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PubMed Journals Articles About "Exercise Training Exercise Training Plus Metformin Metformin Educational" - Page: 5 RSS

12:22 EST 15th November 2018 | BioPortfolio

Exercise Training Exercise Training Plus Metformin Metformin Educational PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Exercise Training Exercise Training Plus Metformin Metformin Educational articles that have been published worldwide.

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Showing "Exercise training Exercise training plus metformin Metformin Educational" PubMed Articles 101–125 of 5,700+

Adult Skeletal Muscle Deletion of Mitofusin 1 and 2 Impedes Exercise Performance and Training Capacity.

Endurance exercise has been shown to be a positive regulator of skeletal muscle metabolic function. Changes in mitochondrial dynamics (fusion and fission) have been shown to influence mitochondrial oxidative capacity. We therefore tested whether genetic disruption of mitofusins (Mfns) affected exercise performance in adult skeletal muscle. We generated adult inducible skeletal muscle-specific Mfn1 (iMS-Mfn1KO), Mfn2 (iMS-Mfn2KO) and Mfn1/2 knockout mice (iMS-MfnDKO). We assessed exercise capacity by perform...


Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial.

There is a well-known correlation between obesity, sedentary lifestyle, and breast cancer incidence and outcome. The Arbeitsgemeinschaft Medikamentöse Tumortherapie (AGMT) exercise study was a multicenter, randomized clinical trial and assessed the feasibility and efficacy of physical training in 50 breast cancer patients undergoing aromatase inhibitor treatment.

Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause.

The study aimed at evaluating the effects of combined aerobic and resistance exercise training on cardiac morphometry and function, oxidative stress and inflammatory parameters in diabetic ovariectomized rats. For this, female Wistar rats (10 weeks-old) were divided into 4 groups (n = 8): euglycemic (E), diabetic (streptozotocin, 50 mg/kg, iv) (D), diabetic ovariectomized (DO) and trained diabetic ovariectomized (TDO). The combined exercise training was performed on a treadmill and in a ladder adapted to ra...


Metformin Is Associated with Improved Survival and Decreased Cardiac Events With No Impact on Patency and Limb Salvage After Revascularization for Peripheral Arterial Disease.

The incidence of cardiovascular and limb-specific adverse outcomes is higher in PAD patients with diabetes. Metformin is associated with improved cardiovascular morbidity and mortality. However, the effect of metformin on limb-specific outcomes is unclear. The objective of this study was to assess the effect of metformin on outcomes following intervention for PAD.

Effects of High-Intensity Inspiratory Muscle Training Associated with Aerobic Exercise in Patients Undergoing CABG: Randomized Clinical Trial.

Evaluate the interaction between high-intensity inspiratory muscle training (IMT) and aerobic exercise on physical capacity, respiratory muscle strength, peripheral muscle strength, and quality of life of patients who underwent coronary artery bypass grafting (CABG).

Enhanced erythrocyte antioxidant status following an 8-week aerobic exercise training program in heavy drinkers.

Alcohol-induced oxidative stress is involved in the development and progression of various pathological conditions and diseases. On the other hand, exercise training has been shown to improve redox status, thus attenuating oxidative stress-associated disease processes. The purpose of the present study was to evaluate the effect of an exercise training program that has been previously reported to decrease alcohol consumption on blood redox status in heavy drinkers. In a non-randomized within-subject design, ...

Acute Effect of Popular High-Intensity Functional Training Exercise on Physiologic Markers of Growth.

Kliszczewicz, B, Markert, CD, Bechke, E, Williamson, C, Clemons, KN, Snarr, RL, and McKenzie, MJ. Acute effect of popular high-intensity functional training exercise on physiologic markers of growth. J Strength Cond Res XX(X): 000-000, 2018-Constantly evolving, high-intensity functional training (HIFT) exercise consists of various modalities, orders, weights, and repetition schemes. High-intensity functional training has gained popularity among the general population, but lacks empirical evidence regarding ...

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.

