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PubMed Journals Articles About "Nivolumab With Ipilimumab Combination Added Benefit Advanced Renal∨derfield=score∨derval=desc" - Page: 5 RSS

02:46 EDT 19th July 2019 | BioPortfolio

Nivolumab With Ipilimumab Combination Added Benefit Advanced Renal∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Nivolumab With Ipilimumab Combination Added Benefit Advanced Renal∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "Nivolumab with ipilimumab Combination added benefit advanced renal" PubMed Articles 101–125 of 10,000+

Erythropoietin improves cardiovascular function in adult rats after acute hemorrhage.

Erythropoietin (EPO) has been linked to cardioprotective effects. However, its effects during the aging process are little known. We investigated the effect of EPO administration on hemodynamic parameters, cardiac function, oxidative damage, and EPO receptor (EPOR) expression pattern in hypovolemic state. EPO was administered (1000 IU/kg/3 days) and then acute hemorrhage (20% blood loss) was induced in young and adult rats. There was no difference in plasmatic EPO in either age group. Hemodynamic basal cond...


Development of a predictive score for potentially avoidable hospital readmissions for general internal medicine patients.

Identifying patients at high risk of hospital preventable readmission is an essential step towards selecting those who might benefit from specific transitional interventions.

Combination of red blood cell distribution width and body mass index (COR-BMI) predicts in-hospital mortality in patients with different diagnoses?

The combination of red blood cell distribution width and body mass index (COR-BMI) is indicated as a new prognostic index of survival in patients with laryngeal cancer. However, the ability of this prediction in other types of cancer or whether its use can be expanded to non-oncological patients is unknown. The aim of this study was to investigate the prediction of prognosis of in-hospital mortality of the COR-BMI in oncological and non-oncological patients.


A Self-supervised Strategy for Fully Automatic Segmentation of Renal DCE-MR Images.

An automated accurate segmentation for dynamic contrast-enhanced magnetic resonance (DCE-MR) image sequences is essential for quantification of renal function. A self-supervised strategy is proposed for fully automatic segmentation of the renal DCE-MR images without using manually labeled data.

Effect of magnesium sulphate added to lidocaine on inferior alveolar nerve block success in patients with symptoms of irreversible pulpitis: a prospective, randomized clinical trial.

To investigate the effect of magnesium sulphate used as an adjuvant to lidocaine with epinephrine local anaesthetic on the success of inferior alveolar nerve blocks (IANB) in patients with irreversible pulpitis undergoing root canal treatment.

Reactive oxygen species and reactive carbonyl species constitute a feed-forward loop in the auxin signaling for lateral root formation.

In auxin-stimulated roots, production of reactive oxygen species (ROS) via the hormone-induced activation of respiratory burst oxidase homologous NADPH oxidases facilitates lateral root (LR) formation. In this study, in order to verify that ROS can modulate auxin signaling, we examined the involvement of the lipid peroxide-derived agents known as reactive carbonyl species (RCS) in LR formation. When auxin was added to Arabidopsis thaliana roots, the levels of RCS, e.g., acrolein, 4-hydroxynonenal and croton...

Transplantation of Kidneys From Hepatitis C Infected Donors To Hepatitis C Negative Recipients: Single Center Experience.

Our aim was to evaluate the safety of transplanting kidneys from HCV infected donors in HCV uninfected recipients. Data collected from 53 recipients in a single center, observational study included donor and recipient characteristics, liver and kidney graft function, new infections and de novo donor specific antibodies and renal histology. Treatment with a direct-acting antiviral regimen(DAA) regimen was initiated when HCV-RNA was detected. The mean±SD age of recipients was 53±11 years, 34% were female, 1...

Oligodendrocyte Precursors Gain Schwann Cell-Like Phenotype and Remyelinate Axons Upon Engraftment into Peripheral Nerves.

The ability to treat large peripheral nerve injuries may be greatly advanced if an accessible source of human myelinating cells is identified, as it overcomes one of the major limitations of acellular or synthetic nerve guides compared to autografts, the gold standard for large defect repair. Methods to derive oligodendrocyte precursor cells (OPCs) from human pluripotent stem cells have advanced to the point where they have been shown capable of myelination and are being evaluated in clinical trials. Here w...

