting, each other. What is missing is how these different domains of motor control become coordinated over the course of development. We investigated how postural-locomotor behaviors may influence vocal development, and the role played by physiological arousal during their interactions. Using infant marmoset monkeys, we densely sampled vocal, postural and locomotor behaviors and estimated arousal fl...


CCAT1 promotes triple-negative breast cancer progression by suppressing miR-218/ZFX signaling.

Long non-coding RNAs (lncRNAs) regulate cancer development and progression. Here, we investigated the role of the lncRNA CCAT1 in triple-negative breast cancer (TNBC). CCAT1 expression was higher in TNBC cells than normal breast epithelial cells. Additionally, CCAT1 expression was higher in TNBC patient tumor tissue than adjacent normal breast tissue. Silencing CCAT1 inhibited TNBC cell proliferation, migration, and invasion , and tumor growth and progression . Bioinformatics analysis revealed that microRNA...

Distribution of Pheromone Biosynthesis-Activating Neuropeptide in the Central Nervous System of Plutella xylostella (Lepidoptera: Plutellidae).

Insect neuropeptides in the pyrokinin/pheromone biosynthesis-activating neuropeptide (PBAN) family are actively involved in many essential endocrinal functions and serve as potential targets in the search for novel insect control agents. Here, we dissect the nervous system of larval, pupal, and adult Plutella xylostella (L.) (Lepidoptera: Plutellidae) and describe the ganglion morphology and localization of PBAN during different insect developmental stages. Our results show that the central nervous system (...

A perspective on risk factors for esophageal adenocarcinoma: emphasis on Helicobacter pylori infection.

Gastroesophageal reflux disease (GERD) and the increasing rate of its associated complications, including esophageal adenocarcinoma (EAC), has stimulated a plethora of studies attempting to evaluate provocative and protective factors. Helicobacter pylori (Hp) infection (Hp-I) was initially considered as a beneficial condition in GERD management based on rather limited data. Large-scale regional studies revealed an alternative approach, by suggesting a positive relationship between Hp-I and EAC development. ...

Application of multiple-population viability analysis to evaluate species recovery alternatives.

Population viability analysis (PVA) is a powerful conservation tool, but one that remains unapproachable for many species. This is particularly true for species with multiple, broadly-distributed populations for which collecting suitable data can be challenging. A recently-developed method of multiple population viability analysis (MPVA), however, addresses many limitations of traditional PVA. We build on previous development of MPVA for Lahontan cutthroat trout (LCT), a species listed under the US Endanger...

Pamidronate Administration during Pregnancy and Lactation Induces Temporal Preservation of Maternal Bone Mass in a Mouse Model of Osteogenesis Imperfecta.

During pregnancy and lactation, the maternal skeleton undergoes significant bone loss through increased resorption to provide the necessary calcium supply to the developing fetus and suckling neonate. This period of skeletal vulnerability has not been clearly associated with increased maternal fracture risk, but these physiological conditions can exacerbate an underlying metabolic bone condition like osteogenesis imperfecta. While bisphosphonates are commonly used in post-menopausal women, there are cases w...

Collaborative Network to Take Responsibility for oral AntiCancer Therapy (CONTACT): Study-protocol investigating the impact of a care pathway.

To evaluate the effectiveness, feasibility, meaningfulness and appropriateness of the development and implementation of a transmural care pathway in four hospitals in Flanders to improve self-management support in healthcare professionals and self-management in patients treated with oral anticancer drugs.

Risk stratification in cardiac sarcoidosis: the tricky business of predicting the future.

In an ideal world, primary prevention defibrillators would be placed only in patients who will suffer from life-threatening ventricular arrhythmias in the future. Since electrophysiologists cannot predict the future, we must settle for risk stratification - identifying patients who are at high enough risk of a life-threatening ventricular arrhythmia that the risk of complication from a device and the inconvenience of having one are outweighed by the potential that it will be needed. This article is protecte...