Metformin has been reported to possess antitumor activity and maintain high cytotoxic T lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of metformin's role in cancer immunity are not fully understood. Here, we show that metformin increases CTL activity by reducing the stability and membrane localization of programmed death ligand-1 (PD-L1). Furthermore, we discover that AMP-activated protein kinase (AMPK) activated by metformin directly phosphorylates S195 of PD-L1. S195...

Acute effect of three different exercise training modalities on executive function in overweight inactive men: The BrainFit Study.

There is currently a consensus about the positive effects of physical exercise on cognition. However, the exercise intensity-dependent effect on executive function remains unclear. Thus, the aim of this study was to compare the acute effects of high-intensity aerobic interval training (HIIT), progressive resistance training (PRT), or combined training (PRT + HIIT) on executive function indicators in overweight inactive adult men (aged 18-30 years old). The participants were screened and excluded for m...

Modality-Specific Exercise Guidelines and Quality of Life in Kidney Cancer Survivors: A Cross-Sectional Study.

Few exercise oncology trials have compared aerobic to strength exercise or compared combined exercise (i.e., aerobic and strength training) to aerobic only or strength only. It is unknown what single or combined exercise modality is optimal for quality of life (QoL) in cancer survivors. The purpose of this study is to estimate the prevalence of meeting the combined and independent aerobic and strength exercise guidelines in kidney cancer survivors (KCS) and determine any associations with QoL.

Functional behaviour of spinal muscles after training with an exercise device developed to recruit and train postural muscles.

This study investigated the effects of a single exercise session using a device developed for postural muscle training on the function of postural muscles in healthy, pain free individuals. During standardised rapid arm movements, timing of onset of electromyography (EMG) was measured using intramuscular and surface recordings of the transversus abdominis (TrA), obliquus internus abdominis (OI), obliquus externus abdominis (OE), lumbar multifidus (LM) and lumbar erector spinae (LES) muscles. A single exerci...

Effects of aerobic training with and without weight loss on insulin sensitivity and lipids.

The purpose of this study is to evaluate the effect of exercise training with modest or greater weight loss (≥3%) or not (

Pentraxin3 increases in adult overweight and obese men after weight-loss by dietary modification with exercise training.

The circulatory level of pentraxin3 (PTX3), an anti-inflammatory cardio-protective protein, has been known to be lower in obese individuals than in those with normal weight. However, reports on the effects of different weight-loss methods on PTX3 were limited. The present study aimed to investigate the effect of weight loss on the circulating PTX3 levels in overweight and obese men and to examine the combined effect of dietary modification and exercise training on PTX3 levels. Forty-eight overweight and obe...

Disparities in the Efficacy of Metformin in Combination with Dipeptidyl Peptidase-4 Inhibitor as Initial Treatment Stratified by Dosage and Ethnicity: A Meta-Analysis.

As initial combination therapy of metformin and dipeptidyl peptidase-4 (DPP-4) inhibitor, the efficacy and safety for the use of high dose of metformin or low dose of metformin and the efficacy and safety for the combination use for Asian and Caucasian patients were not clear.

Effects of an Upper-Body Training Program Involving Resistance Exercise and High-Intensity Arm Cranking on Peak Handcycling Performance and Wheelchair Propulsion Efficiency in Able-Bodied Men.

Chaikhot, D, Reed, K, Petroongrad, W, Athanasiou, F, van Kooten, D, and Hettinga, FJ. Effects of an upper-body training program involving resistance exercise and high-intensity arm cranking on peak handcycling performance and wheelchair propulsion efficiency in able-bodied men. J Strength Cond Res XX(X): 000-000, 2018-The aim of this study was to determine the training effects of an upper-body training program involving resistance exercise and high-intensity arm cranking on peak handcycling performance, pro...

Vastly Different Exercise Programs Similarly Improve Parkinsonian Symptoms: A Randomized Clinical Trial.

To directly compare the effects of agility exergaming (EXE) and stationary cycling (CYC) exercise training on Parkinson's disease (PD) patients' mobility and clinical symptoms.

