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PubMed Journals Articles About "Prominent Animal Cloning Researcher Sentenced Years Prison" - Page: 5 RSS

00:33 EDT 1st April 2020 | BioPortfolio

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Showing "Prominent animal cloning researcher sentenced years prison" PubMed Articles 101–125 of 17,000+

Plant-based and animal-based low-carbohydrate diets and risk of hepatocellular carcinoma among US men and women.

Little is known about the role of low-carbohydrate diets (LCDs) in the development of hepatocellular carcinoma (HCC). We prospectively evaluated the associations between plant-based and animal-based LCDs and risk of HCC in the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Dietary intake was assessed every 4 years using validated food frequency questionnaires. Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (...


Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres.

Non-publication and publication bias in animal research is a core topic in current debates on the "reproducibility crisis" and "failure rates in clinical research". To date, however, we lack reliable evidence on the extent of non-publication in animal research. We collected a random and stratified sample (n = 210) from all archived animal study protocols of two major German UMCs (university medical centres) and tracked their results publication. The overall publication rate was 67%. Excluding doctoral these...

Bacteriological diagnosis of tuberculosis in prison inmates: actions taken by the primary health care teams in prisons.


Novel approaches for the delivery of therapeutics in ischemic stroke.

Ischemic stroke, a prominent cause of mortality and disability, is a combination of neuronal and vascular disorders. Reperfusion techniques, such as administration of tissue-plasminogen activator (t-PA) and endovascular mechanical thrombectomy, are commonly used treatment approaches. In recent years, interest has focused on saving the salvageable penumbra using neuroprotective strategies to improve long-term stroke outcomes. However, insufficient drug delivery to the ischemic brain, especially to penumbra, ...

Evaluation of cephalometric lip morphology in a Saudi sub population: A cross sectional study.

This cross-sectional study was done to evaluate linear and angular measurement of lip morphology in Saudi adults and their comparison with the norms. After taking their history and physical examination, the patients were referred for a lateral Cephalograph using Dolphin Imaging Software. Linear and angular measurements related to lip morphology were recorded. Significant differences were found in the lower lip to E line, upper and lower lip protrusion, upper and lower lip to S line and upper and lower lip t...

The Bard Prison Initiative: Education, Incarceration, and Public Health.

Construction of E. coli-Mycobacterium shuttle vectors with a variety of expression systems and polypeptide tags for gene expression in mycobacteria.

Cloning and expression of a desired gene is indispensable in molecular biology studies. Expression vectors, in this regard, should offer much needed flexibility and choice of cloning strategies for both in vivo and in vitro protein expression experiments. Furthermore, availability of option to choose from various reporter tags allows one to be flexible during designing of an experiment in a more relevant manner. Thus, the need of a versatile expression system cannot be ignored. Although several different ex...

Ship noise inhibits colour change, camouflage, and anti-predator behaviour in shore crabs.

Ship noise is a prominent source of underwater sound pollution. Carter et al. demonstrate that ship noise has multiple negative effects on animal traits that do not primarily rely on acoustics. In shore crabs, color change to improve camouflage and predator escape responses are adversely affected by ship noise but not by equally loud ambient noise.

Cloning of pAhX22, a small cryptic plasmid from Aeromonas hydrophila, and construction of a pAhX22-derived shuttle vector.

In this study, a cryptic plasmid from Aeromonas hydrophila (pAhX22) was cloned and characterized. pAhX22 was 2523 bp long, had a GC content of 59.9%, and contained two putative open reading frames (ORFs). orf1 and orf2 encoded putative proteins of 458 amino acids and 88 amino acids, respectively; these putative proteins might be involved in plasmid replication. An Escherichia coli-A. hydrophila shuttle vector, pAEsv-1 (4587 bp, Kan), was constructed using in-fusion cloning, combining pAhX22 with the kan...

Estimating the size distribution of plastics ingested by animals.

The ingestion of plastics appears to be widespread throughout the animal kingdom with risks to individuals, ecosystems and human health. Despite growing information on the location, abundance and size distribution of plastics in the environment, it cannot be assumed that any given animal will ingest all sizes of plastic encountered. Here, we use published data to develop an allometric relationship between plastic consumption and animal size to estimate the size distribution of plastics feasibly ingested by ...

Beyond a Good Head and a Good Heart for Prison Health.

Recidivism rates in individuals receiving community sentences: A systematic review.

We aimed to systematically review recidivism rates in individuals given community sentences internationally. We sought to explore sources of variation between these rates and how reporting practices may limit their comparability across jurisdictions. Finally, we aimed to adapt previously published guidelines on recidivism reporting to include community sentenced populations.

Microbial production and biotechnological applications of α-galactosidase.

α-Galactosidase, (E.C. 3.2.1.22) is an exoglycosidase that target galactooligosaccharides such as raffinose, melibiose, stachyose and branched polysaccharides like galactomannans and galacto- glucomannans by catalysing the hydrolysis of α-1,6 linked terminal galactose residues. The enzyme has been isolated and characterized from microbial, plant and animal sources. This ubiquitous enzyme possesses physiological significance and immense industrial potential. Optimization of the growth conditions and effici...

