PubMed Journals Articles About "Newer Therapies Superior Injectables Children" - Page: 5 RSS

13:27 EST 15th November 2019 | BioPortfolio

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Showing "Newer Therapies Superior Injectables Children" PubMed Articles 101–125 of 12,000+

Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature.

Midkine (MDK), one of the heparin-binding growth factors, is highly expressed in multiple organs during embryogenesis. Plasma concentrations have been reported to be elevated in patients with a variety of malignancies, in adults with obesity, and in children with short stature, diabetes, and obesity. However, the concentrations in healthy children and their relationships to age, nutrition, and linear growth have not been well studied.

Targeted Therapies for the Treatment of Glioblastoma in Adults.

Targeted therapies are part of biomarker-driven strategies that exploit actionable molecular targets and have gained traction following survival benefits demonstrated in various systemic malignancies. In glioblastoma, where therapeutic options remain scarce and prognosis poor, targeted therapies offer an attractive treatment alternative and are actively examined in clinical trials. In this review, we summarize the targeted therapies, including traditional small molecule inhibitors and monoclonal antibodies ...

Indicators of Risk for Dental Caries in Children: A Holistic Approach.

Dental caries in children is a major public health problem worldwide, with a multitude of determinants acting upon children to different degrees in different communities. The objective of this study was to determine maternal, environmental, and intraoral indicators of dental caries experience in a sample of 6- to 7-y-old children in South East Queensland, Australia.

The subjective well-being of children in kinship care.

Studying the subjective well-being (SWB) of children in out-of-home care is becoming important. However, there is a lack of results on the subjective well-being of children in kinship care. The aim of this study was to analyse and compare the subjective well-being of children at the age of 12 years old in kinship and residential care and in the general population, taking into account gender differences.

Asthma in children with sickle cell disease.

Asthma is common in children with sickle cell disease (SCD) and appears to be associated with increased morbidity. Providers caring for children with SCD have struggled with the question of whether asthma exists as a true comorbidity or whether certain aspects of the chronic inflammatory disease gives children with SCD an asthma-like phenotype.

Toxoplasmosis Seroprevalence in Romanian Children.

The seroprevalence of in Romanian children is currently unknown. A serological survey was undertaken to determine infection among children from Western Romania. Serum samples of 441 children (aged 1-18 years) were screened for immunoglobulin G and immunoglobulin M antibodies. The overall seroprevalence was 16.6% and tended to increase with age. Seroprevalence was 18.4% in children from rural regions and 14.7% in those from urban regions. antibodies were demonstrated in 19.5% of females and 13.3% of mal...

Relationship between dietary patterns and stunting in preschool children: a cohort analysis from Kwale, Kenya.

Stunting is a significant cause of poor cognitive performance and lower school achievement. Stunting is observed among pre-school children in several areas in Africa; however, not all children are affected, and children with and without stunting are seen in the same communities. Therefore, this study aimed to identify nutritional and other factors that prevent stunting that may exist in local communities.

Australian Aboriginal children have higher hospitalization rates for otitis media but lower surgical procedures than non-Aboriginal children: A record linkage population-based cohort study.

Otitis media (OM) is one of the most common infectious diseases affecting children globally and the most common reason for antibiotic prescription and paediatric surgery. Australian Aboriginal children have higher rates of OM than non-Aboriginal children; however, there are no data comparing OM hospitalization rates between them at the population level. We report temporal trends for OM hospitalizations and in-hospital tympanostomy tube insertion (TTI) in a cohort of 469,589 Western Australian children born ...

Is there evidence of benefits associated with dancing in children and adults with cerebral palsy? A scoping review.

Cerebral palsy is a neurological disorder not only affecting motor functions but also cognitive and psychosocial dimension. Multispecialty therapies are needed to address these dimensions. Dance practice provides multidimensional benefits for people with various neurological disorders and may present a real potential for people with cerebral palsy. A scoping review is conducted to evaluate the impact of dance in children and adults with cerebral palsy, based on the Human Development Model-Disability Creatio...

Liver Ultrasound Patterns in Children with Cystic Fibrosis Correlate with Non-Invasive Tests of Liver Disease.

Early identification of children with cystic fibrosis (CF) at risk for severe liver disease (CFLD) would enable targeted study of preventative therapies. There is no gold standard test for CFLD. Ultrasonography (US) is used to identify CFLD, but with concerns for its diagnostic accuracy. We aim to determine if differences in standard blood tests, imaging variables and non-invasive liver fibrosis indices correlate with liver US patterns and thus provide supportive evidence that a heterogeneous US liver patte...

Assessment of anxiety in children and adolescents: A comparative study on the validity and reliability of the Spence Children's Anxiety Scale in children and adolescents with anxiety and Autism Spectrum Disorder.

The present study assessed the utility of the Spence Children's Anxiety Scale - Parent Form (SCAS-P) across parents of children with (i) anxiety and (ii) Autism Spectrum Disorder (ASD).

Congenital superior mesenteric artery aneurysm in a 6-week-old infant presenting with upper gastrointestinal bleeding.

Visceral artery aneurysms are rare in infants and children. The majority of cases are caused by genetic syndromes, trauma, or infection. Although the majority of aneurysms are asymptomatic, visceral artery aneurysms can present with abdominal pain, nausea/vomiting, or rupture. Aneurysm rupture can manifest as hemodynamic instability and/or gastrointestinal bleeding. We present the case of a congenital idiopathic aneurysm of the superior mesenteric artery in a 6-week-old infant who presented with gastrointes...