An evaluation of different Cripto-1 antibodies and their variable results.

Cripto-1 is a protein expressed during embryonal development and has been linked to several malignant processes in cancer. Since the discovery of cripto-1 in the late 1980s, it has become a subject of biomarker investigation in several types of cancer which in many cases relies on immunolocalization of cripto-1 using antibodies. Investigating cripto-1 expression and localization in primary glioblastoma cells, we discovered nonspecific binding of cripto-1 antibody to the extracellular matrix Geltrex. A panel...

A multistate model for early decision-making in oncology.

The development of oncology drugs progresses through multiple phases, where after each phase, a decision is made about whether to move a molecule forward. Early phase efficacy decisions are often made on the basis of single-arm studies based on a set of rules to define whether the tumor improves ("responds"), remains stable, or progresses (response evaluation criteria in solid tumors [RECIST]). These decision rules are implicitly assuming some form of surrogacy between tumor response and long-term endpoints...

Key modules and hub genes identified by coexpression network analysis for revealing novel biomarkers for larynx squamous cell carcinoma.

Larynx squamous cell carcinoma (LSCC) is the second most aggressive head and neck squamous cell carcinoma. Numerous genes have been identified to be aberrantly expressed during the development of LSCC. However, currently, researchers focus more on the individual molecule and downstream genes, leaving the coexpression among genes and key upstream disease driver genes unexploited. In this study, we applied weighted gene coexpression analysis (WGCNA) to decipher potential hub genes driving the development of L...

A recurrent missense mutation in the EDAR gene causes severe autosomal recessive hypohidrotic ectodermal dysplasia in two consanguineous Kashmiri families.

Hypohidrotic ectodermal dysplasia (HED) is a rare congenital disorder arising from the abnormal development of ectoderm derived structures including skin, hair, nails, teeth and glands. These patients have sparse hair on the whole body including scalp and hypoplastic teeth. They have no resistance to heat due to abnormal sweat glands. A total number of four genes namely ectodysplasin A (EDA), ectodysplasin A receptor (EDAR), EDAR-associated death domain protein (EDARADD) and Wnt family member 10A (WNT10A) a...

Physiological polyspermy: Selection of a sperm nucleus for the development of diploid genomes in amphibians.

The union between a sperm and an egg nucleus in egg fertilization is necessary to mix genetic materials to create a new diploid genome for the next generation. In most animals, only one sperm is incorporated into the egg (monospermy), but several animals exhibit physiological polyspermy in which several sperms enter the egg during normal fertilization. However, only one sperm nucleus forms the zygote nucleus with the egg nucleus, even in a polyspermic egg. The cellular and molecular mechanisms involved in t...

Influences of potential oil and gas development and future climate on Sage-grouse declines and redistribution.

Multiple environmental stressors impact wildlife populations, but we often know little about their cumulative and combined influences on population outcomes. We generally know more about past effects than potential future impacts, and direct influences such as changes of habitat footprints than indirect, long-term responses in behavior, distribution, or abundance. Yet, an understanding of all these components is needed to plan for future landscapes that include human activities and wildlife. We developed a ...

Climate change alters elevational phenology patterns of the European spruce bark beetle (Ips typographus).

The European spruce bark beetle Ips typographus is the most important insect pest in Central European forests. Under climate change, its phenology is presumed to be changing and mass infestations becoming more likely. While several studies have investigated climate effects across a latitudinal gradient, it remains an open question how phenology will change depending on elevation and topology. Knowing how an altered climate is likely to affect bark beetle populations, particularly across diverse topographies...

A unifying review of polymer networks: from rubbers and gels to porous frameworks.

Polymer networks, which are materials comprised of many smaller components -referred to as "junctions" and "strands"- that are connected together via covalent or non-covalent/supramolecular interactions, are arguably the most versatile, widely studied, broadly used, and important materials known. From the very first commercial polymers through the plastics revolution of the 20th century to today, there are almost no aspects of modern life that are not impacted by polymer networks. Nevertheless, there are st...