In vitro model for the assessment of human immune responses to subunit RSV vaccines.

Respiratory syncytial virus (RSV) is the single most important cause of serious lower respiratory tract disease in infants and young children worldwide and a high priority for vaccine development. Despite over 50 years of research, however, no vaccine is yet available. One block to vaccine development is an incomplete understanding of the aberrant memory response to the formalin-inactivated RSV vaccine (FI-RSV) given to children in the 1960s. This vaccine caused enhanced respiratory disease (ERD) with later...

Implementation of research on potential drug target cloning and characterization in a biochemistry laboratory.

An approach for incorporating preliminary drug discovery research into a biochemistry laboratory is described. During a total of 42 hr (one 3-hr laboratory section a week for 14 weeks), students were exposed to bioinformatics; molecular cloning; protein expression, purification, and characterization; and enzymatic kinetic assays. This research-oriented laboratory not only includes the standard elements of common undergraduate biochemistry laboratory manuals but also emphasizes the logical connections am...

Engaging Ethicists in Animal Research Policymaking.

The significance of ethical considerations for animal research policy has long been acknowledged but the role of philosophical ethics in the policymaking process has been less clear. By comparing the ethical framework of animal research policy with that for human subjects research, this article considers how the legacies of these two policy areas influence current policy and suggests that ethicists and ethical scholarship have been underutilized in developing animal research policy. An important aspect of p...

Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery.

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease modeling and have unlocked new possibilities for understanding the mechanisms governing human biology, physiology, and genetics. However, hiPSC-derivatives have traditionally been utilized in two-dimensional monocultures, in contrast to the multi-systemic interactions that influence cells in the body. We will discuss recent advances in generating more complex hiPSC-based systems using three-dimensional organoids, tissue-en...

Anterior cervical discectomy and fusion requiring resection of the superior horn of thyroid cartilage: case report.

Anterior cervical discectomy and fusion (ACDF) is the most common surgical procedure utilized for degenerative diseases of the cervical spine. The authors present the case of a 64-year-old man who underwent an ACDF for degenerative changes causing cervical stenosis with myelopathy. The patient's symptoms consisted of pain and weakness of the bilateral upper extremities that slowly progressed over 1.5 years. During the procedure, the superior horn of the thyroid cartilage impeded proper retraction, preventin...

A Salisbury steak is not a steak, it's ground beef. The significance, messages and symbolism of final meals on death row.

The last meal on death row is a person's very last opportunity to eat. It marks the upcoming execution of that person. Therefore these meals represent meaning, symbolism and paradoxes, especially since inmates are free to choose what their last supper will consist of. By connecting investigated last meals in the 20th century from different states in the USA with several theoretical ideas, an attempt is made to shed light on the significance of this meal. Concepts like commensality, agency, power relations a...

Workshop report: Optimization of animal models to better predict influenza vaccine efficacy.

Animal models that can recapitulate the human immune system are essential for the preclinical development of safe and efficacious vaccines. Development and optimization of representative animal models are key components of the NIAID strategic plan for the development of a universal influenza vaccine. To gain insight into the current landscape of animal model usage in influenza vaccine development, NIAID convened a workshop in Rockville, Maryland that brought together experts from academia, industry and gove...

INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges.

Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T c...

A consideration of physiological regulation from the perspective of Bayesian enactivism.

How the animal regulates its internal environment is a central question in physiology. In recent years, the account of biological functions known as Bayesian enactivism has been extended from neuroscience to address processes of physiological regulation. Enactivism understands sensory action cycles of perception and behaviour to entail expectations of the causes of sensations received from the environment. Enactivism is Bayesian in that the organism strives to update expectations to better match the sensati...

Ethics in Farm animals: The role of the veterinarian in animal protection on the example of bovines.

In the present study, farm animal practitioners in Switzerland were questioned about their reported violations of the animal welfare law in cattle and their response to the detection of violations in the year 2017. The answers from 34 participants could be included in the evaluation. In 2017, 7.8% of the farms seen by participating practices were found to be in violation of the animal welfare law. It could be shown that the participating veterinarians reported only a small part (8.7%) of the detected offens...

Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies.

Clinicopathologic and Molecular Features of Intracranial Desmoplastic Small Round Cell Tumors.

Desmoplastic small round cell tumors (DSRCTs) are highly aggressive sarcomas that most commonly occur intra-abdominally, and are defined by EWSR1-WT1 gene fusion. Intracranial DSRCTs are exceptionally rare with only seven previously reported fusion-positive cases. Herein, we evaluate the clinical, morphologic, immunohistochemical, and molecular features of five additional examples. All patients were male (age range 6-25 years; median 11 years), with four tumors located supratentorially and one within the po...


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