Improvements in cognition and associations with measures of aerobic fitness and muscular power following structured exercise.

Cognition, along with aerobic and muscular fitness, declines with age. Although research has shown that resistance and aerobic exercise may improve cognition, no consensus exists supporting the use of one approach over the other. The purpose of this study was to compare the effects of steady-state, moderate-intensity treadmill training (TM) and high-velocity circuit resistance training (HVCRT) on cognition, and to examine its relationships to aerobic fitness and neuromuscular power.

Intense exercise and endurance-training program influence serum kinetics of muscle and cardiac biomarkers in dogs.

Few data exist on the physiological consequences of an incremental exercise test (IET) and training in dogs. Here we evaluated the effect of an endurance-training program (ETP) on the kinetics of the serum biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), myoglobin, cardiac troponin I (cTnI), and creatine kinase isoenzyme MB (CK-MB). Eighteen Beagle dogs were assigned to three groups: sedentary (S), untrained (U), and trained (T). The dogs from the groups T and U underwent IET, and their l...

Non-ischemic heart preconditioning.

Ischemic heart conditioning has been shown to protect the organ against ischemia/reperfusion injury. Animal studies have revealed that the heart can also be conditioned by non-ischemic procedures, namely physical exercise and tachycardia. Long and short term endurance training, sprint training, resistance or interval training and even one bout of exercise induce cardiac preconditioning, which is manifested by a reduction in post ischemia/reperfusion infarct size, ventricular arrhythmia and improved heart fu...

Effect of suspension exercise training on motor and balance functions in children with spastic cerebral palsy.

To study the effect of suspension exercise training on motor and balance functions in children with spastic cerebral palsy.

Effect of a non-systemic, orally-administered hydrogel, GS100, on metformin pharmacokinetics.

Overweight and obesity are major health concerns worldwide, and are major predisposing factors for type 2 diabetes. This single centre, Phase I, randomised, open-label, single-dose, four-arm crossover, device-drug interaction study on 24 healthy volunteers with a body mass index of 25-40 kg/m2 tested the effect of a novel, non-systemic, orally administered hydrogel (GS100) on the pharmacokinetics of the oral antidiabetic drug, metformin. When administered in both the fed and fasted states, the effect of GS1...

Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice.

Although a mountain of papers have showed that metformin plays a role in inhibiting cancers, but the mechanism underpinning this has not yet fully elucidated. Herein, we used AOM/DSS model, the clinicopathological features are similar to those found in humans, to investigate the effects of metformin as well as combination with 5-FU in the prevention of colitis and colitis associated cancer (CAC). Oral metformin significantly inhibited DSS-induced ulcerative colitis and AOM/DSS-induced CAC. Metformin also am...

Training to improve quality of life and physical functioning in cancer; which type of training, for which patient, and at which moment?

To investigate whether the effects of exercise on quality of life and physical functioning in patients with cancer is dependent upon certain patient characteristics or on specific training programmes.

A comparison of blood pressure reductions following 12-weeks of isometric exercise training either in the laboratory or at home.

Isometric exercise training (IET)-induced reductions in resting blood pressure (RBP) have been achieved in laboratory environments, but data in support of IET outside the laboratory are scarce. The aim of this study was to compare 12 weeks of home-based (HOM) IET with laboratory-based, face-to-face (LAB) IET in hypertensive adults. Twenty-two hypertensive participants (24-60 years) were randomized to three conditions: HOM, LAB, or control (CON). IET involved isometric handgrip training (4 × 2 minutes at 3...

Zebrafish (Danio rerio) as a Model for Sprint Exercise Training.

Sprint performance is important ecologically and physiologically, and it can influence fitness by determining outcomes of predator-prey relationships, for example, and it can confer substantial human health benefits. In this article we test whether zebrafish (Danio rerio) are a suitable model to test hypotheses about the effects and consequences of sprint exercise training, and the physiological underpinnings of sprint performance. We show that stage 3 c-starts that capture the initial escape response of fi...


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