Perceived access to resources and young children's fairness judgments.

This study examined how young children's (N = 101, M = 4.14 years, SD = 0.57) perceptions of their families' access to resources affect their views on others' use and distribution of familiar items. Using a simple measure involving stickers, children identified their families as either lower, higher, or in the middle in access to resources. Then, children evaluated a scenario in which an individual took crayons from one person and gave them to another in order to establish equality. Children w...

Changes in the utilization patterns of antifungal agents, medical cost and clinical outcomes of candidemia from the health-care benefit expansion to include newer antifungal agents.

In 2014, South Korea expanded its national health insurance coverage to include newer antifungal agents, such as echinocandins. This study aimed to investigate the effects of policy change on the prescription patterns of antifungals, medical costs and clinical outcomes of candidemia.

Skin color as a predictor of mental health in young Latinx children.

Racial phenotype shapes the ways in which others perceive and interact with children, with implications for their immediate and long-term well-being. Still, few empirical studies have examined these links in Latinx children.

Prospective randomized comparison of early versus newer-generation vertebral access devices for kyphoplasty.

Kyphoplasty is an established method of treating osteoporotic vertebral body compression fractures. In recent years, several techniques to enhance the efficiency and outcomes of this surgery have been developed and implemented in clinical practice. In the present study, we assess the impact of two new access instruments on overall operation time and the administered dose area product in comparison with the standard access instrument used in our clinical practice. The two newer comparator devices have been d...

Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast.

The relationship between the cellular immune response during Trichuris trichiura infection and asthma has not yet been established. In this study, the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17A were evaluated in asthmatic children harboring T. trichiura. For this assessment, asthmatic and non-asthmatic children (ISAAC questionnaire) were submitted to parasitological tests and blood samples were cultured (mitogen stimulation) for cytokine measurements in the supernatant. Ast...

Effects of dual tasking on postural and gait performances in children with cerebral palsy and healthy children.

Simultaneous execution of motor and cognitive tasks is embedded in the daily life of children. 53 children of 7-12 years and 22 adults (study 1), 20 healthy children and 20 children of 7-12 years with cerebral palsy (study 2) performed a Stroop-animal task simultaneously with a standing or a walking task in order to determine the attentional demand of postural control and locomotion. Dual-task cost decreased with advancing age in healthy children during balance. CP and healthy children were similarly affect...

Incompetent lip seal affects the form of facial soft tissue in preschool children.

: To examine whether incompetent lip seal (ILS) influences the form of facial soft tissue. : Four hundred forty-four preschool children 3-5 years of age were selected. The images of the subjects' facial surface were obtained with a three-dimensional laser scanner. Coordinates of 16 facial landmarks were established and identified on the three-dimensional facial images, and the differences between children with (wILS) and without ILS (woILS) were measured. : The angle of sagittal facial convexity, excluding...

Novel approaches to the management of chronic systolic heart failure: future directions and unanswered questions.

Despite improvements in outcomes in the last few decades for heart failure (HF) with reduced ejection fraction (HFrEF), there still remains a need for novel therapies as many patients incompletely recover with existing therapies and progress to advanced HF. In this review, we will discuss recent advances in the management of HFrEF with a focus on upcoming therapies that hold the greatest promise for clinical use. We will discuss novel pharmacological therapies and areas of uncertainty with existing therapie...

Epileptiform EEG discharges and sevoflurane in children: Protocol of a systematic review and meta-analysis.

Epileptiform discharges in electroencephalogram (EEG) have been frequently reported in children undergoing sevoflurane mask induction. However, the incidence, characteristics and risk factors of these epileptiform patterns during sevoflurane anesthesia in children are poorly understood. The aim of this study is to systematically review the epileptic potential of sevoflurane in children with the EEG monitoring.

The Promise of Long-Acting Antiretroviral Therapies: From Need to Manufacture.

Antiretroviral therapy has transformed human immunodeficiency virus infections from certain death to a manageable chronic disease. Achieving strict adherence to drug regimens that limit toxicities and viral resistance is an achievable goal. Success is defined by halting viral transmission and by continuous viral restriction. A step towards improving treatment outcomes is in long-acting antiretrovirals. While early results remain encouraging there remain opportunities for improvement. These rest, in part, on...

Newer-Generation Antidepressants and Suicide Risk.

Compression Therapy in Patients with Leg Ulcers - which Costs do Really Occur?

 Patients with leg ulcers often have severe edema of the lower extremities, which should be treated as part of a successful wound treatment. Today in Germany the necessary compression therapies are often performed with very error-prone and time-consuming short-stretch bandages only. Multicomponent systems, adaptive compression bandages and leg ulcer stocking systems are newer, much less error-prone treatment options. In addition to the often lacking knowledge, the fears of high costs are also mentioned as...

An In-Depth Analysis of Expository Writing in Children With and Without Autism Spectrum Disorder.

Using detailed linguistic analysis, this study examined the expository writing abilities of school-age children with autism spectrum disorder (ASD) in comparison to neurotypical (NT) children. Associations between executive functioning (EF) and writing ability in children with and without ASD were also explored. Compared to NT peers, children with ASD wrote shorter expository texts that contained more grammatical errors, and needed more assistance from the experimenter to complete the writing assessment. Ho...

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