Transplantation of Aggregates of Autologous Synovial Mesenchymal Stem Cells for Treatment of Cartilage Defects in the Femoral Condyle and the Femoral Groove in Microminipigs.

Previous work has demonstrated that patients with cartilage defects of the knee benefit from arthroscopic transplantation of autologous synovial mesenchymal stem cells (MSCs) in terms of magnetic resonance imaging (MRI), qualitative histologic findings, and Lysholm score. However, the effectiveness was limited by the number of cells obtained, so large-sized defects (>500 mm) were not investigated. The use of MSC aggregates may enable treatment of larger defects by increasing the number of MSCs adhering to t...

Hydrogel spacer for borderline resectable and locally advanced pancreatic cancer: a feasibility human study.

Ligand Binding Site Structure Shapes Folding, Assembly and Degradation of Homomeric Protein Complexes.

Ligand binding site structure has profound consequences for the evolution of function of protein complexes, particularly in homomers - complexes comprised of multiple copies of the same protein. Previously we have shown that homomers with multichain binding sites (MBS) are characterized by more conserved binding sites and quaternary structure, and qualitatively different allosteric pathways than homomers with single-chain binding sites (SBS) or monomers. Here, using computational methods, we show that the f...

Anti-PD-1 Blockade with Nivolumab with and without Therapeutic Vaccination for Virally Suppressed Chronic Hepatitis B: A Pilot Study.

To evaluate the hypothesis that increasing T-cell frequency and activity may provide durable control of hepatitis B virus (HBV), we administered nivolumab, a PD-1 inhibitor, with or without GS-4774, an HBV therapeutic vaccine, in virally-suppressed patients with HBeAg negative chronic HBV.

Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity.

Oleanolic acid (OA) is a natural triterpenoid that possesses numerous beneficial health effects such as antioxidant, anti-inflammatory and anti-apoptotic activities. In this study, we investigated the therapeutic effect of OA (10 and 40 mg/kg) on cisplatin (CP)-induced (13 mg/kg) nephrotoxicity. Treatment with OA 40 mg/kg once daily for 2 days, 48 h after CP-intoxication, ameliorated the increased serum markers and histological features of kidney injury. CP administration increased renal expression ...

Expression and characterisation of feruloyl esterases from Lactobacillus fermentum JN248 and release of ferulic acid from wheat bran.

Genes encoding six feruloyl esterases (FAEs; lbff0997, lbff0272, lbff1432, lbff1695, lbff1849, lbff0153) from Lactobacillus fermentum JN248 were cloned, overexpressed and characterised. Maximum enzyme activity was observed at 35 °C for recombinant FAEs LFFae0997, LFFae0272 and LFFae0153, at 30 °C for LFFae1695, and at 40 °C for LFFae1432and LFFae1849. For five of the enzymes, optimal activity was observed at pH 7.0 or pH 8.0, and high thermostability was measured up to 55 °C. By contrast, LF...

Targeted intervention to improve the quality of head and neck radiotherapy treatment planning in the Netherlands: short and long-term impact.

To benchmark and improve, through means of a targeted intervention, the quality of intensity modulated radiotherapy treatment planning for locally-advanced head-and-neck cancer (HNC) in the Netherlands. The short and long-term impact of this intervention was assessed.

3D h9e peptide hydrogel: An advanced three-dimensional cell culture system for anticancer prescreening of chemopreventive phenolic agents.

Traditional 2D monolayer cell culture model may overestimate chemopreventive agent's response due to lacking physiological relevance in three-dimensional microenvironment. This study was aimed to apply a novel 3D h9e peptide hydrogel cell culture system to evaluate the anticancer efficacy of chemopreventive phenolic acid on hepatocarcinoma HepG2 and colon adenocarcinoma SW480 cells. Both cell lines grew better in this 3D system with better cell growth and longer exponential phase than that in 2D model. Chlo...

Pharmacological antagonism of histamine H2R ameliorated L-DOPA-induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD.

Parkinson's disease (PD) is often managed with L-3,4-dihydroxyphenylalanine (L-DOPA), which is still the gold standard to relieve the clinical motor symptoms of PD. However, chronic use of L-DOPA leads to significant motor complications, especially L-DOPA-induced dyskinesia (LID), which limit the therapeutic benefit. Few options are available for the pharmacological management of LID partly due to the inadequacy of our mechanistic understanding of the syndrome. We focused on the role of the histamine (HA) H...

Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Traditional chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC is highly chemo-resistant. Sorafenib is an oral multikinase inhibitor that can suppress tumor cell proliferation, angiogenesis and induce cancer cell apoptosis. However, the poor solubility, rapid metabolism and low bioavailability of sorafenib greatly restricted its further clinical application. During the past decade, numerous sora...

A review of graphene-based nanomaterials for removal of antibiotics from aqueous environments.

Antibiotics as emerging pharmaceutical pollutants have seriously not only threatened human life and animal health security, but also caused environmental pollution. It has drawn enormous attention and research interests in the study of antibiotics removal from aqueous environments. Graphene, an interesting one-atom-thick, 2D single-layer carbon sheet with sp hybridized carbon atoms, has become an important agent for removal of antibiotic, owing to its unique physiochemical properties. Recently, a variety of...

Hierarchically designed bone scaffolds: From internal cues to external stimuli.

Bone tissue engineering utilizes three critical elements - cells, scaffolds, and bioactive factors - to recapitulate the bone tissue microenvironment, inducing the formation of new bone. Recent advances in materials development have enabled the production of scaffolds that more effectively mimic the hierarchical features of bone matrix, ranging from molecular composition to nano/micro-scale biochemical and physical features. This review summarizes recent advances within the field in utilizing these features...

A biodegradable poly(amido amine) based on the antimicrobial polymer polyhexamethylene biguanide for efficient and safe gene delivery.

Inspired by the excellent membrane affinity of antimicrobial polymers, we synthesized a novel biodegradable poly(amino amine) polymer with pendent side chains that mimic the widely used biocide polyhexamethylene biguanide (PHMB) for gene delivery. Michael addition polymerization was utilized to form the polymer scaffold between N,N'-cystaminebisacrylamide (CBA) and N-Boc-1,6-diaminohexane (Boc-DAH) followed by N-Boc deprotection. Then the exposed primary amino groups were partly (about 75%) transformed into...

Red gypsum utilization and acidic wastewater treatment based on metal self-enrichment process.

The massive accumulation of red gypsum has brought great harm to human and environment. In order to achieve low-cost and high-benefit resource utilization of red gypsum, a method of metal self-enrichment during the cycle and transformation of red gypsum was proposed. The carbon dioxide and ammonia water react with red gypsum to manufacture ammonium sulfate and solid phase products. And solid phase products neutralize pickling wastewater to produce metal-enriched red gypsum for the next cycle. After the cycl...

Terpyridine-based complex nanofibers with Eu as a highly selective chemical probes for UO.

Uranyl is a radioactive, toxic pollutant commonly found in the waste remaining after nuclear fuel reprocessing, and it poses several types of risks to human health; therefore, developing absorbents and chemical probes for this compound is crucial to overcoming these issues. This study examined the sensing abilities of terpyridine-appended benzenetricarboxyamide (T-BTA) as a chromogenic probe for detecting uranyl ions (UO). The complex with Eu (1-Eu) spontaneously formed nanostructured fibers in HO owing to ...

A novel process for the mixotrophic production of lutein with Chlorella sorokiniana MB-1-M12 using aquaculture wastewater.

In this study, microalgal cultivation was applied as a feasible strategy for treating shrimp culture wastewater (SCW) from a shrimp farm in southern Tainan. Chlorella sorokiniana MB-1-M12 was first grown on BG-11 medium with 0.5% salinity, obtaining a biomass concentration and productivity of 4.35 g/L and 1.56 g/L/d, respectively. When 80% of BG-11 nutrients were added to 75% strength SCW, lutein content and productivity increased to 5.19 mg/g and 5.55 mg/L/d, respectively. A novel operation strateg...

Reactivity of chromophoric dissolved organic matter (CDOM) to sulfate radicals: Reaction kinetics and structural transformation.

Sulfate radical (SO) has been extensively studied as a promising alternative in advanced oxidation processes (AOPs) for water treatment. However, little is known about its reactivity to the ubiquitous dissolved organic matter (DOM) in water bodies. SO would selectively react with electron rich moieties in DOM, known as chromophoric DOM (CDOM), due to its light absorbing property. In this study, the reactivity and typical structural transformation of CDOM with SO was investigated. Four well characterized hyd...


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