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Showing "expands label Amgen Repatha" PubMed Articles 101–125 of 1,100+

Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS.

Glycoproteins play a central role in diverse biological processes and are linked with many serious human diseases. In this paper we present a simple, reproducible and cost-effective analytical workflow that enables the reliable quantification of clinically relevant human plasma glycoproteins using label free microflow LC-MS/MS analysis. Plasma N-glycoproteins were selectively extracted via ConA Sepharose lectin affinity chromatography then separated into two fractions using reversed-phase solid phase extrac...

Intestinal obstruction caused by a laxative drug (Psyllium): A case report and review of the literature.

Psyllium in granular dosage form is used as an over - the counter safe laxative drug. It has a considerable hygroscopic propriety which allows it to retain water and expands rapidly to become many times of its original size.

Correction: Eco-Label Conveys Reliable Information on Fish Stock Health to Seafood Consumers.

[This corrects the article DOI: 10.1371/journal.pone.0043765.].

Heter-LP: A Heterogeneous Label Propagation Method for Drug Repositioning.

Using existing drugs for diseases which are not developed for their treating (drug repositioning) provides a new approach to developing drugs at a lower cost, faster, and more secured. We proposed a method for drug repositioning which can predict simple and complex relationships between drugs, drug targets, and diseases. Since biological networks typically present a suitable model for relationships between different biological concepts, our primary approach is to analyze graphs and complex networks in the s...

Label-free classification of cells based on supervised machine learning of subcellular structures.

It is demonstrated that cells can be classified by pattern recognition of the subcellular structure of non-stained live cells, and the pattern recognition was performed by machine learning. Human white blood cells and five types of cancer cell lines were imaged by quantitative phase microscopy, which provides morphological information without staining quantitatively in terms of optical thickness of cells. Subcellular features were then extracted from the obtained images as training data sets for the machine...

An Open-Label Study of Sufentanil Sublingual Tablet 30 Mcg in Patients with Postoperative Pain.

Label-free plasmonic biosensors for point-of-care diagnostics: a review.

Optical biosensors and particularly those based on nanoplasmonics technology have emerged in recent decades as a potential solution for disease diagnostics and therapy follow-up at the point-of-care. These biosensor platforms could overcome some of the challenges faced in conventional diagnosis techniques offering label-free assays with immediate results and employing small and user-friendly devices. Areas covered: In this review, we will provide a critical overview of the recent advances in the development...

Simple and effective label free electrochemical immunosensor for Fig mosaic virus detection.

Here, the construction and characterization of the first immunosensor for highly sensitive and label free detection of Fig mosaic virus (FMV) is reported. The specific antibody against nucleocapsid of the virus was raised and immobilized at the surface of 11-mercaptoundecanoic acid (MUA) and 3-mercapto propionic acid (MPA) modified gold electrode, via carbodiimide coupling reaction. The immunosensor fabrication steps were characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy...

High-resolution label-free studies of molecular distribution and orientation in ultrathin, multicomponent model membranes with infrared nano-spectroscopy AFM-IR.

Biological membranes are undoubtedly very interesting systems. Unfortunately, their analysis is very complicated and therefore simplified artificial models, like Langmuir monolayers, are frequently applied. In this work a novel method of label-free monomolecular films analysis based on infrared nano-spectroscopy (AFM-IR) is presented. In order to verify applicability of this approach well-defined referential system of sphingomyelin (SM), cholesterol (Chol) and cyclosporin A (CsA) is applied. AFM-IR method a...

A novel RAD21 p.(Gln592del) variant expands the clinical description of Cornelia de Lange syndrome type 4 - Review of the literature.

Cornelia de Lange syndrome (CdLS) is a heterogeneous developmental disorder where 70% of clinically diagnosed patients harbor a mutation in one of five CdLS associated cohesin proteins. Around 500 mutations have been identified to cause CdLS, however only eight different alterations are identified in RAD21, encoding the RAD21 cohesin complex component protein that constitute the link between SMC1A and SMC3 within the cohesin ring. We report a 15-month-old boy presenting with developmental delay, distinct Cd...

An Open-label Randomized Phase 2 study of Durvalumab Alone or in Combination with Tremelimumab in Patients with Advanced Germ Cell Tumors (APACHE): Results from the First Planned Interim Analysis.

Dual-type responsive electrochemical biosensor for the detection of α2,6-sialylated glycans based on AuNRs-SA coupled with c-SWCNHs/S-PtNC nanocomposites signal amplification.

In this study, a dual-type responsive electrochemical biosensor was developed for the quantitative detection of α2,6-sialylated glycans (α2,6-sial-Gs), a potential biomarker of tumors. The gold nanorods (AuNRs), which exhibited great specific surface area, as well as good biocompatibility, was synthesized by the way of seed growth method. Furthermore, a biotin-streptavidin (biotin-SA) system was introduced to improve the immunoreaction efficiency. Accordingly, a label-free biosensor was fabricated based o...

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial.

Regulatory T cells (Tregs) prevent autoimmunity and control inflammation. Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose interleukin-2 (ld-IL2) expands and activates Tregs, it has a broad therapeutic potential.