Fluorinated Photovoltaic Materials for High-Performance Organic Solar Cells.

Over the past decade, organic solar cells (OSCs) have achieved a dramatic boost from ~6% to over 16% in their power conversion efficiencies. In addition to the development in device engineering, the innovation of photovoltaic materials, especially fluorinated donors and acceptors, has become the dominant factor for the progress of device performance. This minireview highlights the fluorinated photovoltaic materials that enable efficient OSCs. The impressive OSCs have been obtained by developing some importa...

New antimicrobials targeting bacterial RNA polymerase holoenzyme assembly identified with an BRET-based discovery platform.

Bacterial resistance represents a major health threat worldwide and the development of new therapeutics, including innovative antibiotics, is urgently needed. We describe a discovery platform, centered on screening and Bioluminescence Resonance Energy Transfer in yeast cells, for the identification of new antimicrobials that by targeting the protein-protein interaction between the β'-subunit and the initiation factor σ of bacterial RNA polymerase, inhibit holoenzyme assembly and promoter-specific transc...

Tunable Magnetic Transition to a Singlet Ground State in a 2D Van der Waals Layered Trimerized Kagomé Magnet.

Incorporating magnetism into two dimensional (2D) van der Waals (VdW) heterostrutures is crucial for the development of new electronic and magnetic devices. Here we show that Nb3X8 (X = Cl, Br) is a family of 2D layered trimerized kagomé magnets that are paramagnetic at high temperatures and undergo a first order phase transition on cooling to a singlet magnetic state. X-ray diffraction shows that a rearrangement of the VdW stacking accompanies the magnetic transition, with high and low temperature phases ...

The Path of Gallium from Chemical Bath into ZnO Nanowires: Mechanisms of Formation and Incorporation.

ZnO nanowires grown by chemical bath deposition (CBD) are of high interest, but their doping with extrinsic elements including gallium in aqueous solution is still challenging despite its primary importance for transparent electrodes and electronics, and for mid-infrared plasmonics. We elucidate the formation mechanisms of ZnO nanowires by CBD using zinc nitrate and hexamethylenetetramine as standard chemical precursors, as well as gallium nitrate and ammonia as chemical additives. A complete growth diagram...

Growth and fatty acid metabolism of Aphis gossypii parasitized by the parasitic wasp Lysiphlebia japonica.

Parasitism usually causes considerable changes in lipids and fatty acids by redirecting the development of the host. In this study, changes in weight and in free fatty acid content of cotton aphids were recorded after aphids had been parasitized. Results showed that the weight of parasitized A. gossypii were increased compared to non-parasitized aphids and significantly increased weights were detected at 1, 2 and 3 instars after parasitization by L. japonica. than non-parasitized aphids. Free fatty acid tes...

Spin-Hall Topological Hall Effect in Highly Tunable Pt/Ferrimagnetic-Insulator Bilayers.

Electrical detection of topological magnetic textures such as skyrmions is currently limited to conducting materials. While magnetic insulators offer key advantages for skyrmion technologies with high speed and low loss, they have not yet been explored electrically. Here, we report a prominent topological Hall effect in Pt/TmFeO bilayers, where the pristine TmFeO epitaxial films down to 1.25 unit cell thickness allow for tuning of topological Hall stability over a broad range from 200 to 465 K through atomi...

In Silico Re-Optimization of Binding Affinity and Drug-Resistance Circumvention Ability in Kinase Inhibitors:Case study with RL-45 and Src kinase.

A major bottle neck in the development of kinase inhibitors has been the onset of drug resistance around the gate-keeper residues of Src kinase. Although recent time has seen the reports of certain second generation kinase inhibitors which are capable of bypassing the drug resistance by circumventing kinase mutation, their kinase binding efficacy has remained considerably weaker than the classical ATP-competitive kinase inhibitors. Using a recently synthesized second generation kinase inhibitor RL-45 as a t...


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