Label-free ultrasensitive detection of breast cancer miRNA-21 biomarker employing electrochemical nano-genosensor based on sandwiched AgNPs in PANI and N-doped graphene.

MicroRNAs (miRNAs) are small, endogenous, noncoding RNAs, shown to be expressed abnormally in many tumors and identified as predictive biomarkers for early diagnosis of several cancers including the breast. Therefore, the label-free and highly sensitive detection of miRNAs is of critical significance. In this work, a highly sensitive and label-free nano-genosensor is developed for the detection of miRNA-21, a known breast cancer biomarker, based on a specific architecture of nitrogen-doped functionalized gr...

Predicting subcellular localizations of multi-label proteins by incorporating the sequence features into Chou's PseAAC.

Emergence of numerous genome projects has made the experimental classification of the protein localization almost impossible due to exponential increase in the number of protein samples. However, most of the applications are merely developed for single-plex and completely ignored the presence of one protein at two or more locations in a cell. In this regard, few attempts were carried out to target Multi-label protein localizations; consequently, undesirable accuracies are achieved. This paper presents a nov...

Consumer acceptance of natural sweeteners in protein beverages.

Protein beverage consumption by Americans has increased in recent years. Coupled with this increased consumption is an interest in natural sweeteners. The objective of this study was to evaluate the sensory properties of naturally sweetened ready-to-mix (RTM) whey protein beverages using 3 temporal methods and to formulate a natural noncaloric sweetener blend that could be added to RTM protein beverages to provide sweetness while still appealing in flavor to consumers. Iso-sweet concentrations of sweeteners...

Long-term safety results from a Phase 3 open-label study of a fixed combination halobetasol propionate 0.01% and tazarotene 0.045% (HP/TAZ) lotion in moderate-to-severe plaque psoriasis.

Effect of Menopausal Hormone Therapy on Bone Mineral Density in Chinese Women: A 2-Year, Prospective, Open-Label, Randomized-Controlled Trial.

BACKGROUND This study was designed to explore the effect of menopausal hormone therapy (MHT) on bone mineral density (BMD) in Chinese women. MATERIAL AND METHODS This was a prospective, open-label, randomized-controlled clinical trial. We randomly assigned 123 postmenopausal women to 3 groups: group A received 0.625 mg conjugated equine estrogen (CEE) plus 100 mg micronized progesterone (MP), group B received 0.3 mg CEE daily plus 100 mg MP, and group C received 0.625 mg CEE daily plus 10 mg dydrogesterone ...

Costs of streamlined HIV care delivery in rural Ugandan and Kenyan clinics in the search study.

As antiretroviral therapy (ART) rapidly expands in Sub-Saharan Africa using new efficient care models, data on costs of these approaches are lacking. We examined costs of a streamlined HIV care delivery model within a large HIV test-and-treat study in Uganda and Kenya.

Costs of streamlined HIV care delivery in rural Ugandan and Kenyan clinics in the search study.

As antiretroviral therapy (ART) rapidly expands in Sub-Saharan Africa using new efficient care models, data on costs of these approaches are lacking. We examined costs of a streamlined HIV care delivery model within a large HIV test-and-treat study in Uganda and Kenya.

Identification of Nanoparticles via Plasmonic Scattering Interferometry.

The increasing use of nanomaterials calls for the emergence of new technologies to identify and characterize nanosized objects, especially in aqueous solutions. While the development of optical imaging techniques has led to significant advancements in single-nanoparticle tracking and analysis, these techniques are incapable of label-free selective nanoparticle recognition. Here, we demonstrated a label-free plasmonic imaging technology that is able to identify different kinds of nanoparticles in water. We p...

Patient Health Information Shared Electronically by Office-based Physicians: United States, 2015.

This report expands upon previous research that described the percentage of physicians who electronically sent, received, integrated, and searched for patient health information (PHI) by describing types of PHI that are electronically shared in physician offices.

Triamterene-grafted g-C3N4 with electronic potential redistribution for efficient photocatalytic hydrogen evolution.

In this study, we report a photocatalyst with distorted skeleton, which was synthesized by grafting triamterene onto graphitic carbon nitride (g-C3N4) frameworks. Pteridine ring of triamterene-based nitrogen-enriched organic structure, functions as trapped electron sites due to its inductive effect. Benzene ring in triamterene plays an important role on even dispersion of electrons by conjugative effect. Intramolecular electronic potential redistribution caused by synergistic effect between pteridine ring a...

Need for Affect, Interpersonal Psychological Theory of Suicide, and Suicide Proneness.

The present study expands upon the Interpersonal Psychological Theory of Suicide (IPTS), examining its relationship with the need for affect (NFA), a construct explaining attitudes toward seeking both positive and negative emotions.

Dupilumab for off-label treatment of moderate to severe childhood atopic dermatitis.

Atopic dermatitis (AD) is a complex chronic pruritic skin disease in which helper T cell (TH2)-type cytokines IL-4 and IL-13 are key contributors in the inflammatory response. Debate still exists as to whether disease initiation is due to immune responses or barrier dysregulation. The disease course is divided into infantile, childhood, and adolescent/adult stages and exhibits an extensive clinical spectrum. Topical agents have been the mainstay of treatment in childhood AD. Phototherapy has been successful...

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